Influence of Colostral Lymphocytes on the Immune System of the Newborn Calf

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Publisher :
ISBN 13 :
Total Pages : 324 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Influence of Colostral Lymphocytes on the Immune System of the Newborn Calf by : Brian Aldridge

Download or read book Influence of Colostral Lymphocytes on the Immune System of the Newborn Calf written by Brian Aldridge and published by . This book was released on 1999 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Characterization of Bovine Mammary Lymphocytes and Their Effects on Neonatal Calf Immunity

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Publisher :
ISBN 13 :
Total Pages : 346 pages
Book Rating : 4.:/5 (34 download)

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Book Synopsis Characterization of Bovine Mammary Lymphocytes and Their Effects on Neonatal Calf Immunity by : Gerald Ernest Duhamel

Download or read book Characterization of Bovine Mammary Lymphocytes and Their Effects on Neonatal Calf Immunity written by Gerald Ernest Duhamel and published by . This book was released on 1986 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Effect of Feeding Different Amounts of Colostrum and Milk on Immunity and Performance of Dairy Calves

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Publisher :
ISBN 13 :
Total Pages : 516 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Effect of Feeding Different Amounts of Colostrum and Milk on Immunity and Performance of Dairy Calves by : Leovegildo Lopes de Matos

Download or read book Effect of Feeding Different Amounts of Colostrum and Milk on Immunity and Performance of Dairy Calves written by Leovegildo Lopes de Matos and published by . This book was released on 1988 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Development, Nutrition, and Management of the Young Calf

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Publisher : Iowa State Press
ISBN 13 : 9780813829807
Total Pages : 339 pages
Book Rating : 4.8/5 (298 download)

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Book Synopsis The Development, Nutrition, and Management of the Young Calf by : Carl L. Davis

Download or read book The Development, Nutrition, and Management of the Young Calf written by Carl L. Davis and published by Iowa State Press. This book was released on 1998-01-01 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: An indispensable resource for the dairy farmer or veterinarian, the researcher, teacher, or advanced student, this book puts the cutting–edge science of raising dairy calves into an accessible, usable form. Geared to those with a basic understanding of principles of animal nutrition and husbandry, the volume gives a comprehensive account of all aspects of calf rearing, from the rudiments of anatomy and development through the practicalities of feeding and housing. The Development, Nutrition and Management of the Young Calf begins with an overview of how the calf′s digestive system develops, highlighting the period of transition from preruminant to ruminant digestion. Here the authors provide information essential to understanding nutritional needs and restrictions during the liquid–feeding phase in the young calf as well as those factors that govern the development of a functional rumen. Major emphasis is given to the energy and protein requirements of the young calf, with attention to the effects of environmental temperature on energy requirements. The authors also review the adequacy of current National Research Council recommendations on the energy and protein requirements of young calves. They discuss the management, nutrition, and care of the pregnant cow as well as calving management necessary to deliver a healthy calf. Other topics include liquid–feeding systems, formulation and use of milk replacers and starter feeds, the weaning process, housing principles, and the interactions of nutrition and disease

Bovine Reproduction

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Publisher : John Wiley & Sons
ISBN 13 : 1118470850
Total Pages : 2206 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Bovine Reproduction by : Richard M. Hopper

Download or read book Bovine Reproduction written by Richard M. Hopper and published by John Wiley & Sons. This book was released on 2014-08-18 with total page 2206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bovine Reproduction is a comprehensive, current reference providing information on all aspects of reproduction in the bull and cow. Offering fundamental knowledge on evaluating and restoring fertility in the bovine patient, the book also places information in the context of herd health where appropriate for a truly global view of bovine theriogenology. Printed in full color throughout, the book includes 83 chapters and more than 550 images, making it the most exhaustive reference available on this topic. Each section covers anatomy and physiology, breeding management, and reproductive surgery, as well as obstetrics and pregnancy wastage in the cow. Bovine Reproduction is a welcome resource for bovine practitioners, theriogenologists, and animal scientists, as well as veterinary students and residents with an interest in the cow.

