Interferon Alpha-2: Pre-Clinical and Clinical Evaluation

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Publisher : Springer Science & Business Media
ISBN 13 : 146132579X
Total Pages : 117 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Interferon Alpha-2: Pre-Clinical and Clinical Evaluation by : Daniel L. Kisner

Download or read book Interferon Alpha-2: Pre-Clinical and Clinical Evaluation written by Daniel L. Kisner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interferon alpha-2 is a genetically engineered, highly purified pharmaceutical agent that has undergone extensive phase I and phase II clinical study in more than 1000 patients. The material has biological activity by intravenous, intramus cular and subcutaneous routes. Clinical toxicity principally involves the 'influen za like' syndrome previously seen with native interferons. Other important toxi cities include anorexia, hepatitis, confusion and myelosuppression. Tolerable doses in multiple schedules and routes of administration have been determined. Phase II clinical trials with multiple routes and schedules of administration have been performed. Significant clinical activity has been found in non Hodgkin's lymphomas (both low grade and high grade), refractory and relapsing multiple myeloma, hairy cell leukemia, Kaposi's sarcoma, with suggestions of activity in Hodgkin's disease, renal cell carcinoma, and melanoma. The studies performed to date have for the most part involved small numbers of heavily pre-treated patients. Large-scale clinical trials in some of these disea ses are now warranted in populations of patients with as little bulk disease and prior treatment as is feasible for each tumour type. This is particularly the case in . Hodgkin's disease and subcategories of the non-Hodgkin's lymphomas. Alterna tely, interferon alpha-2 might be used to maintain remissions induced by other modalities (i. e. , in NHL, multiple myeloma, ovarian cancer). In some advanced disease settings, combinations of interferon alpha-2 with chemotherapeutic agents should now be investigated.

Concepts, Clinical Developments, and Therapeutic Advances in Cancer Chemotherapy

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Publisher : Springer Science & Business Media
ISBN 13 : 1461320615
Total Pages : 271 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Concepts, Clinical Developments, and Therapeutic Advances in Cancer Chemotherapy by : Franco M. Muggia

Download or read book Concepts, Clinical Developments, and Therapeutic Advances in Cancer Chemotherapy written by Franco M. Muggia and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfor tunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung can cer, genitourinary cancer, pediatric oncology, etc. Second, by asking emi nent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

National Library of Medicine Current Catalog

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Publisher :
ISBN 13 :
Total Pages : 1728 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1985 with total page 1728 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hepatotoxicity

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781719520
Total Pages : 850 pages
Book Rating : 4.7/5 (195 download)

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Book Synopsis Hepatotoxicity by : Hyman J. Zimmerman

Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Clinical and Experimental Pathology of Lung Cancer

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Publisher : Springer Science & Business Media
ISBN 13 : 9400950365
Total Pages : 189 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Clinical and Experimental Pathology of Lung Cancer by : J. Gordon McVie

Download or read book Clinical and Experimental Pathology of Lung Cancer written by J. Gordon McVie and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: J. G. MCVIE The impact of therapy on one subset of lung cancer, the "small cell" type has been significant and lasting. The reality of cure for even a fraction of patients with this disease has caused reverberations in the pathology lab where the responsibili. '~y and challenge of diagnosis of this vital sub group lies. No less dramatic has been the discovery that the cell types of lung cancer have recognisable growth characteristics in serum free culture, they are recognisable by patterns of markers and some produce growth factors which autoregulate their eventual fate. Many of the discoveries from the biological studies have impacted on the pathologist in the form of disturbing evidence for a single stem cell origin for all the cell types of lung cancer and in the shape of new facilitation in diagnosis by appli cation of immunoperoxidase techniques. Monoclonal antibodies raised against oncogene products, growth factor receptor sites, "bystander" cell membrane proteins can all be applied to cytology specimens and frozen or paraffin fixed tissue sections to aid diagnosis and some can be used in sequential serum assay to monitor therapy and predict prognosis. Adding to these extraordinary tools, the sophistication of electron micro scopy and immuno-electrcn microscopy, new techniques for preparation of tissue and novel methods for studying vital cells in "kinesis", you sense the flavour of the future of lung cancer which is captured in this book.

