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Author : Mauricio J. Reginato
Publisher :
ISBN 13 :
Total Pages : 183 pages
Book Rating : 4.:/5 (187 download)
Download or read book Inhibitory Mechanisms Regulating Nuclear Hormone Receptor Action written by Mauricio J. Reginato and published by . This book was released on 1998 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Iain J. McEwan
Publisher : Springer
ISBN 13 : 3319187295
Total Pages : 236 pages
Book Rating : 4.3/5 (191 download)
Download or read book Nuclear Receptors: From Structure to the Clinic written by Iain J. McEwan and published by Springer. This book was released on 2015-08-20 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity. The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.
Author : Malcolm G. Parker
Publisher :
ISBN 13 :
Total Pages : 434 pages
Book Rating : 4.3/5 (91 download)
Download or read book Nuclear Hormone Receptors written by Malcolm G. Parker and published by . This book was released on 1991 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the supergene family made up of those nuclear hormone receptors which recognize thyroid and steroid hormones, vitamen D and retinoic acid and which are characterized by their ability to bind both ligands and the genes which respond to them.
Author : P Karlson
Publisher : Elsevier
ISBN 13 : 1483267628
Total Pages : 288 pages
Book Rating : 4.4/5 (832 download)
Download or read book Mechanisms of Hormone Action written by P Karlson and published by Elsevier. This book was released on 2013-10-22 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of Hormone Action: A NATO Advanced Study Institute focuses on the action mechanisms of hormones, including regulation of proteins, hormone actions, and biosynthesis. The selection first offers information on hormone action at the cell membrane and a new approach to the structure of polypeptides and proteins in biological systems, such as the membranes of cells. Discussions focus on the cell membrane as a possible locus for the hormone receptor; gaps in understanding of the molecular organization of the cell membrane; and a possible model of hormone action at the membrane level. The text also ponders on insulin and regulation of protein biosynthesis, including insulin and protein biosynthesis, insulin and nucleic acid metabolism, and proposal as to the mode of action of insulin in stimulating protein synthesis. The publication elaborates on the action of a neurohypophysial hormone in an elasmobranch fish; the effect of ecdysone on gene activity patterns in giant chromosomes; and action of ecdysone on RNA and protein metabolism in the blowfly, Calliphora erythrocephala. Topics include nature of the enzyme induction, ecdysone and RNA metabolism, and nature of the epidermis nuclear RNA fractions isolated by the Georgiev method. The selection is a valuable reference for readers interested in the mechanisms of hormone action.
Author : Helen B. Hartman
Publisher :
ISBN 13 :
Total Pages : 101 pages
Book Rating : 4.:/5 (244 download)
Download or read book Mechanism of Transcriptional Regulation by Nuclear Hormone Receptors written by Helen B. Hartman and published by . This book was released on 2005 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Subhrangsu S. Mandal
Publisher : John Wiley & Sons
ISBN 13 : 3527322817
Total Pages : 678 pages
Book Rating : 4.5/5 (273 download)
Download or read book Gene Regulation, Epigenetics and Hormone Signaling written by Subhrangsu S. Mandal and published by John Wiley & Sons. This book was released on 2017-10-23 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.
Author : Jonathan M. Shipley
Publisher :
ISBN 13 :
Total Pages : 428 pages
Book Rating : 4.:/5 (298 download)
Download or read book Cross-talk Between Hormone-regulated Transcription Factors, STAT5b and ER, and Xenochemical Receptors, PPAR and AhR written by Jonathan M. Shipley and published by . This book was released on 2005 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Nuclear receptors are ligand-inducible transcription factors that bind to DNA-response elements of target genes as monomers, homodimers, or as heterodimers with the retinoid X receptor. Two members of the nuclear receptor superfamily are peroxisome proliferator activated receptors (PPAR) and the estrogen receptor (ER). JAK-STAT signaling is activated by multiple cytokines and hormones, including growth hormone (GH), and leads to the translocation of dimerized STAT proteins to the nucleus where they activate transcription of target genes. Previous studies have demonstrated that STAT5b can inhibit PPAR-regulated transcription. Herein this inhibitory cross-talk is shown to be mutual, and that GH-induced, STAT5b-regulated, luciferase reporter gene transcription is inhibited up to 80% by ligand-activated PPAR. Mechanistic studies characterize aspects of PPAR/STAT5b cross-talk, including the effect of PPAR on STAT5b protein levels and DNA-binding activity, as well as the role of specific PPAR protein domains. A PPAR-activated Renilla luciferase reporter plasmid was constructed and used in combination with a STAT5b firefly luciferase reporter to show that in cells co-stimulated with GH and a PPAR agonist, STAT5b inhibition of PPAR-regulated transcription occurs simultaneous with PPAR inhibition of STAT5b-regulated transcription. Another example of cross-talk involving a nuclear receptor is aryl hydrocarbon receptor (AhR) inhibition of ER-regulated transcription. Recent studies have demonstrated a pro-estrogenic action of the AhR that proceeds via the formation of an (AhR-Arnt)-ER complex, which binds to estrogen response elements (EREs) and stimulates transcription of ER target genes. Activation by the AhR ligand, 3-methylcholanthrene (3MC), of an ER-regulated luciferase reporter and ER target genes in the breast cancer cell line MCF-7 is demonstrated. ER reporter activity is additionally activated by 3MC in the AhR-positive mouse hepatoma 5L cell line and its AhR-negative variant BP8. The ability of 3MC to activate ER-regulated transcription in the absence of AhR suggests that this AhR ligand may activate ER directly, instead of, or in addition to, the AhR-dependent mechanism proposed. Together, these studies elucidate mechanisms through which the xenochemical receptors PPAR and AhR may respectively exert crosstalk with hormone-activated signaling pathways involving STAT5b and ER.
