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Interaction Of Nanomaterials With Living Cells
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Book Synopsis Interaction of Nanomaterials With Living Cells by : Faheem Arjamend Sheikh
Download or read book Interaction of Nanomaterials With Living Cells written by Faheem Arjamend Sheikh and published by Springer Nature. This book was released on 2023-11-10 with total page 936 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the interactions of nanomaterials with the biological system. The chapters of the book explore the natural and synthetic biomaterials that modulate immune responses for their applications in drug delivery and tissue engineering. Further, the book discusses the implications of the physiochemical properties of nanoparticles and their microenvironment on their interactions with biological systems. The chapters also present the recognitive capabilities of biomaterials for the development of novel strategies for the detection and treatment of autoimmune disorders. The book also introduces nanotechnology platforms for drug delivery and highlights current and emerging nanotechnologies that could enable novel classes of therapeutics. Towards the end, the book reviews the efficiency of drug-loaded nanoparticles in modulating the functioning of the biological milieu for improved disease treatment. Lastly, the book outlines the ethical issues regarding the use of nanoparticles for in vitro and in vivo applications. Given its scope, it is a valuable resource for graduate students and researchers interested in understanding the biomedical applications of nanoparticles and their interactions with the biological milieu.
Download or read book Nanotoxicology written by Yuliang Zhao and published by . This book was released on 2007 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization of Nanomaterial Interactions at the Biological Interfaces by : Kyoungtea Kim
Download or read book Characterization of Nanomaterial Interactions at the Biological Interfaces written by Kyoungtea Kim and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in nanomaterials has arisen from their unique physiochemical properties with applications in medicine, industrial processing, consumer goods, and agriculture due to their unique physicochemical properties and applications. With the increase in industrial scale nanomaterial synthesis and application, living cells are increasingly likely to be exposed to nanomaterials in the environment. Given that the cell membrane/wall is the initial point of contact for living cells with foreign materials, understanding nanomaterial interactions with extracellular surfaces at the molecular level is required to assess and predict the potential deleterious impacts of nanomaterials on living cells/organisms. In terms of abundance, proteins in biological fluids or serums are highly likely to interact with nanomaterials. Protein association with nanomaterials is known to accompany subsequent protein conformational changes. Considering protein conformation is finely regulated in living cells, altered protein conformations induced by interactions with nanomaterials need to be investigated to better understand potential adverse impacts on living organisms. The overarching goal of the studies presented here is to construct model biological systems and elucidate their interaction with nanomaterials. We here developed model biological interfaces, investigated their molecular level interactions with nanomaterial, and demonstrated that some of our model biological interfaces are representative of actual biological interfaces. We also summarized nanomaterial interactions with proteins and subsequent protein conformational changes. The characterization of the nano-bio interactions, at the molecular level, would contribute to establishing nanomaterial design rules to improve their properties for applications and ultimately supports the implementation of sustainable nanotechnology.
Book Synopsis Interaction of Nanomaterials with the Immune System by : James C. Bonner
Download or read book Interaction of Nanomaterials with the Immune System written by James C. Bonner and published by Springer Nature. This book was released on 2020-01-30 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.
Book Synopsis Protein-Nanoparticle Interactions by : Masoud Rahman
Download or read book Protein-Nanoparticle Interactions written by Masoud Rahman and published by Springer Science & Business Media. This book was released on 2013-06-24 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a “biological identity” to their surfaces (referred to as a “corona”), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called “bio-nano interface,” has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts.
Book Synopsis Biointeractions of Nanomaterials by : Vijaykumar B. Sutariya
Download or read book Biointeractions of Nanomaterials written by Vijaykumar B. Sutariya and published by CRC Press. This book was released on 2014-07-29 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: An examination of the widespread application of nano materials in biology, medicine, and pharmaceuticals and the accompanying safety concerns, Bio-interactions of Nano Materials addresses the issues related to toxicity and safety of nano materials and nano systems. It covers the interactions in biological systems and presents various tools and methods used to evaluate the nano toxicity and nano safety issues. Written by leading scientists, the book focuses on the bio-interaction of nano materials, covering various techniques and tests which have been developed to evaluate the toxicity of materials at the nano level. The book highlights the challenges of bio-interactions of nano materials and possible solutions to those challenges. It addresses the assessment and characterization of nano systems in bio-environments, toxicity and bio-sensing devices for toxicity assessment, carbon nano tubes and pulmonary toxicity, and nano toxicity of solid lipid nanoparticles. It also discusses nano safety concerns and solutions, including the effects of nano particles on different organs and regulatory implications of nano materials. These particles may be used to encapsulate drugs, recognize biological markers, or visualize body tissues among many other possibilities, all enabling their widespread application in biology, medicine, and pharmaceutics. Indeed, these nano materials may have beneficial effects that have not even been imagined. This book gives you an understanding of the safety issues, how to assess for them, and how to mitigate them to move forward in research and development of new applications for nano materials.
