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Immunotoxicology Of Exposure To Jp 8 Jet Fuel
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Book Synopsis Immunotoxicology of Exposure to JP-8 Jet Fuel by :
Download or read book Immunotoxicology of Exposure to JP-8 Jet Fuel written by and published by . This book was released on 1997 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic jet fuel exposure could be detrimental to Air Force personnel, by not only adversely affecting their work performance but also by predisposing these individuals to increased incidences of infectious disease, cancer and autoimmune dysfunctions. Chronic exposure to jet fuel has been shown to adversely affect human liver function, to cause emotional dysfunction, to cause abnormal electroencephalograms, to cause shortened attention spans, and to decrease sensorimotor speed. Currently, there are no standards for personnel exposure to jet fuels of any kind, let along JP-8 jet fuel. Kerosene based petroleum distillates have been associated with hepatic, renal, neurologic and pulmonary toxicity in animals models and human occupational exposures. The U.S. Department of Labor, Bureau of Labor statistics estimates that over 1.3 million workers were exposed to jet fuels in 1992. Thus, jet fuel exposure may not only have serious consequences for USAF personnel, but also may have potential harmful effects upon a significant number of civilian workers. Short-term (7 day) JP-8 jet fuel exposure causes lung injury as evidenced by increased pulmonary resistance, a decrease in bronchoalveolar lavage concentrations of substance P, increased wet lung/body weight ratio, and increased alveolar permeability. Long-term exposures, although demonstrating evidence of lung recovery, results in injury to secondary organis such as liver, kidneys and spleen.
Book Synopsis Immunotoxicology of JP-8 Jet Fuel by :
Download or read book Immunotoxicology of JP-8 Jet Fuel written by and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic jet fuel exposure could be detrimental to Air Force personnel, not only by adversely affecting their work performance but also by predisposing these individuals to increased incidences of infectious disease and cancer. Chronic exposure to jet fuel has been shown to adversely affect human liver function, to cause emotional dysfunction, to cause abnormal electroencephalograms, to cause shortened attention spans, and to decrease sensorimotor speed. Currently, there are no standards for personnel exposure to jet fuels of any kind, let alone JP-8 jet fuel. Kerosene based petroleum distillates have been associated with hepatic, renal, neurologic and pulmonary toxicity in animals models and human occupational exposures. The U.S. Department of Labor, Bureau of Labor Statistics estimates that over 1.3 million workers were exposed to jet fuels in 1992. Thus, jet fuel exposure may not only have serious consequences for USAF personnel, but also may have potential harmful effects upon a significant number of civilian workers. Short-term (7 day) JP-8 jet fuel exposure causes lung injury as evidenced by increased pulmonary resistance, a decrease in bronchoalveolar lavage concentrations of substance P, increased wet lung/body weight ratio, and increased alveolar permeability. Long-term exposures, although demonstrating evidence of lung recovery, results in injury to secondary organs such as liver, kidneys and spleen.
Book Synopsis Jet Fuel Toxicology by : Mark L. Witten
Download or read book Jet Fuel Toxicology written by Mark L. Witten and published by CRC Press. This book was released on 2010-07-30 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently serving as a resource for the National Center for Toxological Research in their work with the Gulf Coast oil spill, this book presents current research conducted primarily by the airforce on the toxic effects of JP-8 jet fuel on the pulmonary, immune, dermal, and nervous systems. In all, the book considers 13 toxicology studies
Book Synopsis Immunotoxicology of JP-8 Jet Fuel: Mechanisms by :
Download or read book Immunotoxicology of JP-8 Jet Fuel: Mechanisms written by and published by . This book was released on 2008 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experiments were performed exposing mice to varying doses of either JP-8 or S-8 jet fuel for 1h/day for 7 days, using the new exposure apparatus with in-line monitoring of jet fuel concentrations (aerosol and vapor). Six controls, 6 JP-8 exposed and 6 S-8 exposed animals examined. There were no significant effect on body weight due to JP-8 or S-8 exposure, and no effect on immune cell viability from any immune organ due to JP-8 or S-8 exposure. There was a 53% decrease in Spleen weight due to S-8 exposure and a corresponding 40% decrease due to JP-8 exposure. There was a 36% decrease in Thymus weight due to S-8 exposure and a corresponding 60% decrease due to JP-8 exposure. There was a 64% decrease in Thymus cell numbers due to S-8 exposure and a corresponding 46% decrease due to JP-8 exposure. There was a 20% decrease in Spleen cell numbers due to JP-8 exposure only. No significant change in composition in any immune organ due to JP-8 or S-8 exposure. Both JP-8 and S-8 exposures using the new exposure chamber resulted in changes in immune function.
