Immunopharmacology Of The Gastrointestinal System

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Immunopharmacology of the Gastrointestinal System

Author : John L. Wallace
Publisher : Academic Press
ISBN 13 : 1483289338
Total Pages : 198 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Immunopharmacology of the Gastrointestinal System by : John L. Wallace

Download or read book Immunopharmacology of the Gastrointestinal System written by John L. Wallace and published by Academic Press. This book was released on 1993-03-01 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diseases of the digestive system have a higher morbidity rate than any other group of disorder. There is a growing body of evidence that the immune system participates in the pathogenesis of a wide range of these diseases, including peptic ulcer disease and the gastropathy induced by nonsteroidal anti-inflammatory drugs (NSAIDS). For these reasons, efforts to develop novel therapies for digestive diseases are increasingly focused on the immune system. This volume reviews the immunopharmacology of the gastrointestinal tract at four distinct levels: Immunomodulation at a cellular level Cellular targers for immunomodulating drugs Specific classes of inflammatory mediators Utility and mechanisms of action of glucocorticoids in the treatment of diseases of the gastrointestinal tract.

The Kinin System

Author : Stephen G. Farmer
Publisher : Academic Press
ISBN 13 : 0080542522
Total Pages : 371 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Kinin System by : Stephen G. Farmer

Download or read book The Kinin System written by Stephen G. Farmer and published by Academic Press. This book was released on 1997-04-01 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities. From the prepublication reviews:"A delicious masterpiece."--Chef's DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases. * * Offers new information on kinin reception, regulation of gene expression of receptors, and kinin-generating proteins.* Provides a distinctly immunopharmacological approach to the kinin system.* Reviews of the role of kinins in disease and inlcudes data from human studies.* Includes information that is fully up-to-date and comprehensive.

Innervation of the Gut

Author : Yvette Tache
Publisher : CRC Press
ISBN 13 : 9780849347184
Total Pages : 380 pages
Book Rating : 4.3/5 (471 download)

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Book Synopsis Innervation of the Gut by : Yvette Tache

Download or read book Innervation of the Gut written by Yvette Tache and published by CRC Press. This book was released on 1993-12-02 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Innervation of the Gut provides a stimulating discussion of gut innervations based on exciting developments generated by advanced neuroanatomical and electrophysiological approaches. All components of the nervous system are covered, including central, spinal, autonomic, and enteric systems. This information is relative to secretory, motor, and immune regulatory functions of the gut, as well as visceral sensation. Brain transmitters involved in mediating stress-induced alterations of gastrointestinal motor function and the central regulation of vagal outflow to the gut are discussed in detail. The book will stimulate basic scientists and gastroenterologists to expand research efforts that may enable them to unravel the mechanisms of brain-gut interactions under physiological and pathological conditions. Students, psychologists, and psychiatrists will find Innervation of the Gut an essential reference for their studies.

Immunopharmacology

Author : Manzoor M. Khan
Publisher : Springer Science & Business Media
ISBN 13 : 0387779760
Total Pages : 275 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Immunopharmacology by : Manzoor M. Khan

Download or read book Immunopharmacology written by Manzoor M. Khan and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.

Phosphodiesterase Inhibitors

Author :
Publisher : Elsevier
ISBN 13 : 0080538819
Total Pages : 228 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Phosphodiesterase Inhibitors by :

Download or read book Phosphodiesterase Inhibitors written by and published by Elsevier. This book was released on 1996-08-16 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting. Utilizes actual testing and research of new PDE inhibitors Valuable for researchers and students alike

Lipid Mediators

Author : Fiona M. Cunningham
Publisher : Elsevier
ISBN 13 : 1483217639
Total Pages : 392 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Lipid Mediators by : Fiona M. Cunningham

Download or read book Lipid Mediators written by Fiona M. Cunningham and published by Elsevier. This book was released on 2016-10-27 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Immunopharmacology: Lipid Mediators covers a comprehensive overview of lipid mediators, from synthesis through to inhibition. The book discusses the metabolism of arachidonic acid; the measurement of fatty acids and their metabolites; and the biological properties of cyclooxygenase products. The text also describes other essential fatty acids, their metabolites and cell-cell interactions; the inhibitors of fatty acid-derived mediators; as well as the biosynthesis and catabolism of platelet-activating factor. The cellular sources of platelet-activating factor and related lipids; the biological properties of platelet-activating factor; and the effects of platelet-activating factor receptor antagonists are also considered. Immunopharmacologists, immunologists, and pharmacologists will find the book invaluable.

