Interpretation And Extrapolation Of Chemical And Biological Carcinogenicity Data To Establish Human Safety Standards

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Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards

Author : H.C. Grice
Publisher : Springer
ISBN 13 : 9783540136965
Total Pages : 0 pages
Book Rating : 4.1/5 (369 download)

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Book Synopsis Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards by : H.C. Grice

Download or read book Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards written by H.C. Grice and published by Springer. This book was released on 1984-11-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Life Sciences Institute (lLSI) is a scientific foundation wh ich addresses critical health and safety issues of national and international concern. ILSI promotes international cooperation by pro viding the mechanism for scientists from government, industry and universities to work together on cooperative programs to generate and disseminate scientific data. The members and trustees of the Institute believe that questions regarding health and safety are best resolved when scientists can ex amine and discuss issues, as an independent body, se~arate from the political pressures of individual countries and the economic concerns of individual companies. Frequently, meaningful assessment of the risk of a test substance is hindered by the inherent inconsistencies in the system. The development and refinement of methods and systems to evaluate the safety of chemicals have evolved in a rapid and largely unplanned fashion. Attempts to improve the system have largely been directed toward broad general concerns, with little attention being given to specific problems or issues. A failure to resolve these problems has frequently resulted in increased testing costs and complications in the assessment and extrapolation of the results. Publicity surrounding toxicologic issues has created chronic public apprehension about the ability of science and government to deal effectively with these problems. In response to these difficulties, ILSI has assembled highly qualified and renowned scientists from research institutes, universities, government and industry, with relevant scientific knowledge and expertise regarding the issues that complicate risk assessment procedures.

Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards

Author : H C Grice
Publisher :
ISBN 13 : 9783642493720
Total Pages : 208 pages
Book Rating : 4.4/5 (937 download)

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Book Synopsis Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards by : H C Grice

Download or read book Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards written by H C Grice and published by . This book was released on 1984-11-01 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards ; The Use of Short-term Tests for Mutagenicity and Carcinogenicity in Chemical Hazard Evaluation

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Author : International Life Sciences Institute
Publisher : Springer
ISBN 13 :
Total Pages : 218 pages
Book Rating : 4.:/5 (3 download)

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Book Synopsis Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards ; The Use of Short-term Tests for Mutagenicity and Carcinogenicity in Chemical Hazard Evaluation by : International Life Sciences Institute

Download or read book Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards ; The Use of Short-term Tests for Mutagenicity and Carcinogenicity in Chemical Hazard Evaluation written by International Life Sciences Institute and published by Springer. This book was released on 1984 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:

CURRENT ISSUES IN TOXICOLOGY; Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards; The Use of Short-Term Tests for Mutagenicity and Carcinogenicity in Chemical Hazard Evaluation

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Author : GRICE HC.
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)

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Book Synopsis CURRENT ISSUES IN TOXICOLOGY; Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards; The Use of Short-Term Tests for Mutagenicity and Carcinogenicity in Chemical Hazard Evaluation by : GRICE HC.

Download or read book CURRENT ISSUES IN TOXICOLOGY; Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards; The Use of Short-Term Tests for Mutagenicity and Carcinogenicity in Chemical Hazard Evaluation written by GRICE HC. and published by . This book was released on 1984 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards

Author : H.C. Grice
Publisher : Springer Science & Business Media
ISBN 13 : 3642493718
Total Pages : 200 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards by : H.C. Grice

Download or read book Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards written by H.C. Grice and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Life Sciences Institute (lLSI) is a scientific foundation wh ich addresses critical health and safety issues of national and international concern. ILSI promotes international cooperation by pro viding the mechanism for scientists from government, industry and universities to work together on cooperative programs to generate and disseminate scientific data. The members and trustees of the Institute believe that questions regarding health and safety are best resolved when scientists can ex amine and discuss issues, as an independent body, se~arate from the political pressures of individual countries and the economic concerns of individual companies. Frequently, meaningful assessment of the risk of a test substance is hindered by the inherent inconsistencies in the system. The development and refinement of methods and systems to evaluate the safety of chemicals have evolved in a rapid and largely unplanned fashion. Attempts to improve the system have largely been directed toward broad general concerns, with little attention being given to specific problems or issues. A failure to resolve these problems has frequently resulted in increased testing costs and complications in the assessment and extrapolation of the results. Publicity surrounding toxicologic issues has created chronic public apprehension about the ability of science and government to deal effectively with these problems. In response to these difficulties, ILSI has assembled highly qualified and renowned scientists from research institutes, universities, government and industry, with relevant scientific knowledge and expertise regarding the issues that complicate risk assessment procedures.

ILAR News

Author : Institute of Laboratory Animal Resources (U.S.)
Publisher :
ISBN 13 :
Total Pages : 326 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis ILAR News by : Institute of Laboratory Animal Resources (U.S.)

