Integrative Computational Modeling Of Calcium Handling And Cardiac Arrhythmias

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Integrative Computational Modeling of Calcium Handling and Cardiac Arrhythmias

Author : Henry Sutanto
Publisher : Henry Sutanto
ISBN 13 : 946423105X
Total Pages : 350 pages
Book Rating : 4.4/5 (642 download)

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Book Synopsis Integrative Computational Modeling of Calcium Handling and Cardiac Arrhythmias by : Henry Sutanto

Download or read book Integrative Computational Modeling of Calcium Handling and Cardiac Arrhythmias written by Henry Sutanto and published by Henry Sutanto. This book was released on 2021-01-01 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiomyocyte calcium handling is a major determinant of excitation-contraction coupling. Alterations in one or more calcium-handling proteins may induce arrhythmias through the formation of ectopic activity, direct and indirect ion-channel regulation, and structural remodeling. Due to the complex and tight interactions between calcium and other molecules within a cardiomyocyte, it remains experimentally challenging to study the exact contributions of calcium-handling abnormalities to arrhythmogenesis. Multiscale computational studies performed in close collaboration with laboratory experiments create new opportunities to unravel the mechanisms of arrhythmogenesis. This thesis describes the roles of integrative computational modeling in unraveling the arrhythmogenic consequences of calcium-handling abnormalities.

IX Latin American Congress on Biomedical Engineering and XXVIII Brazilian Congress on Biomedical Engineering

Author : Jefferson Luiz Brum Marques
Publisher : Springer Nature
ISBN 13 : 3031494016
Total Pages : 623 pages
Book Rating : 4.0/5 (314 download)

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Book Synopsis IX Latin American Congress on Biomedical Engineering and XXVIII Brazilian Congress on Biomedical Engineering by : Jefferson Luiz Brum Marques

Download or read book IX Latin American Congress on Biomedical Engineering and XXVIII Brazilian Congress on Biomedical Engineering written by Jefferson Luiz Brum Marques and published by Springer Nature. This book was released on 2023-12-16 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reports on the latest research and developments in Biomedical Engineering, with a special emphasis on topics of interest and findings achieved in Latin America. This first volume of a 4-volume set covers advances in modeling and simulation of biological and biomedical systems, mechanical characterization, and biological evaluation of biomaterials for medical applications, including tissues regeneration. It also covers some related special topics, such as advanced methodologies for agricultural and food production and public health management. Throughout the book, a special emphasis is given to low-cost technologies and to their development for and applications in clinical settings. Based on the IX Latin American Conference on Biomedical Engineering (CLAIB 2022) and the XXVIII Brazilian Congress on Biomedical Engineering (CBEB 2022), held jointly, and virtually on October 24-28, 2022, from Florianópolis, Brazil, this book provides researchers and professionals in the biomedical engineering field with extensive information on new technologies and current challenges for their clinical applications. .

Computational Science – ICCS 2008

Author : Marian Bubak
Publisher : Springer
ISBN 13 : 3540693890
Total Pages : 770 pages
Book Rating : 4.5/5 (46 download)

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Book Synopsis Computational Science – ICCS 2008 by : Marian Bubak

Download or read book Computational Science – ICCS 2008 written by Marian Bubak and published by Springer. This book was released on 2008-06-25 with total page 770 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three-volume set LNCS 5101-5103 constitutes the refereed proceedings of the 8th International Conference on Computational Science, ICCS 2008, held in Krakow, Poland in June 2008. The 167 revised papers of the main conference track presented together with the abstracts of 7 keynote talks and the 100 revised papers from 14 workshops were carefully reviewed and selected for inclusion in the three volumes. The main conference track was divided into approximately 20 parallel sessions addressing topics such as e-science applications and systems, scheduling and load balancing, software services and tools, new hardware and its applications, computer networks, simulation of complex systems, image processing and visualization, optimization techniques, numerical linear algebra, and numerical algorithms. The second volume contains workshop papers related to various computational research areas, e.g.: computer graphics and geometric modeling, simulation of multiphysics multiscale systems, computational chemistry and its applications, computational finance and business intelligence, physical, biological and social networks, geocomputation, and teaching computational science. The third volume is mostly related to computer science topics such as bioinformatics' challenges to computer science, tools for program development and analysis in computational science, software engineering for large-scale computing, collaborative and cooperative environments, applications of workflows in computational science, as well as intelligent agents and evolvable systems.

