Immunological And Endometrial Changes Of Early Pregnancy In Dairy Cattle

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Immunological and Endometrial Changes of Early Pregnancy in Dairy Cattle

Author : Maria Da Silva
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (142 download)

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Book Synopsis Immunological and Endometrial Changes of Early Pregnancy in Dairy Cattle by : Maria Da Silva

Download or read book Immunological and Endometrial Changes of Early Pregnancy in Dairy Cattle written by Maria Da Silva and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in bovine reproduction is crucial for enhancing fertility, efficiency, and sustainability in dairy production. Despite progress in breeding practices and herd health management, a significant number of bovine embryos do not survive past the first month of pregnancy. Factors like the immune system play a critical role in protecting against pathogens and tolerating the semiallogeneic embryo. Immune cells also mediate endometrial tissue remodeling and homeostasis during successful reproduction. However, little is known about immunological and endometrial changes during early pregnancy. To support pregnancy, the early conceptus secretes crucial proteins, including interferon tau (IFNT) that maintains the corpus luteum. Pregnancy-associated glycoproteins (PAGs) are another group of conceptus molecules abundantly secreted from the time of conceptus attachment until parturition, but their specific function remains unknown. In our first study (Chapter 2), we analyzed the transcriptome of the endometrium and blood leukocytes in cyclic heifers treated in vivo with intrauterine infusions of IFNT and PAG. IFNT activated interferon response, immune activation, inflammation, and cell death pathways in the endometrium, while downregulating genes related to vesicle transport and extracellular matrix (ECM) remodeling. Prolonged IFNT altered genes linked to cell invasion, retinoic acid (RA) signaling, and embryo implantation. In peripheral blood, PAG stimulated genes involved in leukocyte differentiation and TGFB signaling but had limited effects on endometrial genes. These findings shed light on how conceptus secretions impact endometrial and immune function during maternal recognition of pregnancy and embryo attachment/implantation. Shortly after attachment/implantation, the endometrium undergoes vascular remodeling to establish the maternal placenta. Adequate blood flow and vascular development are essential for successful embryo implantation, nutrient exchange, and overall fetal development. In the second study (Chapter 3), expression of HIF1A, AHR, and angiogenic factors were characterized in the cyclic and pregnant endometrium at the time of attachment/implantation. Contrary to our hypothesis, the expression of HIF1A, AHR, and angiogenic factors remains low during the attachment/implantation period. Moreover, our results suggest that IFNT may exert a suppressive effect on the expression of molecules of HIF signaling. Understanding the timing and mechanisms governing blood vessel growth, structure, and function in the placenta is crucial for the prevention of placental disorders that impact embryonic health and survival. Although the uterine environment undergoes major immunological adaptations to accommodate the developing embryo, the peripheral immune system is not isolated from pregnancy changes. Hormonal and metabolic signals associated with pregnancy have systemic effects on the immune response in the blood and extrauterine organs. It is generally accepted that systemic immunity must balance tolerance to the developing embryo while also remaining vigilant in eliminating pathogens and threats to pregnancy health. Understanding this delicate immunological balance can support efforts in the prevention of pregnancy loss and complications. In the third study (Chapter 4), we characterized changes in circulating leukocytes during early pregnancy and investigated peripheral immunity differences between lactating cows and heifers. In the first experiments, heifers and cows were studied separately, revealing both similarities and differences in the phenotype of blood leukocytes in response to early pregnancy. In the final experiment, we simultaneously compared samples from heifers and cows, and the results indicated that cows exhibited greater expression of proinflammatory cytokines and molecules associated with leukocyte migration and phagocytosis compared to heifers. Moreover, animals that failed to become pregnant showed altered expression of anti-inflammatory molecules compared to pregnant and cyclic animals. Overall, these findings support the notion that immune responses to early pregnancy differ in heifers and cows, which may contribute to the reduced fertility observed in lactating cows. During our experiments with PBL, we observed that some heifers experienced luteolysis between days 16 and 17 of the estrous cycle, while cows experienced it after day 18. Progesterone primarily regulates cell function via the nuclear progesterone receptor (PGR) and can also signal through membrane-associated receptors of the PAQR and PGRMC family. In cattle, progesterone secretion remains elevated throughout pregnancy, but there is conflicting evidence regarding the presence of PGR in leukocytes of both cattle and humans. In our last study (Chapter 5), we aimed to determine the expression of progesterone and estradiol receptors in bovine peripheral blood leukocytes (PBL) and if their expression was affected by reproductive status, parity, or the day of pregnancy. We also investigated the correlation between steroid hormone concentrations in plasma and the phenotype of blood leukocytes. The results revealed that bovine leukocytes lack PGR during early and mid-pregnancy but express nuclear ESR and membrane PGR (mPGR). Additionally, there was a positive correlation between plasma estradiol and a negative correlation of plasma progesterone with changes in the proportion of myeloid cells and the expression of molecules involved in leukocyte migration during proestrus. Contrary to some published literature, these findings suggest that bovine PBL do not express PGR, and instead, mPGR of the PAQR and PGRMC family may mediate progesterone effects on leukocyte function. In summary, the findings presented in this dissertation have expanded our understanding in several areas: (1) the effects of IFNT and PAG on gene expression in the endometrium and circulating leukocytes, (2) the expression of angiogenic factors in the uterus, (3) the peripheral immune response to early pregnancy in heifers and lactating cows, and (4) the expression of progesterone receptors in immune cells. Our results provide support for the hypothesis that uterine and peripheral immunity is regulated by conceptus and maternal signals to facilitate the establishment of successful pregnancies. The insights gained from this research can help identify immunological factors associated with embryo loss and offer valuable perspectives on the application of strategies to enhance fertility in dairy cattle, other domestic species, and potentially even in humans.

