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Identifying Biological Pathways Implicated In Defined Subgroups Of Phenotypic Expression For Autism Spectrum Disorders Evaluating Small Molecule Effects On Expression Of Asmt
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Book Synopsis Identifying Biological Pathways Implicated in Defined Subgroups of Phenotypic Expression for Autism Spectrum Disorders & Evaluating Small Molecule Effects on Expression of ASMT by : Olivia Jean Veatch
Download or read book Identifying Biological Pathways Implicated in Defined Subgroups of Phenotypic Expression for Autism Spectrum Disorders & Evaluating Small Molecule Effects on Expression of ASMT written by Olivia Jean Veatch and published by . This book was released on 2013 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Time for Metabolism and Hormones by : Paolo Sassone-Corsi
Download or read book A Time for Metabolism and Hormones written by Paolo Sassone-Corsi and published by Springer. This book was released on 2016-04-04 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.
Book Synopsis Comprehensive Guide to Autism by : Vinood B. Patel
Download or read book Comprehensive Guide to Autism written by Vinood B. Patel and published by Springer. This book was released on 2013-10-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism is a complex multifaceted disorder affecting neurodevelopment during the early years of life and, for many, throughout the life span. Inherent features include difficulties or deficits in communication, social interaction, cognition, and interpersonal behavioral coordination, to name just a few. Autism profoundly impacts the affected individual, the family, and, in many cases, the localized communities. The increased prevalence of childhood autism has resulted in rapid developments in a wide range of disciplines in recent years. Nevertheless, despite intensive research, the cause(s) remain unresolved and no single treatment strategy is employed. To address these issues, Comprehensive Guide to Autism is an all-embracing reference that offers analyses and discussions of contemporary issues in the field of autism. The work brings together scientific material from leading experts in the field relating to a wide range of important current topics, such as the early identification and treatment of children with autism, pertinent social and behavioral studies, recent developments in genetics and immunology, the influence of diet, models of autism, and future treatment prospects. Comprehensive Guide to Autism contains essential readings for behavioral science researchers, psychologists, physicians, social workers, parents, and caregivers.
Book Synopsis Autism Spectrum Disorders by : Stephen Deutsch
Download or read book Autism Spectrum Disorders written by Stephen Deutsch and published by BoD – Books on Demand. This book was released on 2011-08-01 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Estimated prevalence rates of autism spectrum disorders (ASDs) have increased at an alarming rate over the past decade; current estimates stand as high as 1 in 110 persons in the population with a higher ratio of affected males to females. In addition to their emotional impact on the affected persons and their family members (in fact, the latter are often unrecognized unaffected “patients” themselves), the economic and social impacts of ASDs on society are staggering. Persons with ASDs will need interdisciplinary approaches to complex treatment and life planning, including, but not limited to, special education, speech and language therapy, vocational skills training and rehabilitation, social skills training and cognitive remediation, in addition to pharmacotherapy. The current book highlights some of the recent research on nosology, etiology, and pathophysiology. Additionally, the book touches on the implications of new research for treatment and genetic counseling. Importantly, because the field is advancing rapidly, no book can be considered the final word or finished product; thus, the availability of open access rapid publication is a mechanism that will help to assure that readers remain current and up-to-date.
Book Synopsis Translational Approaches to Autism Spectrum Disorder by : Maria de los Angeles Robinson-Agramonte
Download or read book Translational Approaches to Autism Spectrum Disorder written by Maria de los Angeles Robinson-Agramonte and published by Springer. This book was released on 2015-06-10 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses and synthesizes recent basic, translational, and clinical research with the goal of understanding the mechanisms behind autism spectrum disorder (ASD) and how they lead to altered brain function and behavior. Bringing clarity to these mechanisms will lead to more effective therapies for the various heterogeneous pathologies that comprise ASD. Currently there are few, if any, proven therapies for the majority of the disorders. Among the topic addressed are neural plasticity, neuroimmunology, neuroinflammation, neuroimaging, and appropriate animal and genetic models.