Bioactive Components of Milk

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Publisher : Springer Science & Business Media
ISBN 13 : 0387740872
Total Pages : 492 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Bioactive Components of Milk by : Zsuzsanna Bosze

Download or read book Bioactive Components of Milk written by Zsuzsanna Bosze and published by Springer Science & Business Media. This book was released on 2007-12-26 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dairy foods have huge potential concerning functional foods. Therefore, there is a tremendous amount of interest in value-added milk products and the identification of components in food which have health benefits. This book provides an overview of these derived components and their diverse activities including: the stimulation of beneficial microflora, alerting the immune system to the presence of potential pathogens and allergens, binding and eliminating toxins, etc.

Immunology,An Issue of Veterinary Clinics of North America: Food Animal Practice

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323683460
Total Pages : pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Immunology,An Issue of Veterinary Clinics of North America: Food Animal Practice by : Christopher Chase

Download or read book Immunology,An Issue of Veterinary Clinics of North America: Food Animal Practice written by Christopher Chase and published by Elsevier Health Sciences. This book was released on 2019-10-12 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Veterinary Clinics: Food Animal Practice, guest edited by Dr. Christopher Chase in collaboration with Consulting Editor Dr. Robert Smith, focuses on Ruminant Immunology. Article topics include: Herd immunity: an epidemiologist's view; Genetics of immunoresponsive and correlates of immunity; Microbiome and immunity: an evolving field; Vaccine administration dos and don'ts (endotoxin stacking; delayed MLV); Mycoplasma bovis: interations with the immune system and failure to generate an immune response; Nutriceuticals and their effect on immune response; Adjuvants; Immunology of maximizing passive transfer; Mucosal immunity and common mucosal response; Vaccinating in the face of maternal immunity; and Gamma Delta T cells in ruminants: their role, function, and importance.

Veterinary Immunology - E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323291694
Total Pages : 568 pages
Book Rating : 4.3/5 (232 download)

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Book Synopsis Veterinary Immunology - E-Book by : Ian R. Tizard

Download or read book Veterinary Immunology - E-Book written by Ian R. Tizard and published by Elsevier Health Sciences. This book was released on 2013-12-27 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only complete resource on immunology for veterinary students and practitioners, Veterinary Immunology: An Introduction features a straightforward presentation of basic immunologic principles with comprehensive information on the most significant immunological diseases and responses seen in domestic animals. This meticulously updated new edition explores the latest advances in the field and provides a wealth of clinical examples that illustrate and clarify important concepts. Comprehensive coverage of vaccines and vaccine usage, allergies and allergic diseases, and autoimmunity and immunodeficiencies, prepare you for the multiple immunologic issues you will encounter in practice. A wealth of clinical examples clearly illustrate key concepts and offer practical strategies for diagnosing and treating immunologic disorders in the clinical setting. More than 500 full-color diagrams and illustrations visually demonstrate and clarify complex issues. Completely updated section on innate immunity includes new chapters on natural killer (NK) cells and systemic responses to infection to ensure you have the most up-to-date information. New information on genomics and molecular diagnostic techniques explores how the emerging field of genomics impacts disease resistance and immunology in general, as well as the diagnosis and treatment of immunological and infectious diseases. Updated content provides new information on well-recognized older diseases such as rheumatoid arthritis, systemic lupus, and inflammatory bowel disease, as well as current information on new diseases such as devil facial tumor disease and bovine neonatal pancytopenia. Expanded coverage brings you the latest knowledge on resistance to infection, such as vaccine usage, especially with respect to duration of immunity, the effects of key vitamins and lipids on immune responses, the effects of old age on immunity, and both antiviral and parasitic immunity. Diagnostic tests described throughout the text include a new section on the analysis of ELISA test data, as well as a brief summary of molecular diagnostic techniques. Coverage reflecting a significant change in the overall view of immunology provides you with the foundational knowledge needed to grasp the broad pattern of immunologic reactions and understand how the immune system functions as an interconnected network, rather than a series of independent pathways. New discussions of the critical importance of commensal bacteria and intestinal flora explain help you understand the importance of this normal flora with respect to antibacterial immunity, allergies, and autoimmunity, while at the same time providing a broader view of the animal body and its microflora as a "superorganism." A discussion of the importance of adipose tissue in immunity and inflammation addresses the epidemic of obesity in domestic pets and the extraordinary growth rates expected of domestic livestock. The section on inflammatory mechanisms has been divided into separate chapters focusing on the detection of invaders and the mediators of inflammation to incorporate the vast amount of new information on pattern recognition receptors and the ways in which they warn the body of microbial invasion.

