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Author : Charles A. Janeway
Publisher :
ISBN 13 :
Total Pages : 952 pages
Book Rating : 4.3/5 (91 download)
Download or read book Immunoglobulin Idiotypes written by Charles A. Janeway and published by . This book was released on 1981 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mark Greene
Publisher : Springer Science & Business Media
ISBN 13 : 1468447394
Total Pages : 498 pages
Book Rating : 4.4/5 (684 download)
Download or read book The Biology of Idiotypes written by Mark Greene and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: The phenomenon of idiotypy was discovered almost thirty years ago, but it was only during the past decade that it attracted widespread interest and became the subject of numerous research investigations. From the outset, much of the interest in idiotypy was based on its implications with respect to the repertoire of antibodies. Kunkel showed, for example, that idiotypes associated with certain human myeloma or Bence-Jones proteins were present in normal human globulins at levels of less than one part per million. Also, Oudin's original definition of idiotypy implied that idiotypes could be uniquely associated with individual rabbits as well as with particular antigen-binding specificities. Such observations provided some of the earliest evidence for an extensive repertoire of immunoglobulin molecules. The implications of these findings have been amply confirmed by recent studies of protein struc ture and molecular genetics; many of these studies are reviewed in the present volume. It is known now that the diversity of antibodies is based on the presence of numerous V and L V H genes, on recombinatorial events involving D and] segments, on somatic mutations, and on processes involving deletion of DNA followed by repair with errors, including inser tions. Each of these parameters is capable of influencing the idiotype expressed by the final immunoglobulin product. Regulation of the immune response is another area in which idiotypy has significantly influenced modern immunology.
Author : Morris Reichin
Publisher : Elsevier
ISBN 13 : 032315137X
Total Pages : 417 pages
Book Rating : 4.3/5 (231 download)
Download or read book Idiotypes written by Morris Reichin and published by Elsevier. This book was released on 2012-12-02 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Idiotypes documents the proceedings of an International Conference on Idiotypes held in Oklahoma City, Oklahoma, at the Oklahoma Medical Research Foundation, October 20-23, 1985. The aims of the conference were to gather active investigators in the study of idiotypes; to assess progress in the field; and to explore directions for future research. The papers presented at the conference cover a wide range of subjects. Several papers deal with defining protein and DNA sequences which determine idiotypes. Evidence points to germ line genes encoding the V region structures which underlie idiotypy. Another subtheme which concerns several contributions is the occurrence of dominant idiotypes in induced immune responses (e.g., arsonate and lysozyme) and autoimmunity (e.g., thyroglobulin and rheumatoid factors). The presence of such dominant idiotypes is discussed from several viewpoints, but the recurrent theme is that such dominance is a manifestation of a selection process inherent in the idiotypic network. Two papers deal with idiotypic structures in T cells: on the one hand, identifying idiotypes on T helper cells and, on the other, I-J and Iat related structures which tightly govern cellular interactions in the evolution of an immune response. Network interactions through autoanti-idiotypic responses are shown to be associated with the effects on the specificity of both induced and naturally occurring immune responses. Autoanti-idiotypic responses are also shown to be correlated with the regulation of the anti-DNA response in human systemic lupus erythematosus. These data pointed to a role of the idiotype network in immune regulation.
Author : Yehuda Shoenfeld
Publisher : Newnes
ISBN 13 : 0444593772
Total Pages : 917 pages
Book Rating : 4.4/5 (445 download)
Download or read book Autoantibodies written by Yehuda Shoenfeld and published by Newnes. This book was released on 2013-11-26 with total page 917 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune diseases are characterized by the occurrence of antibodies reacting with self-constituents of the body. The fully updated third edition of Autoantibodies is an in-depth review of the main autoantibodies identified up to now, with particular emphasis on those that display a diagnostic or prognostic clinical value. The new edition covers recent scientific advances, diagnostic techniques, and therapeutic technologies. Each chapter is focused on a single family of autoantibodies. This important reference contains historical notes, definitions, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value). This is an ideal reference for anyone involved in the field of autoimmune diseases. - Presents all known, important autoantibodies in a single source, focusing on the antibodies needed for autoimmune disorder diagnosis - Includes clinical applications for each autoantibody along with general information - Organized by disease and disorder type, by autoantibody family, and completely cross-referenced
Author : Library of Congress
Publisher :
ISBN 13 :
Total Pages : 1480 pages
Book Rating : 4.:/5 (3 download)
Download or read book Library of Congress Subject Headings written by Library of Congress and published by . This book was released on 2013 with total page 1480 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Hans-Werner Vohr
Publisher : Springer
ISBN 13 : 9783540441724
Total Pages : 0 pages
Book Rating : 4.4/5 (417 download)
Download or read book Encyclopedic Reference of Immunotoxicology written by Hans-Werner Vohr and published by Springer. This book was released on 2005-06-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides rapid access to focused information on topics of Immunotoxicology not only for scientists and those dealing with laboratory aspects but also for lecturers and advanced students. Over 200 contributing authors – including many of the world’s top specialists – have contributed full essays on all relevant topics, supplemented by keyword definitions of related terms. Full essays are structured uniformly to provide reader-friendly information on all aspects of Immunotoxicology, including methods of testing and analysis, characteristics of substances, the regulatory environment and the relevance of these to humans. The single A–Z format of both types of entry makes this reference book very easy to use. The Encyclopedic Reference of Immunotoxicology is intended to be a comprehensive work of reference which will provide easy access to relevant information in the fast-growing field of Immunotoxicology.