Book Synopsis Microbial Interactions at Nanobiotechnology Interfaces by : R. Navanietha Krishnaraj
Download or read book Microbial Interactions at Nanobiotechnology Interfaces written by R. Navanietha Krishnaraj and published by John Wiley & Sons. This book was released on 2021-10-26 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: MICROBIAL INTERACTIONS AT NANOBIOTECHNOLOGY INTERFACES This book covers a wide range of topics including synthesis of nanomaterials with specific size, shape, and properties, structure-function relationships, tailoring the surface of nanomaterials for improving the properties, interaction of nanomaterials with proteins/microorganism/eukaryotic cells, and applications in different sectors. This book also provides a strong foundation for researchers who are interested to venture into developing functionalized nanomaterials for any biological applications in their research. Practical concepts such as modelling nanomaterials, and simulating the molecular interactions with biomolecules, transcriptomic or genomic approaches, advanced imaging techniques to investigate the functionalization of nanomaterials/interaction of nanomaterials with biomolecules and microorganisms are some of the chapters that offer significant benefits to the researchers.
Book Synopsis Interaction of Nanomaterials With the Immune System: Role in Nanosafety and Nanomedicine by : Paola Italiani
Download or read book Interaction of Nanomaterials With the Immune System: Role in Nanosafety and Nanomedicine written by Paola Italiani and published by Frontiers Media SA. This book was released on 2018-04-10 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: The immune system has the double role of maintaining tissue integrity and homeostasis and of protecting the organism from possible dangers, from invading pathogens to environmentally-borne dangerous chemicals. New chemicals recognisable by the immune system are engineered nanomaterials/ nanoparticles, new agents in our environment that are becoming common due to their presence in many products, from constructions and building material (e.g., solar cells, pigments and paints, tilesand masonry materials) to daily products (e.g., food packaging, cosmetics, and cigarettes). Human beings can be accidentally exposed to engineered nanomaterials when these are released from products containing them or during production in workplaces. Furthermore, intentional exposure occurs in medicine, as engineered nanoparticles are used as tools for improving delivery of drugs and vaccines, vaccine adjuvants and contrast agents in therapeutic, preventive and diagnostic strategies. Nanoparticles that come in contact with the immune system after unintentional exposure need to be eliminated from the organism as they represent a potential threat. In this case, however, due to their peculiar characteristics of size, shape, surface charge and persistence, nanoparticles may elicit undesirable reactions and have detrimental effects on the immune system, such as cytotoxicity, inflammation, anaphylaxis, immunosuppression. Conversely, nanomedicines need to escape immune recognition/elimination and must persist in the organism long enough for reaching their target and exerting their beneficial effects. Immune cells and molecules at the body surface (airway and digestive mucosae, skin) are the first that come in contact with nanomaterials upon accidental exposure, while immune effectors in blood are those that more easily come in contact with nanomedical products. Thus, evaluating the interaction of the immune system with nanoparticles/nanomaterials is a topic of key importance both in nanotoxicology and in nanomedicine. Immuno-nanosafety studies consider both accidental exposure to nanoparticles, which may occur by skin contact, ingestion or inhalation (at doses and with a frequency that are not known), and medical exposure, which takes place with a defined administration schedule (route, dose, frequency). Many studies focus on the interaction between the immune system and nanoparticles that, for medical purposes, have been specifically modified to stimulate immunity or to avoid immune recognition, as in the case of vaccine carriers/adjuvants or drug delivery systems, respectively. The aims of this Research Topic is to provide an overview of recent strategies: 1.for assessing the immunosafety of engineered nanomaterials/nanoparticles, in particular in terms of activation of inflammatory responses, such as complement activation and allergic reactions, based on the nanomaterial intrinsic characteristics and on the possible carry-over of bioactive contaminants such as LPS. Production of new nanoparticles taking into account their effects on immune responses, in order to avoid undesirable effects on one hand, and to design particles with desirable effects for medical applications on the other hand; 2.for designing more effective nanomedicines by either avoiding or exploiting their interaction with the immune systems, with particular focus on cancer diagnosis and therapy, and vaccination. This collection of articles gives a comprehensive view of the state-of-the-art of the interaction of nanoparticles with the immune system from the two perspectives of safety and medical use, and aims at providing immunologists with the relevant knowledge for designing improved strategies for immunologically safe nanomaterial applications.