Veterinary Immunology

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Publisher : Elsevier Health Sciences
ISBN 13 : 145570363X
Total Pages : 615 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Veterinary Immunology by : Ian R. Tizard

Download or read book Veterinary Immunology written by Ian R. Tizard and published by Elsevier Health Sciences. This book was released on 2012-05-17 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only complete resource on immunology for veterinary students and practitioners, Veterinary Immunology: An Introduction features a straightforward presentation of basic immunologic principles with comprehensive information on the most significant immunological diseases and responses seen in domestic animals. This meticulously updated new edition explores the latest advances in the field and provides a wealth of clinical examples that illustrate and clarify important concepts. Comprehensive coverage of vaccines and vaccine usage, allergies and allergic diseases, and autoimmunity and immunodeficiencies, prepare you for the multiple immunologic issues you will encounter in practice. A wealth of clinical examples clearly illustrate key concepts and offer practical strategies for diagnosing and treating immunologic disorders in the clinical setting. More than 500 full-color diagrams and illustrations visually demonstrate and clarify complex issues. Completely updated section on innate immunity includes new chapters on natural killer (NK) cells and systemic responses to infection to ensure you have the most up-to-date information. New information on genomics and molecular diagnostic techniques explores how the emerging field of genomics impacts disease resistance and immunology in general, as well as the diagnosis and treatment of immunological and infectious diseases. Updated content provides new information on well-recognized older diseases such as rheumatoid arthritis, systemic lupus, and inflammatory bowel disease, as well as current information on new diseases such as devil facial tumor disease and bovine neonatal pancytopenia. Expanded coverage brings you the latest knowledge on resistance to infection, such as vaccine usage, especially with respect to duration of immunity, the effects of key vitamins and lipids on immune responses, the effects of old age on immunity, and both antiviral and parasitic immunity. Diagnostic tests described throughout the text include a new section on the analysis of ELISA test data, as well as a brief summary of molecular diagnostic techniques. Coverage reflecting a significant change in the overall view of immunology provides you with the foundational knowledge needed to grasp the broad pattern of immunologic reactions and understand how the immune system functions as an interconnected network, rather than a series of independent pathways. New discussions of the critical importance of commensal bacteria and intestinal flora explain help you understand the importance of this normal flora with respect to antibacterial immunity, allergies, and autoimmunity, while at the same time providing a broader view of the animal body and its microflora as a "superorganism." A discussion of the importance of adipose tissue in immunity and inflammation addresses the epidemic of obesity in domestic pets and the extraordinary growth rates expected of domestic livestock. The section on inflammatory mechanisms has been divided into separate chapters focusing on the detection of invaders and the mediators of inflammation to incorporate the vast amount of new information on pattern recognition receptors and the ways in which they warn the body of microbial invasion.

