Inherited Gastrointestinal Cancers: Identification, Management and the Role of Genetic Evaluation and Testing, An Issue of Gastrointestinal Endoscopy Clinics, E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323849598
Total Pages : 201 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Inherited Gastrointestinal Cancers: Identification, Management and the Role of Genetic Evaluation and Testing, An Issue of Gastrointestinal Endoscopy Clinics, E-Book by : Fay Kastrinos

Download or read book Inherited Gastrointestinal Cancers: Identification, Management and the Role of Genetic Evaluation and Testing, An Issue of Gastrointestinal Endoscopy Clinics, E-Book written by Fay Kastrinos and published by Elsevier Health Sciences. This book was released on 2021-11-26 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Gastrointestinal Endoscopy Clinics provides a multidisciplinary approach to the evaluation and care of individuals with inherited gastrointestinal cancer conditions. With the many recent advances made in genomic medicine and the potential impact on medical management, the articles in this issue disseminate new knowledge on the identification and management of individuals and families with a genetic susceptibility to the development of gastrointestinal cancers, including the genetic basis and cancer risks associated with inherited cancer syndromes and integrated familial cancer risk assessment; genetic testing approaches; and incorporating genetic risk counseling into routine medical care. The goal is to improve detection of GI cancer syndromes, understand related cancer risks, and optimize strategies for the prevention and early detection of cancers to minimize morbidity and mortality. Integrating genetic assessment into gastrointestinal cancer care is highly relevant across the cancer care spectrum and gastroenterologists will come away with the most current evidence to enhance and improve their clinical practice. - Provides in-depth, clinical reviews on Inherited GI Cancers: Identification, Management and the Role of Genetic Evaluation and Testing, providing actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. - Contains 11 relevant, practice-oriented topics including Defining High-Risk Individuals for Pancreatic Cancer and the Role of Genetic Testing; Endoscopic Management and Surgical Consideration for FAP-Related Polyposis; Genetic Syndromes Associated with Gastric Cancer; Screening and Surgical Considerations in Hereditary Diffuse Gastric Cancer; and more.

Inherited Gastrointestinal Cancers: Identification, Management and the Role of Genetic Evaluation and Testing, an Issue of Gastrointestinal Endoscopy Clinics

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Author :
Publisher : Elsevier
ISBN 13 : 9780323849586
Total Pages : 240 pages
Book Rating : 4.8/5 (495 download)

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Book Synopsis Inherited Gastrointestinal Cancers: Identification, Management and the Role of Genetic Evaluation and Testing, an Issue of Gastrointestinal Endoscopy Clinics by : Fay Kastrinos

Download or read book Inherited Gastrointestinal Cancers: Identification, Management and the Role of Genetic Evaluation and Testing, an Issue of Gastrointestinal Endoscopy Clinics written by Fay Kastrinos and published by Elsevier. This book was released on 2021-11-22 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Gastrointestinal Endoscopy Clinics provides a multidisciplinary approach to the evaluation and care of individuals with inherited gastrointestinal cancer conditions. With the many recent advances made in genomic medicine and the potential impact on medical management, the articles in this issue disseminate new knowledge on the identification and management of individuals and families with a genetic susceptibility to the development of gastrointestinal cancers, including the genetic basis and cancer risks associated with inherited cancer syndromes and integrated familial cancer risk assessment; genetic testing approaches; and incorporating genetic risk counseling into routine medical care. The goal is to improve detection of GI cancer syndromes, understand related cancer risks, and optimize strategies for the prevention and early detection of cancers to minimize morbidity and mortality. Integrating genetic assessment into gastrointestinal cancer care is highly relevant across the cancer care spectrum and gastroenterologists will come away with the most current evidence to enhance and improve their clinical practice. Provides in-depth, clinical reviews on Inherited GI Cancers: Identification, Management and the Role of Genetic Evaluation and Testing, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 11 relevant, practice-oriented topics including Defining High-Risk Individuals for Pancreatic Cancer and the Role of Genetic Testing; Endoscopic Management and Surgical Consideration for FAP-Related Polyposis; Genetic Syndromes Associated with Gastric Cancer; Screening and Surgical Considerations in Hereditary Diffuse Gastric Cancer; and more.

