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Immune Regulation And Immunotherapy In Autoimmune Disease
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Book Synopsis Immune Regulation and Immunotherapy in Autoimmune Disease by : Jingwu Zhang
Download or read book Immune Regulation and Immunotherapy in Autoimmune Disease written by Jingwu Zhang and published by Springer Science & Business Media. This book was released on 2007-01-25 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the most recent advances in the understanding of cellular and molecular mechanisms for immune responses and immune regulation. The books editor, Dr. Zhang, is well-known internationally, particularly in the field of multiple sclerosis and T-cell vaccination as a potential treatment of multiple sclerosis. He has much experience and expertise in both basic and clinical aspects of autoimmune disease.
Book Synopsis Innate Immune Regulation and Cancer Immunotherapy by : Rong-Fu Wang
Download or read book Innate Immune Regulation and Cancer Immunotherapy written by Rong-Fu Wang and published by Springer Science & Business Media. This book was released on 2012-02-02 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non self-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer.
Book Synopsis Mechanisms of Lymphocyte Activation and Immune Regulation VIII by : Sudhir Gupta
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation VIII written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in biochemistry, cell biology, genome-wide mutagenesis - coupled with molecular technology, including gene microarray and transgenic and knock-out animals - have been instrumental in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases. The molecular definition of these pathways and processes has led to novel treatments for certain auto-immune diseases that are based on the pathogenesis of diseases rather than on broad-spectrum immunosuppression. This book reviews many of these current developments and proposes future novel approaches for understanding the pathogenesis of auto-immune diseases and designing novel therapy. This book covers three major areas of auto-immunity: the basic mechanisms of immunological tolerance, pathogenesis of auto-immune diseases, and some novel therapies. This book should be useful for immunologists, molecular biologists, rheumatologists, and clinical scientists.
Book Synopsis Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity by : Akihiko Yoshimura
Download or read book Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity written by Akihiko Yoshimura and published by Springer. This book was released on 2017-11-25 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.
Book Synopsis Co-signal Molecules in T Cell Activation by : Miyuki Azuma
Download or read book Co-signal Molecules in T Cell Activation written by Miyuki Azuma and published by Springer Nature. This book was released on 2019-11-22 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.
Book Synopsis T–cell Activation in Health and Disease by : M Feldmann
Download or read book T–cell Activation in Health and Disease written by M Feldmann and published by Academic Press. This book was released on 2017-05-04 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: T-cell Activation in Health and Disease is a collection of papers presented at the "T-cell Activation in Health and Disease—Disorders of Immune Regulation—Infection and Autoimmunity" workshop held in Oxford on September 25-29, 1988. This book discusses the progress occurring in T-cell immunity research. One paper discusses the effects of two interaction clones of T-cells that can define the T-cell immunoregulatory network. Another paper discusses the relationship between connectivity and tolerance of the immune network. This paper then suggests the possibility that autoimmunity arises because self-reactive clones are inadequately connected to the network. Another paper reviews the cell-mediated responses in the synovial fluids, as well as the interaction of rheumatoid arthritis synovial fluid dendritic cells and T lymphocytes. The book also examines why attempts for protective immunity to the HIV virus have not been successful. One article then discusses the goals of immunologic intervention in autoimmune disease by using an approach involving the cellular and cytokine targets and their deployment. This text can prove significant for scientists in the field of pharmacology, cellular biology, and researchers in the field of immunology and infectious diseases.
Book Synopsis Defects in Regulation: How, Where and When The Immune System Can Go Wrong by : Ger Rijkers
Download or read book Defects in Regulation: How, Where and When The Immune System Can Go Wrong written by Ger Rijkers and published by Frontiers Media SA. This book was released on 2022-02-03 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Immunotherapy – A Novel Facet of Modern Therapeutics by : Sujata P. Sawarkar
Download or read book Immunotherapy – A Novel Facet of Modern Therapeutics written by Sujata P. Sawarkar and published by Springer Nature. This book was released on 2020-12-16 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the significance and relevance of immunotherapy in modern-day therapeutics. Focusing on the application of immunotherapy in oncology, neurodegenerative and autoimmune diseases, it discusses the drug delivery systems, and pre-clinical and clinical methodologies for immunotherapy-based drugs. It also comprehensively reviews various aspects of immunotherapy, such as regulatory affairs, quality control, safety, and pharmacovigilance. Further, the book discusses the in vitro validation of therapeutic strategies prior to patient application and management of immunotherapy-related side effects and presents case studies demonstrating the design and development (pre-clinical to clinical) of immunotherapy for various diseases. It also describes various design considerations and the scale-up synthesis of immunotherapeutics and screening methods. Lastly, it explores the important aspect of cost-effectiveness and rational immunotherapy strategies.