Book Synopsis Pharmacoepigenetics by : Ramón Cacabelos
Download or read book Pharmacoepigenetics written by Ramón Cacabelos and published by Academic Press. This book was released on 2019-06-04 with total page 986 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacoepigenetics provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. - Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development - Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry - Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety - Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine
Book Synopsis Sleep in Children with Neurodevelopmental Disabilities by : Jennifer A. Accardo
Download or read book Sleep in Children with Neurodevelopmental Disabilities written by Jennifer A. Accardo and published by Springer. This book was released on 2018-12-13 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical guide presents approaches to working with children and adolescents with neurodevelopmental disabilities who have sleep problems. Divided into four sections, the book begins with the impact of sleep problems in children with disabilities and the evaluation of sleep complaints. The next two sections cover the major categories of sleep disorders as they apply in children with disabilities, and specific neurodevelopmental disabilities with their characteristic sleep manifestations. The last section details options for treatment, which include behavioral and environmental strategies, occupational therapy, exercise, and medications. Chapters feature case studies that introduce and reinforce diagnostic and therapeutic approaches. Those engaged in the care of children with neurodevelopmental disabilities and sleep problems will find this text to be an invaluable guide when assessing and treating sleep disorders.
Book Synopsis Psychiatric Symptoms and Comorbidities in Autism Spectrum Disorder by : Luigi Mazzone
Download or read book Psychiatric Symptoms and Comorbidities in Autism Spectrum Disorder written by Luigi Mazzone and published by Springer. This book was released on 2016-05-19 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains in detail the diagnosis, management, and treatment of comorbid disorders in patients with autism spectrum disorders (ASD). Important insights are provided into the nature of the symptoms of psychiatric comorbidities in these patients, and particularly children and adolescents, with a view to assisting clinicians in reaching a correct diagnosis that will permit the implementation of appropriate treatment strategies, whether psychological or pharmacological. The full range of potential comorbidities is considered, including mood disorders, anxiety disorders, obsessive-compulsive disorder, schizophrenia spectrum and other psychotic disorders, eating disorders, disruptive behavioral disorders, Tourette’s disorder, and substance-related disorders. In each case guidance is provided on how to avoid incorrectly attributing symptoms to ASD and on treatment options. Psychiatric Comorbidities in Autism Spectrum Disorders will be of value to all practitioners who are confronted by patients with these complex co-occurring conditions.
Book Synopsis The Comorbidities of Epilepsy by : Marco Mula
Download or read book The Comorbidities of Epilepsy written by Marco Mula and published by Academic Press. This book was released on 2019-04-20 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epilepsy is one of most frequent neurological disorders affecting about 50 million people worldwide and 50% of them have at least another medical problem in comorbidity; sometimes this is a the cause of the epilepsy itself or it is due to shared neurobiological links between epilepsy and other medical conditions; other times it is a long-term consequence of the antiepileptic drug treatment. The Comorbidities of Epilepsy offers an up-to-date, comprehensive overview of all comorbidities of epilepsy (somatic, neurological and behavioral), by international authorities in the field of clinical epileptology, with an emphasis on epidemiology, pathophysiology, diagnosis and management. This book includes also a critical appraisal of the methodological aspects and limitations of current research on this field. Pharmacological issues in the management of comorbidities are discussed, providing information on drug dosages, side effects and interactions, in order to enable the reader to manage these patients safely. The Comorbidities of Epilepsy is aimed at all health professionals dealing with people with epilepsy including neurologists, epileptologists, psychiatrists, clinical psychologists, epilepsy specialist nurses and clinical researchers. - Provides a comprehensive overview of somatic, neurological and behavioral co-morbidities of epilepsy - Discusses up-to-date management of comorbidities of epilepsy - Written by a group of international experts in the field
Book Synopsis The Autism Revolution by : Dr. Martha Herbert
Download or read book The Autism Revolution written by Dr. Martha Herbert and published by Ballantine Books. This book was released on 2013-03-12 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: “An in-depth, scientific—yet hopeful and positive—look at how the brain and body work together . . . [Dr. Martha Herbert] has developed a new way of seeing autism.”