Colorectal Polyps, An Issue of Gastrointestinal Endoscopy Clinics. E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323986749
Total Pages : 225 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Colorectal Polyps, An Issue of Gastrointestinal Endoscopy Clinics. E-Book by : Aasma Shaukat

Download or read book Colorectal Polyps, An Issue of Gastrointestinal Endoscopy Clinics. E-Book written by Aasma Shaukat and published by Elsevier Health Sciences. This book was released on 2022-04-07 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue, guest editors bring their considerable expertise to this important topic.Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Advances in Biliary Endoscopy, An Issue of Gastrointestinal Endoscopy Clinics, E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323986846
Total Pages : 233 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Advances in Biliary Endoscopy, An Issue of Gastrointestinal Endoscopy Clinics, E-Book by : Mouen Khashab

Download or read book Advances in Biliary Endoscopy, An Issue of Gastrointestinal Endoscopy Clinics, E-Book written by Mouen Khashab and published by Elsevier Health Sciences. This book was released on 2022-06-15 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Gastrointestinal Endoscopy Clinics of North America, guest editor Dr. Mouen Khashab brings his considerable expertise to the topic of Advances in Biliary Endoscopy. Several novel diagnostic and therapeutic interventions can now be accomplished endoscopically both easily and safely in patients with liver disease, including cholangioscopy, endoscopic ultrasound, and endoscopic retrograde cholangiopancreatography. In this issue, top experts in the field have contributed state-of-the art reviews on these interventions, providing endoscopists and surgeons with the information they need to improve patient outcomes. - Contains 12 relevant, practice-oriented topics including basic and advanced biliary cannulation: how do I do it?; multidisciplinary approach to indeterminate biliary strictures; EUS-guided biliary interventions; endoscopic management of acute cholecystitis; future of cholangioscopy; and more. - Provides in-depth clinical reviews on biliary endoscopy, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Interventional Inflammatory Bowel Disease: Endoscopic Treatment of Complications, An Issue of Gastrointestinal Endoscopy Clinics, E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323987249
Total Pages : 305 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Interventional Inflammatory Bowel Disease: Endoscopic Treatment of Complications, An Issue of Gastrointestinal Endoscopy Clinics, E-Book by : Bo Shen

Download or read book Interventional Inflammatory Bowel Disease: Endoscopic Treatment of Complications, An Issue of Gastrointestinal Endoscopy Clinics, E-Book written by Bo Shen and published by Elsevier Health Sciences. This book was released on 2022-10-09 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue, guest editors bring their considerable expertise to this important topic.Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Management of Benign Pancreatic Disease, An Issue of Gastrointestinal Endoscopy Clinics

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323642268
Total Pages : 217 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Management of Benign Pancreatic Disease, An Issue of Gastrointestinal Endoscopy Clinics by : John Poneros

Download or read book Management of Benign Pancreatic Disease, An Issue of Gastrointestinal Endoscopy Clinics written by John Poneros and published by Elsevier Health Sciences. This book was released on 2018-09-22 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: With consultation of Dr. Charles J. Lightdale, Consulting Editor, Dr. Poneros has created created a state-of-the-art look at endoscopy for pancreatic disease. Top authors have contributed clinical reviews in the following areas: Acute Pancreatitis: Evidence Based Management Decisions ; Endoscopic Cyst Gastrostomy; ERCP for Recurrent Acute Pancreatitis ; Autoimmune Pancreatitis; Total Pancreatectomy with Autologous Islet Cell Transplantation; Pancreatic Insufficiency: What is the Gold Standard?; Current Guideline Controversies in the Management of Pancreatic Cystic Neoplasms; How to Manage Incidentally Found Pancreatic Neuroendocrine Tumors; Update in Celiac Block; The Use of Biomarkers in Risk Stratification of Cystic Neoplasms; Interventional EUS in the Pancreas; How to Avoid Post-ERCP Pancreatitis; and The Role of Genetic in Pancreatitis. Readers will come away with the clinical information they need to utilize endoscopic procedures in the treatment and management of pancreatic disease.

