Immune Dysfunction And Immunotherapy In Heart Disease

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Immune Dysfunction and Immunotherapy in Heart Disease

Author : Ronald Ross Watson
Publisher : John Wiley & Sons
ISBN 13 : 9780470766514
Total Pages : 328 pages
Book Rating : 4.7/5 (665 download)

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Book Synopsis Immune Dysfunction and Immunotherapy in Heart Disease by : Ronald Ross Watson

Download or read book Immune Dysfunction and Immunotherapy in Heart Disease written by Ronald Ross Watson and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current heart failure therapeutics affects symptoms without appreciably reducing the mortality rate of 50% in five years -- suggesting a failure in treating the underlying mechanism. This book proposes a new mechanism for heart failure; immune mediated cardiac remodelling for cardiac dysfunction. The outstanding editor team of two internationally recognized immunologists -- Ronald Watson, who has studied heart disease in immune dysfunction for a decade and has a patent for an immunotherapy of heart disease by immune regulation, and Douglas Larson, whose experience in cardiac transplantation immunology has provided the foundation for research into novel therapeutics for heart failure and hypertension – makes Immune Dysfunction and Immunotherapy in Heart Disease the definitive reference to the state of the science in this area. The four parts of the book address: Immune Dysfunction Leading to Heart Disease: Induction by Physiological Changes Immune Dysfunction Promoting CVD: Induction by Transplantation Drugs Immune Dysfunction Leading to Heart Dysfunction: Induction or Prevention by Cardiotherapeutic Drugs Immune Dysfunction Leading to Heart Disease: Induction by Pathogens Both researchers and practitioners will find this authoritative volume an excellent source of information on novel immune targeted therapeutics.

Cardio-Oncology

Author : Antonio Russo
Publisher : Springer Nature
ISBN 13 : 3030977447
Total Pages : 127 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis Cardio-Oncology by : Antonio Russo

Download or read book Cardio-Oncology written by Antonio Russo and published by Springer Nature. This book was released on 2022-08-09 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of immunotherapy in oncology field has revolutionized the prognosis of many types of cancer. The immune checkpoint inhibitors target receptors whose inhibition increases the activity of immune system cells against tumor cells. In recent years, new immunotherapies have been studied and approved in a growing number of tumors including melanoma, non-small cell lung cancer (NSCLC), and renal cell cancer (RCC). This volume provides a complete and updated state-of-art review regarding the management of cardiovascular toxicities from new immunotherapies. The manuscript is divided into different sections starting from the relationship between cancer and immune system to let the reader understand the new molecular concepts under immunotherapy development. Subsequent chapters describe specifically the immunotherapy options in solid tumor treatment and the main features of the immuno-related cardiovascular complications. This volume is written by experts in the oncological and cardiovascular fields and aims to provide to clinicians who approach current cancer patients a useful tool to move through the paths of modern cardio-oncology. An important section would afford the most relevant interventions needed to manage the cardiac events, suggesting how to reduce their impact and effects on oncological outcomes. The text concludes by addressing future perspectives in the cardio-immunology field, discussing many aspects such as the early detection of cardiovascular damage and the potential role of liquid biopsy in new damage-related biomarkers discovery.

SITC’s Guide to Managing Immunotherapy Toxicity

Author : Marc S. Ernstoff, MD
Publisher : Springer Publishing Company
ISBN 13 : 0826172156
Total Pages : 250 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis SITC’s Guide to Managing Immunotherapy Toxicity by : Marc S. Ernstoff, MD

