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Immunodiagnostic Technologies From Laboratory To Point Of Care Testing
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Book Synopsis Immunodiagnostic Technologies from Laboratory to Point-Of-Care Testing by : Pankaj Suman
Download or read book Immunodiagnostic Technologies from Laboratory to Point-Of-Care Testing written by Pankaj Suman and published by Springer Nature. This book was released on 2020-10-12 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the timeline of immunodiagnostics evolution, including advancements in immunological/nucleic acid probes, assay design, labelling techniques, and devices for signal transduction and acquisition. In the past few years, enzyme and nanocatalyst-based immune assays have undergone numerous modifications to enhance their sensitivity and potential for automation. Further, to reduce production costs and the use of laboratory animals, engineering small antibodies and nucleic acid probes (aptamers) has become increasingly popular in the development of novel and powerful bioassays. In light of the notable advancements in immunodiagnostics, this book highlights the combined efforts of clinicians, biotechnologists, material scientists, nanotechnologists and basic scientists in a coherent and highly structured way. The book takes readers on the journey of immunodiagnostic technologies, from their introduction to the present.
Book Synopsis Surface Engineering and Functional Nanomaterials for Point-of-Care Analytical Devices by : Buddhadev Purohit
Download or read book Surface Engineering and Functional Nanomaterials for Point-of-Care Analytical Devices written by Buddhadev Purohit and published by Springer Nature. This book was released on 2023-09-22 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book chronicles the role of advanced nanomaterials and surface engineering technologies in the development of point-of-care biosensors for health and environmental monitoring. All aspects of nanomaterial synthesis and characterization, functionalization methods, sensing surface engineering, signal amplification strategies, use of innovative technologies to enhance sensor efficiency and performances, and innovative applications of nanobiosensors to tackle real-life problems are discussed in this book with a focus on optical and electrochemical based sensing. It also covers the detection of infectious diseases and various disease biomarkers, smartphone-based biosensing, and portable diagnostics module developments with a discussion on the working mechanisms of these devices in various domains. The book also illustrates the recent trends in biosensing, and an overview of the challenges and probable solutions for the translation of biosensors from laboratory prototypes to commercial success.
Book Synopsis Proof and Concepts in Rapid Diagnostic Tests and Technologies by : Shailendra K. Saxena
Download or read book Proof and Concepts in Rapid Diagnostic Tests and Technologies written by Shailendra K. Saxena and published by BoD – Books on Demand. This book was released on 2016-09-07 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives a comprehensive overview of the recent advancements and developments of rapid diagnostic tests (RDTs) and technologies, which are quite novel approaches and might be used as laboratory bench manual for the rapid diagnosis of the various disease conditions. The book focuses on various aspects and properties of RDTs, point-of-care tests (POCTs), quality control, assurance, calibration, safety, nano-/microfluidic technologies, and fusion with DNA technologies. I hope that this work might increase the interest in this field of research and that the readers will find it useful for their investigations, management, and clinical usage.
Book Synopsis BioSensing, Theranostics, and Medical Devices by : Vivek Borse
Download or read book BioSensing, Theranostics, and Medical Devices written by Vivek Borse and published by Springer Nature. This book was released on 2021-12-09 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides up-to-date information on the prototypes used to develop medical devices and explains the principles of biosensing and theranostics. It also discusses the development of biosensor and application-orientated design of medical devices. In addition to summarizing the clinical validation of the developed techniques and devices and the regulatory steps involved in their commercialization, the book highlights the latest research and translational technologies toward the development of point-of-care devices in the health care. Lastly, it explores the current opportunities, challenges and provides troubleshooting on the use of biosensors in precision medicine. The book is helpful for researchers and medical professionals working in the field of clinical theranostics, and medical-device development wanting to gain a better understanding into the principles and processes involved in the development of biosensors.
Book Synopsis Clinical Immunodiagnostics: Laboratory Principles and Practices by : Ian C. Clift
Download or read book Clinical Immunodiagnostics: Laboratory Principles and Practices written by Ian C. Clift and published by Jones & Bartlett Learning. This book was released on 2020-02-07 with total page 770 pages. Available in PDF, EPUB and Kindle. Book excerpt: A contemporary guide to the diagnostic principles and practices of immunology and serology in the clinical laboratory.
Book Synopsis Sustainable Agriculture Reviews 54 by : Vinod Kumar Yata
Download or read book Sustainable Agriculture Reviews 54 written by Vinod Kumar Yata and published by Springer Nature. This book was released on 2021-09-29 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews concepts and recent advances of biotechnological approaches for livestock production. Indeed, biotechnologies have recently emerged as powerful tools for animal breeding, genetics, production, nutrition, and animal health. Applications to the production of livestock such as cattle, camel, and poultry are detailed. Chapters also present biotechnological applications for diagnostics, animal nutrition, and animal food production.