Effects of Pregnancy and Pregnancy Specific Protein B on Lymphoid Lineage Cells in Diary Heifers

Author : Sreelakshmi Vasudevan
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (971 download)

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Book Synopsis Effects of Pregnancy and Pregnancy Specific Protein B on Lymphoid Lineage Cells in Diary Heifers by : Sreelakshmi Vasudevan

Download or read book Effects of Pregnancy and Pregnancy Specific Protein B on Lymphoid Lineage Cells in Diary Heifers written by Sreelakshmi Vasudevan and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The dairy industry has remarkably improved milk production per cow over the last century. However, the reproductive efficiency of dairy farms has decreased due to the excessive focus on milk production and inadvertent inattention of reproductive performance in genetic selection decisions. This has led to a near 50% reduction in conception rates and high economic loss to the industry. Most of the embryo loss occurs during peri-implantation period. The hypothesis for this study is that conceptus secretions alter the uterine mucosal immune system to facilitate a tolerogenic environment for the conceptus and failure or inadequate modulation leads to embryo loss Whether Natural Killer (NK) cells and other lymphoid lineage cells have a role in the uterine environment during early pregnancy in cattle was investigated as their dysfunction causes infertility in other species. A 30% increase in CD45+ CD8+ (cytotoxic T cell) and CD45+ NKp46+ (NK) cells in the endometrium during early pregnancy using flow cytometry was observed. This is the first report of these cells increasing during bovine pregnancy and it was further established that CD8 and NKp46 molecules are co-localized on significant portion of cells. These cells could be similar to nonconventional CD3+ NK cell subset reported in bovine peripheral mononuclear cells (PBMC). To assess whether uterine immune cells from pregnant animals could suppress autologous peripheral T cells, T cells were cultured in the presence of uterine immune cells. No effect of uterine immune cells from pregnant heifers was observed on peripheral T cell proliferation. Interestingly, uterine immune cells from cyclic heifers did stimulate proliferation of autologous peripheral T cells. Therefore, uterine immune cells from pregnant animals are less stimulatory compared to those from cyclic animals. CD45+ uterine cells from day 17 of pregnancy exhibited greater degranulation against K562 cells compared to those from day 17 of cycle and to autologous peripheral immune cells from day 17 pregnant animals. Interferon tau can induce cytotoxicity of NK cells and this could explain increase in degranulation during day 17 of pregnancy. Inhibitory interactions between lymphocytes and antigen presenting cells (APC) could be regulating immune cell function to facilitate a tolerogenic environment during pregnancy. The inhibitory molecule, CD274 can interact with programmed cell death 1 (PDCD1) on lymphocytes and induce T cell anergy. An 18-fold increase in CD274 transcripts were observed with pregnancy and also a decrease between day 17 and day 20 of pregnancy in the endometrium. An increase in cytotoxic T lymphocyte antigen 4 (CTLA-4) with pregnancy was also noted. When CTLA-4 interacts with CD80/86 on APC, it leads to development of tolerogenic APC, which can, in turn, cause T cell anergy. This is the first report of the presence of these inhibitory molecules during pregnancy in the bovine endometrium. The secretion of cytokines by uterine immune cells during pregnancy was also investigated. An increase in CD45+ interleukin (IL)10+ cells with pregnancy and increase in CD45+ interferon gamma (IFNG)+ cells between day 17 and day 20 of pregnancy was observed. The proportion of CD45+ CD8+ cells decreased between day 17 and day 20 of pregnancy along with the abundance of cytotoxic granule, Granzyme A (GZMA) mRNA suggesting CD8 T cells are functional. Endometrial protein expression was evaluated and a decrease in IL10, transforming growth factor beta (TGFB) and vascular endothelial growth factor (VEGF) protein expression between day 17 and day 20 of pregnancy was observed. This decrease in protein expression of several immune related factors between day 17 and 20 of pregnancy led to investigation of effects of conceptus secretions, interferon tau (IFNT) and pregnancy specific protein B (PSPB) during this period.Pregnancy specific glycoprotein B is a member of the large the pregnancy associated glycoprotein family and is produced by the bovine trophectoderm during early pregnancy. These proteins are detectable in the maternal blood stream as early as day 24 of gestation. A 200-fold increase in the concentration of PSPB in the uterus between day 17 and 20 of pregnancy was observed. This led to evaluation of whether PSPB affects immune cell function during pregnancy. Uterine immune cell proliferation was inhibited by addition of physiological concentrations of PSPB in vitro. This effect was more pronounced in the CD3 (T cell) subset of uterine immune cells. There was no effect of PSPB on peripheral blood immune cell proliferation even in the presence of uterine parenchymal cell secretions. This led to the conclusion that uterine immune cells are unique in their response to conceptus secretions. No effects of PSPB on degranulation of immune cells were observed. To summarize, this study aimed at evaluating the lymphocyte phenotype and functions during early pregnancy in dairy heifers. There was an increase in CD8+ immune cells in the endometrium with pregnancy. The uterine immune cells from day 17 pregnant animals have higher degranulation, increased production of IL10 and were not able to suppress proliferation of autologous immune cells. Data from this study suggest a role for conceptus secreted protein PSPB in inhibiting immune cell proliferation. Thus results from the study provide new insights into the role of immune cells and their regulation during early pregnancy in cattle and can lead to further studies evaluating the immunological causes of infertility in mature lactating dairy cows.

Changes in Phenotype and Function of Myeloid Lineage Cells During Early Pregnancy in Dairy Heifers

Author : Manasi Kamat
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (959 download)

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Book Synopsis Changes in Phenotype and Function of Myeloid Lineage Cells During Early Pregnancy in Dairy Heifers by : Manasi Kamat

