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Author :
Publisher :
ISBN 13 :
Total Pages : 294 pages
Book Rating : 4.:/5 (174 download)
Download or read book Innate Immunity and Environmental Airway Disease written by and published by . This book was released on 2007 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 294 pages
Book Rating : 4.:/5 (245 download)
Download or read book Innate Immunity and Environmental Airway Disease written by and published by . This book was released on 2007 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Marc A. Williams
Publisher : Elsevier
ISBN 13 : 1908818069
Total Pages : 315 pages
Book Rating : 4.9/5 (88 download)
Download or read book Allergens and Respiratory Pollutants written by Marc A. Williams and published by Elsevier. This book was released on 2011-07-18 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Allergens and respiratory pollutants is a collection of 12 authoritative papers that draws upon the collective expertise of world leaders in the fields of innate immunity, immunotoxicology and pulmonary biology. The book critically explores the biological and immunological mechanisms that contribute to immune dysfunction on exposure to allergens and the susceptibility to infectious disease on exposure to ambient pollutants. The clinical relevance of exposure to ambient airborne xenobiotics is critically discussed and collectively, this book provides an educational forum that links the health effects of environmental exposures, immune dysfunction and inflammatory airways disease. - Discusses recent advances in our understanding of cell-mediated innate immune mechanisms that occur during allergic inflammation and provides important timely coverage of diseases of concern and how such diseases are influenced by a dysfunctional immune system - Provides useful information on linking environmental 'danger signals' that provoke immune dysfunction and exacerbation of existing disease - Draws upon the collective expertise of an international college of leaders in the field, but also provides chapters that provide essential reference material
Author : Derek J. Chadwick
Publisher : John Wiley & Sons
ISBN 13 : 0470035382
Total Pages : 238 pages
Book Rating : 4.4/5 (7 download)
Download or read book Innate Immunity to Pulmonary Infection written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2007-01-11 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the prestigious Novartis Foundation series, this volume uniquely addresses the use of innate immunity to treat or prevent infectious diseases of the lung. Innate Immunity to Pulmonary Infection: Provides a comprehensive overview of pulmonary infectious diseases, including basic pathology, current and potential therapies, and detailed consideration of the innate biological resistance mechanisms in the lung Thoroughly examines the major topic of innate immunity in immunology, which is now seen as key to the pathogenesis of and vaccination strategies for infectious diseases Describes the genetic and environmental factors which determine the outcome of infection, such as latency of Tuberculosis, blood stream invasion from local infection, and local target tissue damage Covers the roles of cells such as neutrophils, macrophages and dendritic cells and of molecular components such as Toll-like receptors Discusses the clinical applications of the new knowledge regarding innate immunity and how this can be used in both treatment and prevention (vaccination) strategies Includes contributions from an international and interdisciplinary group of experts Innate Immunity to Pulmonary Infection is an essential resource for researchers in both industry and academia. It is of interest for all those interested in the disciplines of immunology, virology, biology, biotechnology and genetics.
Author : Marc A. Williams
Publisher : Woodhead Publishing
ISBN 13 : 9780081017166
Total Pages : 316 pages
Book Rating : 4.0/5 (171 download)
Download or read book Allergens and Respiratory Pollutants: The Role of Innate Immunity written by Marc A. Williams and published by Woodhead Publishing. This book was released on 2011-08-01 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Charlotte Esser
Publisher : Springer
ISBN 13 : 3709118905
Total Pages : 389 pages
Book Rating : 4.7/5 (91 download)
Download or read book Environmental Influences on the Immune System written by Charlotte Esser and published by Springer. This book was released on 2016-02-04 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together articles on the overarching theme of how the environment shapes the immune system. The immune system is commonly assumed to respond to harmful pathogens such as bacteria and viruses. However, harmless bacteria, chemicals, stress, normal food and other factors can also trigger, shape or interfere with the immune system, often producing adverse effects. Yet, it is also becoming increasingly accepted that some of these interactions are physiological and necessary for a healthy immune system. Examples of negative effects include the immunosuppressive effects of UV irradiation, or the immunotoxic effects of man-made chemicals such as polycyclic aromatic hydrocarbons. Autoimmunity or allergies can be the adverse consequences of interaction between the immune system and chemical compounds such as drugs. Positive effects can come from natural exposure levels to bacteria, healthy life-style or the diet. There is a great need to understand how communication between the environment and the immune system works. This book addresses this need. It covers environmental factors (such as bacteria, sun exposure), human factors (such as age, exercise or stress), and important man-made factors (such as air pollution). A chapter on human rights complements the scientific chapters. The book is intended for immunologists, toxicologists and researchers who want to know how the immune system works and is triggered, as well as for medical doctors in environmental medicine and the general public interested in immunology.
Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author : David S. Hui
Publisher : European Respiratory Society
ISBN 13 : 1849840709
Total Pages : 148 pages
Book Rating : 4.8/5 (498 download)
Download or read book SARS, MERS and other Viral Lung Infections written by David S. Hui and published by European Respiratory Society. This book was released on 2016-06-01 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral respiratory tract infections are important and common causes of morbidity and mortality worldwide. In the past two decades, several novel viral respiratory infections have emerged with epidemic potential that threaten global health security. This Monograph aims to provide an up-to-date and comprehensive overview of severe acute respiratory syndrome, Middle East respiratory syndrome and other viral respiratory infections, including seasonal influenza, avian influenza, respiratory syncytial virus and human rhinovirus, through six chapters written by authoritative experts from around the globe.
Author : Korneliusz Gołębski
Publisher :
ISBN 13 :
Total Pages : 187 pages
Book Rating : 4.:/5 (18 download)
Download or read book Regulation and Cross-talk Between Environmental Triggers of Local Immune Responses in Airway Epithelial Cells written by Korneliusz Gołębski and published by . This book was released on 2017 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Airway epithelium plays an important role in the regulation of the innate immune responses and in this thesis I investigated the role of epithelial cells in the local regulation of inflammatory responses in relation to allergy and other airway diseases. I studied the commonalities and differences of the pro-inflammatory responses induced in airway epithelial cells by viral infections and by allergens and a role of the EGR-1 and DUSP-1 genes in the regulation of these responses. To mimic the real life constant exposure to variety of microbial challenges, I explored the functional interaction between TLR-3 and TLR-2 in primary nasal epithelial cells and sought whether the functional collaboration of TLRs can be extended to lower airways, in the lung epithelium. Moreover, I demonstrated how to overcome the natural occurring tolerance of nasal epithelium to LPS or P. aeruginosa by co-stimulating the cells with immunoglobulin G. Since the local tissue environment consists of epithelial cells that co-operate directly or indirectly with other immune cells, I explored the importance of epithelium in polarization and activation of other immune cells in pathogenesis of upper airway diseases. I showed that nasal polyps of patients with chronic rhinosinusitis, a typical type-2 mediated disease are enriched with type 2 innate lymphoid cells (ILC2). Moreover, I demonstrated the evidence that nasal epithelium is the major source of the type 2 skewing cytokines necessary for ILC2s activation in chronic rhinosinusitis with nasal polyps.
Author : Louise Fornander
Publisher : Linköping University Electronic Press
ISBN 13 : 9175191296
Total Pages : 86 pages
Book Rating : 4.1/5 (751 download)
Download or read book Upper Airway Mucosal Inflammation written by Louise Fornander and published by Linköping University Electronic Press. This book was released on 2015-04-23 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: People are, in their daily lives, exposed to a number of airborne foreign compounds that do not normally affect the body. However, depending on the nature of these compounds, dose and duration of exposure, various airway symptoms may arise. Early symptoms are often manifested as upper airway mucosal inflammation which generates changes in protein composition in the airway lining fluid. This thesis aims at identifying, understanding mechanisms and characterizing protein alterations in the upper airway mucosa that can be used as potential new biomarkers for inflammation in the mucosa. The protein composition in the mucosa was studied by sampling of nasal lavage fluid that was further analyzed with a proteomic approach using twodimensional gel electrophoresis and mass spectrometry. Additionally, by studying factors on site through environmental examination, health questionnaires and biological analyses, we have tried to understand the background to these protein alterations and their impact on health. Respiratory symptoms from the upper airways are common among people who are exposed to irritative and microbial agents. This thesis have focused on personnel in swimming pool facilities exposed to trichloramine, metal industry workers exposed to metalworking fluids, employees working in damp and moldy buildings and infants diagnosed with respiratory syncytial virus infection. The common denominator in these four studies is that the subjects experience upper airway mucosal inflammation, which is manifested as cough, rhinitis, phlegm etc. In the three occupational studies, the symptoms were work related. Notably, a high prevalence of perceived mucosal symptoms was shown despite the relatively low levels of airborne irritants revealed by the environmental examination. Protein profiling verified an ongoing inflammatory response by identification of several proteins that displayed altered levels. Interestingly, innate immune proteins dominated and four protein alterations occurred in most of the studies; SPLUNC1, protein S100A8 and S100A9 and alpha-1-antitrypsin. Similarly, these proteins were also found in nasal fluid from children with virus infection and in addition a truncated form of SPLUNC1 and two other S100 proteins (S100A7-like 2 and S100A16), not previously found in nasal secretion, were identified. Altogether, the results indicate the potential use of a proteomic approach for identifying new biomarkers for the upper respiratory tract at an early stage in the disease process after exposure to irritant and microbial agents. The results indicate an effect on the innate immunity system and the proteins; SPLUNC1, protein S100A8 and S100A9 and alpha-1-antitrypsin are especially promising new biomarkers. Moreover, further studies of these proteins may help us to understand the molecular mechanisms involved in irritant-induced airway inflammation.