—Library Journal After years of treating patients and analyzing scientific data, Harvard Medical School researcher and clinician Dr. Martha Herbert offers a revolutionary new view of autism and a transformative strategy for dealing with it. Autism, she concludes, is not a hardwired impairment programmed into a child’s genes and destined to remain fixed forever. Instead, it is the result of a cascade of events, many seemingly minor. And while other doctors may dismiss your child’s physical symptoms—the anxiety, sensory overload, sleeplessness, frequent illnesses or seizures—as coincidental or irrelevant, Dr. Herbert sees them as vital clues to what the underlying problems are, and how to help. Drawing from the newest research, technologies, and insights, as well as inspiring case studies of both children and adults, Dr. Herbert guides you toward restoring health and resiliency in your loved one with autism. Her specific recommendations aim to provide optimal nutrition, reduce toxic exposures, limit stress, and open the door to learning and creativity. As thousands of families who have cobbled together these solutions themselves already know, this program can have dramatic benefits—for your child with autism, and for you, your whole family, and perhaps your next baby as well. “Invaluable . . . a must-read . . . Dr. Martha Herbert gets it. She not only gets it, but she puts it out there in an awesome book so the rest of us can get it, too.”—Autism Watch “[Herbert] goes further than most autism specialists. Her impressive science background merges with common sense and even intuitive sense [making] complex scientific and medical materials seamlessly blend with a holistic viewpoint.”—Relieve Autism “Hope and practical guidance . . . With this easy-to-read book, parents can gain wisdom on how to guide your child to achieve a healthy and thriving life.”—Mom Central
Book Synopsis Biophysics and Neurophysiology of the Sixth Sense by : Nima Rezaei
Download or read book Biophysics and Neurophysiology of the Sixth Sense written by Nima Rezaei and published by Springer. This book was released on 2019-04-26 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple senses, like multiple intelligences, are a key to brain variability and therefore human evolution. Besides the traditional five senses (vision, olfaction, gustation, audition, and somatosensory), humans can also perceive the body’s own position (the sense of proprioception) and movement (the vestibular sense). Interoception is the feeling one has about the internal physiological conditions of the entire body. Additionally there is a sense of intuition, also known as the sixth sense. Despite their best efforts, researchers are still unable to concur in specifying the nature of the sixth sense; some consider the sense of proprioception as the sixth sense, whereas others prefer to consider that as a part of interoception. This book will provide a scientific system for the human sixth sense using relevant biophysical and neurophysiological evidence. The power of “sixth sense” seems to be underestimated, due to difficulties in defining the concept clearly. According to socioeconomics and neural physics, the sixth sense is that which permits humans to create perception or to enhance the quality of their perception of events. Roughly speaking, the sixth sense engages a metacognitive process through which prior knowledge and the information received from other sensory modalities are synergized. It is not restricted to specific arrow of time and type of mind or to the observer’s body, but it considers all arrows of time (past, present, future), types of mind (conscious and unconscious), and physical bodies (self and other). However it is expected that the observer has specific biases towards what happens now or would happen in the future and its relation to himself. Particularly, humans appeal to the sixth sense on the road to achieving success in social competitions and to reduce uncertainty in complex decision making processes. In addition to evidence linking genetic components to the sixth sense submodalities, there have been developed strategies for increasing the quality of perceptions provided by the sixth sense. Meditation, through which individuals try to be detached from the world, increases gamma-band activity and that increased gamma-band activity is found following top-down processing. Therefore it can be inferred that the detachment from the environment may enhance synchronization of the wave functions in favor of strengthening the sixth sense. It can serve as the mechanism of enhancement of the sixth sense in those whose sensory systems are intact, it can also serve as the mechanism of compensation in those who have sensory deficiencies. In the latter case, it in fact encourages creativity in the use of relatively strong senses. This justifies Beethoven's deafness and his great musical creativity or Bramblitt's blindness and his enormous capability to paint and many other similar examples. In summary, the present book is divided into five parts. Part 1 (chapters 1-6) provides information about the system of proprioception and its neurophysiology and biophysics. Part 2 (chapters 7-10) examines the system of interoception. The information provided in these two parts would enable us to move towards the next three parts of the story, aimed at developing a scientific system of the sixth sense. The first chapter of part 3 begins with concepts and uses them to arrive at reasonable conclusion that there must be a sense that requires multistep information processing and that is separate from the sense of proprioception and the sense of interoception. Such sense is commonly known as the sixth sense. However it should be re-numbered because the sense of proprioception is already known as the sixth sense. The second chapter of this part is to draw neurocircuitry that innervates the sixth sense in the mind of a man, while the third chapter would address the questions whether the sixth sense system requires an optimal competence or consciousness of mind to function properly and if so which is the optimal state: conscious or unconscious and competence or incompetence. In the fourth chapter of this part, we will focus on the self-other mergence as a pivotal step of the sixth sense system. The next chapter would be of great interest to neurobiologists. It