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I Guanidinium Rich Molecular Transporters
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Book Synopsis I. Guanidinium Rich Molecular Transporters by : Lisa Renee Jones
Download or read book I. Guanidinium Rich Molecular Transporters written by Lisa Renee Jones and published by . This book was released on 2008 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis I. Guanidinium Rich Molecular Transporters. II. Progress Towards the Total Synthesis of Kirkinine by :
Download or read book I. Guanidinium Rich Molecular Transporters. II. Progress Towards the Total Synthesis of Kirkinine written by and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: I. Guanidinium rich molecular transporters. II. Progress towards the total synthesis of kirkinine.
Book Synopsis The Design, Synthesis and Evaluation of Guanidinium-rich Molecular Transporters for the Delivery of Antibiotics and Oligonucleotides by : Melanie Ann Huttner
Download or read book The Design, Synthesis and Evaluation of Guanidinium-rich Molecular Transporters for the Delivery of Antibiotics and Oligonucleotides written by Melanie Ann Huttner and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The delivery of cell-impenetrable therapeutic agents across biological barriers represents a challenging problem in the field of life science research and medicine. Many bacterial pathogens are inherently resistant to glycopeptide antibiotics such as vancomycin due to the antibiotic's relatively large size and mode of action, which requires actively growing cells. Recently, genetically-resistant vancomycin strains have emerged, adding to vancomycin's inefficaciousness against certain bacterial populations. The emergence and understanding of phenotypically and genetically resistant bacteria coupled to a declining pipeline of antibiotic development necessitates new strategies to combat bacterial infections. As part of a collaboration between the Wender and Cegelski labs, we have designed, synthesized and evaluated a novel vancomycin cell-penetrating peptide conjugate. We have shown that this new conjugate exhibits a unique mode of action compared to vancomycin, allowing it to be extremely effective against vancomycin-insensitive bacterial populations.
Book Synopsis Molecular Transporters for Drug Delivery by : Theodore C. Jessop
Download or read book Molecular Transporters for Drug Delivery written by Theodore C. Jessop and published by . This book was released on 2005 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Design, Synthesis and Evaluation of Guanidine-based Molecular Transporters by : Kanaka Pattabiraman
Download or read book The Design, Synthesis and Evaluation of Guanidine-based Molecular Transporters written by Kanaka Pattabiraman and published by . This book was released on 2004 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Guanidine Based Molecular Transporters for Drug Delivery by : Christopher L. VanDeusen
Download or read book Guanidine Based Molecular Transporters for Drug Delivery written by Christopher L. VanDeusen and published by . This book was released on 2003 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Exploring Guanidinoglycoside Molecular Transporters by : Andrew Vincent Dix
Download or read book Exploring Guanidinoglycoside Molecular Transporters written by Andrew Vincent Dix and published by . This book was released on 2011 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Guanidinium-rich molecular transporters have been shown to deliver otherwise non-permeable biologically relevant cargo into cells. While many such transporters have been reported, the studies reported here focus on guanidinoglycosides, which have been shown to permeate the cell-membrane in a heparan sulfate-dependent manner. In attempt to promote a cooperative interaction with cell-surface heparan sulfate, dimeric guanidinoglycosides were synthesized and studied for their cellular uptake properties in various Chinese hamster ovary (CHO) cell lines. Flow cytometry studies revealed that conjugates prepared with the monomeric compounds showed reduced uptake in mutant cells expressing heparan sulfate chains with altered patterns of sulfation, whereas the dimeric constructs could distinguish the various mutants and maintain high levels of uptake. These findings suggest that uptake depends on the valency of the transporter and the sulfate content on the cell surface receptors, thereby providing reagents that could distinguish cell types based on the composition of their cell surface heparan sulfate proteoglycans. To further investigate the viability of these transporters, their potential to escape endosomal vesicles and diffuse into the cytosol was examined using a FRET-based cellular assay in HeLa cells. Findings indicate that guanidinoglycosides appear to enter the cytosol at around half the rate of poly9arginine. Interestingly, confocal microscopy studies indicate co-localization of the two different transporters.
