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Author : Peter Baram
Publisher : North-Holland
ISBN 13 :
Total Pages : 288 pages
Book Rating : 4.:/5 (44 download)
Download or read book Immunologic Tolerance and Macrophage Function written by Peter Baram and published by North-Holland. This book was released on 1979 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Peter Baram
Publisher :
ISBN 13 :
Total Pages : 266 pages
Book Rating : 4.:/5 (79 download)
Download or read book Immunologic Tolerance and Macrophage Function written by Peter Baram and published by . This book was released on with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (141 download)
Download or read book Immunologic Tolerance and Macrophage Function written by and published by . This book was released on 1979 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David S. Nelson
Publisher : Academic Press
ISBN 13 : 1483274772
Total Pages : 652 pages
Book Rating : 4.4/5 (832 download)
Download or read book Immunobiology of the Macrophage written by David S. Nelson and published by Academic Press. This book was released on 2014-06-28 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunobiology of the Macrophage presents an account of the state of knowledge of the immunobiology of the macrophage. The book's contributors—immunologists of diverse scientific and geographic backgrounds—have been encouraged to give personal accounts of developments in their special fields of interest as well as critical surveys of the backgrounds leading to these developments. The book begins with a study on the functions of macrophages in the initiation and regulation of antibody responses in vitro. This is followed by separate chapters on topics such as the role of macrophages in making antigen more immunogenic and less tolerogenic; functional distinctions between macrophages at different sites; and the role of the macrophage in antigen recognition by T lymphocytes. Subsequent chapters examine interactions between macrophages and lymphocytes in the production of interferon and other mediators of cellular immunity; macrophage cell lines and their uses in immunobiology; and cytotoxic macrophages in allograft rejection.
Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author : Duncan Howie
Publisher : Frontiers Media SA
ISBN 13 : 2889457257
Total Pages : 116 pages
Book Rating : 4.8/5 (894 download)
Download or read book Metabolism and Immune Tolerance written by Duncan Howie and published by Frontiers Media SA. This book was released on 2019-01-21 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Historically the study of the immune system and metabolism have been two very separate fields. In recent years, a growing literature has emerged illustrating how the multiple processes of cellular metabolism are intricately linked to several aspects of immune function and development. This Research Topic covers recent progress in the field now known as “Immunometabolism” and the role of metabolism in immune tolerance. Immune tolerance is operationally defined as a state where a host’s immune system is balanced such that although self-reactive lymphocytes are present, they are kept in check by immune regulation. Perturbations to this homeostasis may result in self-reactive lymphocytes gaining the upper hand and mediating auto-immune disease. Maintenance of immune tolerance involves a large cast of different cell types including effector T cells, regulatory T cells, B cells, stromal cells, dendritic cells and macrophages. Intracellular pathways and individual enzymes of metabolism have been shown to be harnessed by cells of both the adaptive and innate immune system to allow particular immune functions to be achieved. Examples include metabolic enzymes serving ‘moonlighting’ functions in mRNA translation, gene splicing, and kinase activation. Other examples include the requirement for de novo fatty acid synthesis for differentiation into Th17 effectors and CD8 memory T cells or products of the TCA cycle promoting pro-inflammatory cytokine production. Likewise, the availability of extracellular metabolic substrates has a large impact on the maintenance of local immune tolerance. For example, there are different requirements for glucose, glutamine and fatty acids for effector versus regulatory T cell development. Also tolerogenic dendritic cells mediate lowering of extracellular essential amino acids by their enhanced catabolism, promoting the induction of regulatory T cells. The purpose of this Research Topic is to provide an update on the current understanding of the multiple roles for metabolism in regulating the immune system.
Author : Tamás Röszer
Publisher : Springer Nature
ISBN 13 : 3030504808
Total Pages : 224 pages
Book Rating : 4.0/5 (35 download)
Download or read book The M2 Macrophage written by Tamás Röszer and published by Springer Nature. This book was released on 2020-08-03 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key questions that remain unanswered.