Author : Nagy László
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (18 download)
Download or read book Molecular Mechanisms Involved in Nuclear Hormone Receptor Action in Health and Disease written by Nagy László and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Brian J Arey
Publisher : Elsevier
ISBN 13 : 0124115071
Total Pages : 317 pages
Book Rating : 4.1/5 (241 download)
Download or read book Biased Signaling in Physiology, Pharmacology and Therapeutics written by Brian J Arey and published by Elsevier. This book was released on 2014-06-05 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling
Author : Scott M. Dehm
Publisher : Springer Nature
ISBN 13 : 303032656X
Total Pages : 483 pages
Book Rating : 4.0/5 (33 download)
Download or read book Prostate Cancer written by Scott M. Dehm and published by Springer Nature. This book was released on 2020-01-03 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to provide a contemporary overview of the causes and consequences of prostate cancer from a cellular and genetic perspective. Written by experts in the fields of epidemiology, toxicology, cell biology, genetics, genomics, cell-cell interactions, cell signaling, hormone signaling, and transcriptional regulation, the text covers aspects of prostate cancer from disease initiation to metastasis. Chapters explore in depth the cells of origin for prostate cancer, its genomic subtypes, neural transcription factors in disease progression, epigenetic regulation of chromatin, and many other topics. This book distinguishes itself from other texts on prostate cancer by its focus on cellular and genetic mechanisms, as opposed to clinical diagnosis and management. As a result, this book will be of broad interest to basic and translational scientists with familiarity of these topics, as well as to trainees at earlier stages of their research careers.
Author :
Publisher : Academic Press
ISBN 13 : 0128021969
Total Pages : 422 pages
Book Rating : 4.1/5 (28 download)
Download or read book Nuclear Receptors in Development and Disease written by and published by Academic Press. This book was released on 2017-05-17 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Receptors in Development and Disease, Volume 125, the latest volume in the Current Topics in Developmental Biology series, covers nuclear receptors in development and disease, and includes contributions from an international board of authors. New chapters in this release cover the Evolution of Nuclear Receptors and Ligand Signaling: Towards a Soft Key–Lock Model?, The Function and Evolution of Nuclear Receptors in Insect Embryonic Development, Nuclear Receptors in Skeletal Homeostasis, Estrogen Hormone Biology, and the Mechanisms of Glucocorticoid Action During Development. The book's chapters provide a comprehensive set of reviews that cover such topics as nuclear differentiation and remodeling, evolution of receptors, ligand signaling and neural development. Covers the area of nuclear receptors in development and disease Includes contributions from an International board of authors Provides a comprehensive set of reviews on topics as nuclear differentiation and remodeling, evolution of receptors, ligand signaling and neural developments
Author : Eric Y. Huang
Publisher :
ISBN 13 :
Total Pages : 113 pages
Book Rating : 4.:/5 (244 download)
Download or read book Mechanisms of Repression by Nuclear Receptor Corepressors written by Eric Y. Huang and published by . This book was released on 2001 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Vincent Goffin
Publisher : Springer Science & Business Media
ISBN 13 : 9780792376606
Total Pages : 340 pages
Book Rating : 4.3/5 (766 download)
Download or read book Hormone Signaling written by Vincent Goffin and published by Springer Science & Business Media. This book was released on 2002-03-31 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis. The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.
Author : Mostafa Z. Badr
Publisher : Springer Nature
ISBN 13 : 3030783154
Total Pages : 676 pages
Book Rating : 4.0/5 (37 download)
Download or read book Nuclear Receptors written by Mostafa Z. Badr and published by Springer Nature. This book was released on 2021-09-28 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological conditions in experimental animals and humans. Thus, nuclear receptors have become a major target in the effort to treat numerous diseases. This book will shed light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins. World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working with nuclear receptors. Chapters address the various means and consequences of modulating nuclear receptor activity will be presented and discussed. These modulators cover a wide span of moieties ranging from synthetic chemicals to natural products. In addition, the classification of these chemicals ranges from pan agonists to selective agonists and inverse agonists to antagonists. They also include proteolytic means to obliterate the receptor in the event that modulating its activity through canonical pharmacological agents becomes less effective and/or less desirable due to anticipated or experienced toxicities. Modulation of receptor activity may also take place in the absence of a ligand or through manipulating the structure of the receptor itself by controlling posttranslational events.
Author : Richard E. Brown
Publisher : Cambridge University Press
ISBN 13 : 9780521426657
Total Pages : 434 pages
Book Rating : 4.4/5 (266 download)
Download or read book An Introduction to Neuroendocrinology written by Richard E. Brown and published by Cambridge University Press. This book was released on 1994-01-27 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.
Author : Noriyuki Koibuchi
Publisher : Springer
ISBN 13 : 1493937375
Total Pages : 207 pages
Book Rating : 4.4/5 (939 download)
Download or read book Thyroid Hormone Disruption and Neurodevelopment written by Noriyuki Koibuchi and published by Springer. This book was released on 2016-11-11 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood.
Author : Eckhard Ottow
Publisher : Wiley-VCH
ISBN 13 : 9783527318728
Total Pages : 522 pages
Book Rating : 4.3/5 (187 download)
Download or read book Nuclear Receptors as Drug Targets written by Eckhard Ottow and published by Wiley-VCH. This book was released on 2008-10-13 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR. Authors from leading pharmaceutical companies around the world present examples and real-life data from their own work.