Book Synopsis Design, Synthesis, and Evaluation of Molecular Transporters for Probe, Drug, and SiRNA Delivery by : Christina Barnes Cooley
Download or read book Design, Synthesis, and Evaluation of Molecular Transporters for Probe, Drug, and SiRNA Delivery written by Christina Barnes Cooley and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: My graduate studies have focused on the design, synthesis, and biological evaluation of novel probe and drug delivery technologies. This research has explored the development of new molecular transporter scaffolds with a focus on step economy and translational costs as well as evaluation of their uptake and delivery properties in cells and animals. Chapter 1 provides a historical context and overview of guanidinium-rich molecular transporter technology. Chapter 2 describes the development of a new family of guanidinium-rich oligocarbonate molecular transporter which are flexibly and efficiently assembled by a one-step oligomerization strategy. These novel oligocarbonate transporters were shown to exhibit excellent uptake properties both in cells and animal models. Chapter 3 is directed at the utility of an oligomerization approach to generate molecular transporters by the design, synthesis, and evaluation of new aphipathic co-oligomers for the delivery of siRNA, an oligonucleotide cargo of intense therapeutic interest. Amphipathic carbonate co-oligomers were prepared by an oligomerization strategy and demonstrated to effectively package, deliver, and release functional siRNA in cells. Chapter 4 describes the effects of a branched guanidinium array on the transport and delivery efficiency of releasable dendrimeric guanidinium-rich transporters. These transporters were synthesized and demonstrated to deliver and release a small molecule for turnover by its intracellular target enzyme by bioluminescence assays in cells and transgenic animal models. Chapter 5 describes the design, synthesis, and preliminary biological evaluation of lipidated molecular transporter derivatives of the immunosuppressant drug rapamycin for topical delivery.
Book Synopsis Molecular Transporters for Drug Delivery by : Elena A. Goun
Download or read book Molecular Transporters for Drug Delivery written by Elena A. Goun and published by . This book was released on 2007 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Design, Synthesis, and Evaluation of Molecular Transporters for the Delivery of SiRNA, and the Application of Molecular Transporters to New Cell Types and New Release Strategies by : Erika Isabella Geihe Stanzl
Download or read book The Design, Synthesis, and Evaluation of Molecular Transporters for the Delivery of SiRNA, and the Application of Molecular Transporters to New Cell Types and New Release Strategies written by Erika Isabella Geihe Stanzl and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: My graduate studies have focused on the development of novel drug delivery technologies of research, clinical, and industrial significance. More specifically, my research has focused on the design, synthesis, and application of guanidinium-rich molecular transporters for the delivery of siRNA into cells. My studies have also focused on using molecular transporters to develop the first molecular method to deliver cargo into algae, and on the development of new strategies to control the timing and amount of drug or probe release in cells. Though all of this research is fundamentally based on organic chemistry, these projects have broad applications in research, industrial and clinical settings. Chapter 1 reviews the strategies that have been developed for the delivery of siRNA in both cells and animals. Rather than divide the field by chemical type (e.g. peptide vs. protein) or disease indication, this review categorizes siRNA deliver agents by the identity of their cationic moiety for siRNA complexation. Guanidinium-containing delivery vectors are presented, as are vectors containing ammonium and phosphonium groups. Highlighting this field by cationic moiety reveals how little research has been done to compare the effects of the cation's identity on deliver efficacy, toxicity, and pharmacokinetics. Chapter 2 describes the design, synthesis, and evaluation of guanidinium-rich amphipathic oligocarbonate molecular transporters for the complexation, delivery, and release of siRNA in cells. The synthetic ease of the metal-free carbonate oligomerization to synthesize these transporters afforded fast access to a series of transporters that systematically probed the functionality required for effective complexation, delivery, and release of siRNA. Transporters were characterized and evaluated for biological activity in immortalized human keratinocytes. The transporters discovered in this study were highly effective, with target gene silencing of up to 90% observed. Chapter 3 focuses on efforts towards expanding the scope of both the chemical space and cell types tested in the delivery of siRNA with amphipathic oligocarbonate molecular transporters. These second generation delivery systems have improved physical properties, including smaller and more stable particle sizes, relative to their first generation counterparts described in Chapter 2. These transporters delivered siRNA to primary keratinocytes, melanoma cells, and ovarian cancer cells. Chapter 4 details the development of the first molecular method for the delivery of small molecule probes and large protein cargos into algal cells. It was shown that oligoarginine could facilitate the uptake of fluorescein, or the larger, FAM-streptavidin protein, into cells. A catalytically active protein was delivered into cells and was shown to maintain catalytic activity even after delivery. Chapter 5 describes the design of new strategies to control the timing and amount of cargo released inside cells. Efforts towards a novel linker carrying two copies of drug or probe are described, as well as the combination of microneedles and luciferin-transporter conjugates for transdermal delivery in vivo.