Author : Judit Svensson?Arvelund
Publisher : Linköping University Electronic Press
ISBN 13 : 9175191172
Total Pages : 150 pages
Book Rating : 4.1/5 (751 download)
Download or read book Immune regulation at the fetal?maternal interface with focus on decidual macrophages written by Judit Svensson?Arvelund and published by Linköping University Electronic Press. This book was released on 2015-04-21 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: A successful pregnancy requires that the maternal immune system adapts to tolerate the semi-allogeneic fetal-placental unit. This adaptation mainly occurs locally, i.e. at the fetal-maternal interface, where fetal-derived tissues come into close contact with maternal cells in the uterine endometrium (called decidua during pregnancy). Macrophages and regulatory T (Treg) cells are maternal immune cells that are enriched in the decidua and they likely play a central role in promoting fetal tolerance. However, the precise function of decidual macrophages and the factors regulating both macrophages and Treg cells in humans are unknown. The aim of this thesis was to characterize the phenotype and function of decidual macrophages from first trimester human pregnancy and to identify factors responsible for inducing tolerogenic properties in both decidual macrophages and Treg cells. CD14+ decidual macrophages showed characteristics of immune suppressive or homeostatic macrophages (expression of CD163, CD206 and CD209), mainly produced immunosuppressive cytokines, like IL-10 and IL-35, while levels of inflammatory cytokines, for instance IL-12 and IL-23, were low. Decidual macrophages also induced the expansion of CD25highFoxp3+ Treg cells, but not of Th1, Th2 and Th17 cells, in vitro. In addition, decidual macrophages preferentially secreted the monocyte- and Treg cell-associated chemokines CCL2 and CCL18, while Th1-, Th2- and Th17-related chemokines were produced at low levels. These results suggest that decidual macrophages contribute to create the unique decidual cell composition and a tolerogenic immune environment that is compatible with fetal development. Further, by comparing decidual macrophages with different in vitro macrophage subsets, we showed that M-CSF and IL-10, but not GM-CSF, Th1 or Th2 stimuli, induced macrophages that resemble decidual macrophages in terms of cell surface marker expression, cytokine andchemokine production and gene expression profile. First trimester placental tissue, in particular placental trophoblast cells, was identified as an important source of M-CSF and IL-10. We also demonstrated that human fetal-derived placental tissue can induce the characteristics of decidual macrophages (CD163+CD206+CD209+IL-10+CCL18+) and the selective expansion of functionally suppressive CD25highFoxp3+ Treg cells, the latter partly mediated through IL-10, TGF-? and TRAIL. The placenta also limited activation of Th cells, for instance by generally reduced cytokine production. Our data show that the placenta has a unique ability to induce tolerogenic immune cells with a reduced inflammatory potential, which is essential for maintaining tissue integrity and preventing inflammation-induced fetal loss.
Author : Maurice Landy
Publisher : Academic Press
ISBN 13 : 1483270653
Total Pages : 369 pages
Book Rating : 4.4/5 (832 download)
Download or read book Immunological Tolerance written by Maurice Landy and published by Academic Press. This book was released on 2014-06-28 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunological Tolerance: A Reassessment of Mechanisms of the Immune Response presents the basic biological phenomena of immunological tolerance. This book discusses immunology as a critical field for the analysis of molecular features of mammalian cell genetics, biosynthesis, differentiation, and interactions among cell types. Organized into six chapters, this book begins with an overview of the relationship between antigen structure and its ability to induce tolerance. This text then examines the essentiality of antigen for the proliferation of activated antibody-forming clones and discusses the role of antibody in homeostasis and suppression. Other chapters consider the restoration and transfer of immunological responsiveness by thoracic duct lymphocytes. This book discusses as well the distribution of antigen in tissues and cells. The final chapter deals with the origin of carrier antibody and the significance of maternal transfer of antibodies and antigens. This book is a valuable resource for immunologists, microbiologists, scientists, and clinicians.