Book Synopsis Biological Responses to Nanoscale Particles by : Peter Gehr
Download or read book Biological Responses to Nanoscale Particles written by Peter Gehr and published by Springer. This book was released on 2019-04-16 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book the recent progress accumulated in studies of the interaction of engineered nanoparticles with cells and cellular constituents is presented. The focus is on manufacturing and characterization of nanosized materials, their interactions with biological molecules such as proteins, the mechanisms of transport across biological membranes as well as their effects on biological functions. Fundamental molecular and cellular aspects are in the foreground of the book. A further particularity is the interdisciplinary approach, including fields such as preparatory and analytical chemistry, biophysics and the physics of colloids, advanced microscopy and spectroscopy for in-situ detection of nanoparticles, cellular toxicology and nanomedicine. Nanoscale particles are known to exhibit novel and unprecedented properties that make them different from their corresponding bulk materials. As our ability to control these properties is further advanced, a huge potential to create materials with novel properties and applications emerges. Although the technological and economic benefits of nanomaterials are indisputable, concerns have also been raised that nanoscale structuring of materials might also induce negative health effects. Unfortunately, such negative health effects cannot be deduced from the known toxicity of the corresponding macroscopic material. As a result, there is a major gap in the knowledge necessary for assessing their risk to human health.
Book Synopsis Measuring Biological Impacts of Nanomaterials by : Joachim Wegener
Download or read book Measuring Biological Impacts of Nanomaterials written by Joachim Wegener and published by Springer. This book was released on 2016-02-02 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews several aspects of the biological response to nanoscale particles on a molecular and cellular level. Nanoscale materials and nanoscale particles in particular have interesting properties and beneficial applications. While they thus have entered our daily lifes on many different levels (from electronics, over textiles, packaging or surface modifications, to biomedical applications), general rules describing their interaction with biological structures and biological matter are still difficult to derive. The existing literature suggests a variety of interaction schemes between nanoparticles and biological objects, not dispelling the public concerns about possible health effects and harmful properties. A systematic approach to the problem is needed and timely. This book specifically emphasizes bioanalytical problems starting from the characterization of the nanomaterials to the pitfalls and potential artifacts of state-of-the-art cytotoxicity assays that are frequently used to study harmful effects on cells. It also highlights the application of label-free bioanalytical techniques that can potentially complement the present approaches and hence provide new perspectives on this highly discussed cutting-edge field of research and public concern.
Download or read book Nanomaterial written by David G. Capco and published by Springer Science & Business Media. This book was released on 2014-03-28 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapidly developing field of nanomaterials has expanded in many commercial areas. More recent studies have begun to provide a foundation for understanding how nanomaterials influence cells and how they also can serve as methodological tools for studies in medicine and cell biology, including research into stem cells. Recent investigations have shown affects of nanomaterials on specific subcellular structures, such as the actin-based brush border network in cells with an increasing emphasis on the barrier function of epithelial tissues. While other studies have shown involvement of nanoparticles in specific cytoplasmic signal transduction events such as the rise in intracellular free calcium, a signaling event known to regulate many changes in cell architecture and function. In parallel, nanomaterials are increasingly used in medicine for drug delivery, treatment of cancer and an increasing number of new applications. This book investigates these areas and also includes new methods for assessment in cell biology and medicine.