Methods and applications in integrative physiology

Author : Ovidiu Constantin Baltatu
Publisher : Frontiers Media SA
ISBN 13 : 2832510493
Total Pages : 190 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Methods and applications in integrative physiology by : Ovidiu Constantin Baltatu

Download or read book Methods and applications in integrative physiology written by Ovidiu Constantin Baltatu and published by Frontiers Media SA. This book was released on 2023-01-04 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is part of the Methods and Applications in Physiology series. Other titles in this series are: • Methods and Applications in Aquatic Physiology • Methods and Applications in Clinical and Translational Physiology • Methods and Applications in Computational Physiology and Medicine • Methods and Applications in Environmental, Aviation and Space Physiology • Methods and Applications in Exercise Physiology • Methods and Applications in Fractal Physiology • Methods and Applications in Invertebrate Physiology • Methods and Applications in Metabolic Physiology • Methods and Applications in Physio-logging • Methods and Applications in Striated Muscle Physiology • Methods and Applications in Respiratory Physiology • Methods and Applications in Vascular Physiology • New Methods for Red Blood Cell Research and Diagnosis, Volume II • Combining Computational and Experimental Approaches to Characterize Ion Channels and Transporters

Familial Cardiomyopathies

Author : Michael Regnier
Publisher : Springer Nature
ISBN 13 : 1071635271
Total Pages : 239 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Familial Cardiomyopathies by : Michael Regnier

Download or read book Familial Cardiomyopathies written by Michael Regnier and published by Springer Nature. This book was released on 2023-12-01 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the latest advances in technologies that look at familial cardiomyopathies in greater detail, and provides new computational and experimental models that model, study, and detect disease at earlier stages. Together, this allows interdisciplinary research experiments to provide new insights for the development of novel interventions that slow, stop, or even reverse the disease process. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Familial Cardiomyopathies: Methods and Protocols aims to inspire further development of techniques used to study myocardial disease and the development of new, sarcomere-targeted therapeutic approaches for the maintenance of heart health and the treatment of heart failure.

Multiscale Modelling of Rhythm, Pattern and Information Generation: from Genome to Physiome

Author : Shangbin Chen
Publisher : Frontiers Media SA
ISBN 13 : 2889637468
Total Pages : 197 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Multiscale Modelling of Rhythm, Pattern and Information Generation: from Genome to Physiome by : Shangbin Chen

Download or read book Multiscale Modelling of Rhythm, Pattern and Information Generation: from Genome to Physiome written by Shangbin Chen and published by Frontiers Media SA. This book was released on 2020-06-08 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cardiac Mapping

Author : Mohammad Shenasa
Publisher : John Wiley & Sons
ISBN 13 : 1119152623
Total Pages : 1304 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Cardiac Mapping by : Mohammad Shenasa

Download or read book Cardiac Mapping written by Mohammad Shenasa and published by John Wiley & Sons. This book was released on 2019-04-04 with total page 1304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The expanded guide to cardiac mapping The effective diagnosis and treatment of heart disease may vitally depend upon accurate and detailed cardiac mapping. However, in an era of rapid technological advancement, medical professionals can encounter difficulties maintaining an up-to-date knowledge of current methods. This fifth edition of the much-admired Cardiac Mapping is, therefore, essential, offering a level of cutting-edge insight that is unmatched in its scope and depth. Featuring contributions from a global team of electrophysiologists, the book builds upon previous editions' comprehensive explanations of the mapping, imaging, and ablation of the heart. Nearly 100 chapters provide fascinating accounts of topics ranging from the mapping of supraventricular and ventriculararrhythmias, to compelling extrapolations of how the field might develop in the years to come. In this text, readers will find: Full coverage of all aspects of cardiac mapping, and imaging Explorations of mapping in experimental models of arrhythmias Examples of new catheter-based techniques Access to a companion website featuring additional content and illustrative video clips Cardiac Mapping is an indispensable resource for scientists, clinical electrophysiologists, cardiologists, and all physicians who care for patients with cardiac arrhythmias.

Cardiac Repolarization

Author : Nabil El-Sherif
Publisher : Springer Nature
ISBN 13 : 3030226727
Total Pages : 354 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Cardiac Repolarization by : Nabil El-Sherif

Download or read book Cardiac Repolarization written by Nabil El-Sherif and published by Springer Nature. This book was released on 2019-08-29 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive, up-to-date overview of clinical and research aspects of cardiac repolarization geared toward practicing cardiologists and physicians. It analyzes elements of pathophysiology and molecular biology as they relate to the clinical aspects of cardiac repolarization, long QT syndromes, early repolarization syndromes, and special cardiac repolarization syndromes. Each chapter examines different aspects of the field with basic and clinical overviews and highlights the impact on medical management. The book covers a variety of repolarization topics including the influence of the autonomic system, racial and gender differences in patients, the future role of stem cells, inflammation and autoimmunity, and cardiovascular risk. Cardiac Repolarization: Basic Science and Clinical Management is an essential resource for physicians and related professionals, residents, fellows, and graduate students in cardiology, clinical cardiac electrophysiology, internal medicine, and cardiovascular biology.