Download or read book Changes in Phenotype and Function of Myeloid Lineage Cells During Early Pregnancy in Dairy Heifers written by Manasi Kamat and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Successful establishment of pregnancy requires interaction between the developing conceptus and the uterine mucosal immune system. Little is known regarding the role of myeloid lineage cells (macrophages and dendritic cells) during early pregnancy in ruminants. The effects of early pregnancy on endometrial and circulating immune cells of the myeloid lineage were studied here. Dairy heifers were inseminated using sperm from a single bull (Day 0), and uteri and blood were collected at slaughter on Day 17 and 20 of pregnancy to investigate the response of uterine myeloid lineage cells to the presence of a conceptus. Responses were compared to uterine myeloid lineage cells of noninseminated heifers on Day 17 of the estrous cycle. The immune cells were isolated from the endometrium using enzymatic digestion, followed by magnetic sorting to obtain a pure CD45+ cell population. Flow cytometry was used to examine surface proteins. Immunofluorescence and quantitative polymerase chain reaction were used to evaluate immune cell proteins and transcripts in myeloid cells in the uterus. Total CD45+ immune cells were fewer (P 0.05) in pregnant compared to cyclic heifers. Abundance of transcripts for major histocompatibility complex (MHC) II, cluster of differentiation (CD) 80 and CD86, CD163 and indoleamine 2,3-dioxygenase (IDO) 1 were greater (P 0.05) in the endometrium of pregnant compared to cyclic heifers. Proteins for MHC II, IDO1, signal regulatory protein alpha (SIRPA), CD163 and CD47 were greater (P 0.05) in pregnant compared to cyclic heifers. Many of these proteins were spatially regulated in the uterine wall, with the shallow stroma and shallow glands showing the most prominent differences. Transcripts for dectin1, mannose receptor C 1 (MRC1), aryl hydrocarbon receptor (AHR) and thrombospondin 1 (TSP1) were not affected (P > 0.1) by pregnancy. There were 50 % more CD14+CD11c+ cells (dendritic cells) in the peripheral circulation of pregnant compared to cyclic heifers. Overall, there were a greater (P 0.05) number of myeloid lineage cells in the endometrium during early pregnancy compared to the cycle. These cells were then evaluated for their ability to phagocytose, which is a primary function of myeloid cells.Functional phagocytic assay using propidium iodide-labeled Streptococcus uberis did not show any difference in the phagocytic ability of macrophages treated with interferon tau (IFNT) and pregnancy specific protein B (PSPB). There were no differences in the phagocytic ability of the macrophages with or without interferon gamma (IFNG) and lipopolysaccharide (LPS) stimulation, both for resident and circulating immune cells. We also studied two immune cell-related signaling pathways. Upregulation of IDO1 during early pregnancy could result in tryptophan catabolism leading to formation of kynurenine. Kynurenine is a ligand for the AHR and we studied the spatial and temporal regulation of AHR in the bovine uterus. There was a tendency for greater (P

Regulation of Implantation and Establishment of Pregnancy in Mammals

Author : Rodney D. Geisert
Publisher : Springer
ISBN 13 : 3319158562
Total Pages : 271 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Regulation of Implantation and Establishment of Pregnancy in Mammals by : Rodney D. Geisert

