Author : Claude L. Malmendier
Publisher : Springer Science & Business Media
ISBN 13 : 146845904X
Total Pages : 430 pages
Book Rating : 4.4/5 (684 download)
Book Synopsis Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics by : Claude L. Malmendier
Download or read book Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics written by Claude L. Malmendier and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past two decades have seen steady progress in our understanding of the pathogenesis of atherosclerosis. The role of low density lipoprotein (LOL) increase and of LOL receptor deficiency or malfunctions in familial hypercholesterolemia has been largely enlightened by the works of Brown and Goldstein. These authors postulated also that modification of LOL to a form recognized by the scavenger or acetyl-LOL receptor may be required for lipid loading of macrophage-derived foam cells in the lesions. A growing body of evidence suggests that oxidative modification of LOL could enhance its atherogenicity by its implication as a factor in the generation of foam cells. Thus, if the role of LOL in the pathogenesis of hypercholesterolemia was well established a great deal of information appears currently on new approaches such as the mechanisms leading to the accumulation of foam cells, the impact of LOL structural alterations, notably oxidation and the role of gene mutations of apolipoprotein Band/or LOL receptor The opening topic is devoted to these new avenues outlined in the field of hypercholesterolemia. The first part concerns the genetic aspects of atherosclerosis: mainly the genetics of apo 1 ipoprote ins , their transcriptional regulation, the amino acid mutations of the apo B gene and of the LOL receptor gene, the structural domains and the acylation sites of apoprotein B.