Book Synopsis Miniaturized Biosensing Devices by : Pranjal Chandra
Download or read book Miniaturized Biosensing Devices written by Pranjal Chandra and published by Springer Nature. This book was released on 2022-05-06 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents tools and techniques for the development of miniature biosensors and their applications. The initial chapters discuss the advancements in the development of the transduction techniques, including optical, electrochemical, and piezoelectric, which are used for miniaturized biosensors. The book also reviews several technologies, such as nanotechnology, nanobiotechnology, immune-technology, DNA-technology, micro-manufacturing technology, electronic-circuit technology to increase the miniaturization and sensitivity of the biosensor platform. Subsequently, the chapters illustrate the applications of miniaturized biosensing systems in point-of-care monitoring of treatment and disease progression, environmental monitoring, food control, drug discovery, forensics, and biomedical research. Towards the end, the book discusses the advanced applications of biosensors in water quality monitoring, especially on-line detection systems and on-site detection of pesticides, heavy metals and bacteria in water. This book is an invaluable source for scientists working in biochemical engineering, bioengineering, and biomedical engineering in academia and industry.
Book Synopsis Nanosensing and Bioanalytical Technologies in Food Quality Control by : Pranjal Chandra
Download or read book Nanosensing and Bioanalytical Technologies in Food Quality Control written by Pranjal Chandra and published by Springer Nature. This book was released on 2022-03-25 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews applications of nanomaterial and nanodevices in the food industry. It also discusses the advanced bioanalytical techniques, including Enzyme-Linked Immunosorbent Assay (ELISA), immunoanalytical techniques, monoclonal antibody-based immunological techniques for detecting food adulterations and allergens. It comprehensively covers electrode modification and nano-engineered fabrication of biosensors to enhance their functionalities for utilization in food industries. The book highlights the utilization of nanobiosensors for food safety and quality analysis, such as detection of toxin, food-borne pathogen, allergen, and evaluation of toxicity. Further, it also summarizes the recent advances in nanodevices such as nano-systems, nano-emulsions, nanopesticide, nanocapsule and their applications in the food industry. Lastly, it covers nanomaterial-based sensors for drug analysis in diverse matrices. It serves as an invaluable source of information for professionals, researchers, academicians, and students related to food science and technology.
Book Synopsis The Coronavirus Pandemic and the Future by : Michael D Waters
Download or read book The Coronavirus Pandemic and the Future written by Michael D Waters and published by Royal Society of Chemistry. This book was released on 2022-04-27 with total page 695 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second volume chronicles the later stages of the outbreak of SARS-Cov-2 (COVID-19) and delineates the role of several disciplines in therapeutic and control measures highliting the response from specific coutries of note and efforts to repurpose and produce new therapeutics and vaccines. By addressing considerations of efficacy and safety of drugs and chemicals used to combat COVID-19, virtually in real-time, this book documents and highlights the advances in science and place the toxicology, pharmaceutical science, public health and medical community in a better position to advise in future epidemics.
Book Synopsis Point-of-care testing by : Peter Luppa
Download or read book Point-of-care testing written by Peter Luppa and published by Springer. This book was released on 2018-07-18 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: The underlying technology and the range of test parameters available are evolving rapidly. The primary advantage of POCT is the convenience of performing the test close to the patient and the speed at which test results can be obtained, compared to sending a sample to a laboratory and waiting for results to be returned. Thus, a series of clinical applications are possible that can shorten the time for clinical decision-making about additional testing or therapy, as delays are no longer caused by preparation of clinical samples, transport, and central laboratory analysis. Tests in a POC format can now be found for many medical disciplines including endocrinology/diabetes, cardiology, nephrology, critical care, fertility, hematology/coagulation, infectious disease and microbiology, and general health screening. Point-of-care testing (POCT) enables health care personnel to perform clinical laboratory testing near the patient. The idea of conventional and POCT laboratory services presiding within a hospital seems contradictory; yet, they are, in fact, complementary: together POCT and central laboratory are important for the optimal functioning of diagnostic processes. They complement each other, provided that a dedicated POCT coordination integrates the quality assurance of POCT into the overall quality management system of the central laboratory. The motivation of the third edition of the POCT book from Luppa/Junker, which is now also available in English, is to explore and describe clinically relevant analytical techniques, organizational concepts for application and future perspectives of POCT. From descriptions of the opportunities that POCT can provide to the limitations that clinician’s must be cautioned about, this book provides an overview of the many aspects that challenge those who choose to implement POCT. Technologies, clinical applications, networking issues and quality regulations are described as well as a survey of future technologies that are on the future horizon. The editors have spent considerable efforts to update the book in general and to highlight the latest developments, e.g., novel POCT applications of nucleic acid testing for the rapid identification of infectious agents. Of particular note is also that a cross-country comparison of POCT quality rules is being described by a team of international experts in this field.