Comparative Mammalian Immunology

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Publisher : Elsevier
ISBN 13 : 0323952208
Total Pages : 460 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Comparative Mammalian Immunology by : Ian R Tizard

Download or read book Comparative Mammalian Immunology written by Ian R Tizard and published by Elsevier. This book was released on 2023-02-09 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comparative Mammalian Immunology: The Evolution and Diversity of the Immune Systems of Mammals provides a review on the current knowledge of mammalian immune systems from a comparative viewpoint. This reference encompasses recent work on the immune systems of marine mammals, bats and marsupials in addition to other lesser-known species, with the immune systems of humans and laboratory mice as components of chapters on primates and rodents respectively. The book also makes use of the most recent studies on the genomic sequences of the mammals to identify both common and unique features of each mammal's immune system. The book elucidates the complex, but coordinated and controlled series of interactions involving cells and molecules that has evolved to protect the host against disease. Mammals consist of a highly diverse group of animals in which the immune system has been subjected to a variety of selective pressures. This is reflected in differences in the organization and function of their immune systems, and is especially seen in those gene families characterized by complexity and polymorphism. Demonstrates multiple diverse pathways and mechanisms to optimize resistance and survival in the face of infectious diseases Shows the clear patterns of emergence of different immunologic traits among the diverse orders of mammals Reflects issues with innate or adaptive immune systems Serves as a comprehensive review of the current state of knowledge of the immune system of each mammalian order

Bovine Reproduction

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Publisher : John Wiley & Sons
ISBN 13 : 1119602467
Total Pages : 1236 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Bovine Reproduction by : Richard M. Hopper

Download or read book Bovine Reproduction written by Richard M. Hopper and published by John Wiley & Sons. This book was released on 2021-05-11 with total page 1236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ein umfassendes Nachschlagewerk mit praktischen, maßgeblichen Informationen zu allen Aspekten der Rindertheriogenologie Die neu überarbeitete zweite Ausgabe von Bovine Reproduction bietet einen ausführlichen Überblick über alle wichtigen Themen rund um die Rinderreproduktion. Das Werk wurde von führenden Experten auf dem Gebiet verfasst und ist ein unverzichtbares Referenzwerk für alle Tierärzte, die sich mit der Fruchtbarkeit von Rindern beschäftigen. Bovine Reproduction ist in mehrere Abschnitte unterteilt: über den Bullen, die Kuh, das neugeborene Kalb und Techniken der assistierten Reproduktion. Die neue Ausgabe enthält Kapitel über neue Genmanipulationstechniken, den Umgang mit problematischen Spendern, Lähmung und viele weitere Themen. Veraltete und überflüssige Angaben aus der ersten Ausgabe wurden entfernt und durch Informationen über neue Krankheiten, Technologien, Verfahren, Techniken und Behandlungsmöglichkeiten von Fertilitätsproblemen ersetzt. Auf der neuen begleitenden Website stehen Bilder und Tabellen aus dem Buch im PowerPoint-Format zur Verfügung. Neben den über 675 vollfarbigen Abbildungen bietet das Werk insbesondere: * Eine ausführliche Diskussion der Anatomie und Physiologie des Bullen, auch in Bezug auf die endokrine und exokrine Funktion der Rinderhoden und die Thermoregulation der Hoden * Eine Betrachtung des Zucht- und Gesundheitsmanagements bei Bullen mit einer Bewertung der Zuchttauglichkeit und einem Abschnitt über Ultraschalluntersuchungen des Fortpflanzungstrakts * Eine Analyse der Anatomie, Physiologie sowie des Zucht- und Gesundheitsmanagements bei Kühen, auch in Bezug auf fötale Programmierung, das Mikrobiom des Fortpflanzungstrakts und mit einem Abschnitt über Geburtshilfe und Reproduktionschirurgie * Einen Überblick über die Intensivpflege des neugeborenen Kalbes und die wirksame Untersuchung und Gabe von Kolostrum * Eine Einführung in assistierte moderne Reproduktionstechnologien Das praktische umfassende Nachschlagewerk ist ein unverzichtbarer Ratgeber für Rinderzüchter, Theriogenologen, Tierzuchtwissenschaftler, Studierende der Veterinärmedizin und angehende Ärzte mit einer Spezialisierung auf Rinder.

