Innovative 3d Models For Understanding Mechanisms Underlying Lung Diseases Powerful Tools For Translational Research

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Innovative 3D models for Understanding Mechanisms underlying Lung Diseases: Powerful Tools for Translational Research

Author : Janette K. Burgess
Publisher : Frontiers Media SA
ISBN 13 : 2832544177
Total Pages : 180 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Innovative 3D models for Understanding Mechanisms underlying Lung Diseases: Powerful Tools for Translational Research by : Janette K. Burgess

Download or read book Innovative 3D models for Understanding Mechanisms underlying Lung Diseases: Powerful Tools for Translational Research written by Janette K. Burgess and published by Frontiers Media SA. This book was released on 2024-02-05 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mechanisms underlying acute and chronic lung diseases are complex, reflecting the interplay between multiple cell types, their microenvironment and exogenous challenges. While traditional in vitro cell culture approaches have been instrumental in advancing our knowledge of cellular signalling and function, they typically lack the cell-cell and cell-matrix interactions that define the niche in which lung cell and tissue functions emerge. Implementing in vivo and ex vivo three-dimensional (3D) models more realistically mimicking the in vivo cell-extracellular matrix (ECM) crosstalk should facilitate a considerable leap towards better understanding lung diseases and thus in investigating new pharmacological tools. We are experiencing a revolution in our understanding of the cell types that deposit and remodel ECM in the lung, the dynamic spatial composition of the ECM and cell-cell interactions during disease, and the influence of ECM and cell-derived cues on lung cell biology. In concert, the ex vivo and in vitro models that are being used to examine the role of the 3D microenvironment of the cell in the lung are rapidly developing. The European Respiratory Society has partnered with Frontiers in Pharmacology to launch this research topic in conjunction with the ERS Research Seminar “Innovative 3D models for understanding mechanisms underlying lung diseases: powerful tools for translational research”.

Cell Interaction

Author : Bhawana Singh
Publisher : BoD – Books on Demand
ISBN 13 : 183968416X
Total Pages : 230 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Cell Interaction by : Bhawana Singh

Download or read book Cell Interaction written by Bhawana Singh and published by BoD – Books on Demand. This book was released on 2021-04-07 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses contemporary ideas on different molecular and immunological aspects of diseases. Different signaling mediators drive the production of messenger molecules that mediate their action, leading to the elicitation/suppression of immune responses. It provides a balanced approach to the study of different molecular phenomena that eventually drive infection outcomes and that can be manipulated for therapeutic benefits.

Tissue Engineering and Regenerative Medicine

Author : Phuc Van Pham
Publisher : Springer
ISBN 13 : 303019857X
Total Pages : 232 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Tissue Engineering and Regenerative Medicine by : Phuc Van Pham

Download or read book Tissue Engineering and Regenerative Medicine written by Phuc Van Pham and published by Springer. This book was released on 2019-08-14 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new series, based on a bi-annual conference and its topics, represents a major contribution to the emerging science of cancer research and regenerative medicine. Each volume brings together some of the most pre-eminent scientists working on cancer biology, cancer treatment, cancer diagnosis, cancer prevention and regenerative medicine to share information on currently ongoing work which will help shape future therapies. These volumes are invaluable resources not only for already active researchers or clinicians but also for those entering these fields, plus those in industry. Tissue Engineering and Regenerative Medicine is a proceedings volume which reflects papers presented at the 3rd bi-annual Innovations in Regenerative Medicine and Cancer Research conference; taken with its companion volume Stem Cells: Biology and Engineering it provides a complete overview of the papers from that meeting of international experts.

Lung Stem Cells in Development, Health and Disease

Author : Nikolic, Marko Z.
Publisher : European Respiratory Society
ISBN 13 : 1849841349
Total Pages : 395 pages
Book Rating : 4.8/5 (498 download)

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Book Synopsis Lung Stem Cells in Development, Health and Disease by : Nikolic, Marko Z.