talks about that the human sixth sense of the unseen world, either the unseen arrow of time or the unseen events, requires creativity and therefore the human sixth sense should be considered a source of creativity, variability and thus evolution. In the sixth chapter, the sixth sense is viewed as an economic activity stimulated by social environments. This chapter arisen from the fact that humans are full of enthusiasm to heighten their sixth sense and its accuracy and that they owe their enthusiasm largely to achieving the best possible profit and in other words to wining intense competitions in their life holds mainly on the concept of elasticity. Finally this part is finished by an amazing discussion on the art of the sixth sense. The first chapter of part 4 discusses physical theories that support the existence of sixth sense in the universe. The next chapter is to apply the Bayes’ theory to the sixth sense, leading to the conclusion that the sixth sense improves multisensory integration through optimizing uncertainty of information received from other sensory modalities. Chapter three in this part would address whether relative timing is applicable to the sixth sense like other senses. The last part of book aimed at directly discussing the sixth sense into the context of human health and behavior is organized into four chapters. The first chapter is to discuss neurodevelopmental changes in the sixth sense, while the second and third ones will discuss that in relation to psychiatric and neurological disorders. The most striking question how much power the sixth sense the sixth sense have over human health and behavior is addressed in the fourth chapter of this part and final chapter of book, which will be prepared using neural network models and sophisticated portraits possible for the system of sixth sense.
Book Synopsis Scientific Tourism by : Susan Slocum
Download or read book Scientific Tourism written by Susan Slocum and published by Routledge. This book was released on 2015-05-15 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: As researchers in emerging economies, scientists are often the first foreign visitors to stay in remote rural areas and, on occasion, form joint venture ecotourism and community tourism projects or poverty alleviation schemes between local agencies or NGOs, the local community, and their home institution or agency. They therefore can contribute to avenues for the conservation of natural resources and the development of rural communities as well as influencing the future tourism development through its perceived legitimacy and the destination image it promotes. This book for the first time critically reviews tourism debates surrounding this emerging market of scientific and research oriented tourism. It is divided into three inter-related sections. Section 1 sets the stage of the discourse of scientific research in tourism; Section 2 evaluates the key players of scientific tourism looking particularly at the roles of NGOs, government agencies and university academic staff and Section 3 contains case studies documenting the niche of researchers as travelers in a range of geographical locations including Tanzania, Australia, Chile, Peru and Mexico. The title’s multidisciplinary approach provides an informed, interesting and stimulating addition to the existing limited literature and raises many issues and associated questions including the role of science tourism in tourism development and expansion, the impacts of scientific and research-based tourism, travel behaviors and motivations of researchers to name but a few. This significant volume will provide the reader with a better understanding of scientists as travelers, their relationship to the tourism industry, and the role they play in community development around tourism sites. It will be valuable reading for students and academics across the fields of Tourism, Geography and Development Studies as well as other social science disciplines.
Book Synopsis Rare Diseases Epidemiology by : Manuel Posada de la Paz
Download or read book Rare Diseases Epidemiology written by Manuel Posada de la Paz and published by Springer. This book was released on 2012-11-07 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: In our etiologic research, we epidemiologists need to leave behind the concepts of ‘cohort’ study and ‘case–control’ study and adopt that of the etiologic study as the singular substitute for these. With this sentence, the famous epidemiologist Professor Olli S. Miettinen began his personal re ection on the future of the epidemiology [1]. He sought to highlight the fact that the role of the epidemiologist should be mainly focused on aetiological research. Nevertheless, the widespread idea still exists that epidemiology is limited to purely providing gures and descriptive data on the frequency and distribution of disease. Indeed, it is more than likely that the precise aim of those rst classic epidemiological steps, i. e. , methods essentially based on describing the distri- tion of a given disease, is still not all that well understood by many scientists, let alone the general public. Such descriptions seek to generate hypotheses and afford explanations for key factors (be these risk factors or the presumable causes th- selves), which might justify differences in terms of persons, time or place and, in turn, ultimately serve to develop preventive measures and/or gain quality-adjusted life years. To restrict the goals of epidemiology to activities exclusively concerned with reporting gures or even complex statistical results is a great mistake, one that renders it dif cult to take full advantage of the epidemiologist’s true role, which is “to study disease determinants and to assess the actual impact of factors involved in their development, distribution and dissemination”.