Download or read book Regulation of Implantation and Establishment of Pregnancy in Mammals written by Rodney D. Geisert and published by Springer. This book was released on 2015-10-08 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past few decades technological advances in transcriptomics, proteomics, metabolomics, and glycomics along with the ability to selectively knockout genes of interest has greatly advanced our understanding of maternal-conceptus interactions that are essential for the establishment and maintenance of a successful pregnancy. This knowledge provides a foundation from which to build research endeavors to help resolve infertility, embryonic loss and recurrent abortion in humans, captive wild animals and important farm species. The present volume on “Regulation of Implantation and Establishment of Pregnancy in Mammals” brings together current reviews from leading experts to address the diversity of mechanisms by which species establish and maintain pregnancy. Implantation in rodents, dogs, pigs, cattle, sheep, horses, primates, humans and embryonic diapause in wild species are discussed. Reviews will provide current knowledge on the role of endometrial steroid receptors, adhesion factors, cytokines, interferons, steroids, prostaglandins, growth factors and immune cells involved with regulation of conceptus development.

Maternal Recognition of Pregnancy

Author : Julie Whelan
Publisher : John Wiley & Sons
ISBN 13 : 0470718145
Total Pages : 192 pages
Book Rating : 4.4/5 (77 download)

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Book Synopsis Maternal Recognition of Pregnancy by : Julie Whelan

Download or read book Maternal Recognition of Pregnancy written by Julie Whelan and published by John Wiley & Sons. This book was released on 2009-09-16 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Maternal Immune Changes During Bovine Pregnancy

Author : Lilian De Jesus Oliveira
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (7 download)

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Book Synopsis Maternal Immune Changes During Bovine Pregnancy by : Lilian De Jesus Oliveira

Download or read book Maternal Immune Changes During Bovine Pregnancy written by Lilian De Jesus Oliveira and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophages co-expressing CD68+CD14+ present in the stroma of the interplacentomal endometrium and in the caruncular septa of the placentome were regionally differentiated with regards to expression of CD11b and MHC class II. Moreover the macrophages present in the pregnant endometrium are regionally differentiated perhaps as a result of the different maternal and fetal interaction between the interplacentomal and placentome region in the cow. Transcriptomal analysis of endometrial CD14+ cells showed that these cells express genes characteristic of macrophages; the endometrial macrophages over-expressed genes related to alternative (M2) activation pathway. Gene ontology analysis comparing differentially-regulated genes between endometrium and blood CD14+ cells showed an enrichment of ontologies related to proteolysis activity which suggests a tissue remodeling role for the endometrial macrophages. Despite differences in the types of placentation between human and bovine, many genes preferentially regulated in decidual macrophages were also differentially regulated between blood and endometrial macrophage in the cow. Around 17% of the genes found to be differentially expressed between decidual and blood human monocytes were also differentially expressed in the same direction for the cow. Presence of macrophages in the endometrium during late pregnancy suggests a role for these cells in parturition, expulsion of fetal membranes, and the process of uterine involution. Better understanding of the complex role of the endometrial macrophages may help researchers develop new practical techniques to positively affect the ability of cows to establish pregnancy following parturition.