Download or read book Lung Stem Cells in Development, Health and Disease written by Nikolic, Marko Z. and published by European Respiratory Society. This book was released on 2021-04-01 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most organs in the adult human body are able to maintain themselves and undergo repair after injury; these processes are largely dependent on stem cells. In this Monograph, the Guest Editors bring together leading authors in the field to provide information about the different classes of stem cells present both in the developing and adult lung: where they are found, how they function in homeostasis and pathologic conditions, the mechanisms that regulate their behaviour, and how they may be harnessed for therapeutic purposes. The book focuses on stem cells in the mouse and human lung but also includes the ferret as an increasingly important new model organism. Chapters also discuss how lung tissue, including endogenous stem cells, can be generated in vitro from pluripotent stem cell lines. This state-of-the-art collection comprehensively covers one of the most exciting areas of respiratory science

The Impact of Food Bioactives on Health

Author : Kitty Verhoeckx
Publisher : Springer
ISBN 13 : 3319161040
Total Pages : 341 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis The Impact of Food Bioactives on Health by : Kitty Verhoeckx

Download or read book The Impact of Food Bioactives on Health written by Kitty Verhoeckx and published by Springer. This book was released on 2015-04-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Infogest” (Improving Health Properties of Food by Sharing our Knowledge on the Digestive Process) is an EU COST action/network in the domain of Food and Agriculture that will last for 4 years from April 4, 2011. Infogest aims at building an open international network of institutes undertaking multidisciplinary basic research on food digestion gathering scientists from different origins (food scientists, gut physiologists, nutritionists...). The network gathers 70 partners from academia, corresponding to a total of 29 countries. The three main scientific goals are: Identify the beneficial food components released in the gut during digestion; Support the effect of beneficial food components on human health; Promote harmonization of currently used digestion models Infogest meetings highlighted the need for a publication that would provide researchers with an insight into the advantages and disadvantages associated with the use of respective in vitro and ex vivo assays to evaluate the effects of foods and food bioactives on health. Such assays are particularly important in situations where a large number of foods/bioactives need to be screened rapidly and in a cost effective manner in order to ultimately identify lead foods/bioactives that can be the subject of in vivo assays. The book is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest and highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated and, as noted above, highlight the strengths and weaknesses of the various assays. It is also an important resource for undergraduate students in the ‘food and health’ arena.

Mechanisms of Molecular Carcinogenesis – Volume 2

Author : Johannes Haybaeck
Publisher : Springer
ISBN 13 : 3319536613
Total Pages : 373 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Mechanisms of Molecular Carcinogenesis – Volume 2 by : Johannes Haybaeck

Download or read book Mechanisms of Molecular Carcinogenesis – Volume 2 written by Johannes Haybaeck and published by Springer. This book was released on 2017-05-22 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Together with Volume 1, this book provides an inclusive overview of the molecular and cellular mechanisms of carcinogenesis and offers comprehensive insights into related clinical and therapeutic aspects. This second volume complements the first by presenting and concisely explaining the carcinogenesis of various tumor entities such as non-melanoma skin cancers, bone and soft tissue tumors, pancreatic cancers, hepatocellular cancer and neuroendocrine tumors. As in volume one, each chapter illuminates the similarities and dissimilarities of changed signaling pathways in the different organ systems and depicts potential therapeutic strategies. The focus of volume two lies on the presentation of modern molecular biological techniques for diagnosis, as well as strategies for biomarker identification and validation. Furthermore, it discusses potential therapeutic targets and individualized treatment strategies, offering a valuable resource for all basic scientists and medical researchers interested in translational cancer research.

Bioengineering systems for therapeutic and in vitro platforms

Author : Loredana De Bartolo
Publisher : Frontiers Media SA
ISBN 13 : 2832509460
Total Pages : 210 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Bioengineering systems for therapeutic and in vitro platforms by : Loredana De Bartolo

Download or read book Bioengineering systems for therapeutic and in vitro platforms written by Loredana De Bartolo and published by Frontiers Media SA. This book was released on 2022-12-22 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Stem Cells and Regenerative Medicine

Author : Walter C. Low
Publisher : World Scientific
ISBN 13 : 9812775773
Total Pages : 571 pages
Book Rating : 4.8/5 (127 download)

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Book Synopsis Stem Cells and Regenerative Medicine by : Walter C. Low