Book Synopsis Behavioral Neuroscience of Orexin/Hypocretin by : Andrew J Lawrence
Download or read book Behavioral Neuroscience of Orexin/Hypocretin written by Andrew J Lawrence and published by Springer. This book was released on 2017-05-29 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Current Topics in Behavioral Neuroscience focuses on the neuropeptide orexin (hypocretin) and brings together scientists from around the world who will provide a timely discussion of how this peptide regulates behavior. This is a fast-moving field, and with the incorporation of novel technologies, new breakthroughs are likely to continue. For example, the use of optogenetic approaches has enabled the identification of the role of orexin-containing neurons in arousal states, critical for higher order functioning. From a clinical perspective, genetic polymorphisms in hypocretin/orexin and orexin receptors are implicated in a number of psychiatric disorders. In addition, advanced clinical trials are currently underway for orexin receptor antagonists in the treatment of insomnia and sleep disorders. We aim to capture a broad audience of basic scientists and clinicians.
Download or read book Perchlorate written by Baohua Gu and published by Springer Science & Business Media. This book was released on 2006-07-02 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a detailed description of perchlorate chemistry and recent advances in innovative remediation technologies for perchlorate contamination and their pros and cons Additionally, the first book to describe the natural occurrence of perchlorate and its unique isotopic signatures for environmental forensics and its detection in the environment, particularly the real-time analysis using surface enhanced Raman spectroscopy
Book Synopsis Sleep Disorders in Children by : Soňa Nevšímalová
Download or read book Sleep Disorders in Children written by Soňa Nevšímalová and published by Springer. This book was released on 2016-10-03 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is both an exam guide to children ́s sleep medicine and a practical manual for diagnosis and management of sleep disorders in children. An overview of the most frequent sleep disorders encountered in newborns, infants, children and adolescents is provided. This book discusses the main sleep disorders in detail, including insomnia, respiratory disturbances, movement disorders during sleep, circadian rhythm disorders, parasomnias, and disorders associated with increased sleepiness. It also covers sleep disorders associated with neurological, psychiatric, and medical diseases. This book is divided into two parts. The first part is an introduction to childhood sleep physiology and pathology, epidemiology of sleep disorders, and diagnostic procedures. The second part describes the most frequent sleep disorders in greater depth. Sleep Disorders in Children is aimed at sleep researchers, pediatricians, child neurologists and child psychiatrists, as well as patient organizations and families with affected children.
Book Synopsis Turner Syndrome by : Patricia Y. Fechner
Download or read book Turner Syndrome written by Patricia Y. Fechner and published by Springer Nature. This book was released on 2020-03-20 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive and practical, this is a unique and multidisciplinary resource for the clinician caring for the girl or woman with Turner syndrome. Although approximately one in 2000 women are affected, many have not been diagnosed; as the advent of prenatal genetic testing becomes more prevalent, the diagnosis of Turner syndrome will be made much more frequently. There is therefore a greater need for this single source that provides the clinician with the information required to care for this multifaceted disorder. The opening chapters discuss the biology, genetics and current standard of care for females with Turner syndrome in order to provide proper background and context for the remaining chapters. The main section of the book, taking a body system approach, is comprised of chapters written by an expert in his or her subspecialty and will discuss pathophysiology and diagnosis, as well as therapeutic options. Reproductive, cardiac, renal, endocrine, neurologic, musculoskeletal, and sensory issues and symptoms associated with Turner syndrome are all covered in detail. Additional chapters describe current resources available to both caregiver and patient as well as future directions for research and management. Currently, there are no similar books on the market that take an all-inclusive, multidisciplinary approach in the care of individuals with Turner syndrome. As such, this book should be the standard of care for management of this challenging and multifaceted condition.