Book Synopsis Toxicologic Assessment of Jet-Propulsion Fuel 8 by : National Research Council
Download or read book Toxicologic Assessment of Jet-Propulsion Fuel 8 written by National Research Council and published by National Academies Press. This book was released on 2003-02-14 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report provides a critical review of toxicologic, epidemiologic, and other relevant data on jet-propulsion fuel 8, a type of fuel in wide use by the U.S. Department of Defense (DOD), and an evaluation of the scientific basis of DOD's interim permissible exposure level of 350 mg/m3
Book Synopsis Sundry Items and Letters Pertaining to Irvine Families in Pennsylvania by :
Download or read book Sundry Items and Letters Pertaining to Irvine Families in Pennsylvania written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunotoxicity of Jet Fuel written by and published by . This book was released on 1995 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: During our preliminary year of experimentation we have made an initial examination Off the immunotoxicological effects of JP-8 jet fuel exposure. Inbred C57BL6 mice were exposed to varying concentrations (either 500, 1000 or 2500 mg/m3) of aerosolized JP-8 jet fuel for a period of 7 days with an exposure period of 1 hour per day. Animal exposure was performed via nose-only presentation while the animals were held in individual subject loading tubes. The tubes were nose cone fitted to receiving adapters that originated from a common anodized aluminum exposure chamber. Nose only exposure was utilized to minimize ingestion of jet fuel during self grooming. Animals were rotated on a daily basis through the 12 adapter positions on the exposure chamber. This rotation was done to minimize proximity to the jet fuel source as a variable in exposure concentration or composition. Exposure concentration was determined by a seven stage --cascade impactor, and were measured after each exposure (1,2). 24 hours after the last exposure the animals were sacrificed and examined for changes in immune system composition and function. The major immune system organ systems (i.e., spleen, thymus, lymph nodes, blood and bone marrow) were recovered and examined for changes in organ weight total cell numbers, immune cell components (by differential histochemical staining).
Book Synopsis Immune Suppression by Dermal Exposure to JP-8 Jet Fuel by :
Download or read book Immune Suppression by Dermal Exposure to JP-8 Jet Fuel written by and published by . This book was released on 2005 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the next funding period we intend to address four major questions. 1) How does JP-8 induce immune suppression? Does JP-8 alter immune responsiveness through its effect on cytokine production or does it alter the ability of antigen presenting cells to present antigen? 2) Does JP-8 exposure affect ongoing immune reactions? Will exposure to JP-8 interfere with the immune response to recall antigens and block the protective effect of prior immunization? 3) How can we prevent JP-8 induced immune suppression? Once a better understanding of the suppressive mechanism is obtained, we will begin to design rational steps aimed at preventing its immune suppressive effect. 4) What components in JP-8 induce dermal immunotoxicity? JP-is produced from commercial Jet-A by use of an additive package containing diethylene glycol monomethyl ether, (DiEGME) an anti-icing compound. Because some have suggested DiEGME is a dermal immunotoxin we will concentrate on determining if application of DiEGME induces immune suppression. The specific aims of this proposal are designed to gain an understanding of the mechanism(s) involved in JP-8-induced immune suppression. The long-term of this work is to use the knowledge obtained here to design a procedure to prevent JP-8-induced immune suppression and limit its potential harmful effect on USAF personnel.