Book Synopsis Handbook of Cell-Penetrating Peptides by : Ulo Langel
Download or read book Handbook of Cell-Penetrating Peptides written by Ulo Langel and published by CRC Press. This book was released on 2006-08-15 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first Handbook of Cell-Penetrating Peptides was prepared in 2001, the wealth of new information on the use of these peptides as transport systems has in fact served to confound the field. The constant internal change in the field of cell-penetrating peptides (CPPs) is due to recent research uncovering apparent ambiguities in cellular upta
Book Synopsis Cellular Structures—Advances in Research and Application: 2013 Edition by :
Download or read book Cellular Structures—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 948 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular Structures—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Intracellular Space. The editors have built Cellular Structures—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Intracellular Space in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cellular Structures—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis CPP, Cell-Penetrating Peptides by : Ülo Langel
Download or read book CPP, Cell-Penetrating Peptides written by Ülo Langel and published by Springer Nature. This book was released on 2023-10-18 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, a summary and update of the most important areas of cell-penetrating peptides (CPP) research are presented, while raising relevant questions for further development. The CPP sequences are presented and discussed throughout the book. The methods for testing CPP mechanisms are discussed in detail. Various approaches for the testing of endocytotic pathways of CPP uptake are also described. Different CPP uptake experiments are compared since it is becoming clear that it is often best to apply several methods in a complementary manner in order to most comprehensively evaluate CPP uptake mechanisms due to the complexity of these processes. A brief summary of functionality issues of CPPs, both in vitro and in vivo, is discussed. Therapeutic potential of CPPs and commercial developments are discussed. The present, second edition of this book is the updated and expanded version of the first edition, published in 2019. The development of the field of cell-penetrating peptides in these five years has been obvious and exciting. This second edition of the book has been partly reorganized and comprehensively expanded with the exciting research in 2019-2023. Around 2500 novel scientific articles have become available, most of them are reviewed in the second edition. Additional rapidly growing areas of high impact presented in this second edition are therapeutic developments (Chapter 16) and delivery of oligonucleotides and proteins/peptides (Chapters 5 and 6) including novel reports on genome editing with CPP assistance. Also, several additional examples are available now on clinical trials using CPPs (Chapter 15). The book is written for researchers and students in the field.
Book Synopsis Cell-Penetrating Peptides by : Ulo Langel
Download or read book Cell-Penetrating Peptides written by Ulo Langel and published by CRC Press. This book was released on 2002-05-29 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major problems with drug delivery is the inability of large hydrophilic compounds to pass through the lipid membrane of the cell, thus making drugs such as polypeptides and oligonucleotides of limited therapeutic value. Until recently, the transport of such molecules into the cytoplasmic and nuclear compartments of living cells seemed a
Book Synopsis Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Chemical, Optical and Bioorthogonal Methods by :
Download or read book Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Chemical, Optical and Bioorthogonal Methods written by and published by Academic Press. This book was released on 2020-07-24 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Chemical, Optical and Bioorthogonal Methods, Volume 641 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include caged cyclopropanes with improved tetrazine ligation kinetics, an analysis of metabolically labeled inositol phosphate messengers by NMR, cell-permeant caged inositol pyrophosphates for probing ß-cells, imaging phospholipase D activity with clickable alcohols via transphosphatidylation, fluorescent biorthogonal labeling of class B GPCRs in live cells, near-infrared photoactivatable nitric oxide donors with integrated photoacoustic monitoring, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on retinoid signaling pathways
Book Synopsis Metal Ligand Chromophores for Bioassays by : Kenneth Kam-Wing Lo
Download or read book Metal Ligand Chromophores for Bioassays written by Kenneth Kam-Wing Lo and published by Springer Nature. This book was released on 2022-12-10 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Chapters “Metal Peptide Conjugates in Cell and Tissue Imaging and Biosensing”, “Luminescent Metal Complexes as Emerging Tools for Lipid Imaging” and “Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex‐Based Chemosensors” are available open access under a CC BY 4.0 License via link.springer.com.
Book Synopsis Cell-Penetrating Peptides by : Makoto Oba
Download or read book Cell-Penetrating Peptides written by Makoto Oba and published by John Wiley & Sons. This book was released on 2022-11-30 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell-Penetrating Peptides The definitive reference on the rational design of cell-penetrating peptides enables readers to develop tailor-made peptides for their specific needs. In recent years, cell-penetrating peptides (CPPs) have become valuable tools for the cellular delivery of proteins, nucleic acids, and drugs. These small peptide sequences can be artificially designed and synthesized with custom-made characteristics to mediate the efficient and non-toxic transport of biomolecules, drugs, or nanoparticles into the cell. Cell-Penetrating Peptides: Design, Development, and Applications provides an up-to-date account of the development and use of CPPs for delivering membrane-impermeable bioactive molecules into cells. Bringing together contributions from leading researchers from around the world, this comprehensive volume describes the characteristics and mechanisms of CPPs as well as their application in both medicine, biotechnology and agriculture. Covers rational design and development of cell-penetrating peptides for use in cellular delivery of small molecule drugs, proteins, nucleic acids, and nanoparticles Presents the chemical and biological characteristics of CPP action in vitro and in vivo Describes the structure and design principles of both synthetic and naturally occurring CPPs Discusses key medical applications of CPPs such as oral delivery, intranasal delivery, and clinical trials Cell-Penetrating Peptides: Design, Development, and Applications is an essential resource for biochemists, medicinal chemists, molecular biologists, biotechnologists, and researchers studying CPPs in both academia and industry.