Book Synopsis Emerging Therapeutics for Immune Tolerance by : Hyewon Phee
Download or read book Emerging Therapeutics for Immune Tolerance written by Hyewon Phee and published by Frontiers Media SA. This book was released on 2021-11-30 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Autoimmune Diseases by : Noel R. Rose
Download or read book The Autoimmune Diseases written by Noel R. Rose and published by Academic Press. This book was released on 2019-10-15 with total page 1532 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P’s" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunologic diagnostic methods and treatments. The book also covers several cross-cutting issues related to the recognition and treatment of autoimmune diseases, including chapters on the measurement of autoantibodies and T cells, the use of biomarkers as early predictors of disease, and new methods of treatment. Gives a thorough and important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and its therapy Provides thorough, up-to-date information on specific diseases, along with clinical applications in an easily found reference for clinicians and researchers interested in certain diseases Keeps readers abreast of current trends and emerging areas in the field Ensures that content is not only up-to-date, but applicable and relevant Includes new, updated chapters that emphasize hot topics in the field, e.g., research on auto inflammatory diseases and autoimmune responses following cancer immunotherapy
Book Synopsis The Epigenetics of Autoimmune Diseases by : Moncef Zouali
Download or read book The Epigenetics of Autoimmune Diseases written by Moncef Zouali and published by John Wiley & Sons. This book was released on 2009-04-01 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often debilitating and fatal diseases. Drawing on the research of leading experts, this book provides a valuable insight into this important new area of autoimmunity research and a clear, up-to-date view on the major advances in the field. Specific coverage includes: How highly developed epigenetic mechanisms are involved in several aspects of normal immune regulation, in addition to maintaining immune tolerance to self-determinants. Specific epigenetic aspects of human autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, autoimmune diabetes, thyroid autoimmunity, inflammatory bowel disease and autoimmune hepatitis. How understanding epigenetic mechanisms can lead to therapeutic strategies based on manipulation of this previously unexploited facet of immune regulation. Discussion of the novel approaches that are being investigated to prevent or treat autoimmune diseases. This book is an essential resource for those actively involved in the field. It is also of interest to basic researchers interested in understanding the origin of autoimmunity and clinical specialists interested in gaining in-depth understanding of the pathogenesis of autoimmune diseases and their treatment.
Book Synopsis Immunoregulatory Aspects of Immunotherapy by : Seyyed Shamsadin Athari
Download or read book Immunoregulatory Aspects of Immunotherapy written by Seyyed Shamsadin Athari and published by BoD – Books on Demand. This book was released on 2018-08-01 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunotherapy is an innovative, leading and valuable approach to the treatment and control of many diseases. It can solve many problems of public health worldwide. Many people in numerous countries are suffering from a wide range of diseases (communicable and non-communicable) that can be cured or controlled by the immune system and immunotherapy. Some immunological diseases (i.e. allergic reactions and asthma, autoimmune disease, immunodeficiency disease, hypersensitivity reactions, etc.) have immune response pathophysiology and by controlling immune system mechanisms, these diseases can be controlled and cured. Immunoregulatory Aspects of Immunotherapy focuses on immune system mechanism, diagnosis, treatment and other related problems. The chapters have applicable and scientific data in immunotherapeutic approaches based on medical sciences, and would be of benefit to all researchers in immunology, allergy and asthma fields. The book discusses the prevention, diagnosis, treatment and follow-up of patients who have dangerous diseases. We hope this book will be a new approach to the immunotherapy of diseases and will improve public health and wellbeing.
Book Synopsis Mediators of Immune Regulation and Immunotherapy by : S. K. Singhal
Download or read book Mediators of Immune Regulation and Immunotherapy written by S. K. Singhal and published by Elsevier Publishing Company. This book was released on 1986 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting the proceedings of an international symposium entitled Mediators of Immune Regulation and Immunotherapy, this collection of authoritative papers encompasses the five major areas discussed at the meeting: T-Cell and Antigen Presenting Cell Regulatory Molecules; Immunoregulatory Cells and Molecules; Stem Cell Differentiation and Regulatory Molecules; B-Cell Differentiation and Promoting Molecules; Molecular Manipulation and Immunotherapy. This volume contains up-to-date data that will be of great practical value to immunologists worldwide.