Parasites and Pathogens

Author : N.E. Beckage
Publisher : Springer Science & Business Media
ISBN 13 : 1461559839
Total Pages : 353 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Parasites and Pathogens by : N.E. Beckage

Download or read book Parasites and Pathogens written by N.E. Beckage and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: When Nancy Beckage and I first met in Lynn Riddiford's laboratory at the University of Washington in the mid 1970s, the fields of parasitology, behavior, and endocrinology were thriving and far-flung--disciplines in no serious danger of intersecting. There were rumors that they might have some common ground: Behavioural Aspects of Parasite Transmission (Canning and Wright, 1972) had just emerged, with exciting news not only of the way parasites themselves behave, but also of Machiavellian worms that caused intermediate hosts to shift fundamental responses to light and disturbance, becoming in the process more vulnerable to predation by the next host (Holmes and Bethel, 1972). Meanwhile, biologists such as Miriam Rothschild (see Dedication), G. B. Solomon (1969), and Lynn Riddiford herself (1975) had suggested that the endocrinological rami of parasitism might be subtle and pervasive. In general, however, para fications sites were viewed as aberrant organisms, perhaps good for a few just-so stories prior to turning our attention once again to real animals. In the decade that followed, Pauline Lawrence (1986a,b), Davy Jones (Jones et al. , 1986), Nancy Beckage (Beckage, 1985; Beckage and Templeton, 1986), and others, including many in this volume, left no doubt that the host-parasite combination in insect systems was physiologically distinct from its unparasitized counterpart in ways that went beyond gross pathology.

Animal Cell Technology: Basic & Applied Aspects

Author : T. Kobayashi
Publisher : Springer Science & Business Media
ISBN 13 : 940110848X
Total Pages : 578 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Animal Cell Technology: Basic & Applied Aspects by : T. Kobayashi

Download or read book Animal Cell Technology: Basic & Applied Aspects written by T. Kobayashi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal cell technology is a growing discipline of cell biology which aims to understand the structure, function and behaviour of differentiated animal cells, and especially the development of such abilities as are useful for industrial purposes. These developments range from clonal expansion of differentiated cells with useful abilities, to optimization of cell culture on industrial scale and modulation of the cells' abilities to produce drugs and monoclonal antibodies. The sixth volume in this series gives a complete review of today's state of the art in Japan, a country where this field is especially well advanced. It will be of interest to cell biologists, biochemists, molecular biologists, immunologists and other disciplines related to animal cell culture, working in the academic environment as well as in (biotechnology or pharmaceutical) industry.

Probiotics 2

Author : R. Fuller
Publisher : Springer Science & Business Media
ISBN 13 : 9401158606
Total Pages : 220 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Probiotics 2 by : R. Fuller

Download or read book Probiotics 2 written by R. Fuller and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: R. Fuller 1.1 DEVELOPMENT OF COMMERCIAL PREPARATIONS The history of the probiotic effect has been well documented many times previously (see e.g. Bibel, 1982; Fuller, 1992). The consumption of fermented milks dates from pre-biblical times but the probiotic concept was born at the end of the last century with the work of Metchnikoff at the Pasteur Institute in Paris. In the century that has elapsed since Metchnikoff's work, the probiotic concept has been accepted by scientists and consumers throughout the world. Attempts to refine the practice from the use of traditional soured milks to preparations containing specific micro organisms have occupied the thoughts and endeavours of scientists in many different countries. But, in spite of the large amount of effort expended in attempting to explain and define the effect, it has to be admitted that little is known of the way in which probiotics operate. There are likely to be several different mechanisms because it seems highly improbable that a mode of action that explains resistance to microbial infection will also hold true for improved milk production or alleviation of lactose malabsorption.

Inflammatory Bowel Disease

Author : Stephan R. Targan
Publisher : John Wiley & Sons
ISBN 13 : 1444359118
Total Pages : 1429 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis Inflammatory Bowel Disease by : Stephan R. Targan

Download or read book Inflammatory Bowel Disease written by Stephan R. Targan and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 1429 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the state-of–the-art book on inflammatory bowel disease you have been waiting for Written and edited by international experts in gastroenterology this up-to-date volume provides a complete review of the basic science behind inflammatory bowel disease (IBD), as well as evidence-based clinical guidance on diagnosis, treatment and long-term management of IBD. In 50 chapters the authors cover the latest and most promising treatment modalities and the science behind them. There are chapters which cover the advances in the medical and surgical treatment of conditions such as Crohn's disease and ulcerative colitis, as well as chapters focusing on nutrition, imaging and complementary medicine. This is an invaluable information resource for all those in the medical team treating patients with IBD. Whether you are a gastroenterologist, gastrointestinal surgeon or GI nurse specialist this book deserves a place in your library.