Femtosecond Technology for Technical and Medical Applications

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Publisher : Springer Science & Business Media
ISBN 13 : 146132615X
Total Pages : 431 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Femtosecond Technology for Technical and Medical Applications by : Jose Russo

Download or read book Femtosecond Technology for Technical and Medical Applications written by Jose Russo and published by Springer Science & Business Media. This book was released on 2013-12-14 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is no doubt that the advent of immunocytochemical techniques, by enhancing our ability to detect specific cell products or markers, has opened new avenues in the understanding of human diseases, and in our ability to perform better diagnosis in surgical pathology. The rapid development of this field has resulted in thousands of publications in the literature regarding immunocytochemistry in diagnostic pathology. This explosion of knowledge makes necessary publications summarizing what are the main markers available and how they can be used in the diagnosis of tumors. The need of a more organized and structured knowledge was evident during the workshop in Immunocytochemistry of Tumor Diagnosis that took place in the City of Detroit an October 1984. This book is the result of that workshop in which 22 chapters are focusing an the main subject of differential diagnosis of tumors. Jose Russo, M.D. Editor xiii ACKNOWLEDGEMENTS I wish to thank my many associates at the Michigan Cancer Foundation for their help in the preparation of this manuscript. I give thanks to Dr.

Small Clinical Trials

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Publisher : National Academies Press
ISBN 13 : 0309171148
Total Pages : 221 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Small Clinical Trials by : Institute of Medicine

Download or read book Small Clinical Trials written by Institute of Medicine and published by National Academies Press. This book was released on 2001-01-01 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.

Women at High Risk to Breast Cancer

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Publisher : Springer Science & Business Media
ISBN 13 : 9400913273
Total Pages : 140 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Women at High Risk to Breast Cancer by : B.A. Stoll

Download or read book Women at High Risk to Breast Cancer written by B.A. Stoll and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: A reprint of the 1989 edition of this book has been made necessary by continuing demand after rapid exhaustion of the first printing. In the two years since its appearance, there has been relatively little expansion of knowledge on this topic, and its massive accumulation of references still remains an authoritative guide in the difficult task of developing a national breast cancer prevention model. At the same time, its thesis has been sharpened by the publication of a companion volume Approaches to Breast Cancer Prevention (Kluwer, 1991) similarly edited byrne. Breast cancer is on the increase throughout the Western world where it is a major source of anxiety among women. The disease is also becoming more frequent in Asian and South American countries where once it was relatively uncommon. Multiple fac tors are suspected of promoting the disease and the increasing risk is attributed to recent changes in life-style and diet. This book is intended to provide an authorita tive and balanced survey of the latest research into the genetic, familial, hormonal, reproductive, nutritional, social and geographic factors known to be associated with an increased predisposition to the disease.

Head and Neck Management of the Cancer Patient

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Publisher : Springer Science & Business Media
ISBN 13 : 1461322898
Total Pages : 520 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Head and Neck Management of the Cancer Patient by : Douglas E. Peterson

Download or read book Head and Neck Management of the Cancer Patient written by Douglas E. Peterson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents in a comprehensive way cur the clinical care of the patient with head and neck rent advances in the management of neoplasia cancer involvement and/or its complications. and associated complications of the head and Today's complex treatments in oncology re neck. A broad range of clinical considerations is quire a comprehensive approach to effect a posi discussed following overviews of relevant basic tive result for the cancer patient whose facial biologic issues and the roles of various disci appearance and function are compromised. We plines. Each chapter has been structured to trust that physicians, dentists, nurses, dental "stand by itself"; at the same time, obvious rela hygienists, and individuals in the supportive ser tionships with other chapters have been noted. vices involved in the management of the cancer We are pleased that this book represents, in our patient will find this book beneficial. opinion, a truly multidisciplinary approach to Xl I. INTRODUCTION 1. CANCER, ITS COMPLICATIONS, AND THE HEAD AND NECK Stephen T. Sanis Few diseases are as complex in their biology, tumors, such as colorectal cancers, seems physiology, pathology, or management as can equivocal [3]. cer [1, 2]. In addition, the disease concurrently has extensive psychological impact on patients.