Endometrial Gene Expression

Author : Joanne Kwak-Kim
Publisher : Springer
ISBN 13 : 9783030285869
Total Pages : 0 pages
Book Rating : 4.2/5 (858 download)

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Book Synopsis Endometrial Gene Expression by : Joanne Kwak-Kim

Download or read book Endometrial Gene Expression written by Joanne Kwak-Kim and published by Springer. This book was released on 2020-11-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endometrium goes through cyclical changes under the influence of hormones, and immune effectors in the endometrium change their populations cyclically as well. Dynamic changes in immune effectors determine endometrial cytokine and chemokine milieus and, consequently, the endometrial immune response. Endometrial immune responses have been shown to be important for trophoblast invasion and early pregnancy. Indeed, dysregulated endometrial inflammatory immune responses are associated with reproductive failures, such as recurrent pregnancy losses, repeated implantation failure, and gynecological diseases with oncogenic potential. Hence, the investigation of endometrial gene expression may predict infertility, gynecological and oncological conditions. This book presents the state of the art in endometrial gene expression as well as recent developmental findings relating to reproduction and reproductive disorders. It begins with a review of the genetic regulation of urogenital tract formation and molecular mechanism underlying the physiology of menstrual cycle before moving on to the current and emerging technological advances in molecular biology. Endometrial gene expressions of immune inflammatory conditions, viral infection, metabolic and nutritional conditions, and reproductive disorders are then presented in following chapters. Examples of the use and interpretation of gene expression in clinical scenarios including recurrent pregnancy losses, infertility and multiple implantation failures are presented with currently available endometrial gene analysis. Utilizing the latest evidence and clinical guidelines, Endometrial Gene Expression will be a cutting-edge resource for gynecologist, reproductive immunologist, reproductive endocrinologists, obstetrician, maternal fetal medicine specialist and other health care providers in the field of reproductive medicine.

Bovine Reproduction

Author : Richard M. Hopper
Publisher : John Wiley & Sons
ISBN 13 : 1118470850
Total Pages : 2206 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Bovine Reproduction by : Richard M. Hopper

Download or read book Bovine Reproduction written by Richard M. Hopper and published by John Wiley & Sons. This book was released on 2014-08-18 with total page 2206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bovine Reproduction is a comprehensive, current reference providing information on all aspects of reproduction in the bull and cow. Offering fundamental knowledge on evaluating and restoring fertility in the bovine patient, the book also places information in the context of herd health where appropriate for a truly global view of bovine theriogenology. Printed in full color throughout, the book includes 83 chapters and more than 550 images, making it the most exhaustive reference available on this topic. Each section covers anatomy and physiology, breeding management, and reproductive surgery, as well as obstetrics and pregnancy wastage in the cow. Bovine Reproduction is a welcome resource for bovine practitioners, theriogenologists, and animal scientists, as well as veterinary students and residents with an interest in the cow.

The Life Cycle of the Corpus Luteum

Author : Rina Meidan
Publisher : Springer
ISBN 13 : 3319432389
Total Pages : 288 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis The Life Cycle of the Corpus Luteum by : Rina Meidan

Download or read book The Life Cycle of the Corpus Luteum written by Rina Meidan and published by Springer. This book was released on 2016-11-02 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the life cycle of a unique endocrine gland that is absolutely essential for the establishment and maintenance of pregnancy in all mammalian species. The corpus luteum is unique because it is formed and destroyed every (non-fertile) reproductive cycle. When fertilization occurs, the corpus luteum is rescued or maintained. The processes that control corpus luteum formation, demise (luteolysis), or maintenance are just beginning to be unraveled in recent years; they involve diverse cell types and mechanisms. Some of these processes resemble tumor development—angiogenesis, for instance—but interestingly enough, this resemblance is only up to a point. The corpus luteum uses mechanisms that allow its normal, physiological growth and disappearance. Pulling together key research on the corpus luteum, this volume is of interest to both reproductive endocrinologists and comparative physiologists, with clinical relevance spanning comparative animal studies to women's health.

