Intervertebral Disc Regeneration By Use Of Autologous Mesenchymal Stem Cells

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Finding What Works in Health Care

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309164257
Total Pages : 267 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Finding What Works in Health Care by : Institute of Medicine

Download or read book Finding What Works in Health Care written by Institute of Medicine and published by National Academies Press. This book was released on 2011-07-20 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare decision makers in search of reliable information that compares health interventions increasingly turn to systematic reviews for the best summary of the evidence. Systematic reviews identify, select, assess, and synthesize the findings of similar but separate studies, and can help clarify what is known and not known about the potential benefits and harms of drugs, devices, and other healthcare services. Systematic reviews can be helpful for clinicians who want to integrate research findings into their daily practices, for patients to make well-informed choices about their own care, for professional medical societies and other organizations that develop clinical practice guidelines. Too often systematic reviews are of uncertain or poor quality. There are no universally accepted standards for developing systematic reviews leading to variability in how conflicts of interest and biases are handled, how evidence is appraised, and the overall scientific rigor of the process. In Finding What Works in Health Care the Institute of Medicine (IOM) recommends 21 standards for developing high-quality systematic reviews of comparative effectiveness research. The standards address the entire systematic review process from the initial steps of formulating the topic and building the review team to producing a detailed final report that synthesizes what the evidence shows and where knowledge gaps remain. Finding What Works in Health Care also proposes a framework for improving the quality of the science underpinning systematic reviews. This book will serve as a vital resource for both sponsors and producers of systematic reviews of comparative effectiveness research.

Intervertebral Disc Regeneration

Author : Benjamin Gantenbein
Publisher : Mdpi AG
ISBN 13 : 9783036527543
Total Pages : 138 pages
Book Rating : 4.5/5 (275 download)

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Book Synopsis Intervertebral Disc Regeneration by : Benjamin Gantenbein

Download or read book Intervertebral Disc Regeneration written by Benjamin Gantenbein and published by Mdpi AG. This book was released on 2022-01-11 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a brief snapshot of recent research on the subject of intervertebral disc degeneration and how this specific organ could be regenerated. It provides stimuli to the reader in representing research from different angles in this cross-disciplinary field of spine surgeons, mechanical engineers and biologists. In particular, it is instructive as to how disc herniations could be successfully induced in vitro and, also, to how novel cell-based therapies using rare autochthonous stem cells could potentially be used in the future.

The Intervertebral Disc

Author : Irving M. Shapiro
Publisher : Springer Science & Business Media
ISBN 13 : 3709115353
Total Pages : 440 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis The Intervertebral Disc by : Irving M. Shapiro

Download or read book The Intervertebral Disc written by Irving M. Shapiro and published by Springer Science & Business Media. This book was released on 2013-09-02 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intervertebral disc is a complex structure that separates opposing vertebrae, permits a wide range of motion, and accommodates high biomechanical forces. Disc degeneration leads to a loss of function and is often associated with excruciating pain. Written by leading scientists and clinicians, the first part of the book provides a review of the basic biology of the disc in health and disease. The second part considers strategies to mitigate the effects of disc degeneration and discusses the possibility of engineering replacement tissues. The final section is devoted to approaches to model normal development and elucidate the pathogenesis of degenerative disc disease using animal, organ and cell culture techniques. The book bridges the gap between the basic and clinical sciences; the target audience includes basic scientists, orthopaedists and neurologists, while at the same time appealing to the needs of graduate students, medical students, interns and fellows.

Mesenchymal Stem Cell Therapy

Author : Lucas G. Chase
Publisher : Springer Science & Business Media
ISBN 13 : 1627032002
Total Pages : 458 pages
Book Rating : 4.6/5 (27 download)

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Book Synopsis Mesenchymal Stem Cell Therapy by : Lucas G. Chase

Download or read book Mesenchymal Stem Cell Therapy written by Lucas G. Chase and published by Springer Science & Business Media. This book was released on 2012-12-12 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Advances In Tissue Engineering

Author : Julia M Polak
Publisher : World Scientific
ISBN 13 : 1908978902
Total Pages : 947 pages
Book Rating : 4.9/5 (89 download)

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Book Synopsis Advances In Tissue Engineering by : Julia M Polak