Author : Catherine M. Greene
Publisher : Bentham Science Publishers
ISBN 13 : 1608055094
Total Pages : 172 pages
Book Rating : 4.6/5 (8 download)
Download or read book Toll-Like Receptors in Diseases of the Lung written by Catherine M. Greene and published by Bentham Science Publishers. This book was released on 2012-06-12 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This e-book is a review on current understanding of the role of toll-like receptors (TLRs) in the lung in health and disease. Topics covered include 1) the expression, function and activation of TLRs during bacterial, viral and fungal infection of the airways, 2) the role of TLRs in the pathogenesis of genetic and environmental pulmonary disorders, and 3) TLR biology in lung transplantation. Each chapter highlights recent advances in a selected domain in lung disease research. This e-book serves as a comprehensive resource for both scientists and clinicians studying innate immune mechanisms in the lung and provides a single reference comprising both basic and specialized information.
Author : Gregory W. Konat
Publisher : CRC Press
ISBN 13 : 1420043196
Total Pages : 222 pages
Book Rating : 4.4/5 (2 download)
Download or read book Signaling by Toll-Like Receptors written by Gregory W. Konat and published by CRC Press. This book was released on 2008-06-20 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology,
Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author : Nathan Bartlett
Publisher : Academic Press
ISBN 13 : 0128164182
Total Pages : 316 pages
Book Rating : 4.1/5 (281 download)
Download or read book Rhinovirus Infections written by Nathan Bartlett and published by Academic Press. This book was released on 2019-06-12 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rhinovirus Infections: Rethinking the Impact on Human Health and Disease provides a timely review of the impact of rhinovirus infections on human health. It identifies disease mechanisms relating to the virus, human host and environmental factors. This viewpoint allows us to look forward to the development of treatments for a virus for which treatment options are currently non-existent. By providing detailed insights into this virus, its host and the environmental factors that play into rhinovirus induced diseases, this book explains disease mechanisms and summarizes existing and developing therapeutic approaches for better research, diagnosis and potential treatments. - Provides insight into viral diversity and identification of virulence factors, showing how the subtype of rhinovirus affects susceptibility to diseases - Explores host and environmental factors, explaining how age, health status, genotype, lifestyle and environment influence the outcome of a rhinovirus infection - Covers vaccines and treatments, discussing the health burden associated with rhinovirus infections and the driving development of an increasing array of treatment approaches
Author :
Publisher :
ISBN 13 :
Total Pages : 10 pages
Book Rating : 4.:/5 (318 download)
Download or read book Environmental Health Sciences Research Center written by and published by . This book was released on 2013 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Patricia Silveyra
Publisher : Springer Nature
ISBN 13 : 303063549X
Total Pages : 500 pages
Book Rating : 4.0/5 (36 download)
Download or read book Sex-Based Differences in Lung Physiology written by Patricia Silveyra and published by Springer Nature. This book was released on 2021-03-18 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the latest experimental work on sex-based differences in lung function and inflammation. Readers will learn how these differences relate to individual predispositions for the development of lung disease in men and women, and in different stages of their reproductive lives. Further, the book focuses on diseases that predominantly affect women or men, with an emphasis on the physiological mechanisms underlying their pathobiology. In turn, these findings are complemented by chapters on recent studies, which investigate how circulating sex hormone levels impact the lung’s innate immune response to environmental agents and air pollution. The pathogeneses of asthma and viral respiratory infection are also major focus areas. As an outlook, the book also discusses current and future research directions aimed at developing sex-specific therapies for lung disease. To examine these anatomical and physiological differences in the male and female respiratory systems, the authors employ a broad range of methods from molecular and clinical biology. Accordingly, the book will be a fascinating read for physiologists and clinicians alike.
Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