Book Synopsis Evaluation of Immunotoxicity Due to Concurrent Exposure to DEET, Pyridostignine, and JP-8 Jet Fuel by :
Download or read book Evaluation of Immunotoxicity Due to Concurrent Exposure to DEET, Pyridostignine, and JP-8 Jet Fuel written by and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Military personnel during the Gulf War were exposed to various compounds including N, N-diethyl-m-toluarmide (DEET), pyridostigmine bromide (PYR), and W-8 jet fuel. The effects of concurrent exposure to these agents co%could potentially result in significant health effects or contribute to the manifestations of Gulf War Syndrome. Adenopathy, fever, joint pain, and skin rash are reported by veterans and these signs may be linked to immune dysfunction. Recent studies indicate that neurotoxicity increases during concurrent exposure to both PYR and DEET with other agents. Due to known interdependencies of the immune and nervous systems, it is hypothesized that the effects of PYR and DEET may affect the immune system. Additionally, single low-level exposures to W-8 have been reported to significantly affect T- and B-lymphocyte populations. Thus, the possibility exists that combinations of DEET and PYR could exacerbate the effects of W-8 or cause a predisposition to other immune conditions such as autoimmune disease. Therefore, this investigation will evaluate the effects of concurrent exposure to these common military agents on immunological parameters (i.e., natural killer cell activity, macrophage function, etc.) and - susceptibility to diseases such as cancer, infections, and autoimmune disease.
Book Synopsis Toxicological Profile for Toluene by :
Download or read book Toxicological Profile for Toluene written by and published by . This book was released on 2000 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Contaminated Water Supplies at Camp Lejeune by : National Research Council
Download or read book Contaminated Water Supplies at Camp Lejeune written by National Research Council and published by National Academies Press. This book was released on 2009-09-06 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the early 1980s, two water-supply systems on the Marine Corps Base Camp Lejeune in North Carolina were found to be contaminated with the industrial solvents trichloroethylene (TCE) and perchloroethylene (PCE). The water systems were supplied by the Tarawa Terrace and Hadnot Point watertreatment plants, which served enlisted-family housing, barracks for unmarried service personnel, base administrative offices, schools, and recreational areas. The Hadnot Point water system also served the base hospital and an industrial area and supplied water to housing on the Holcomb Boulevard water system (full-time until 1972 and periodically thereafter). This book examines what is known about the contamination of the water supplies at Camp Lejeune and whether the contamination can be linked to any adverse health outcomes in former residents and workers at the base.
Book Synopsis Jet Fuel Toxicology by : Mark L. Witten
Download or read book Jet Fuel Toxicology written by Mark L. Witten and published by CRC Press. This book was released on 2010-07-30 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently serving as a resource for the National Center for Toxological Research in their work with the Gulf Coast oil spill, this book presents current research conducted primarily by the airforce on the toxic effects of JP-8 jet fuel on the pulmonary, immune, dermal, and nervous systems. In all, the book considers 13 toxicology studies
Book Synopsis Toxicological Profile for Chlordane by :
Download or read book Toxicological Profile for Chlordane written by and published by . This book was released on 1994 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Immunotoxicology and Immunopharmacology by : Robert V. House
Download or read book Immunotoxicology and Immunopharmacology written by Robert V. House and published by CRC Press. This book was released on 2006-12-26 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuing the tradition set by the first and second editions, each a bestseller in its own right, the third edition of Immunotoxicology and Immunopharmacology provides reviews of environmental agents, updated to reflect the latest information on how these agents influence immune system function and health. For the first time in the book's history,
Book Synopsis Toxicological Profile for Fuel Oils by :
Download or read book Toxicological Profile for Fuel Oils written by and published by . This book was released on 1995 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Toxicological Profile for Polycyclic Aromatic Hydrocarbons by :
Download or read book Toxicological Profile for Polycyclic Aromatic Hydrocarbons written by and published by . This book was released on 1995 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Identifying and Controlling Immunotoxic Substances by :
Download or read book Identifying and Controlling Immunotoxic Substances written by and published by Office of Technology Assessment. This book was released on 1991 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