Download or read book SITC’s Guide to Managing Immunotherapy Toxicity written by Marc S. Ernstoff, MD and published by Springer Publishing Company. This book was released on 2019-03-15 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Society for Immunotherapy of Cancer's handbook,SITC’s Guide to Managing Immunotherapy Toxicity, is a practical reference to managing side effects associated with FDA-approved cancer immunotherapy drugs. Separated into two parts, Part I contains chapter-based overviews of immune checkpoint inhibitors in the clinic, starting with anti-CTLA4 agents, anti-PD1/PD-L1 agents, and approved immunotherapeutic combinations. These chapters cover relevant mechanisms of action, indications, and toxicities seen while combating early, advanced, and metastatic stages in cancer patients. Part II is structured by common and uncommon toxicities that affect major organ sites throughout the body. It begins with a general summary of principles and management options followed by chapters focusing on specific toxicities such as rash and mucosal irritation, muscle and joint toxicity, diarrhea and colitis, pneumonitis, endocrine toxicities, neurological toxicities, cardiac toxicity, renal toxicity, hematologic toxicity, and ocular toxicities. Each chapter provides guidance on how to assess and treat the toxicity and how to support the patient through acute and chronic effects with detailed summary tables for quick reference. Part II concludes with chapters covering management of special patient populations, including patients with autoimmune disease and geriatric patients, treatment and management of fatigue, and a final chapter dedicated to cost effectiveness and the toll of financial toxicity on patients and caregivers. With chapters written by world-recognized leaders in the immuno-oncology field, this text provides thorough coverage of the toxicity and management of adverse effects for immune checkpoint inhibitors. It is an indispensable resource for clinical oncologists, emergency physicians, hospitalists and other medical practitioners in both the hospital and community clinic settings, especially as the use of immune checkpoint inhibitors becomes a fixture in oncology care. Key Features: Outlines strategies for treating high-risk patients facing an acute or chronic side effect to immunotherapy Provides numerous tables that condense and highlight pertinent information for quick reference Describes the various clinical presentations and toxic reactions caused by immunotherapy Purchase includes access to the eBook for use on most mobile devices or computer

Immunotherapy

Author : Aung Naing
Publisher : Springer Nature
ISBN 13 : 3030793087
Total Pages : 445 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Immunotherapy by : Aung Naing

Download or read book Immunotherapy written by Aung Naing and published by Springer Nature. This book was released on 2022-01-01 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of immuno-oncology continues to rapidly evolve as new insights to fight and treat cancer emerge. The fourth edition of Immunotherapy provides the most current overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. While immunotherapy has revolutionized the treatment landscape of several solid malignancies, several challenges still exist. Only a subset of patients derive clinical benefits; some do not respond at all, and others respond initially, only for their disease to progress later. Because these drugs can activate a broad range of immune cells, patients suffer from a unique set of side effects known as immune-related adverse events. As more immunotherapeutic agents are used in the clinic, it is important to provide updates about current and ongoing developments in the field to further research efforts and inform treatment decisions. The fourth edition will have a new focus on strategies to overcome the challenges associated with immunotherapy. Chapters will discuss topics such as biomarkers of response, resistance mechanisms, role of imaging in predicting immune-related adverse events, and management of immune-related adverse events. Written by leading experts conducting cutting-edge research, readers will gain up-to-date knowledge on the current state and future of immunotherapy.

Drug-Induced Liver Injury

Author :
Publisher : Academic Press
ISBN 13 : 0128173173
Total Pages : 288 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Drug-Induced Liver Injury by :

Download or read book Drug-Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Immune Checkpoint Inhibitors in Cancer

Author : Fumito Ito
Publisher : Elsevier Health Sciences
ISBN 13 : 0323549500
Total Pages : 400 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Immune Checkpoint Inhibitors in Cancer by : Fumito Ito

Download or read book Immune Checkpoint Inhibitors in Cancer written by Fumito Ito and published by Elsevier Health Sciences. This book was released on 2018-09-03 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get a quick, expert overview of the latest clinical information and guidelines for cancer checkpoint inhibitors and their implications for specific types of cancers. This practical title by Drs. Fumito Ito and Marc Ernstoff synthesizes the most up-to-date research and clinical guidance available on immune checkpoint inhibitors and presents this information in a compact, easy-to-digest resource. It’s an ideal concise reference for trainee and practicing medical oncologists, as well as those in research. Discusses the current understanding of how to best harness the immune system against different types of cancer at various stages. Helps you translate current research and literature into practical information for daily practice. Presents information logically organized by disease site. Covers tumor immunology and biology; toxicities associated with immune checkpoint inhibitors; and future outlooks. Consolidates today’s available information on this timely topic into one convenient resource.