Biochemistry and Molecular Genetics of Cancer Metastasis

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Publisher : Springer Science & Business Media
ISBN 13 : 1461322995
Total Pages : 339 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Biochemistry and Molecular Genetics of Cancer Metastasis by : Karoly Lapis

Download or read book Biochemistry and Molecular Genetics of Cancer Metastasis written by Karoly Lapis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: The success rate for treatment of primary neoplasms has improved sig nificantly due to improved surgical, radiotherapy, and chemotherapy methods, and by supportive patient care. In contrast, the treatment of cancer metastases, the cause of most cancer deaths, has not been very successful. Approximately 50% or more of patients with primary malignant neoplasms already have established metastases. Consequently, the most important problem in cancer treatment is the destruction or prevention of metastases. Metastases research has obvious clinical importance. Yet it has only been recently that investigators have attempted to study the mechanisms in volved in this process. This is in part due to the complexity of metastases formation. A metastatic colony is the result of a complicated series of steps involving mUltiple tumor host interactions. It is expected that multiple biochemical factors and gene products derived both from the host and the tumor cell may be required for the metastasizing tumor cell to invade, survive host defenses, travel in the circulation, arrest and adhere in the target organ, invade out, and grow as a metastatic colony. Some of these factors have recently been identified by investigators who have focused on individual steps in the metastatic process and have employed new technologies in immunology, biochemistry and molecular biology. The purpose of this volume is to capture some of the excitement in the field of metastases based on such new discoveries.

The Role of Pharmacology in Pediatric Oncology

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Publisher : Springer Science & Business Media
ISBN 13 : 9400942672
Total Pages : 308 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis The Role of Pharmacology in Pediatric Oncology by : D.G. Poplack

Download or read book The Role of Pharmacology in Pediatric Oncology written by D.G. Poplack and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: The dramatic improvement made in recent years in the treatment of child hood malignancies has been in large part the result of advances in the field of pharmacology. Chemotherapy is the major therapeutic modality used to treat childhood cancer. Rational administration of antineoplastic chemo therapy to the child with cancer requires the pediatric oncologist to have a thorough understanding of the fundamental principles of clinical pharmaco logy, an intimate knowledge of the specific agents being used, and an aware ness of the unique biologic and physiologic features of children. In mid 1985, a distinguished group of pediatric oncologists and clinical pharmacologists convened in a unique workshop to review the subject of pharmacology in pediatric oncology. A goal of this workshop was to pro duce a book which would review this topic and present it in a format useful for the clinician. In this book basic principles of pharmacology, mechanisms of drug resis tance, new methods of drug delivery, guidelines for studying new agents in children, new biological response modifiers and the pharmacology of the most commonly used chemotherapeutic agents in children are reviewed in depth. Particular emphasis is given to discussing those topics which unique ly apply to the use of antineoplastic agents in children with cancer. The Editors VII Contents Preface . v Contents Vll List of Major Contributors Xl Principles of Antineoplastic Therapy in Children 1. Clinical pharmacokinetics for the pediatric oncologist ................ .

Recent Concepts in Sarcoma Treatment

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Publisher : Springer Science & Business Media
ISBN 13 : 9780898383768
Total Pages : 348 pages
Book Rating : 4.3/5 (837 download)

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Book Synopsis Recent Concepts in Sarcoma Treatment by : J.R. Ryan

Download or read book Recent Concepts in Sarcoma Treatment written by J.R. Ryan and published by Springer Science & Business Media. This book was released on 1988-05-31 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: There have been significant advances in the treatment of sarcomas in the past several years. Further, different clini cal treatment programs are being advocated in different areas including surgery alone, surgery with preoperative or post operative chemotherapy, surgery with different radiotherapy modalities, with each investigator espousing his own treat ment program. On the other side, there is the question of whether these treatment programs are offering better results or whether the natural history of sarcomas has changed. The International Symposium on Sarcomas was held at Innisbrook Resort, Tarpon Springs, Florida, October 8-10, 1987. This was the first international symposium to date involving all of the disciplines treating sarcomas including pathologists, orthopaedic surgeons, general surgeons, medical oncologists, pediatric oncologists, and radiation oncol ogists. The Symposium brought together a number of special ists working in the clinical field of sarcomas for a presen tation of their specific treatment programs and their results. The presentations were followed by panel discussions to stimulate educational debate as to the different forms of treatment for sarcomas and to formulate some conformity in control of disease, control of spread, and ultimate function for the patient. James R. Ryan, M.D.