Book Synopsis Single-Chain Polymer Nanoparticles by : José A. Pomposo
Download or read book Single-Chain Polymer Nanoparticles written by José A. Pomposo and published by John Wiley & Sons. This book was released on 2017-08-18 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first book on this important and emerging topic presents an overview of the very latest results obtained in single-chain polymer nanoparticles obtained by folding synthetic single polymer chains, painting a complete picture from synthesis via characterization to everyday applications. The initial chapters describe the synthetics methods as well as the molecular simulation of these nanoparticles, while subsequent chapters discuss the analytical techniques that are applied to characterize them, including size and structural characterization as well as scattering techniques. The final chapters are then devoted to the practical applications in nanomedicine, sensing, catalysis and several other uses, concluding with a look at the future for such nanoparticles. Essential reading for polymer and materials scientists, materials engineers, biochemists as well as environmental chemists.
Book Synopsis Multiscale Biomechanics and Tribology of Inorganic and Organic Systems by : Georg-Peter Ostermeyer
Download or read book Multiscale Biomechanics and Tribology of Inorganic and Organic Systems written by Georg-Peter Ostermeyer and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book gathers authoritative contributions concerning multiscale problems in biomechanics, geomechanics, materials science and tribology. It is written in memory of Sergey Grigorievich Psakhie to feature various aspects of his multifaceted research interests, ranging from theoretical physics, computer modeling of materials and material characterization at the atomic scale, to applications in space industry, medicine and geotectonics, and including organizational, psychological and philosophical aspects of scientific research and teaching as well. This book covers new advances relating to orthopedic implants, concerning the physiological, tribological and materials aspects of their behavior; medical and geological applications of permeable fluid-saturated materials; earthquake dynamics together with aspects relating to their managed and gentle release; lubrication, wear and material transfer in natural and artificial joints; material research in manufacturing processes; hard-soft matter interaction, including adhesive and capillary effects; using nanostructures for influencing living cells and for cancer treatment; manufacturing of surfaces with desired properties; self-organization of hierarchical structures during plastic deformation and thermal treatment; mechanics of composites and coatings; and many more. Covering established knowledge as well as new models and methods, this book provides readers with a comprehensive overview of the field, yet also with extensive details on each single topic.
Book Synopsis Nanomaterial Interactions with Plant Cellular Mechanisms and Macromolecules and Agricultural Implications by : Jameel M. Al-Khayri
Download or read book Nanomaterial Interactions with Plant Cellular Mechanisms and Macromolecules and Agricultural Implications written by Jameel M. Al-Khayri and published by Springer Nature. This book was released on 2023-01-01 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the recent progress of nanotechnology with emphasis on the interaction between nanoparticles and plants on the cellular level. It is devoted to understanding the pathways of nanomaterials entry into plant cell and their influence on cellular organelle processes and influence on crop yield. It consists of 16 chapters grouped in 3 parts: Part I Cellular mechanisms, Part II Cellular macromolecules, and Part III Implications of nanomaterials. Chapters present the plant response to nanomaterial applications including morphological, physiochemical, and anatomical changes and their effect on plant growth and productivity. The book discusses the mechanisms of absorbance and translocation of nanoparticles and their interaction with the plant cellular biochemical compounds and organelles. It presents the current perspective of nanomaterials influence on cellular processes which include photosynthesis, photorespiration and pigment synthesis and accumulation. In addition, it provides current understanding of the impact of nanomaterials on cellular macromolecules including carbohydrates, lipids, nucleic acids, proteins, hormones, and antioxidant defense activities. Collectively, these processes and biochemical compounds have implications on crop yield. Chapters are written by globally recognized scientists and subjected to a rigorous review process to ensure quality presentation and scientific precision. Chapter begins with an introduction that covers similar contexts and includes a detailed discussion of the topic accompanied by high-quality color images, diagrams, and relevant details and concludes with recommendations for future study directions. Chapter "Impact of Nanomaterials on Plant Secondary Metabolism" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Book Synopsis Nanomaterials and Their Interactive Behavior with Biomolecules, Cells and Tissues by : Yogendrakumar H. Lahir
Download or read book Nanomaterials and Their Interactive Behavior with Biomolecules, Cells and Tissues written by Yogendrakumar H. Lahir and published by Bentham Science Publishers. This book was released on 2020-08-04 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoscience is a multidisciplinary area of science which enables researchers to create tools that help in understanding the mechanisms related to the interactions between nanomaterials and biomolecules (nanotechnology). Nanomaterials represent nanotechnology products. These products have an enormous impact on technical industries and the quality of human life. Nanomaterials directly or indirectly have to interact with biosystems. It is, therefore, essential to understand the beneficial and harmful interactions of nanomaterials with and within a biosystem, especially with reference to humans. This book provides primary and advanced information concerning the interactions between nanomaterials and the components of a typical biosystem to readers. Chapters in the book cover, in a topic-based approach, the many facets of nanomolecular interactions with biological molecules and systems that influence their behavior, bioavailability and biocompatibility (including nucleic acids, cell membranes, tissues, enzymes and antibodies). A note on the applications of nanomaterials is also presented in the conclusion of the book to illustrate the usefulness of this class of materials. The contents of the book will benefit students, researchers, and technicians involved in the fields of biological sciences, such as cell biology, medicine, molecular biology, food technology, cosmetology, pharmacology, biotechnology, and environmental sciences. The book also provides information for the material science personnel, enabling them to understand the basics of target-oriented nanomaterials design for specific objectives.