Gastric Cancer, An Issue of Gastrointestinal Endoscopy Clinics, E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323775454
Total Pages : 225 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Gastric Cancer, An Issue of Gastrointestinal Endoscopy Clinics, E-Book by : Chin Hur

Download or read book Gastric Cancer, An Issue of Gastrointestinal Endoscopy Clinics, E-Book written by Chin Hur and published by Elsevier Health Sciences. This book was released on 2021-06-04 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: - Provides in-depth, clinical reviews on Gastric Cancer, providing actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. - Provides in-depth, clinical reviews on Gastric Cancer, providing actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Diagnosis and Treatment of Gastrointestinal Cancers, An Issue of Gastroenterology Clinics of North America, E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 032385012X
Total Pages : 241 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Diagnosis and Treatment of Gastrointestinal Cancers, An Issue of Gastroenterology Clinics of North America, E-Book by : Marta Davila

Download or read book Diagnosis and Treatment of Gastrointestinal Cancers, An Issue of Gastroenterology Clinics of North America, E-Book written by Marta Davila and published by Elsevier Health Sciences. This book was released on 2022-09-25 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Diagnosis and Treatment of Gastrointestinal Cancers, guest editors Drs. Marta Davila and Raquel E. Davila bring their considerable expertise to the topic of Diagnosis and Treatment of Gastrointestinal Cancers. The early detection, diagnosis, and accurate staging of GI cancers, along with enhanced imaging techniques, new therapies, and a greater understanding of GI tumors at the molecular level, has revolutionized the approach to GI cancer patients in recent years. In this issue, distinguished authors recognized internationally as leading authorities in the field provide an exhaustive review of the latest topics in GI cancer. - Contains 13 practice-oriented topics including management of Barrett's esophagus and early esophageal adenocarcinoma; familial pancreatic cancer; colorectal cancer: screening and early detection; the microbiome in gastrointestinal cancers; and more. - Provides in-depth clinical reviews on diagnosis and treatment of gastrointestinal cancers, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Gastrointestinal Neoplasia, An Issue of Gastroenterology Clinics of North America

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323462782
Total Pages : 185 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Gastrointestinal Neoplasia, An Issue of Gastroenterology Clinics of North America by : Paul J. Limburg

Download or read book Gastrointestinal Neoplasia, An Issue of Gastroenterology Clinics of North America written by Paul J. Limburg and published by Elsevier Health Sciences. This book was released on 2016-08-24 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastrointestinal (GI) cancers account for nearly 150,000 deaths each year, in the United States alone. Encouragingly, environmental risk factors, premalignant conditions, and high-risk familial kindreds are well described for many GI cancers. In this comprehensive volume on GI Neoplasia, all luminal cancers will be discussed, along with pancreas cancer, gastrointestinal stromal tumors (GISTs), carcinoid tumors, and neuroendocrine tumors. Hepatobiliary cancers are not addressed, as these tumors could form the basis of a separate volume. Articles are organized to address several key topics for each cancer type, such as: public health burden, molecular pathways, risk and protective factors, early detection, clinical evaluation, management, and survivorship.