Allergy and Allergic Diseases

Author : Judah A. Denburg
Publisher : Springer Science & Business Media
ISBN 13 : 1475727763
Total Pages : 589 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Allergy and Allergic Diseases by : Judah A. Denburg

Download or read book Allergy and Allergic Diseases written by Judah A. Denburg and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: Allergy and Allergic Diseases has been organized to provide an up-to-date, clinically relevant compilation of one of the most exciting areas of investigation in medicine today-allergic disease, especially as it pertains to the skin, airways, and bowel. With the dramatic rise in the incidence of various allergic disorders worldwide, and the coming of age of the discipline of Clinical Immunology and Allergy, the interface between basic and clinical science in this arena demands highlighting in this comprehensive new syn thesis.1t is with the hope of filling this evident need that Allergy and Allergic Diseases: The New Mechanisms and Therapeutics has been put together. The book's content is divided into both basic and clinical sections, with emphasis on various components of the immune and inflammatory response as they relate to the development of allergic disease. Topics span the range from molecular biology to clinical symptomatology, with an effort to make this of interest to as broad a constituency as possible. This book will therefore be of substantial interest to specialists in Clinical Immunology and Allergy, scientists studying the cellular and molecular biology of in flammation and immunity, as well as internists, teachers, developers of medical school curricula, and members of industry focused on drug discovery and therapeutics. Indeed, a separate section has been added to deal with some specific issues in this latter field.

Helicobacter pylori

Author : R.H. Hunt
Publisher : Springer Science & Business Media
ISBN 13 : 9401114188
Total Pages : 618 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Helicobacter pylori by : R.H. Hunt

Download or read book Helicobacter pylori written by R.H. Hunt and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Helicobacter pylori has attracted widening interest from basic scientists and clinical investigators and the information on this organism is increasing exponentially. It is now accepted that H. Pylori is the most important cause of chronic active gastritis. Furthermore, data have confirmed a marked reduction in the relapse rate of both duodenal and gastric ulcer after eradication of the organism. These important clinical observations have served as a strong stimulus to the investigation of the basic mechanisms involved in the pathogenesis of H. pylori-associated inflammation and the subsequent alterations of gastroduodenal function and gastric mucosal architecture. The book contains chapters by a multidisciplinary, international group of basic scientists and clinical investigators who focus on various microbiological aspects of H. pylori, on the role of H. pylori in peptic ulcer and gastric cancer, and the current status of therapy. The book contains the proceedings of the conference on `Helicobacter pylori: Basic Mechanisms to Clinical Cure', held at Amelia Island, Florida, U.S.A., on November 3--6, 1993.

Essentials of Experimental Surgery

Author : H Gregerson
Publisher : CRC Press
ISBN 13 : 9783718654963
Total Pages : 802 pages
Book Rating : 4.6/5 (549 download)

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Book Synopsis Essentials of Experimental Surgery by : H Gregerson

Download or read book Essentials of Experimental Surgery written by H Gregerson and published by CRC Press. This book was released on 1996-05-28 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all aspects of experimental gastrointestinal research including anatomy, physiology, surgical procedures and animal experimental models As well as being a useful reference guide to established scientists, it serves as an ideal introduction to the field of gastroenterology By consulting the book, the appropriate animal species and experimental model can be chosen for physiological and pathophysiological studies

The Sepsis Text

Author : Jean-Louis Vincent
Publisher : Springer Science & Business Media
ISBN 13 : 0306476649
Total Pages : 848 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis The Sepsis Text by : Jean-Louis Vincent

Download or read book The Sepsis Text written by Jean-Louis Vincent and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is written at the dawn of a new era in the management of sepsis. Recent achievements in the clinical management of septic shock are the culmination of decades of basic and applied research by innovative researchers and clinical investigators worldwide. The contributing authors to this book have spearheaded much of this research and the Editors have endeavored to create a textbook that is comprehensive in nature while maintaining a specific focus upon the multitude of work that constitutes the spectrum of sepsis research including: pathophysiology; monitoring systems; general support; microbial aspects; complications; and anti-sepsis therapies.

