Author : Asja Muhiu0107
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (116 download)
Book Synopsis In-vivo Animal Model Histological Analysis of TiMg Composite Material for Dental Implants by : Asja Muhiu0107
Download or read book In-vivo Animal Model Histological Analysis of TiMg Composite Material for Dental Implants written by Asja Muhiu0107 and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In-vivo animal model histological analysis of TiMg composite material for dental implantsu0106atiu0107 Amir, Muhiu0107 Asja, Beu0161iroviu0107 Hajrudin, Balog Martin, Krizik Peter, Schauperl ZdravkoBackground: One of the main issues concerning dental implant materials arises from their Youngu2019s modulus being considerably higher than that of bone, which can generate stress-shielding effect and periimplant bone atrophy during loading. By use of advanced powder metallurgy novel titanium-magnesium (Ti12Mg) composite has been designed and consolidated. Results of ISO-standard based tests for dental implants demonstrated superior mechanical properties, in-vitro tests showed adequate biocorrosion.Aim: The aim of the study was to produce common dimension implants and assess the in-vivo osseointegration potentials of Ti12Mg composite metal on animal model. Materials and methods: Study design was presented to ethical committees of both UNIZG School of Dental Medicine and UNISA Faculty of Veterinary Medicine, and the approvals acquired. Consolidated Ti12Mg implant material was roll-pressed into a 3,5mm diameter bar and machined into 12 implants of 11mm length. Implant neck geometry was modeled to allow for screw-motion placement. Four sheep of various ages were chosen from natural pasture farm with HACCP certificate and kept 30 days in controlled conditions with identical pasture prior to surgery. At the day of surgery three implants were epicrestally placed using regular implant surgical protocol in right tibia of each sheep 2cm apart. After 4, 8 and 12 weeks from each sheep one implant and the surrounding bone were removed by a 7mm diameter trephine bur, the samples prepared and histologically analyzed. All surgeries were performed in general anesthesia. After completion of the investigation sheep were healthy and in normal function. Results: Histological analyzes demonstrated formation of bone at the bone to implant contact. Time-related bone maturation was typical for dental implants. However, BIC at 12 weeks was more mature at Ti12Mg implants in comparison to the commercially available implant. Histomorphometric analysis showed average BIC values within the bone marrow at 4 weeks 52%, at 8 weeks 81% and at 12 weeks 96%. BIC values within the cortical bone were 59% at 4 weeks, 89% at 8 weeks and 98% at 12 weeks. No signs of gaseous enclosures were determined in the surrounding bone. Conclusions and clinical implications: Proposed Ti12Mg composite, with Mg phase acting as beneficiary modulator for generating an osseoconductive surface via spontaneous dilution in body environment as well as bone formation stimulant, suggests this material answers crucial demands for dental implants. Information concerning similar studies is scarce, and implant material where porous bioactive bimetallic composite is obtained with similar properties, has not so far been proposed.