Recent Advances in Understanding the Basic Mechanisms of Atrial Fibrillation Using Novel Computational Approaches

Author : Jichao Zhao
Publisher : Frontiers Media SA
ISBN 13 : 2889631842
Total Pages : 413 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Recent Advances in Understanding the Basic Mechanisms of Atrial Fibrillation Using Novel Computational Approaches by : Jichao Zhao

Download or read book Recent Advances in Understanding the Basic Mechanisms of Atrial Fibrillation Using Novel Computational Approaches written by Jichao Zhao and published by Frontiers Media SA. This book was released on 2019-11-25 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Role of Calcium Handling in Heart Failure and Heart Failure Associated Arrhythmias

Author : Elisabetta Cerbai
Publisher : Frontiers Media SA
ISBN 13 : 2889458253
Total Pages : 191 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis The Role of Calcium Handling in Heart Failure and Heart Failure Associated Arrhythmias by : Elisabetta Cerbai

Download or read book The Role of Calcium Handling in Heart Failure and Heart Failure Associated Arrhythmias written by Elisabetta Cerbai and published by Frontiers Media SA. This book was released on 2019-05-15 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Under normal, healthy conditions, the contraction of cardiac myocytes, leading to the pump function of this organ, is driven by calcium-dependent mechanisms. Entry of calcium into the myocyte during the cardiac action potential causes activation of the ryanodine receptors and release of calcium from the sarcoplasmic reticulum. This process termed calcium-induced calcium release is essential for excitation-contraction coupling and enables each action potential to be transduced into a mechanical event. Indeed, in healthy myocytes, the calcium concentration in the cytosol of is elevated approximately 10-fold from a resting level of ∼100 nM to ∼1 μM. This process is finely orchestrated by a number of key proteins, which can be specifically regulated by various pathways depending on the oxygen demand. Furthermore, the specific structure of the myocyte allows certain calcium-dependent processes to be compartmentalised, increasing the efficiency and safety of this regulation. Heart failure is a common, costly, and life-threatening condition. In 2015, for example, it affected around 40 million people globally. In patients with heart failure, the risk of sudden cardiac death and arrhythmias increases substantially. Cellular remodelling and alterations in calcium handling, which appear to contribute to the arrhythmogenic burden in heart failure, have been extensively reported. However, a number of unanswered questions remain, and each new study - while continuing to shed light on this subject - raises additional novel questions. This current compendium of articles covers a number of aspects and comprehensively reviews current knowledge and perspectives regarding the link between calcium handling, arrhythmias and heart failure providing at the same time insights that may lead to novel therapeutic options for the future.

Exploring Mechanisms of Cardiac Rhythm Disturbances Using Novel Computational Methods: Prediction, Classification, and Therapy

Author : Xin Li
Publisher : Frontiers Media SA
ISBN 13 : 2832517587
Total Pages : 232 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Exploring Mechanisms of Cardiac Rhythm Disturbances Using Novel Computational Methods: Prediction, Classification, and Therapy by : Xin Li

Download or read book Exploring Mechanisms of Cardiac Rhythm Disturbances Using Novel Computational Methods: Prediction, Classification, and Therapy written by Xin Li and published by Frontiers Media SA. This book was released on 2023-03-16 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nanodomain Regulation of Muscle Physiology and Alterations in Disease

Author : Niall Macquaide
Publisher : Frontiers Media SA
ISBN 13 : 2832510264
Total Pages : 202 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Nanodomain Regulation of Muscle Physiology and Alterations in Disease by : Niall Macquaide

Download or read book Nanodomain Regulation of Muscle Physiology and Alterations in Disease written by Niall Macquaide and published by Frontiers Media SA. This book was released on 2023-01-03 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond

Author : Esther Pueyo
Publisher : Frontiers Media SA
ISBN 13 : 2889455394
Total Pages : 385 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond by : Esther Pueyo

Download or read book Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond written by Esther Pueyo and published by Frontiers Media SA. This book was released on 2018-08-16 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading to early withdrawal of potentially safe drugs. Here we collected a series of articles presenting new technological and conceptual advances, including refinement of ex vivo and in vitro assays, screens and models, and in silico approaches reflecting the increasing effort that has been put forward by regulatory agencies, industry, and academia to try and address the need of a more accurate, mechanistically-based paradigm of proarrhythmic potential of drugs. This Research Topic is dedicated to the memory of Dr. J. Jeremy Rice, our wonderful friend and colleague.