Download or read book Advances In Tissue Engineering written by Julia M Polak and published by World Scientific. This book was released on 2008-08-20 with total page 947 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Tissue Engineering is a unique volume and the first of its kind to bring together leading names in the field of tissue engineering and stem cell research. A relatively young science, tissue engineering can be seen in both scientific and sociological contexts and successes in the field are now leading to clinical reality. This book attempts to define the path from basic science to practical application. A contribution from the UK Stem Cell Bank and opinions of venture capitalists offer a variety of viewpoints, and exciting new areas of stem cell biology are highlighted. With over fifty stellar contributors, this book presents the most up-to-date information in this very topical and exciting field./a

In Situ Tissue Regeneration

Author : Sang Jin Lee
Publisher : Academic Press
ISBN 13 : 012802500X
Total Pages : 460 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis In Situ Tissue Regeneration by : Sang Jin Lee

Download or read book In Situ Tissue Regeneration written by Sang Jin Lee and published by Academic Press. This book was released on 2016-07-17 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body's ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body's own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications. - Explores the body's ability to mobilize endogenous stem cells to the site of injury - Details the latest strategies developed for inducing and supporting the body's own regenerating capacity - Presents smart biomaterials in cell-based tissue engineering applications—from the cell level to applications—in the first unified volume - Features chapter authors and editors who are authorities in this emerging field - Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry

Handbook of Spine Technology

Author : Boyle C. Cheng
Publisher : Springer
ISBN 13 : 9783319444239
Total Pages : 0 pages
Book Rating : 4.4/5 (442 download)

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Book Synopsis Handbook of Spine Technology by : Boyle C. Cheng

Download or read book Handbook of Spine Technology written by Boyle C. Cheng and published by Springer. This book was released on 2021-04-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is the most authoritative and up-to-date reference on spine technology written for practitioners, researchers, and students in bioengineering and clinical medicine. It is the first resource to provide a road map of both the history of the field and its future by documenting the poor clinical outcomes and failed spinal implants that contributed to problematic patient outcomes, as well as the technologies that are currently leading the way towards positive clinical outcomes. The contributors are leading authorities in the fields of engineering and clinical medicine and represent academia, industry, and international government and regulatory agencies. The chapters are split into five sections, with the first addressing clinical issues such as anatomy, pathology, oncology, trauma, diagnosis, and imaging studies. The second section, on biomechanics, delves into fixation devices, the bone implant interface, total disc replacements, injury mechanics, and more. The last three sections, on technology, are divided into materials, commercialized products, and surgery. All appropriate chapters will be continually updated and available on the publisher’s website, in order to keep this important reference as up-to-date as possible in a fast-moving field.

Mesenchymal Stem Cell in Veterinary Sciences

Author : Mudasir Bashir Gugjoo
Publisher : Springer Nature
ISBN 13 : 9811560374
Total Pages : 347 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Mesenchymal Stem Cell in Veterinary Sciences by : Mudasir Bashir Gugjoo

Download or read book Mesenchymal Stem Cell in Veterinary Sciences written by Mudasir Bashir Gugjoo and published by Springer Nature. This book was released on 2020-11-09 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on mesenchymal stem cells (MSCs) of animal origin, including their isolation, characterization, and clinical applications. After briefly discussing the historical development of the field of stem cell research, it describes the basic properties and nature of stem cells particularly in relation to MSCs. In turn, it reviews materials and methods used to isolate MSCs from various sources, culture expansion, characterization and long-term storage. It also explores the therapeutic efficacy, immunomodulation and anti-inflammatory, and differentiation properties of MSCs. Importantly, the book discusses the applications of genetic engineering to enhance the efficacy and potential of MSCs in regenerative medicine. The book largely addresses the potential applications of mesenchymal stem cells in therapies for important species of domesticated animals including sheep, goats, cattle, buffalo, cats, dogs and horses. Finally, the book presents an abridgement of challenges and future prospects of stem cell research and application in medicine, in general and veterinary sciences, in particular.