Hereditary Colorectal Cancer

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Publisher : Springer Science & Business Media
ISBN 13 : 144196603X
Total Pages : 615 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Hereditary Colorectal Cancer by : Miguel A. Rodriguez-Bigas

Download or read book Hereditary Colorectal Cancer written by Miguel A. Rodriguez-Bigas and published by Springer Science & Business Media. This book was released on 2010-09-10 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer is the third most commonly diagnosed cancer in the US and the third most recently linked to cancer deaths. The national annual incidence rate of colorectal cancer is approximately 148,000+, striking slightly more females than males. The lifetime risk of colorectal cancer is 5-6%, however patients with a familial risk (with two or more first or second degree relatives) make up 20% of the patients. Persons who carry genetic mutations linked to hereditary colorectal cancer are the most likely to develop the disease.

Imaging and Cancer Screening, An Issue of Radiologic Clinics of North America

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323549004
Total Pages : 185 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Imaging and Cancer Screening, An Issue of Radiologic Clinics of North America by : Dushyant V Sahani

Download or read book Imaging and Cancer Screening, An Issue of Radiologic Clinics of North America written by Dushyant V Sahani and published by Elsevier Health Sciences. This book was released on 2017-10-16 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Radiologic Clinics of North America focuses on Imaging and Cancer Screening, and is edited by Dr. Dushyant Sahani. Articles will include: Imaging and Screening of Thyroid Cancer; Imaging and Screening of Lung Cancer; Imaging and Screening of Breast Cancer; Imaging and Screening of Liver Cancer; Imaging and Screening of Cancer of the Gall Bladder and Bile Ducts; Imaging and Screening of Pancreatic Cancer; Imaging and Screening of Kidney Cancer; Imaging and Screening of Cancer of the Small Bowel; Imaging and Screening of Colon Cancer; Imaging and Screening of Ovarian Cancer; Imaging and Screening of Genetic Syndromes; and more!

Surgical Oncology for the General Surgeon, An Issue of Surgical Clinics

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323710719
Total Pages : 233 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Surgical Oncology for the General Surgeon, An Issue of Surgical Clinics by : Randy Zuckerman

Download or read book Surgical Oncology for the General Surgeon, An Issue of Surgical Clinics written by Randy Zuckerman and published by Elsevier Health Sciences. This book was released on 2020-06-04 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Surgical Clinics of North America focuses on Surgical Oncology for the General Surgeon and is edited by Drs. Neal Wilkinson and Randall Zuckerman. Articles will include: Cancer Incidence and Trends; Cancer Genetics; Imaging and Interventional Radiology for Cancer Management; Esophagus and GE Junction Tumors; Gastric Cancer; Primary Liver Cancers; Metastatic Cancer to Liver; Pancreas Solid Tumors; Pancreas Cystic Lesions; Peritoneal Cancers and HIPEC; Rectal Cancer; Anal Cancer; Neuroendocrine Tumors; Soft Tissue Tumors of the Abdomen; Soft Tissue Tumors of the Extremities; and more!

The Role of Genetic Testing in Surgical Oncology, An Issue of Surgical Oncology Clinics of North America

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323401090
Total Pages : 233 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis The Role of Genetic Testing in Surgical Oncology, An Issue of Surgical Oncology Clinics of North America by : Thomas K. Weber

Download or read book The Role of Genetic Testing in Surgical Oncology, An Issue of Surgical Oncology Clinics of North America written by Thomas K. Weber and published by Elsevier Health Sciences. This book was released on 2016-01-07 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Surgical Oncology Clinics of North America, edited by Thomas Weber, MD, is devoted to Genetic Testing in Surgical Oncology. Articles in this issue include: The Critical Importance of Timely Genetic Testing; Securing and Documenting Cancer Family History in the Age of the Electronic Medical Record; Cancer Family Registries: Vital Tools for Patient Management and Cancer Genetics Translational Research; The Genetics of Breast Cancer; The Genetics of Colorectal Cancer: HNPCC, FAP MYH, and Hamartomatous Syndromes Including Peutz-Jeghers and Jevenile Polyposis; Hereditary Gastric Cancer Syndromes; Hereditary Pancreatic Cancer Syndromes; Hereditary Melanoma: Genetics and Multidisciplinary Management; Multiple Endocrine Neoplasia: Genetics and Clinical Management; Sequence Variants of Uncertain Significance (VUS): What To Do When Genetic Testing Results Are Not Definitive; Confidentiality and the Risk of Genetic Discrimination: What Surgeons Need to Know; and A Certified Genetic Counselor: A Crucial Clinical Resource in the Management of Patients with Suspected Hereditary Solid Tumor Syndromes.