Author : David H. Katz
Publisher : Academic Press
ISBN 13 : 1483273431
Total Pages : 662 pages
Book Rating : 4.4/5 (832 download)
Download or read book Immunological Tolerance written by David H. Katz and published by Academic Press. This book was released on 2014-06-28 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunological Tolerance: Mechanisms and Potential Therapeutic Applications documents the proceedings of a conference held at Brook Lodge, Michigan, April 27-May 1, 1974. The conference brought together many of the investigators who have actively contributed to furthering knowledge and understanding of immunological tolerance. It will be immediately clear to the reader that the conference was structured in a way to consider phenomena of tolerance and immune suppression as interrelated entities with a certain degree of emphasis on the possible common cellular mechanisms involved. The volume contains 36 contributions presented during the seven sessions of the conference. The papers presented in Session I examined T-cell tolerance. The presentations in Session II focused on B cell tolerance. The papers in Sessions III and IV focused on the mechanisms of B cell and T cell tolerance, respectively. Session V dealt with the activity of suppressor cells as a mechanism of tolerance. The papers in Session VI investigated the suppressive activity of antibody and antigen-antibody complexes. In Session VII a final General Discussion was held in order to identify what has been established concerning the phenomenology and mechanisms of specific immunological tolerance, what are the major unresolved issues, and what approaches appear most promising to answer these questions.
Author : Jeffrey Mark McCormack
Publisher :
ISBN 13 :
Total Pages : 104 pages
Book Rating : 4.:/5 (126 download)
Download or read book Regulation of Macrophage Phagocytosis in Immune Tolerance written by Jeffrey Mark McCormack and published by . This book was released on 1985 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lucienne Chatenoud
Publisher : Frontiers Media SA
ISBN 13 : 2832536255
Total Pages : 193 pages
Book Rating : 4.8/5 (325 download)
Download or read book Insights in Immunological Tolerance and Regulation: 2022 written by Lucienne Chatenoud and published by Frontiers Media SA. This book was released on 2023-10-25 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Tomáš Hraba
Publisher :
ISBN 13 :
Total Pages : 608 pages
Book Rating : 4.:/5 (44 download)
Download or read book Cellular and Molecular Mechanisms of Immunologic Tolerance written by Tomáš Hraba and published by . This book was released on 1981 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Khalid Hussain Bhat
Publisher : BoD – Books on Demand
ISBN 13 : 1789846447
Total Pages : 134 pages
Book Rating : 4.7/5 (898 download)
Download or read book Macrophage Activation written by Khalid Hussain Bhat and published by BoD – Books on Demand. This book was released on 2020-03-25 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophages are the sentinels of the immune system whose role has evolved beyond providing aseptic conditions to homeostasis, immune regulation, development, and behaviour. These cells have varied ontogenetic origins which reflects in their phenotypic and functional heterogeneity. Macrophage functions are fine-tuned by exogenous and endogenous signals and once tweaked, the information is included in their genetic makeup, albeit not indefinitely. Subversion of the macrophage functions is the hallmark of many pathogenic organisms and modulation of macrophage activity is pivotal to many therapeutic strategies. Fascinating and rapid developments in this field have necessitated the maintenance of currency of knowledge. This book provides a current account of information on varied topics in macrophage biology. Literature surveys have been presented in a captivating and lucid language. The contributing authors have also provided brief accounts of their own research. Every chapter provides a future perspective of what more could be achieved in the context of the current knowledge. The book will be of interest to students and researchers in microbiology, immunobiology, translational research, pathology, and related fields.
Author : Hyewon Phee
Publisher : Frontiers Media SA
ISBN 13 : 2889717410
Total Pages : 327 pages
Book Rating : 4.8/5 (897 download)
Download or read book Emerging Therapeutics for Immune Tolerance written by Hyewon Phee and published by Frontiers Media SA. This book was released on 2021-11-30 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Zlatko Dembic
Publisher : Academic Press
ISBN 13 : 0124200109
Total Pages : 323 pages
Book Rating : 4.1/5 (242 download)
Download or read book The Cytokines of the Immune System written by Zlatko Dembic and published by Academic Press. This book was released on 2015-05-23 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. - Supplies new ideas for basic and clinical research - Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials - Offers a textbook-style view on the immune system with the immunologic role of each cytokine