The Human Endometrium

Author : Carlo Bulletti
Publisher :
ISBN 13 :
Total Pages : 522 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis The Human Endometrium by : Carlo Bulletti

Download or read book The Human Endometrium written by Carlo Bulletti and published by . This book was released on 1994 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structural, biochemical and clinical events related to menstruation, implantation, parturition, endometriosis, abnormal uterine bleeding and endometrial cancer are discussed in this comprehensive volume on the biological functions of the endometrium. New topics, such as the biochemical and molecular mechanisms regulating maternal embryonic interaction, are explored, and gynecologic endoscopy and therapeutic tools are discussed. The proceedings of the first conference is also available from the Academy, as volume 622 of The Annals of The New York Academy of Science.

Developments in Bovine Immunology - An Integrated View

Author : Kieran G. Meade
Publisher : Frontiers Media SA
ISBN 13 : 2889196321
Total Pages : 104 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Developments in Bovine Immunology - An Integrated View by : Kieran G. Meade

Download or read book Developments in Bovine Immunology - An Integrated View written by Kieran G. Meade and published by Frontiers Media SA. This book was released on 2015-07-22 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world’s population is predicted to hit 9 Billion by 2050, and with it food demand is predicted to increase substantially. The World Bank estimates that cereal and meat production needs to increase by 50% and 85% respectively between 2000 and 2030 to meet demand, putting serious pressure on the global agricultural industry. Critical to meeting this demand for food are mechanisms to reduce the incidence of animal disease. With in excess of 1.3 billion cattle globally, the total cost of infectious diseases is difficult to estimate. However in North America alone, the cost is predicted to be $18 billion annually. Non-infectious diseases also account for another major impediment to the production capacity and welfare of animals as well as the economic sustainability of farming. However animal diseases have implications that spread far beyond the farm gate. Infectious agents can also contaminate the food chain, and potentially affect human health. Controlling diseases, through better preventative and treatment methods requires a detailed understanding of the immune response in livestock species. Multiple studies have identified associations between variation in immune genes and disease susceptibility, which potentially opens up new avenues to select animals with superior disease resistance. Detailed understanding of immunity in cattle is leading to the design of more effective vaccines. Furthermore, appreciation of the significant differences between rodent and human immune responses has also led to bovine models being developed for some human diseases. The publication of the bovine genome and the advent of next-generation sequencing technologies have facilitated a massive expansion in our knowledge of the immune response in cattle. As a result there has been an explosion of exciting research findings including in metagenomics and epigenetics. Recently, there has been a welcome move to integrate our emerging understanding of the immune response with detailed studies of other important physiological processes including nutrition and reproduction. The interactions between the reproductive system, nutrition and the immune system are of particular interest, since each places significant demands on the animal at various stages through the production cycle. The interplay between these morphologically diffuse systems involves widely distributed chemical signals in response to environmental input, and each system must interact for the normal functioning of the other. A comprehensive “systems” approach is improving our understanding of normal physiological interactions between these systems and furthermore, how dysregulation can lead to disease. The successful translation of bovine immunological research into improved treatments for animal disease requires tight interaction between diverse scientific and clinical disciplines including immunology, microbiology, endocrinology, physiology, nutrition, reproduction and clinical veterinary medicine. With so much recent progress in the field, we believe that it is valuable and well-timed to review the broad variety of the relevant studies that attempt to increase our understanding through comprehensive collaboration between these disciplines. We are looking forward to a wide and vivid discussion of developments in bovine immunology and related issues, and we expect that our readers profoundly benefit from new exciting insights and fruitful collaborations.