Book Synopsis Point of Care Testing, An Issue of the Clinics in Laboratory Medicine, E-Book by : Linoj Samuel
Download or read book Point of Care Testing, An Issue of the Clinics in Laboratory Medicine, E-Book written by Linoj Samuel and published by Elsevier Health Sciences. This book was released on 2023-05-15 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Clinics in Laboratory Medicine, guest editor Dr. Linoj Samuel brings his considerable expertise to the topic of Point of Care Testing. Top experts discuss the challenges, techniques, and data collection for point of care and at-home testing options for COVID-19, fungal pathogens, and STDs in various demographics, among other key topics. Contains 10 practice-oriented topics including point of care testing during the COVID-19 pandemic: challenges and pitfalls; will antigen testing remain relevant in point of care testing; the role of point of care testing in specific populations; lab at home: is at-home testing the new normal; point of care testing for sexually transmitted diseases; and more. Provides in-depth clinical reviews on point of care testing, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Book Synopsis The Immunoassay Handbook by : David Wild
Download or read book The Immunoassay Handbook written by David Wild and published by Elsevier. This book was released on 2005-06-20 with total page 968 pages. Available in PDF, EPUB and Kindle. Book excerpt: Containing updated and new information on advanced technology - including micro and nanoscale immunoassays - this text provides a mix of practical information coupled with a review of clincal applications and practical examples.
Book Synopsis Point of Care Testing, an Issue of the Clinics in Laboratory Medicine: Volume 43-2 by : Linoj Samuel
Download or read book Point of Care Testing, an Issue of the Clinics in Laboratory Medicine: Volume 43-2 written by Linoj Samuel and published by Clinics: Internal Medicine. This book was released on 2023-06-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Clinics in Laboratory Medicine, guest editor Dr. Linoj Samuel brings his considerable expertise to the topic of Point of Care Testing. Top experts discuss the challenges, techniques, and data collection for point of care and at-home testing options for COVID-19, fungal pathogens, and STDs in various demographics, among other key topics. Contains 10 practice-oriented topics including point of care testing during the COVID-19 pandemic: challenges and pitfalls; will antigen testing remain relevant in point of care testing; the role of point of care testing in specific populations; lab at home: is at-home testing the new normal; point of care testing for sexually transmitted diseases; and more. Provides in-depth clinical reviews on point of care testing, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Book Synopsis Development of Point-of-Care Diagnostic Technologies Utilizing Aqueous Two-Phase Systems by : Shin Ting Sherine Frieda Cheung
Download or read book Development of Point-of-Care Diagnostic Technologies Utilizing Aqueous Two-Phase Systems written by Shin Ting Sherine Frieda Cheung and published by . This book was released on 2019 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are one of the major causes of death in developing countries. These diseases are caused by pathogenic organisms, such as bacteria, viruses, and parasites. Current gold standard methods of detection include cell culturing, the enzyme-linked immunosorbent assay (ELISA), and the polymerase chain reaction (PCR); however, these methods are often complex, have a long time-to-result, and require expensive equipment and trained personnel. Such limitations make it difficult for these standard diagnostics to be used in resource-poor settings. Unfortunately, it is also these developing countries that could currently benefit most from these early diagnosis assays. Therefore, there is a growing need for simple, sensitive, and efficient diagnostic methods. To this end, researchers have made efforts to design diagnostics with the aim to be viable at the point-of-care (POC). While there have been great advances in converting complicated laboratory-based assays into POC-friendly diagnostics, the ability to simplify the method while maintaining the diagnostic test's effectiveness remains a primary concern. Often, low assay sensitivity as a result of poor processing of samples in complex media or low concentration of biomarkers are the main challenges. One example of a POC-friendly diagnostic is the paper-based lateral-flow immunoassay (LFA). While the advantages of the LFA are that it is low-cost, rapid, user-friendly, and does not require laboratory equipment, the main drawback of the LFA is that it is not as sensitive as traditional laboratory tests. To address this problem, our laboratory has previously utilized aqueous two-phase systems (ATPSs) to concentrate biomarkers via partitioning into one of the two phases of an ATPS prior to its application to the LFA. Using this pre-concentration step, the detection limit of the LFA was improved 10-fold. While our lab has had much success in combining ATPSs and LFA to predictably concentrate biomarkers and improve the LFA limit of detection, this thesis expands the application of ATPSs for the development of other POC diagnostic formats. Chapter 2 describes the application of an ATPS to a paper-based spot immunoassay for detection of foodborne pathogens in food samples. We designed a spot immunoassay that utilizes a UCON-potassium phosphate salt ATPS for the pre-concentration