Diagnosis and Management of Malignant Solid Tumors in Infants and Children

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Publisher : Springer Science & Business Media
ISBN 13 : 1461326230
Total Pages : 531 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Diagnosis and Management of Malignant Solid Tumors in Infants and Children by : Daniel M. Green

Download or read book Diagnosis and Management of Malignant Solid Tumors in Infants and Children written by Daniel M. Green and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of pediatric oncology encompasses four groups of malignancies - acute leukemias, brain tumors, lymphomas and solid tumors. 1'he history, diagnosis and management of children with acute leukemias and lymphomas has been thoroughly examined in several excellent textbooks of pediatric hematology and oncology. Bl"ain tumors have historically been managed by neurosurgeons and radiation therapists. 1'he role of the pediatric oncologist in the management of these patients is evolving. This book was written to provide a thorough historical evaluation of the most frequent solid tumors of children. A detailed examination of the natural history of these tumors is essential to the design and evaluation of therapeutic trials. The highly lethal nature of many of these tumors, the occurrence of some of them at several different primary sites and the rarity of these tumors have made systematic study of them difficult. Conclusions regarding the efficacy of a particular modification of the therapeutic strategy can be strongly influenced by the assumed natural history of the tumor. I have tried to develop as accurateJy as the literature would allow a picture of the natural history of the common malignant solid tumors, knowing that the image would be imperfect. I adopted a convention which was employed in all graphs constructeil from case reports summarized from the literature.

Monoclonal Antibody Therapy of Human Cancer

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Publisher : Springer Science & Business Media
ISBN 13 : 9780898387544
Total Pages : 186 pages
Book Rating : 4.3/5 (875 download)

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Book Synopsis Monoclonal Antibody Therapy of Human Cancer by : Kenneth A. Foon

Download or read book Monoclonal Antibody Therapy of Human Cancer written by Kenneth A. Foon and published by Springer Science & Business Media. This book was released on 1985-09-30 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: KENNETH A. FOON and ALTON C. MORGAN, JR. Passive immunotherapy using heteroantisera for the treatment of cancer in animals and humans has been studied for over 50 years. Attempts have been made to treat animal tumors with sera from immunized syngeneic, allogeneic, or xenogeneic animals. A number of studies of passive immunotherapy using heterologous antisera in humans have also been performed. These studies have generally been attempted in patients with large tumor burdens, and as would be expected, results have been transient at best. A wide variety of solid tumors as well as leukemias and lym­ phomas have been treated with antisera raised in sheep, horses, rabbits, and goats. Problems such as anaphylaxis, serum sick­ ness, and severe cytopenias have been encountered with these antisera. There are a number of potential mechanisms by which unconju­ gated antibodies might be cytotoxic to tumor cells. Antibodies bound to the cell surface membrane of tumor cells may lead to cell lysis by complement-dependent or antibody-dependent cellu­ lar cytotoxicity. Circulating tumor cells bound by antibody may be more susceptible to phagocytosis by the reticuloendothelial system. Antibody bound to the cell surface membrane of tumor cells may enhance immunogenicity of the tumor cell leading to activation of the host's immune system.