Author : Library of Congress. Cataloging Policy and Support Office
Publisher :
ISBN 13 :
Total Pages : 1512 pages
Book Rating : 4.3/5 (91 download)
Download or read book Library of Congress Subject Headings written by Library of Congress. Cataloging Policy and Support Office and published by . This book was released on 2007 with total page 1512 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Library of Congress. Subject Cataloging Division
Publisher :
ISBN 13 :
Total Pages : 1534 pages
Book Rating : 4.3/5 (91 download)
Download or read book Library of Congress Subject Headings: F-O written by Library of Congress. Subject Cataloging Division and published by . This book was released on 1989 with total page 1534 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Library of Congress. Subject Cataloging Division
Publisher :
ISBN 13 :
Total Pages : 1436 pages
Book Rating : 4.:/5 (31 download)
Download or read book Library of Congress Subject Headings: P-Z written by Library of Congress. Subject Cataloging Division and published by . This book was released on 1988 with total page 1436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Library of Congress. Office for Subject Cataloging Policy
Publisher :
ISBN 13 :
Total Pages : 1692 pages
Book Rating : 4.3/5 (91 download)
Download or read book Library of Congress Subject Headings written by Library of Congress. Office for Subject Cataloging Policy and published by . This book was released on 1991 with total page 1692 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 804 pages
Book Rating : 4.:/5 (3 download)
Download or read book CRISP Thesaurus written by and published by . This book was released on 1989 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 866 pages
Book Rating : 4.3/5 (91 download)
Download or read book Biomedical Index to PHS-supported Research written by and published by . This book was released on 1990 with total page 866 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 1488 pages
Book Rating : 4.:/5 (319 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1993 with total page 1488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gary Litman
Publisher : Springer Science & Business Media
ISBN 13 : 1468408054
Total Pages : 391 pages
Book Rating : 4.4/5 (684 download)
Download or read book Immunoglobulins written by Gary Litman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery more than thirty years ago that antibody actlvlty could be localized to discrete plasma protein fractions, the study of immunoglobulin struc ture and function has dominated the field of immunochemistry. During this time, sources of homogeneous immunoglobulin molecules have been discovered, the subunit nature of the proteins has been defined, and the three-dimensional struc tures of the antigen-recognition portion of several antibody molecules have been elucidated. Insights into the complicated genetic control of these proteins are being gained rapidly through analysis of amino acid sequences of naturally occurring and induced homogeneous immunoglobulins. Immunoglobulins have been analyzed by protein chemists as models of complex multimeric systems, examined by geneticists studying serum protein polymorphisms, and employed by molecular biologists as highly selective probes capable of distinguishing minor features of molecular topog raphy. Clinical applications have ranged from the now routine quantitation of immunoglobulin levels to the use of antibodies to detect trace levels of a variety of natural products and drug metabolites. All these applications have depended ulti mately on a thorough understanding of the immunoglobulin and its antigen-combin ing site. To cover the entire field of immunoglobulin structure and function would require many volumes this size; therefore, subjects presented in this volume represent those which we felt contribute most to our current understanding of this protein family. The first chapters deal with the structure and function of the immunoglobulin molecule.
Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 348 pages
Book Rating : 4.3/5 (91 download)
Download or read book Permuted Medical Subject Headings written by National Library of Medicine (U.S.) and published by . This book was released on 1979 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Library of Medicine (U.S.). Medical Subject Headings Section
Publisher :
ISBN 13 :
Total Pages : 530 pages
Book Rating : 4.0/5 ( download)
Download or read book Medical Subject Headings written by National Library of Medicine (U.S.). Medical Subject Headings Section and published by . This book was released on 1989 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Larry W. Moreland
Publisher : Springer Science & Business Media
ISBN 13 : 3540206256
Total Pages : 933 pages
Book Rating : 4.5/5 (42 download)
Download or read book Rheumatology and Immunology Therapy written by Larry W. Moreland and published by Springer Science & Business Media. This book was released on 2004-07-20 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: Entries in a practical A to Z Format Highly therapy-focused Uniform and clearly arranged entries for ease of reference Comprehensive information on symptoms and therapeutical possibilities of rheumatologic and musculoskeletal diseases as well as drugs Written by leading experts in the field