Download or read book Immunoregulation written by Nicola Fabris and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunoregulation is one of the areas which has witnessed the most explosive advances of immunology during the past decade. It is in this area that the current view of the immune system has arisen and developed. There is indeed little doubt that immune reactions are primarily determined by messages which are genera ted within the immune system and passed among different types of immunologie cells. This cell communication not only determines the type, intensity and duration of the response after perturbation of the immune system by exogenous antigens, but it is also essential for preventing autoimmune reactions and their clinical conse quences. In order to assure aperfect balance within the enormous com plexity of the immune system, it is not surprising that multiple self-regulatory mechanisms are organized at different levels, such as antibody feedback, idiotypic-anti-idiotypic responses, suppres sor and helper T cells, lymphokine signals and genetic require ments. A nu mb er of observations in recent years have, however, demonstrated that consistent contributions to the immunological homeostasis are given also by signals generated outside of the immune system, namely,in the central and autonomous nervous system as weIl as in the endocrine apparatus. Furthermore, the interactions between the immune system and the other body homestatic mechanisms seem to be bidirectional: if immunological cells may be targets of neuroendocrinological factors, immunological products seem in turn to contribute to the neuro endocrine homeostasis.
Book Synopsis Regulatory T Cells in Inflammation by : Leonie S. Taams
Download or read book Regulatory T Cells in Inflammation written by Leonie S. Taams and published by Springer Science & Business Media. This book was released on 2006-03-30 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory T-cells are essential components of the immune system, and several different subsets of regulatory T-cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T-cell subset. These cells act by suppressing adaptive and possibly innate immune responses thereby maintaining or restoring the balance between immunity and tolerance. The suppressive effects of CD4+CD25+ regulatory T-cells are cell-contact dependent. Recent developments and viewpoints in the field of CD4+CD25+ regulatory T-cells as well as the potential use of regulatory T-cells in immunotherapy of inflammatory diseases are discussed in this volume. By linking data from experimental models with recent findings from the clinic, this book will be of interest to immunologists and other biomedical researchers as well as clinicians interested in the regulation and manipulation of the immune response during inflammatory disease.
Book Synopsis Immune Mediated Diseases by : Michael R. Shurin
Download or read book Immune Mediated Diseases written by Michael R. Shurin and published by Springer Science & Business Media. This book was released on 2007-07-25 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume includes contributions from the speakers of the Second IMD Congress (September 10-15, 2007; Moscow, Russia) who were eager to share some of the academic and clinical enthusiasm that defines the IMD meetings. The goal of the International Immune-Mediated Diseases: From Theory to Therapy (IMD) Congress is to bring the world’s best immunologists and clinicians to Moscow.
Book Synopsis Immune System Q&A by : Ahmed Bayouda
Download or read book Immune System Q&A written by Ahmed Bayouda and published by Ahmed Bayouda. This book was released on 2024-06-18 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover the Secrets of the Immune System with "Immune System Q&A" Unlock the mysteries of your body's most vital defense mechanism with "Immune System Q&A" by Ahmed Bayouda. This comprehensive and engaging ebook offers a deep dive into the complex world of the immune system through an accessible question-and-answer format, perfect for readers of all backgrounds. Why Read "Immune System Q&A"? Clear and Concise Explanations: Understand the immune system's intricate workings with straightforward, easy-to-follow explanations. Comprehensive Coverage: From the basics of immune function to the detailed roles of specific cells, this ebook covers it all. Practical Insights: Learn how your lifestyle affects your immunity and discover practical tips for boosting your immune health. Who Should Read This Ebook? Students: Gain a solid foundation for your studies in biology, medicine, and health sciences. Healthcare Professionals: Enhance your understanding of immune system mechanisms and their practical applications. Health Enthusiasts: Empower yourself with knowledge to make informed health decisions and improve your wellbeing. Curious Minds: Satisfy your curiosity about how your body defends itself against diseases. What You'll Learn: ü The essential components and functions of the immune system ü How the immune system differentiates between self and non-self ü The various types of immunity and their roles ü The body's response to different infections ü The impact of stress on immune function ü Lifestyle factors that can enhance your immunity Join the Journey to Better Health: Don't miss out on this valuable resource that combines scientific accuracy with readability. Whether you're looking to boost your knowledge, support your studies, or improve your health, "Immune System Q&A" is the perfect guide. Purchase "Immune System Q&A" and embark on a journey to understand and optimize your immune health. Elevate your understanding of the immune system and empower your health journey with "Immune System Q&A" Order your copy today!