Lactation and the Mammary Gland

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Publisher : John Wiley & Sons
ISBN 13 : 1119279674
Total Pages : 291 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Lactation and the Mammary Gland by : R. Michael Akers

Download or read book Lactation and the Mammary Gland written by R. Michael Akers and published by John Wiley & Sons. This book was released on 2016-02-10 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Michael Akers provides the basics for understanding mammary development and lactation and conveys the critical regulatory events in lactation. This text willl prove to be an invaluable overview of mamorary development and lactation for undergraduates and graduates studying lactation, new researchers, and as a review for established scientists. Additionally, the book will be an important resource for professionals in the animal and dairy industry and for those in other scientific disciplines such as food chemistry, cell biology, and endocrinology whose work is closely tied to mammary gland development and function. Lactation and the Mammary Gland covers growth and development of the mammary gland including comparisons between species. It imparts and emphasizes the critical nature of mammary growth and the onset of lactation at the time of parturition. Special emphasis is given to the endocrine and growth factor regulation of both mammogenesis and lactogenesis. A thorough discussion of the role of growth hormone in development and maintenance of lactation or galactopoiesis adds to this book's value as a text and reference. The author reviews the presence of hormones, growth factors, and other bioactive compounds in milk and mammary secretions as well as the potential for use of the mammary gland as a bioreactor in the pharmaceutical industry. A description of the nutritional and management factors in milk production round out the book's comprehensive coverage.

Large Animal Internal Medicine - E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 032355444X
Total Pages : 2279 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Large Animal Internal Medicine - E-Book by : Bradford P. Smith

Download or read book Large Animal Internal Medicine - E-Book written by Bradford P. Smith and published by Elsevier Health Sciences. This book was released on 2019-05-21 with total page 2279 pages. Available in PDF, EPUB and Kindle. Book excerpt: **Selected for Doody’s Core Titles® 2024 with "Essential Purchase" designation in Veterinary Medicine** Utilize a problem-oriented approach to the diagnosis of diseases of horses, cattle, sheep, and goats. Large Animal Internal Medicine, 6th Edition covers the diagnosis and management of disease in both ruminant and equine internal medicine. As the first veterinary internal medicine text to use a problem-based approach, it offers discussions of over 150 clinical signs and manifestations, as well as comprehensive coverage of laboratory and diagnostic testing. New to this edition is a versatile online reference platform and coverage of conditions that exist in Europe, Central and South America, Australia, and New Zealand. In addition, thoroughly revised and updated content includes new vaccines and vaccination protocols; the most current laboratories for DNA, genetic, and PCR testing; and colostrum supplements and replacers. It’s everything you need to stay up to date with the latest information on preventing and treating disease in large animals. Discussions of over 150 clinical signs or manifestations of disease provide you with a problem-based approach to diagnosis based on what you’ve observed and what laboratory tests reveal. Causes of Presenting Signs boxes offer quick access to the common, less common, and uncommon diseases associated with manifestations or signs of disease. Causes of Abnormal Laboratory Values boxes highlight the possible interpretations of abnormalities in clinical chemistry, hematology, blood proteins, and clotting tests. More than 200 expert authors contribute information in their areas of expertise for the most current, authoritative information on each topic. NEW! Expert Consult platform provides a versatile digital resource including bonus content, useful references, and videos to meet the needs of practicing equine and large animal veterinarians. NEW! Global conditions of importance are covered, including those previously not discussed, that exist in Europe, Central and South America, Australia, and New Zealand. NEW! Coverage of emerging and re-emerging diseases includes the new pathogen discovery. NEW! Assessment of vaccination status and susceptibility to infection discusses how antibody titers can predict protection for some pathogens. NEW! Description of epigenetics and metagenomics provides detailed coverage of these emerging areas of interest. NEW! Table of zoonoses obtained from large animals includes symptoms and disinfection needs. NEW! Videos demonstrate how to perform ultrasound imaging on an equine and cow abdomen clearly showing where to position the probe, and what depth to use for scans of the kidneys, liver, and bowel. NEW! Coverage of genetic disorders, Hydrocephalus in Fresians and Pulmonary hypoplasia with Anasarca in Dexter cattle help you to treat these disorders. NEW! Extensively updated content clarifies the latest research and clinical findings on the West Nile Virus, therapeutic drug monitoring, muscle disorders, GI microbiota, the genetic basis for Immune-mediated myositis in Quarter Horses, discoveries in antimicrobial drugs, anthelmintic, and vaccines, and more!