Download or read book Stem Cells and Regenerative Medicine written by Walter C. Low and published by World Scientific. This book was released on 2008 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: The commercialization of biotechnology has resulted in an intensive search for new biological resources for the purposes of increasing food productivity, medicinal applications, energy production, and various other applications. Although biotechnology has produced many benefits for humanity, the exploitation of the planet's natural resources has also resulted in some undesirable consequences such as diminished species biodiversity, climate change, environmental contamination, and intellectual property right and patent concerns.This book discusses the role of biological, ecological, environmental, ethical, and economic issues in the interaction between biotechnology and biodiversity, using different contexts. No other book has discussed all of these issues in a comprehensive manner. Of special interest is their impact when biotechnology is shared between developed and developing countries, and the lack of recognition of the rights of indigenous populations and traditional farmers in developing countries by large multinational corporations.

Tumor Organoids

Author : Shay Soker
Publisher : Humana Press
ISBN 13 : 3319605119
Total Pages : 225 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Tumor Organoids by : Shay Soker

Download or read book Tumor Organoids written by Shay Soker and published by Humana Press. This book was released on 2017-10-20 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Strengthening Forensic Science in the United States

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309142393
Total Pages : 348 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Strengthening Forensic Science in the United States by : National Research Council

Download or read book Strengthening Forensic Science in the United States written by National Research Council and published by National Academies Press. This book was released on 2009-07-29 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scores of talented and dedicated people serve the forensic science community, performing vitally important work. However, they are often constrained by lack of adequate resources, sound policies, and national support. It is clear that change and advancements, both systematic and scientific, are needed in a number of forensic science disciplines to ensure the reliability of work, establish enforceable standards, and promote best practices with consistent application. Strengthening Forensic Science in the United States: A Path Forward provides a detailed plan for addressing these needs and suggests the creation of a new government entity, the National Institute of Forensic Science, to establish and enforce standards within the forensic science community. The benefits of improving and regulating the forensic science disciplines are clear: assisting law enforcement officials, enhancing homeland security, and reducing the risk of wrongful conviction and exoneration. Strengthening Forensic Science in the United States gives a full account of what is needed to advance the forensic science disciplines, including upgrading of systems and organizational structures, better training, widespread adoption of uniform and enforceable best practices, and mandatory certification and accreditation programs. While this book provides an essential call-to-action for congress and policy makers, it also serves as a vital tool for law enforcement agencies, criminal prosecutors and attorneys, and forensic science educators.

Temporomandibular Disorders

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309670489
Total Pages : 427 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Temporomandibular Disorders by : National Academies of Sciences, Engineering, and Medicine

Download or read book Temporomandibular Disorders written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-07-01 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Temporomandibular disorders (TMDs), are a set of more than 30 health disorders associated with both the temporomandibular joints and the muscles and tissues of the jaw. TMDs have a range of causes and often co-occur with a number of overlapping medical conditions, including headaches, fibromyalgia, back pain and irritable bowel syndrome. TMDs can be transient or long-lasting and may be associated with problems that range from an occasional click of the jaw to severe chronic pain involving the entire orofacial region. Everyday activities, including eating and talking, are often difficult for people with TMDs, and many of them suffer with severe chronic pain due to this condition. Common social activities that most people take for granted, such as smiling, laughing, and kissing, can become unbearable. This dysfunction and pain, and its associated suffering, take a terrible toll on affected individuals, their families, and their friends. Individuals with TMDs often feel stigmatized and invalidated in their experiences by their family, friends, and, often, the health care community. Misjudgments and a failure to understand the nature and depths of TMDs can have severe consequences - more pain and more suffering - for individuals, their families and our society. Temporomandibular Disorders: Priorities for Research and Care calls on a number of stakeholders - across medicine, dentistry, and other fields - to improve the health and well-being of individuals with a TMD. This report addresses the current state of knowledge regarding TMD research, education and training, safety and efficacy of clinical treatments of TMDs, and burden and costs associated with TMDs. The recommendations of Temporomandibular Disorders focus on the actions that many organizations and agencies should take to improve TMD research and care and improve the overall health and well-being of individuals with a TMD.

Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles

Author : Venkatram Prasad Shastri
Publisher : Springer Science & Business Media
ISBN 13 : 9048187885
Total Pages : 414 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles by : Venkatram Prasad Shastri

Download or read book Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles written by Venkatram Prasad Shastri and published by Springer Science & Business Media. This book was released on 2010-08-14 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the NATO Advanced Research Workshop (ARW) on “Nanoengineered Systems for Regenerative Medicine” that was organized under the auspices of the NATO Security through Science Program. I would like to thank NATO for supporting this workshop via a grant to the co-directors. The objective of ARW was to explore the various facets of regenerative me- cine and to highlight role of the “the nano-length scale” and “nano-scale systems” in defining and controlling cell and tissue environments. The development of novel tissue regenerative strategies require the integration of new insights emerging from studies of cell-matrix interactions, cellular signalling processes, developmental and systems biology, into biomaterials design, via a systems approach. The chapters in the book, written by the leading experts in their respective disciplines, cover a wide spectrum of topics ranging from stem cell biology, developmental biology, ce- matrix interactions, and matrix biology to surface science, materials processing and drug delivery. We hope the contents of the book will provoke the readership into developing regenerative medicine paradigms that combine these facets into cli- cally translatable solutions. This NATO meeting would not have been successful without the timely help of Dr. Ulrike Shastri, Sanjeet Rangarajan and Ms. Sabine Benner, who assisted in the organization and implementation of various elements of this meeting. Thanks are also due Dr. Fausto Pedrazzini and Ms. Alison Trapp at NATO HQ (Brussels, Belgium). The commitment and persistence of Ms.

˜Theœ Global Impact of Respiratory Disease

Author : Darcy D. Marciniuk
Publisher :
ISBN 13 : 9781849840880
Total Pages : pages
Book Rating : 4.8/5 (48 download)

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Book Synopsis ˜Theœ Global Impact of Respiratory Disease by : Darcy D. Marciniuk

Download or read book ˜Theœ Global Impact of Respiratory Disease written by Darcy D. Marciniuk and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Tissue Repair and Fibrosis

Author : Alexis Desmouliere
Publisher : Springer Science & Business Media
ISBN 13 : 364258456X
Total Pages : 358 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Tissue Repair and Fibrosis by : Alexis Desmouliere

Download or read book Tissue Repair and Fibrosis written by Alexis Desmouliere and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts

Promoting Access to Medical Technologies and Innovation - Intersections between Public Health, Intellectual Property and Trade

Author : World Intellectual Property Organization
Publisher : WIPO
ISBN 13 : 9280523082
Total Pages : 259 pages
Book Rating : 4.2/5 (85 download)

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Book Synopsis Promoting Access to Medical Technologies and Innovation - Intersections between Public Health, Intellectual Property and Trade by : World Intellectual Property Organization

Download or read book Promoting Access to Medical Technologies and Innovation - Intersections between Public Health, Intellectual Property and Trade written by World Intellectual Property Organization and published by WIPO. This book was released on 2013 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study has emerged from an ongoing program of trilateral cooperation between WHO, WTO and WIPO. It responds to an increasing demand, particularly in developing countries, for strengthened capacity for informed policy-making in areas of intersection between health, trade and IP, focusing on access to and innovation of medicines and other medical technologies.

The Innate Immune Response to Noninfectious Stressors

Author : Massimo Amadori
Publisher : Academic Press
ISBN 13 : 0128019743
Total Pages : 278 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Innate Immune Response to Noninfectious Stressors by : Massimo Amadori

Download or read book The Innate Immune Response to Noninfectious Stressors written by Massimo Amadori and published by Academic Press. This book was released on 2016-02-23 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation. - Provides insights into the fundamental homeostatic processes vis-à-vis stressors to help in investigation - Illustrates the depicted tenets and how to offset them against established models of response to physical and psychotic stressors in both animals and humans - Covers the crucial issue of the immune response to endocrine disruptors - Includes immunological parameters as reporter system of environmental adaptation - Provides many illustrative examples to foster reader understanding

Targeting Cellular Signalling Pathways in Lung Diseases

Author : Kamal Dua
Publisher : Springer Nature
ISBN 13 : 9813368276
Total Pages : 926 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Targeting Cellular Signalling Pathways in Lung Diseases by : Kamal Dua

Download or read book Targeting Cellular Signalling Pathways in Lung Diseases written by Kamal Dua and published by Springer Nature. This book was released on 2021-07-02 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.