Topical Steroids in Gastroenterology and Hepatology

Author : A. Dignass
Publisher : Springer Science & Business Media
ISBN 13 : 9780792387893
Total Pages : 150 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Topical Steroids in Gastroenterology and Hepatology by : A. Dignass

Download or read book Topical Steroids in Gastroenterology and Hepatology written by A. Dignass and published by Springer Science & Business Media. This book was released on 2004-02-29 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, the proceedings of a Falk Workshop on `Topical Steroids in Gastroenterology and Hepatology', held in Berlin, Germany, on 14 June 2003, critically discusses the current role of budesonide in gastroenterology, hepatology, surgery and oncology and focuses especially on potential new indications for the use of budesonide. A number of smaller clinical studies and anecdotal case reports with impressive clinical effects are reported in patients with gastrointestinal, hepatic, oncological and surgical problems. In addition, the use of budesonide for the treatment of distal ulcerative colitis and ileocolonic Crohn's disease is evaluated with respect to its role in an evidence-based management of IBD. Finally, as clinical experience with the use of budesonide is increasing, safety issues and the side-effect profile of budesonide is addressed.

Immunopharmacology of Neutrophils

Author : Paul G. Hellewell
Publisher : Academic Press
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Immunopharmacology of Neutrophils by : Paul G. Hellewell

Download or read book Immunopharmacology of Neutrophils written by Paul G. Hellewell and published by Academic Press. This book was released on 1994-05-06 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: About the Series: The consequences for diseases involving the immune system such as AIDS, and chronic inflammatory diseases such as bronchial asthma, rheumatoid arthritis, and atherosclerosis, now account for a considerable economic burden to governments worldwide. In response there has been an enormous research effort investigating the basic mechanisms underlying such diseases, and a tremendous drive to identify novel therapeutic applications for their prevention and treatment. Though a plethora of immunological studies have been published in recent years, little has been written about the implications of such research for drug development. As a consequence, this area has not gained the prominence of other new fields such as molecular pharmacology or neuropharmacology, and a focal information source for the many pharmacologists interested in diseases of the immune system remains unpublished. The Handbook of Immunopharmacology series provides such a source through the commissioning of a comprehensive collection of volumes on all aspects of immunopharmacology. Editors have been sought after for each volume who are not only active in their respective areas of expertise, but who also have a distinctly pharmacological bias to their research. The series follows three main themes, each represented by volumes on individual component topics. The first covers each of the major cell types and classes of inflammatory mediators ("cells and mediators"). The second covers each of the major organ systems and the diseases involving the immune and inflammatory responses that can affect them ("systems"). The third covers different classes of drugs currently used to treat these diseases as well as those under development ("drugs"). About the Book: This book addresses the key issues that face neutrophils during their very short but extremely important lives. The discovery that neutrophils have the capacity to phagocytose and kill foreign organisms set the stage for a fascinating research field that continues to stimulate exciting new findings throughout the world. Neutrophils target the sites of infection or injury, and are thus equipped with sensors for soluble signals ("chemoattractants") generated in the tissue in response to tissue infection or injury, and sensors for molecules on surfaces. These receptors are important so that the cell can distinguish, for example, activated endothelium to stimulate adherence and emigration, or alternatively the bacterial surface to stimulate phagocytosis and killing. A deficiency in any of these mechanisms can result in life-threatening infection. An over-reaction can result in damage to the tissues that the neutrophil should be programmed to protect.

Cardiovascular Diseases

Author : Y. Robert Li
Publisher : John Wiley & Sons
ISBN 13 : 1118889940
Total Pages : 504 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Cardiovascular Diseases by : Y. Robert Li

Download or read book Cardiovascular Diseases written by Y. Robert Li and published by John Wiley & Sons. This book was released on 2015-02-25 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written in an accessible style and consistent format, the bookcovers both the fundamentals and advances in the pharmacology ofcardiovascular drugs, as well as their integrated applications inthe management of individual cardiovascular diseases. • Integrates fundamentals and recentadvances regarding cardiovascular drugs, blending basic andclinical sciences needed to effectively understand and treatcardiovascular diseases • Facilitates understanding of drug actionand mechanism by covering physiology / pathophysiology andpharmacology • Includes guidelines and algorithms forpharmacotherapeutic management of cardiovascular diseases • Uses case presentations and studyquestions to enhance understanding of the material • Serves as a resource for pharmaceuticaland medical students and researchers interested in cardiovascularissues