Biology of Domestic Animals

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Publisher : CRC Press
ISBN 13 : 1351648136
Total Pages : 509 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Biology of Domestic Animals by : Colin G. Scanes

Download or read book Biology of Domestic Animals written by Colin G. Scanes and published by CRC Press. This book was released on 2017-09-01 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is increasing interest in the biology of domestic animals ranging from genomics, transcriptomics, metabolomics, nutritional physiology, and systems biology. This book touches on all of these, with a particular focus on topics such as domestic animals as comparative models to humans, molecular regulation of growth, metabolic efficiency, reproduction, and the impact of stress on growth and development. The book concludes with a discussion on the current and future directions for researchers.

Animal Stress

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Publisher : Springer
ISBN 13 : 1461475449
Total Pages : 323 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Animal Stress by : Gary P Moberg

Download or read book Animal Stress written by Gary P Moberg and published by Springer. This book was released on 2013-05-27 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on a recent symposium that brought together experts in behavior, nutrition, physiology, immunology, and human and animal medicine, this volume presents an up-to-date discussion of the problems and methods of studying animal stress today. Section one reviews the evolutionary and ontogenetic determinants of animal suffering and the assessment of well-being. The second section examines biological responses to stress and methods of monitoring stress in animals. Section three shows how stress can threaten animal health, disrupt normal reproduction, and influence growth and metabolism. The final section relates the importance of animal stress to developing guidelines on the use of animals in scientific research. This is an invaluable reference for exploring these complex responses

Dairy Production Medicine

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Publisher : John Wiley & Sons
ISBN 13 : 0470960531
Total Pages : 643 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Dairy Production Medicine by : Carlos Risco

Download or read book Dairy Production Medicine written by Carlos Risco and published by John Wiley & Sons. This book was released on 2011-08-04 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive book integrates new technology and concepts that have been developed in recent years to manage dairy farms in a profitable manner. The approach to the production of livestock and quality milk is multidisciplinary, involving nutrition, reproduction, clinical medicine, genetics, pathology, epidemiology, human resource management and economics. The book is structured by the production cycle of the dairy cow covering critical points in cow management. Written and edited by highly respected experts, this book provides a thoroughly modern and up-to-date resource for all those involved in the dairy industry.

Current Therapy in Equine Reproduction E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 1437713009
Total Pages : 512 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Current Therapy in Equine Reproduction E-Book by : Jonathan Pycock

Download or read book Current Therapy in Equine Reproduction E-Book written by Jonathan Pycock and published by Elsevier Health Sciences. This book was released on 2006-11-23 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering the most current insights on horse breeding, this book covers the entire reproductive system, normal and abnormal mare physiology, and a wide range of reproductive problems commonly seen in both the mare and stallion. Coverage includes advanced reproductive techniques, with numerous breeding strategies to help you achieve optimal fertility rates. Features the most current information available on equine reproduction, including the latest therapies and treatments for breeding dysfunction, as well as advances in reproductive techniques Focuses on therapy and treatment to provide practitioners with quick access to key information Features the shared experience and valuable advice of world-renowned experts who have first-hand knowledge of which treatments and therapies are most effective