Facing Immunotherapy

Author : Justine Cohen
Publisher :
ISBN 13 : 9781677234516
Total Pages : 369 pages
Book Rating : 4.2/5 (345 download)

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Book Synopsis Facing Immunotherapy by : Justine Cohen

Download or read book Facing Immunotherapy written by Justine Cohen and published by . This book was released on 2019-12-18 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Facing Immunotherapy is for anyone whose life is affected by cancer and who is considering (or is receiving) immunotherapy. Written by leading physicians in their fields, Facing Immunotherapy combines top-tier medical information and compassionate counsel on the use and tolerability of immunotherapies, with a caring and sensible approach to the emotional aspects of living with cancer treatment and its complications. This book provides easily readable and trustworthy information, which is divided amongst twenty-six chapters that ask and answer pertinent questions about immunotherapy and its medical, surgical, and psychiatric/psychological components. A glossary of terms provides important background information to readers (e.g., about the disease, nutrition, diet, exercise, and risk-reduction); online resources and references are also offered. Each chapter is accompanied by selected reference and internet resources as well as illustrations and photographs.

Immunotherapy of Hepatocellular Carcinoma

Author : Tim F. Greten
Publisher : Springer
ISBN 13 : 9783319879116
Total Pages : 0 pages
Book Rating : 4.8/5 (791 download)

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Book Synopsis Immunotherapy of Hepatocellular Carcinoma by : Tim F. Greten

Download or read book Immunotherapy of Hepatocellular Carcinoma written by Tim F. Greten and published by Springer. This book was released on 2018-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.

Janeway's Immunobiology

Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)

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Book Synopsis Janeway's Immunobiology by : Kenneth Murphy

Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Inflammation and Atherosclerosis

Author : Georg Wick
Publisher : Springer Science & Business Media
ISBN 13 : 370910338X
Total Pages : 628 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Inflammation and Atherosclerosis by : Georg Wick

Download or read book Inflammation and Atherosclerosis written by Georg Wick and published by Springer Science & Business Media. This book was released on 2011-12-03 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been known for over 150 years that hallmarks of inflammation can be observed in the wall of atherosclerotic vessels. It was, however, not clear if this inflammation is the cause or the consequence of atherogenesis. More recently, it has become evident that inflammation mediated both by innate and adaptive immunity is instrumental even in the earliest stages of the development of atherosclerotic lesions, i.e., that it plays an important pathogenetic role. In this volume, international experts in the field discuss the pathogenetic, diagnostic, preventive and possible therapeutic relevance of inflammation in atherogenesis. This book is intended for researchers and physicians in the fields of vascular biology, immunology and atherosclerosis.

An Elegant Defense

Author : Matt Richtel
Publisher : HarperCollins
ISBN 13 : 0062698508
Total Pages : 448 pages
Book Rating : 4.0/5 (626 download)

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Book Synopsis An Elegant Defense by : Matt Richtel

Download or read book An Elegant Defense written by Matt Richtel and published by HarperCollins. This book was released on 2019-03-12 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: National Bestseller "A valuable read that will help you understand what it takes to stop COVID-19. … A super interesting look at the science of immunity.” —Bill Gates, Gates Notes Summer Reading List The Pulitzer Prize–winning New York Times journalist "explicates for the lay reader the intricate biology of our immune system" (Jerome Groopman, MD, New York Review of Books) From New York Times science journalist Matt Richtel, An Elegant Defense is an acclaimed and definitive exploration of the immune system and the secrets of health. Interweaving cutting-edge science with the intimate stories of four individual patients, this epic, first-of-its-kind book “give[s] lay readers a means of understanding what’s known so far about the intricate biology of our immune systems” (The Week). The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. It has been honed by evolution over millennia to face an almost infinite array of threats. For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders. An Elegant Defense effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to today’s laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. Drawing on extensive new interviews with dozens of world-renowned scientists, Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

Coronary Microvascular Dysfunction

Author : Filippo Crea
Publisher : Springer Science & Business Media
ISBN 13 : 8847053676
Total Pages : 263 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Coronary Microvascular Dysfunction by : Filippo Crea

Download or read book Coronary Microvascular Dysfunction written by Filippo Crea and published by Springer Science & Business Media. This book was released on 2013-08-15 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past two decades a number of studies have shown that abnormalities in the function and structure of coronary microcirculation can be detected in several cardiovascular diseases. On the basis of the clinical setting in which it occurs, coronary microvascular dysfunction (CMD) can be classified into four types: CMD in the absence of any other cardiac disease; CMD in myocardial diseases; CMD in obstructive epicardial coronary artery disease; and iatrogenic CMD. In some instances CMD represents an epiphenomenon, whereas in others it represents an important marker of risk or may contribute to the pathogenesis of myocardial ischemia, thus becoming a possible therapeutic target. This book provides an update on coronary physiology and a systematic assessment of microvascular abnormalities in cardiovascular diseases, in the hope that it will assist clinicians in prevention, detection and management of CMD in their everyday activity.