Download or read book ILAR News written by Institute of Laboratory Animal Resources (U.S.) and published by . This book was released on 1984 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Interpretation and Extrapolation of Reproductive Data to Establish Human Safety Standards

Author : K. S. Khera
Publisher : New York : Springer-Verlag
ISBN 13 : 9783540969624
Total Pages : 133 pages
Book Rating : 4.9/5 (696 download)

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Book Synopsis Interpretation and Extrapolation of Reproductive Data to Establish Human Safety Standards by : K. S. Khera

Download or read book Interpretation and Extrapolation of Reproductive Data to Establish Human Safety Standards written by K. S. Khera and published by New York : Springer-Verlag. This book was released on 1989-01-01 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Information Resources in Toxicology

Author : P.J. Bert Hakkinen
Publisher : Elsevier
ISBN 13 : 008053466X
Total Pages : 953 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Information Resources in Toxicology by : P.J. Bert Hakkinen

Download or read book Information Resources in Toxicology written by P.J. Bert Hakkinen and published by Elsevier. This book was released on 2000-01-10 with total page 953 pages. Available in PDF, EPUB and Kindle. Book excerpt: Information Resources in Toxicology, Third Edition is a sourcebook for anyone who needs to know where to find toxicology information. It provides an up-to-date selective guide to a large variety of sources--books, journals, organizations, audiovisuals, internet and electronic sources, and more. For the Third Edition, the editors have selected, organized, and updated the most relevant information available. New information on grants and other funding opportunities, physical hazards, patent literature, and technical reports have also been added.This comprehensive, time-saving tool is ideal for toxicologists, pharmacologists, drug companies, testing labs, libraries, poison control centers, physicians, legal and regulatory professionals, and chemists. - Serves as an all-in-one resource for toxicology information - New edition includes information on publishers, grants and other funding opportunities, physical hazards, patent literature, and technical reports - Updated to include the latest internet and electronic sources, e-mail addresses, etc. - Provides valuable data about the new fields that have emerged within toxicological research; namely, the biochemical, cellular, molecular, and genetic aspects

Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1712 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Current Catalog by : National Library of Medicine (U.S.)

Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1985 with total page 1712 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.

National Library of Medicine Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1728 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1985 with total page 1728 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Drinking Water and Health, Volume 8

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309037751
Total Pages : 507 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Drinking Water and Health, Volume 8 by : National Research Council

Download or read book Drinking Water and Health, Volume 8 written by National Research Council and published by National Academies Press. This book was released on 1987-02-01 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacokinetics, the study of the movement of chemicals within the body, is a vital tool in assessing the risk of exposure to environmental chemicals. This bookâ€"a collection of papers authored by experts in academia, industry, and governmentâ€"reviews the progress of the risk-assessment process and discusses the role of pharmacokinetic principles in evaluating risk. In addition, the authors discuss software packages used to analyze data and to build models simulating biological phenomena. A summary chapter provides a view of trends in pharmacokinetic modeling and notes some prospective fields of study.

Chemical Carcinogenesis

Author : Trevor M. Penning
Publisher : Springer Science & Business Media
ISBN 13 : 1617379956
Total Pages : 447 pages
Book Rating : 4.6/5 (173 download)

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Book Synopsis Chemical Carcinogenesis by : Trevor M. Penning

Download or read book Chemical Carcinogenesis written by Trevor M. Penning and published by Springer Science & Business Media. This book was released on 2011-03-03 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.

National Cancer Institute Safety Standards for Research Involving Chemical Carcinogens

Author : National Cancer Institute (U.S.). Office of Research Safety
Publisher :
ISBN 13 :
Total Pages : 32 pages
Book Rating : 4.:/5 (327 download)

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Book Synopsis National Cancer Institute Safety Standards for Research Involving Chemical Carcinogens by : National Cancer Institute (U.S.). Office of Research Safety

Download or read book National Cancer Institute Safety Standards for Research Involving Chemical Carcinogens written by National Cancer Institute (U.S.). Office of Research Safety and published by . This book was released on 1975 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt:

ICRDB Cancergram

Author :
Publisher :
ISBN 13 :
Total Pages : 28 pages
Book Rating : 4.:/5 (3 download)

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Book Synopsis ICRDB Cancergram by :

Download or read book ICRDB Cancergram written by and published by . This book was released on 1985 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nongenotoxic Mechanisms in Carcinogenesis

Author : Banbury Center
Publisher : Banbury Report
ISBN 13 :
Total Pages : 424 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Nongenotoxic Mechanisms in Carcinogenesis by : Banbury Center

Download or read book Nongenotoxic Mechanisms in Carcinogenesis written by Banbury Center and published by Banbury Report. This book was released on 1987 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of in Vivo Toxicity Testing

Author : Douglas L. Arnold
Publisher :
ISBN 13 :
Total Pages : 702 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Handbook of in Vivo Toxicity Testing by : Douglas L. Arnold

Download or read book Handbook of in Vivo Toxicity Testing written by Douglas L. Arnold and published by . This book was released on 1990 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Intentional Human Dosing Studies for EPA Regulatory Purposes

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309166411
Total Pages : 226 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Intentional Human Dosing Studies for EPA Regulatory Purposes by : National Research Council

Download or read book Intentional Human Dosing Studies for EPA Regulatory Purposes written by National Research Council and published by National Academies Press. This book was released on 2004-06-04 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: The EPA commissioned The National Academies to provide advice on the vexing question of whether and, if so, under what circumstances EPA should accept and consider intentional human dosing studies conducted by companies or other sources outside the agency (so-called third parties) to gather evidence relating to the risks of a chemical or the conditions under which exposure to it could be judged safe. This report recommends that such studies be conducted and used for regulatory purposes only if all of several strict conditions are met, including the following: The study is necessary and scientifically valid, meaning that it addresses an important regulatory question that can't be answered with animal studies or nondosing human studies; The societal benefits of the study outweigh any anticipated risks to participants. At no time, even when benefits beyond improved regulation exist, can a human dosing study be justified that is anticipated to cause lasting harm to study participants; and All recognized ethical standards and procedures for protecting the interests of study participants are observed. In addition, EPA should establish a Human Studies Review Board (HSRB) to evaluate all human dosing studiesâ€"both at the beginning and upon completion of the experimentsâ€"if they are carried out with the intent of affecting the agency's policy-making.