Diagnostic And Therapeutic Techniques In Animal Reproduction Indian Reprint Textbook Student Edition

Author : R. Zemjanis
Publisher :
ISBN 13 : 9788187421252
Total Pages : 238 pages
Book Rating : 4.4/5 (212 download)

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Book Synopsis Diagnostic And Therapeutic Techniques In Animal Reproduction Indian Reprint Textbook Student Edition by : R. Zemjanis

Download or read book Diagnostic And Therapeutic Techniques In Animal Reproduction Indian Reprint Textbook Student Edition written by R. Zemjanis and published by . This book was released on 2002-01-01 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Endocrinology of Pregnancy

Author : Fuller W. Bazer
Publisher : Springer Science & Business Media
ISBN 13 : 1461218047
Total Pages : 579 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Endocrinology of Pregnancy by : Fuller W. Bazer

Download or read book Endocrinology of Pregnancy written by Fuller W. Bazer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, cutting-edge review of the complex interactions between maternal and fetal-placental tissues that control the establishment and maintenance of pregnancy, the proper development of the fetus, the birth process, and the behavioral aspects of bonding between mother and newborn. Expert researchers review the endocrine and physiological events that culminate in the delivery of offspring, and provide a solid base of comparative information on the menstrual cycle of primates, including humans. They also discuss the sources and functions of both steroid and protein hormones from the placenta and the details of their effects on uterine function, placental development, fetal growth and well-being, and maternal responses to pregnancy. This book will become the standard reference source not only for reproductive scientists, but also for those clinicians who want better to understand the complex factors that affect pregnancy-and their pregnant patients.

Veterinary Cytology

Author : Leslie C. Sharkey
Publisher : John Wiley & Sons
ISBN 13 : 1119125723
Total Pages : 1024 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Veterinary Cytology by : Leslie C. Sharkey

Download or read book Veterinary Cytology written by Leslie C. Sharkey and published by John Wiley & Sons. This book was released on 2020-08-04 with total page 1024 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a state-of-the-art, evidence-based reference to all aspects of veterinary cytology. Truly multidisciplinary in its approach, chapters are written by experts in fields ranging from clinical pathology to internal medicine, surgery, ophthalmology, and dermatology, drawing the various specialties together to create a comprehensive picture of cytology's role in diagnosis and treatment of animal disease. Firmly grounded in the primary literature, the book focuses on companion animals, with special chapters for species with fewer publications. Chapters are logically organized by body system, with additional chapters on tumors of particular import and diagnostic decision making. The first two sections of Veterinary Cytology focus on cytology techniques, quality control, and special laboratory techniques. Subsequent sections are organ/tissue-based and reflect what is known about the canine, feline, and equine species. This is followed by chapters on non-traditional species, including exotic companion mammals, rabbits, cattle, camelids, non-human primates, reptiles and birds, amphibians, fish, invertebrates, and sheep and goats. The last section highlights some unique features of the applications of cytology in industry settings. Provides a gold-standard reference to data-driven information about cytologic analysis in companion animal species Brings together authors from a wide range of specialties to present a thorough survey of cytology's use in veterinary medicine Offers broader species coverage and greater depth than any cytology reference currently available Veterinary Cytology is an essential resource for clinical and anatomic pathologists and any specialist in areas using cytology, including veterinary oncologists, criticalists, surgeons, ophthalmologists, dermatologists, and internists.

Dairy 2007: Reference of dairy cattle health and management practices in the United States, 2007

Author :
Publisher :
ISBN 13 :
Total Pages : 132 pages
Book Rating : 4.:/5 (891 download)

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Book Synopsis Dairy 2007: Reference of dairy cattle health and management practices in the United States, 2007 by :

Download or read book Dairy 2007: Reference of dairy cattle health and management practices in the United States, 2007 written by and published by . This book was released on 2007 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Veterinary Reproductive Immunology

Author : Juan G. Maldonado-Estrada
Publisher : Frontiers Media SA
ISBN 13 : 2889743926
Total Pages : 156 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Veterinary Reproductive Immunology by : Juan G. Maldonado-Estrada

Download or read book Veterinary Reproductive Immunology written by Juan G. Maldonado-Estrada and published by Frontiers Media SA. This book was released on 2022-02-14 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Infections in Pregnancy

Author : Adel Elkady
Publisher : Cambridge University Press
ISBN 13 : 1108716636
Total Pages : 215 pages
Book Rating : 4.1/5 (87 download)

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Book Synopsis Infections in Pregnancy by : Adel Elkady

Download or read book Infections in Pregnancy written by Adel Elkady and published by Cambridge University Press. This book was released on 2019-10-24 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides effective diagnosis and management of infectious diseases in pregnant women in a single comprehensive available resource for busy clinicians.