The Epigenome and Developmental Origins of Health and Disease

Author : Cheryl S Rosenfeld
Publisher : Academic Press
ISBN 13 : 0128016728
Total Pages : 560 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Epigenome and Developmental Origins of Health and Disease by : Cheryl S Rosenfeld

Download or read book The Epigenome and Developmental Origins of Health and Disease written by Cheryl S Rosenfeld and published by Academic Press. This book was released on 2015-10-10 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother’s diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples. Informs how everyday choices pregnant women make can impact child development Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress) Includes a boxed-in area in each chapter for further references and resources to keep up with the field Features video interviews with the authors and other key leaders in the field

Management of Cardiovascular Disease in Women

Author : Hanna Z. Mieszczanska
Publisher : Springer Science & Business Media
ISBN 13 : 1447155173
Total Pages : 470 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Management of Cardiovascular Disease in Women by : Hanna Z. Mieszczanska

Download or read book Management of Cardiovascular Disease in Women written by Hanna Z. Mieszczanska and published by Springer Science & Business Media. This book was released on 2014-03-24 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease is the leading cause of death in women in the US, with more women dying from heart disease than men. Women may have different presentation from men and often need a different approach to diagnosis and treatment. There are also unique topics of management of heart disease in women, including issues during pregnancy, lactation, and menopause. Many different health care providers, as well as cardiologists are involved in treating these patients. A manual reviewing diagnosis and treatment of cardiac disease in women would help providers without specific cardiology training to deliver care with greater efficiency. A practical and comprehensive guide geared towards these providers would be a highly practical and valuable resource that would be utilized in everyday practice in offices that include urban clinics, general medicine offices, obstetrics and gynecology offices, as well as in the surgical subspecialties. This book will be a highly practical resource that can be directly applied to the issues that arise in everyday practice. There is no available book on the market that focuses on a broader approach to cardiac disease in women or focuses on non-cardiology providers (and their trainees) who have the need to know more about treatment of cardiovascular disease in women.

Non-Lymphoid Functions of Regulatory T cells in Health and Disease

Author : Dipayan Rudra
Publisher : Frontiers Media SA
ISBN 13 : 2832515843
Total Pages : 246 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Non-Lymphoid Functions of Regulatory T cells in Health and Disease by : Dipayan Rudra

Download or read book Non-Lymphoid Functions of Regulatory T cells in Health and Disease written by Dipayan Rudra and published by Frontiers Media SA. This book was released on 2023-03-01 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Novel Risk Predicting System for Heart Failure

Author : Chen Liu
Publisher : Frontiers Media SA
ISBN 13 : 2889765121
Total Pages : 150 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Novel Risk Predicting System for Heart Failure by : Chen Liu

Download or read book Novel Risk Predicting System for Heart Failure written by Chen Liu and published by Frontiers Media SA. This book was released on 2022-07-05 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Frontiers of Engineering

Author : National Academy of Engineering
Publisher : National Academies Press
ISBN 13 : 0309487501
Total Pages : 125 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Frontiers of Engineering by : National Academy of Engineering

Download or read book Frontiers of Engineering written by National Academy of Engineering and published by National Academies Press. This book was released on 2019-02-28 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents papers on the topics covered at the National Academy of Engineering's 2018 US Frontiers of Engineering Symposium. Every year the symposium brings together 100 outstanding young leaders in engineering to share their cutting-edge research and innovations in selected areas. The 2018 symposium was held September 5-7 and hosted by MIT Lincoln Laboratory in Lexington, Massachusetts. The intent of this book is to convey the excitement of this unique meeting and to highlight innovative developments in engineering research and technical work.