Principles of Regenerative Medicine

Author : Anthony Atala
Publisher : Academic Press
ISBN 13 : 0123814235
Total Pages : 1203 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Principles of Regenerative Medicine by : Anthony Atala

Download or read book Principles of Regenerative Medicine written by Anthony Atala and published by Academic Press. This book was released on 2010-12-16 with total page 1203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. - Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology - The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine - New discoveries from leading researchers on restoration of diseased tissues and organs

Stem Cell and Tissue Engineering

Author : Song Li
Publisher : World Scientific
ISBN 13 : 9814317055
Total Pages : 473 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis Stem Cell and Tissue Engineering by : Song Li

Download or read book Stem Cell and Tissue Engineering written by Song Li and published by World Scientific. This book was released on 2011 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue engineering integrates knowledge and tools from biological sciences and engineering for tissue regeneration. A challenge for tissue engineering is to identify appropriate cell sources. The recent advancement of stem cell biology provides enormous opportunities to engineer stem cells for tissue engineering. The impact of stem cell technology on tissue engineering will be revolutionary. This book covers state-of-the-art knowledge on the potential of stem cells for the regeneration of a wide range of tissues and organs and the technologies for studying and engineering stem cells. It serves as a valuable reference book for researchers and students.

Dental Stem Cells: Regenerative Potential

Author : Barbara Zavan
Publisher : Humana Press
ISBN 13 : 3319332996
Total Pages : 288 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Dental Stem Cells: Regenerative Potential by : Barbara Zavan

Download or read book Dental Stem Cells: Regenerative Potential written by Barbara Zavan and published by Humana Press. This book was released on 2016-07-25 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the basic aspects of dental stem cells (DSCs) as well as their clinical applications in tissue engineering and regenerative medicine. It opens with a discussion of classification, protocols, and properties of DSCs and proceeds to explore DSCs within the contexts of cryopreservation; epigenetics; pulp, periodontal, tooth, bone, and corneal stroma regeneration; neuronal properties, mesenchymal stem cells and biomaterials; and as sources of hepatocytes for liver disease treatment. The fifteen expertly authored chapters comprehensively examine possible applications of DSCs and provide invaluable insights into mechanisms of growth and differentiation. Dental Stem Cells: Regenerative Potential draws from a wealth of international perspectives and is an essential addition to the developing literature on dental stem cells. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is indispensable for biomedical researchers interested in bioengineering, dentistry, tissue engineering, regenerative medicine, cell biology and oncology.

Mesenchymal Stem Cell Derived Exosomes

Author : Yaoliang Tang
Publisher : Academic Press
ISBN 13 : 0128004975
Total Pages : 287 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Mesenchymal Stem Cell Derived Exosomes by : Yaoliang Tang

Download or read book Mesenchymal Stem Cell Derived Exosomes written by Yaoliang Tang and published by Academic Press. This book was released on 2015-09-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. - Introduces the MSC-exosome mediated cell-cell communication - Covers the major functional benefits in current MSC-derived exosome studies - Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles

Author : Venkatram Prasad Shastri
Publisher : Springer Science & Business Media
ISBN 13 : 9048187885
Total Pages : 414 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles by : Venkatram Prasad Shastri

Download or read book Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles written by Venkatram Prasad Shastri and published by Springer Science & Business Media. This book was released on 2010-08-14 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the NATO Advanced Research Workshop (ARW) on “Nanoengineered Systems for Regenerative Medicine” that was organized under the auspices of the NATO Security through Science Program. I would like to thank NATO for supporting this workshop via a grant to the co-directors. The objective of ARW was to explore the various facets of regenerative me- cine and to highlight role of the “the nano-length scale” and “nano-scale systems” in defining and controlling cell and tissue environments. The development of novel tissue regenerative strategies require the integration of new insights emerging from studies of cell-matrix interactions, cellular signalling processes, developmental and systems biology, into biomaterials design, via a systems approach. The chapters in the book, written by the leading experts in their respective disciplines, cover a wide spectrum of topics ranging from stem cell biology, developmental biology, ce- matrix interactions, and matrix biology to surface science, materials processing and drug delivery. We hope the contents of the book will provoke the readership into developing regenerative medicine paradigms that combine these facets into cli- cally translatable solutions. This NATO meeting would not have been successful without the timely help of Dr. Ulrike Shastri, Sanjeet Rangarajan and Ms. Sabine Benner, who assisted in the organization and implementation of various elements of this meeting. Thanks are also due Dr. Fausto Pedrazzini and Ms. Alison Trapp at NATO HQ (Brussels, Belgium). The commitment and persistence of Ms.