of Escherichia coli (E. coli) O157:H7. This platform was tested with samples of O157:H7 spiked in phosphate-buffered saline (PBS) and milk. The ATPS was found to improve the detection limit of the spot test, yielding detection in milk at 106 colony forming units (cfu)/mL within 30 min. In Chapter 3, we extended the application of ATPSs to nucleic acid amplification tests (NAATs) by integrating an ATPS with isothermal DNA amplification. We introduced a novel system that combines thermophilic helicase-dependent amplification (tHDA) with a Triton X-100 micellar ATPS to achieve cell lysis, lysate processing, and enhanced nucleic acid amplification in a simple, one-step process. The combined one-pot system was able to detect whole cell samples containing as few as 102 cfu/mL of E. coli, making it competitive to existing gold standard NAATs. Moreover, the one-pot reaction improved the detection limit of tHDA by 105-fold, and is the first known application of ATPSs to isothermal DNA amplification. This significant improvement in the detection limit was attributed to the synergistic effects of DNA purification and concentration in the ATPS, which rendered the one-pot reaction much more effective at processing whole cell samples compared to the conventional tHDA reaction. While we successfully tested our one-pot system with E. coli as a model pathogen, our system's ease-of-use, sensitivity, and tunability underline its potential as a POC diagnostic platform to detect for a variety of infectious diseases. After demonstrating success with our one-pot reaction, we addressed two challenges that would help further drive the development of a POC NAAT. Specifically, these corresponded to the limited understanding of how to use an ATPS as a sample preparation method and the need to use liquid, test tube-based reactions for the current NAAT technology that could cause difficulties in storage and transportation for POC applications. In Chapter 4, we addressed these challenges by first developing a mathematical model for DNA partitioning to determine which design parameters should be considered for optimal nucleic acid partitioning in a chosen ATPS. Secondly, we assembled a device to perform Recombinase Polymerase Amplification (RPA) and designed an LFA to subsequently detect the amplicons on paper. After development of our model, we identified the electrostatic potential difference and the size of the DNA as potential factors that could influence DNA partitioning. Using these parameters, we determined that a Triton X-114 ATPS containing Mg(CH3COO)2 salt should be used to ensure greater partitioning into the micelle-poor phase. After verifying that our system was optimal for partitioning large genomic DNA fragments, we applied this ATPS as a genomic DNA sample pre-concentration step for the improvement of RPA. Not only did we successfully design and perform RPA on a paper matrix, but we also achieved a 10-fold improvement in the detection limit when our ATPS DNA pre-concentration method was combined with paper-based RPA and LFA. Ultimately, we hope that this increased understanding of DNA partitioning behavior in ATPSs and application of NAAT steps to paper-based formats can lead to better engineered designs to further advance the NAAT for POC use.
Book Synopsis Clinical Immunodiagnostics: Laboratory Principles and Practices by : Ian C. Clift
Download or read book Clinical Immunodiagnostics: Laboratory Principles and Practices written by Ian C. Clift and published by Jones & Bartlett Learning. This book was released on 2020-02-07 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A contemporary guide to the diagnostic principles and practices of immunology and serology in the clinical laboratory.
Book Synopsis Library of Congress Subject Headings by : Library of Congress
Download or read book Library of Congress Subject Headings written by Library of Congress and published by . This book was released on 2013 with total page 1704 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Zakim and Boyer's Hepatology by : Thomas D. Boyer
Download or read book Zakim and Boyer's Hepatology written by Thomas D. Boyer and published by Elsevier Health Sciences. This book was released on 2016-12-13 with total page 1380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get the authoritative, up-to-date information you need on liver disease from the 7th Edition of the most trusted reference worldwide. Covering both basic science and recent clinical developments, this revised edition by Drs. Arun J. Sanyal, Thomas D. Boyer, Norah A. Terrault, and Keith D. Lindor, provides an in-depth, comprehensive look at the pathophysiology, diagnostic, and treatment information related to the liver. More than 1,100 figures and tables, many new and in full color, highlight completely updated content throughout. Expert, international authorship and comprehensive, easy-to-access information makes this edition the gold standard in the field of hepatology. Includes new information on the rapid changes in treatment paradigms for acute liver failure, the latest treatments for primary biliary cholangitis, full coverage of the gut microbiome and its role in liver disease, the newest developments in drug-induced liver injury, and changes in hepatitis C virus treatment and hot-button concerns about access to care. New summary boxes at the end of each chapter and a newly streamlined table of contents make it easier to find and understand the information you’re looking for. Hundreds of brand-new illustrations clearly present key aspects of liver disease.