Book Synopsis Molecular Impacts of Nanoparticles on Plants and Algae by : Huseyin Tombuloglu
Download or read book Molecular Impacts of Nanoparticles on Plants and Algae written by Huseyin Tombuloglu and published by Elsevier. This book was released on 2024-03-26 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Impacts of Nanoparticles on Plants and Algae covers molecular mechanisms of plants/algae related to cellular uptake and translocation of nanoparticles, and genome, transcriptome, proteome, and metabolome responses against it. The book introduces readers to state-of-the-art developments and trends of nanoparticles and plants/algae including interaction of nanoparticles with biological compounds in vitro. Nanoscience and nanotechnology have rapidly been developed in the last few decades, and they have a wide range of applications in industry, medicine, food, and agriculture. In agriculture, nanoparticles (NPs) have successfully been used for growth regulation, crop protection and improvement. They are also employed to cope with plant nutrient deficiencies. A predicted significant increase in the output of NPs will cause the discharge of a remarkable number of NPs to ecosystems, creating a need to understand how to optimize or mitigate their impact depending on their potential impact. These include serious health concerns for living organisms in aquatic, terrestrial, and atmospheric environments as well as human health through their potential existence in plant-based foods. The impact of NPs on living organisms including plants and algae, and uptake, translocation and molecular response mechanisms should be carefully considered before producing and using nanoparticles in large amounts as NPs, when entered to the body, induce changes in gene expressions related to the photosystem, water transport, cell wall formation, and cell division. Further recent studies have showed that NPs are potential agents or stressors to alter proteome, transcriptome, genome and metabolome responses. Impacts of nanoparticles on molecular mechanisms of plants and algae presents the most recent findings on nanoparticle and plant/algae interaction by focusing to molecular response mechanisms at genome, transcriptome, proteome and metabolome levels. In addition, uptake and translocation mechanism of nanoparticles will be assessed both in plant and algae Throughout this book, the latest developments and discoveries will be highlighted as well as open problems and future challenges in molecular mechanisms of plants/algae as a response of nanoparticles. Presents genome, transcriptome, proteome, and metabolome responses in plants/algae, along with cellular uptake and translocation mechanisms Illustrates nano-particle-plant/algae interactions Covers both simple and higher organisms, addressing both algae and plant
Book Synopsis Nanomaterial Biointeractions at the Cellular, Organismal and System Levels by : Nilesh Sharma
Download or read book Nanomaterial Biointeractions at the Cellular, Organismal and System Levels written by Nilesh Sharma and published by Springer Nature. This book was released on 2021-03-26 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: The range of nanomaterial applications has expanded recently from catalysis, electronics, and filtration to therapeutics, diagnostics, agriculture, and food because of unique properties and potentials of different nanoparticles and nanomaterials. Research shows that these exquisite particles can interact with an organism at the cellular, physiological, biochemical, and molecular levels. However, our knowledge of how they affect these changes, selectively or generally, in diverse organism or ecosystems is very limited and far from satisfactory. Data indicate that the biological function largely depends on the shape, size, and surface characteristics of the nanoparticles used besides life cycle stages of an organism. Therefore, this compilation will focus on the body of work carried out by distinguished investigators using diverse nanomaterials and plant and animal species. This book includes specific case studies as well as general review articles highlighting aspects of multilayered interactions, and targets not only research and academic scholars but also the concerned industry and policy makers as well.