Stem Cells in Aesthetic Procedures

Author : Melvin A. Shiffman
Publisher : Springer
ISBN 13 : 3642452078
Total Pages : 815 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Stem Cells in Aesthetic Procedures by : Melvin A. Shiffman

Download or read book Stem Cells in Aesthetic Procedures written by Melvin A. Shiffman and published by Springer. This book was released on 2014-07-21 with total page 815 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the use of stem cells in aesthetic procedures has been increasing rapidly, reflecting the widespread acknowledgment of the tremendous potential of stem cell fat transfer. This is, however, the first book to be devoted entirely to the subject. The book opens by reviewing the history of the development of pluripotent stem cells and the results of research into the biochemistry and physiology of stem cells. Adipose tissue anatomy and survival are discussed and the wide range of aesthetic procedures involving stem cell fat transfer are then described in detail. These procedures relate to the face, breast, buttocks, legs, hands, penis and Poland syndrome. In addition, potential risks and complications are identified. The book has been written by leading experts and will be an invaluable source of information for students, beginners and experienced surgeons in a range of specialties.

Balloon Kyphoplasty

Author : Stephan Becker
Publisher : Springer Science & Business Media
ISBN 13 : 3211742212
Total Pages : 169 pages
Book Rating : 4.2/5 (117 download)

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Book Synopsis Balloon Kyphoplasty by : Stephan Becker

Download or read book Balloon Kyphoplasty written by Stephan Becker and published by Springer Science & Business Media. This book was released on 2008-04-05 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to cover minimal-invasive treatment of osteoporotic, tumorous and traumatic vertebral fractures in the English language. In addition to detailed descriptions of the techniques, including tips and tricks from experts, the book contains a chapter about the medical treatment of osteoporosis, which is indispensable in the interdisciplinary approach to osteoporosis. This acclaimed innovative concept unites several treatment aspects. More conservative treatment methods are also presented in this work. All chapters reflect new developments and clinical findings in the field of orthopaedics, surgery, traumatology and neurosurgery.

Essentials of Regenerative Medicine in Interventional Pain Management

Author : Annu Navani
Publisher : Springer Nature
ISBN 13 : 3031503570
Total Pages : 615 pages
Book Rating : 4.0/5 (315 download)

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Book Synopsis Essentials of Regenerative Medicine in Interventional Pain Management by : Annu Navani

Download or read book Essentials of Regenerative Medicine in Interventional Pain Management written by Annu Navani and published by Springer Nature. This book was released on with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Therapeutic Applications of Mesenchymal Stem Cells in Veterinary Medicine

Author : Mudasir Bashir Gugjoo
Publisher : Springer Nature
ISBN 13 : 9811932778
Total Pages : 418 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Therapeutic Applications of Mesenchymal Stem Cells in Veterinary Medicine by : Mudasir Bashir Gugjoo

Download or read book Therapeutic Applications of Mesenchymal Stem Cells in Veterinary Medicine written by Mudasir Bashir Gugjoo and published by Springer Nature. This book was released on 2022-08-05 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the potential therapeutic and reproductive applications of mesenchymal stem cells in veterinary regenerative and reproductive medicine. The systemic approach focuses on musculoskeletal structures like cartilage, bone, muscle, tendon, ligaments and nervous tissues. It also focuses on other body systems like gastrointestinal, cardiovascular, urogenital, respiratory and integumentary system. Besides, the special glands or organs like endocrine glands and eye and its adnexa are also focused. The book chapters discusses the problems and the need for regenerative medicine employing MSCs. It provides an ex vivo basis of MSCs therapeutics and reproductive potential followed by their in vivo applications. The book further provides an understanding on the behavior and mechanisms of action of mesenchymal stem cells. The book also abridges challenges and provides future prospects of mesenchymal stem cells in clinical and reproductive applications. As such, the book offers a valuable resource for students, veterinarians, and scientists working in the regenerative and reproductive sciences in human and veterinary medicine.