Genetics of Colorectal Cancer

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Author :
Publisher : Springer
ISBN 13 : 9780387095677
Total Pages : 309 pages
Book Rating : 4.0/5 (956 download)

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Book Synopsis Genetics of Colorectal Cancer by : John D. Potter

Download or read book Genetics of Colorectal Cancer written by John D. Potter and published by Springer. This book was released on 2008-12-08 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.

Hereditary Colorectal Cancer

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Author :
Publisher : Springer
ISBN 13 : 3319742590
Total Pages : 494 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Hereditary Colorectal Cancer by : Laura Valle

Download or read book Hereditary Colorectal Cancer written by Laura Valle and published by Springer. This book was released on 2018-05-04 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.

Video Capsule Endoscopy, An Issue of Gastrointestinal Endoscopy Clinics, E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323796192
Total Pages : 209 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Video Capsule Endoscopy, An Issue of Gastrointestinal Endoscopy Clinics, E-Book by : David R. Cave

Download or read book Video Capsule Endoscopy, An Issue of Gastrointestinal Endoscopy Clinics, E-Book written by David R. Cave and published by Elsevier Health Sciences. This book was released on 2021-03-22 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adoption of video capsule endoscopy has been slow, but there are now four FDA-approved devices and others available in China. It is now generally realized that there is an expanding role for these devices, not only in the small intestine but in the GI tract in general. In collaboration with Consulting Editor, Dr. Charles Lightdale, guest editor Dr. David Cave has assembled expert authors to provide clinical reviews that address where we are now, areas of controversy that still need resolution, and where the field is likely to develop over the next 5 to 10 years. Articles are specifically devoted to the following topics: Training, Reading and Reporting for Video Capsule Endoscopy; Indications and Contraindications: Complications of Capsule Endoscopy; Preparation, Prokinetics, and Surface Active Agents; Role of Capsule in Small Intestinal Bleeding; Role of Capsule Endoscopy in IBD; Role of Video Capsule Endoscopy in Liver Disease; Role of Video Capsule Endoscopy in Alternative Settings; Timing and Use of the Capsule Endoscopy in the Acute Care Setting; Role of Video Capsule Endoscopy as a Prelude to Deep Enteroscopy; Location of Capsule and Provocation Testing; Cost Effectiveness of Video Capsule Endoscopy; Artificial Intelligence in Capsule Endoscopy; and Novel Clinical Applications and Technical Developments in Video Capsule Endoscopy.

Management of Pancreatic Diseases, An Issue of Gastroenterology Clinics of North America

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323416470
Total Pages : 193 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Management of Pancreatic Diseases, An Issue of Gastroenterology Clinics of North America by : Nuzhat A. Ahmad

Download or read book Management of Pancreatic Diseases, An Issue of Gastroenterology Clinics of North America written by Nuzhat A. Ahmad and published by Elsevier Health Sciences. This book was released on 2016-02-19 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue details the latest knowledge of early diagnosis, risk factors, limited surgical treatments, and novel therapies for pancreatic diseases. Clinicians will learn the most prognostic scoring systems for acute pancreatitis, review the basics for early management of the disease, and see how current practice guidelines have evolved. Advances in radiological imaging when applied to the pancreas have resulted in enhanced staging and improved selection for surgical intervention. Endoscopy of the pancreas via both ERCP and endoscopic ultrasound has led to unprecedented access and potential for non-operative intervention. Pancreatic surgery now takes advantage of both minimally invasive approaches and techniques learned from organ transplantation. These latest advances are addressed in this issue by key opinion leaders.