Monoclonal Antibodies and Breast Cancer

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Publisher : Springer Science & Business Media
ISBN 13 : 1461326176
Total Pages : 327 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Monoclonal Antibodies and Breast Cancer by : R. Ceriani

Download or read book Monoclonal Antibodies and Breast Cancer written by R. Ceriani and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer, being a disease with very high prevalence in the female population, has permanently attracted the attention of biologists, biochemists, pathologists, surgeons, and oncologists. In the U.S. alone approximately 120,000 new cases are diagnosed and 37,000 deaths a year are recorded as an outcome. Early diagnosis, clear cut prognosis and the hope of new therapeutic approaches has spurred the enthusiasm of researchers, who with the advent of newer methodologies, tried to employ it in different approaches to the breast cancer patient. In spite of the efforts devoted towards the creation of new approaches, reagents and procedures taking advantage of special characteristics of the breast tissue were slow to come. In general, most diagnostic and prognostic techniques were those shared and applied to other carcinomas. In the early seventies we discovered the first sets of antigens associated with breast epithelial tissue both in the mouse and the human. The recognition of such group of molecules, present in the milk fat globule membrane, gave impetus to several studies in these areas. These mammary cell surface antigens proved useful in several diagnostic approaches such as radioimaging, histochemical and serum assay procedures. However, the apparently inherent limitations of polyclonal antibodies reduced the impact of these novel approaches.

Organ Directed Toxicities of Anticancer Drugs

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Publisher : Springer Science & Business Media
ISBN 13 : 1461320232
Total Pages : 259 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Organ Directed Toxicities of Anticancer Drugs by : Miles P. Hacker

Download or read book Organ Directed Toxicities of Anticancer Drugs written by Miles P. Hacker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: The addition of chemotherapy as an effective means to treat cancer has had a major impact on selected human malignancies. Due to a general inability to dif ferentiate between normal and neoplastic cells, little selectivity exists in currently used oncolytic drugs. Consequently, significant toxicity to the patient is expected when systemic cancer chemotherapy is chosen as an appropriate therapeutic in tervention. Much of this toxicity, such as damage to the bone marrow, gastroin testinal tract, or hair follicles, is predictable based upon the fact that anticancer drugs kill actively dividing cells. These types of toxicities, while serious, are usually manageable and reversible and are, therefore, not often considered to be dose limiting. Unfortunately, several of the most important anticancer drugs also damage tissues in which the growth fraction is relatively small. Such toxicities can not be predicted based on the chemical structure of the drugs, are often not detected in preclinical studies, and are encountered frequently for the first time in clinical studies. Further, unlike most of the proliferative-dependent toxicities, the unpre dicted toxicities are usually irreversible or only partially reversible upon cessation of drug administration. Because of this, the unpredicted toxicities are referred to as dose limiting. They represent a significant barrier to the ultimate efficacy of several of our most important anticancer drugs.

New Frontiers in Mammary Pathology 1986

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Publisher : Springer Science & Business Media
ISBN 13 : 9400932979
Total Pages : 456 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis New Frontiers in Mammary Pathology 1986 by : K.H. Hollmann

Download or read book New Frontiers in Mammary Pathology 1986 written by K.H. Hollmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Society The Third Symposium of the International held in against Breast Cancer CONTRA CANCRUM MAMMARIUM was Paris, at UNESCO, on December 9-12, 1985. Scientists and physicians came from allover the world to attend this meeting. They came from Japan, Brazil, the United States and the Middle East, from Belgium, Finland, Germany, Greece, Italy, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland, Yugoslavia, and from allover France. They all contributed to the success of the Symposium and my cordial thanks go to all of them and particularly to the invited speakers and chairmen of the sessions, to the free-paper contributors, and to the contributors to the Slide Seminar. Warm personal thanks go to two friends: to Professor Dan H. Moore from Hahnemann University, Philadelphia, who was always there to help in many ways, and to Professor Pietro Gullino from the National Cancer Institute, Bethesda, and now Torino, Italy, who consistently gave invaluable advice. Special thanks are also due to those who assisted in the preparation and organization of the Symposium: the UNESCO officers, the interpreters, the secretaries and hostesses, the BEBA Company with the help of Dr.Bernard Martin and Mrs.Jacqueline Bouchy, the WILD LEITZ-France S.A. for projection facilities and microscope arrangements for the workshop on mammary cytology which was successfully conducted by Dr.Colette Marsan. During the four days,three main topics were discussed: ~ E~idemiology, genetiCS and oncogenes, related subjects of great actuality.