Cardiac Electrophysiology Methods and Models

Author : Daniel C. Sigg
Publisher : Springer Science & Business Media
ISBN 13 : 1441966587
Total Pages : 490 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Cardiac Electrophysiology Methods and Models by : Daniel C. Sigg

Download or read book Cardiac Electrophysiology Methods and Models written by Daniel C. Sigg and published by Springer Science & Business Media. This book was released on 2010-09-11 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease is the major cause of mortality and morbidity in the Western Hemisphere. While significant progress has been made in treating a major sub-category of cardiac disease, arrhythmias, significant unmet needs remain. In particular, every day, thousands of patients die because of arrhythmias in the US alone, and atrial fibrillation is the most common arrhythmia affecting millions of patients in the US alone at a given time. Therefore, there is a public need to continue to develop new and better therapies for arrhythmias. Accordingly, an ever increasing number of biomedical, pharmaceutical, and medical personnel is interested in studying various aspects of arrhythmias at a basic, translational, and applied level, both in industry (ie Biotech, Pharmaceutical and device), and in academia. Not only has our overall understanding of molecular bases of disease dramatically increased, but so has the number of available and emerging molecular, pharmacological or device treatment based therapies. This practical, state-of-the art handbook will summarize and review key research methods and protocols, their advantages and pitfalls, with a focus on practical implementation, and collaborative cross-functional research. The volume will include visual and easy-to-use graphics, bulleted summaries, boxed summary paragraphs, links to reference websites, equipment manufacturers where appropriate, photographs of typical experimental setups and so forth, to keep this book very focused on practical methods and implementation, and yet, provide enough theory that the principles are clearly understood and can be easily applied.

Calcium and Heart Failure: From Bench to Bedside

Author : Elisabetta Cerbai
Publisher : Frontiers Media SA
ISBN 13 : 2889765547
Total Pages : 148 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Calcium and Heart Failure: From Bench to Bedside by : Elisabetta Cerbai

Download or read book Calcium and Heart Failure: From Bench to Bedside written by Elisabetta Cerbai and published by Frontiers Media SA. This book was released on 2022-07-12 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Systems Biology of Metabolic and Signaling Networks

Author : Miguel A. Aon
Publisher : Springer Science & Business Media
ISBN 13 : 3642385052
Total Pages : 375 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Systems Biology of Metabolic and Signaling Networks by : Miguel A. Aon

Download or read book Systems Biology of Metabolic and Signaling Networks written by Miguel A. Aon and published by Springer Science & Business Media. This book was released on 2013-10-22 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems Biology represents a new paradigm aiming at a whole-organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component parts. The study of network properties, and how they control and regulate behavior from the cellular to organism level, constitutes a main focus of Systems Biology. This book addresses from a novel perspective a major unsolved biological problem: understanding how a cell works and what goes wrong in pathology. The task undertaken by the authors is in equal parts conceptual and methodological, integrative and analytical, experimental and theoretical, qualitative and quantitative, didactic and comprehensive. Essentially, they unravel the spatio-temporal unfolding of interacting mass-energy and information networks at the cellular and organ levels, as well as its modulation through activation or repression by signaling networks to produce a certain phenotype or (patho)physiological response. Starting with the historical roots, in thirteen chapters this work explores the Systems Biology of signaling networks, cellular structures and fluxes, organ and microorganism functions. In doing so, it establishes the basis of a 21st century approach to biological complexity.

Encyclopedia of Cell Biology

Author :
Publisher : Academic Press
ISBN 13 : 0123947960
Total Pages : 2972 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Encyclopedia of Cell Biology by :

Download or read book Encyclopedia of Cell Biology written by and published by Academic Press. This book was released on 2015-08-07 with total page 2972 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Cell Biology, Four Volume Set offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences. Fully annotated color images and videos for full comprehension of concepts, with layered content for readers from different levels of experience Includes information on cytokinesis, cell biology, cell mechanics, cytoskeleton dynamics, stem cells, prokaryotic cell biology, RNA biology, aging, cell growth, cell Injury, and more In-depth linking to Academic Press/Elsevier content and additional links to outside websites and resources for further reading A one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences