Hyaluronan

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Chemistry and Biology of Hyaluronan

Author : Hari G. Garg
Publisher : Elsevier
ISBN 13 : 0080472222
Total Pages : 625 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Chemistry and Biology of Hyaluronan by : Hari G. Garg

Download or read book Chemistry and Biology of Hyaluronan written by Hari G. Garg and published by Elsevier. This book was released on 2004-07-14 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: It was probably the French chemist Portes, who first reported in 1880 that the mucin in the vitreous body, which he named hyalomucine, behaved differently from other mucoids in cornea and cartilage. Fifty four years later Karl Meyer isolated a new polysaccharide from the vitreous, which he named hyaluronic acid. Today its official name is hyaluronan, and modern-day research on this polysaccharide continues to grow. Expertly written by leading scientists in the field, this book provides readers with a broad, yet detailed review of the chemistry of hyaluronan, and the role it plays in human biology and pathology. Twenty-seven chapters present a sequence leading from the chemistry and biochemistry of hyaluronan, followed by its role in various pathological conditions, to modified hylauronans as potential therapeutic agents and finally to the functional, structural and biological properties of hyaluronidases. Chemistry and Biology of Hyaluronan covers the many interesting facets of this fascinating molecule, and all chapters are intended to reach the wider research community. - Comprehensive look at the chemistry and biology of hyaluronans - Essential to Chemists, Biochemists and Medical researchers - Broad yet detailed review of this rapidly growing research area

Hyaluronan in Cancer Biology

Author : Robert Stern
Publisher : Academic Press
ISBN 13 : 0080921086
Total Pages : 467 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Hyaluronan in Cancer Biology by : Robert Stern

Download or read book Hyaluronan in Cancer Biology written by Robert Stern and published by Academic Press. This book was released on 2009-03-07 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal. The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book will offer a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer. - Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer - Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination - Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance

The Chemistry, Biology and Medical Applications of Hyaluronan and Its Derivatives

Author : T. C. Laurent
Publisher : Portland Press, London
ISBN 13 :
Total Pages : 368 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis The Chemistry, Biology and Medical Applications of Hyaluronan and Its Derivatives by : T. C. Laurent

Download or read book The Chemistry, Biology and Medical Applications of Hyaluronan and Its Derivatives written by T. C. Laurent and published by Portland Press, London. This book was released on 1998 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to collect within one volume information on hyaluronan. This polysaccharide has received rapid attention for two reasons: it has important regulative functions within cell biology; and it has become a commercially important product because of its use in ophthalmic surgery and treatment of joint diease. A number of other practical applications are also discussed. The book covers various aspects of hyaluronan from the structure and chemistry of the polymer to its metabolism, cell biological interactions, behaviour in pathological processes, and potentially new medical applications.

Hyaluronan

Author : J F Kennedy
Publisher : Woodhead Publishing
ISBN 13 : 9781855735705
Total Pages : 602 pages
Book Rating : 4.7/5 (357 download)

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Book Synopsis Hyaluronan by : J F Kennedy

Download or read book Hyaluronan written by J F Kennedy and published by Woodhead Publishing. This book was released on 2002-10-04 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hyaluronan and its derivatives has developed very quickly in the last few years from a scientific novelty into an important new material for a diverse range of medical and biomaterial applications. This landmark conference focused on developments and applications in the use of hyaluronan in tissue repair and reconstruction, drug delivery systems, anti-cancer treatments and joint recovery and engineering. The entire range of hyaluronan progress is covered in depth by the more than 135 individual papers: Analytical chemistry Structural elucidation and basic chemistry Electron microscopy and atomic force microscopy Production, purification and characterisation Quality in production systems Chemical modification Derivatives and properties Cross-linking Free radical modification Physical characterisation Rheology Aggregation phenomena Interaction with water and solution properties Cell biology Control and regulation of HA synthases Cell surface chemistry HA cell receptors and cell signalling Interaction with proteins and other biological ligands Biophysical aspects Effects on pain receptors Neurobiology Role in organisation of extracellular matrix Role in development (embryogenesis): cell movement/migration Medical applications Uses in cartilage and wound repair Inflammation Wound regenerative healing Surgery and tissue engineering Viscosupplementation / osteoarthritis Viscoaugmentation and viscoprotection Anti-adhesion applications Brug delivery systems Binding onto tumour cells and metastases Outlines the proceedings of the landmark conference which focused on key developments and applications in the use of hyaluronan in tissue repair and reconstruction, among other uses The entire range of hyaluronan processes is dealt with in depth by more than 135 individual papers presented in two volumes Covers analytical chemistry, chemical modification, physical characterisation, cell biology and medical applications

Hyaluronan

Author : Alberto Passi
Publisher : Springer Nature
ISBN 13 : 3031303008
Total Pages : 220 pages
Book Rating : 4.0/5 (313 download)

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Book Synopsis Hyaluronan by : Alberto Passi

Download or read book Hyaluronan written by Alberto Passi and published by Springer Nature. This book was released on 2023-06-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the structural and biological properties of the extracellular matrix component and glycosaminoglycan polymer hyaluronan (or hyaluronic acid, HA). The book discusses various aspects of HA biology, e.g., HA synthesis and degradation, as well as the role of HA in embryogenesis, development, and cell maintenance. The reader will learn about the role of HA in different tissues as well as its biological activities triggered by the interaction with different HA receptors. A closer look is had at the involvement of HA in human pathologies such as cancer, kidney fibrosis and wound healing. Biotechnological and biomedical applications for HA such as scaffold generation and drug delivery, including the novel synthetic sulphated HA are explored. This work will appeal to a wide readership within the extracellular matrix and hyaluronan field. It can serve as an introduction to the field for junior scientists but can also help senior scientists to gain a broader view of the field beyond their area of specialization. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

The Biology of Hyaluronan

Author : David Evered
Publisher : John Wiley & Sons
ISBN 13 : 0470513780
Total Pages : 308 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis The Biology of Hyaluronan by : David Evered

Download or read book The Biology of Hyaluronan written by David Evered and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents state-of-the-art applications in hyaluronan research, from hyaluronan's physicochemical properties to its clinical role as a connective tissue marker and its surgical implications, particularly in ear, eye and orthopaedic surgery. Covers hyaluronan's synthesis and catabolism, its role in cells, its interactions with specific binding proteins, and its role in the embryonic nervous system.

Hyaluronan Signaling and Turnover

Author : Melanie Simpson
Publisher : Academic Press
ISBN 13 : 0128003936
Total Pages : 418 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Hyaluronan Signaling and Turnover by : Melanie Simpson

Download or read book Hyaluronan Signaling and Turnover written by Melanie Simpson and published by Academic Press. This book was released on 2014-07-26 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume covers hyaluronan signaling and turnover. - Provides information on cancer research - Outstanding and original reviews - Suitable for researchers and students

Essentials of Glycobiology

Author : Ajit Varki
Publisher : CSHL Press
ISBN 13 : 9780879696818
Total Pages : 694 pages
Book Rating : 4.6/5 (968 download)

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Book Synopsis Essentials of Glycobiology by : Ajit Varki

Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Fetal Wound Healing

Author : N. Scott Adzick
Publisher : Elsevier Publishing Company
ISBN 13 :
Total Pages : 376 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Fetal Wound Healing by : N. Scott Adzick

Download or read book Fetal Wound Healing written by N. Scott Adzick and published by Elsevier Publishing Company. This book was released on 1992 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of foetal tissue to heal without scarring is now well documented, but the potentially far-reaching implications of this process for the practice of surgery and the management of healing are just beginning to be understood. This book provides up-to-date information on the subject.

Extracellular Sugar-Based Biopolymers Matrices

Author : Ephraim Cohen
Publisher : Springer
ISBN 13 : 3030129195
Total Pages : 822 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Extracellular Sugar-Based Biopolymers Matrices by : Ephraim Cohen

Download or read book Extracellular Sugar-Based Biopolymers Matrices written by Ephraim Cohen and published by Springer. This book was released on 2019-07-02 with total page 822 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extracellular matrix (ECM) is an acellular three-dimensional network composed of proteins, glycoproteins, proteoglycans and exopolysaccharides. It primarily serves as a structural component in the tissues and organs of plants and animals, or forms biofilms in which bacterial cells are embedded. ECMs are highly dynamic structures that undergo continuous remodeling, and disruptions are frequently the result of pathological processes associated with severe diseases such as arteriosclerosis, neurodegenerative illness or cancer. In turn, bacterial biofilms are a source of concern for human health, as they are associated with resistance to antibiotics. Although exopolysaccharides are crucial for ECM formation and function, they have received considerably little attention to date. The respective chapters of this book comprehensively address such issues, and provide reviews on the structural, biochemical, molecular and biophysical properties of exopolysaccharides. These components are abundantly produced by virtually all taxa including bacteria, algae, plants, fungi, invertebrates and vertebrates. They include long unbranched homopolymers (cellulose, chitin/chitosan), linear copolymers (alginate, agarose), peptoglycans such as murein, heteropolymers like a variety of glycosaminoglycans (hyaluronan, dermatan, keratin, heparin, Pel), and branched heteropolymers such as pectin and hemicellulose. A separate chapter is dedicated to modern industrial and biomedical applications of exopolysaccharides and polysaccharide-based biocomposites. Their unique chemical, physical and mechanical properties have attracted considerable interest, inspired basic and applied research, and have already been harnessed to form structural biocomposite hybrids for tailor-made applications in regenerative medicine, bioengineering and biosensor design. Given its scope, this book provides a substantial source of basic and applied information for a wide range of scientists, as well as valuable textbook for graduate and advanced undergraduate students.

Endogenous Hyaluronan During Corneal Healing

Author : Nils Molander
Publisher :
ISBN 13 :
Total Pages : 166 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Endogenous Hyaluronan During Corneal Healing by : Nils Molander

Download or read book Endogenous Hyaluronan During Corneal Healing written by Nils Molander and published by . This book was released on 1994 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Lactoferrin and its Role in Wound Healing

Author : Yoshiharu Takayama
Publisher : Springer Science & Business Media
ISBN 13 : 9400724675
Total Pages : 118 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Lactoferrin and its Role in Wound Healing by : Yoshiharu Takayama

Download or read book Lactoferrin and its Role in Wound Healing written by Yoshiharu Takayama and published by Springer Science & Business Media. This book was released on 2011-10-25 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lactoferrin is an iron-binding glycoprotein belonging to the transferrin family. It acts as a defense in host animals against microbes and viruses, since it has a broad spectrum of antimicrobial and antiviral activities. Lactoferrin has been shown to regulate the growth and differentiation of many types of cells. The results of recent studies indicate that lactoferrin is a potent regulator of dermal fibroblasts, and promotes cutaneous wound healing. The collagen gel contraction, a model of wound contraction during wound healing process, and migration of human fibroblasts were enhanced by lactoferrin. LRP-1 (LDL Receptor related Protein-1) acts as a signaling receptor for lactoferrin that mediate fibroblast response to lactoferrin by activating ERK/MAPK signaling pathway. In addition, lactoferrin promotes biosynthesis of extracellular matrix (ECM) component such as type-I collagen and hyaluronan. Hyaluronan is a major component of ECM in connective tissue and promotes wound healing. The promoting effect of lactoferrin on hyaluronan production was accompanied by promotion of HAS2 (hyaluronan synthase 2) expression. These observations suggest that lactoferrin promotes the wound healing by providing an ECM that promotes fibroblast migration. Lactoferrin is also known for its anti-inflammatory and immune modulating properties. According to recent in vivo study, lactoferrin promotes wound repair by promoting the early inflammatory phase of wound healing. Based on this, recombinant human lactoferrin was subsequently tested clinically in a Phase II trial in patients with diabetic ulcers and was found to be effective. Lactoferrin should be further evaluated in patients with diabetic and other types of ulcers.

Technology Platforms for 3D Cell Culture

Author : Stefan Przyborski
Publisher : John Wiley & Sons
ISBN 13 : 1118851536
Total Pages : 667 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Technology Platforms for 3D Cell Culture by : Stefan Przyborski

Download or read book Technology Platforms for 3D Cell Culture written by Stefan Przyborski and published by John Wiley & Sons. This book was released on 2017-03-03 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technology Platforms for 3D Cell Culture: A Users Guide points to the options available to perform 3D culture, shows where such technology is available, explains how it works, and reveals how it can be used by scientists working in their own labs. Offers a comprehensive, focused guide to the current state-of-the-art technologies available for 3D cell culture Features contributions from leading developers and researchers active in 3D cell technology Gives clear instruction and guidance on performing specific 3D culture methods, along with colour illustrations and examples of where such technologies have been successfully applied Includes information on resources and technical support to help initiate the use of 3D culture methods

Investigation of Hyaluronan and Hyaluronan Synthase Function During Mouse Development

Author : Janet Yuetsim Lee Tien
Publisher :
ISBN 13 :
Total Pages : 270 pages
Book Rating : 4.:/5 (68 download)

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Book Synopsis Investigation of Hyaluronan and Hyaluronan Synthase Function During Mouse Development by : Janet Yuetsim Lee Tien

Download or read book Investigation of Hyaluronan and Hyaluronan Synthase Function During Mouse Development written by Janet Yuetsim Lee Tien and published by . This book was released on 2004 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nuclear Magnetic Resonance Studies of the Solution Conformation of Hyaluronan Oligosaccharides

Author : Signe Marie Ann Holmbeck
Publisher :
ISBN 13 :
Total Pages : 410 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Nuclear Magnetic Resonance Studies of the Solution Conformation of Hyaluronan Oligosaccharides by : Signe Marie Ann Holmbeck

Download or read book Nuclear Magnetic Resonance Studies of the Solution Conformation of Hyaluronan Oligosaccharides written by Signe Marie Ann Holmbeck and published by . This book was released on 1994 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Bioregulation of Extracellu[l]ar Hyaluronan by Mystixin Peptides

Author : Susan E. Stair
Publisher :
ISBN 13 :
Total Pages : 236 pages
Book Rating : 4.:/5 (34 download)

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Book Synopsis Bioregulation of Extracellu[l]ar Hyaluronan by Mystixin Peptides by : Susan E. Stair

Download or read book Bioregulation of Extracellu[l]ar Hyaluronan by Mystixin Peptides written by Susan E. Stair and published by . This book was released on 2000 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hyaluronic Acid

Author : Riia Rautiola
Publisher :
ISBN 13 : 9781536170597
Total Pages : 128 pages
Book Rating : 4.1/5 (75 download)

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Book Synopsis Hyaluronic Acid by : Riia Rautiola

Download or read book Hyaluronic Acid written by Riia Rautiola and published by . This book was released on 2020-03 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hyaluronic acid, or hyaluronan, is a water soluble, anionic extracellular matrix glycosaminoglycan polymer with variable molecular weight that determines its physiological role, rheological properties and applications. Since its discovery in the early 1930s, there has been an increased awareness concerning the biology of hyaluronic acid, its signaling pathways and its role in the biomedical and cosmeceutical industry. Being an endogenous molecule, hyaluronic acid is biocompatible, biodegradable, and has strong mucoadhesive, viscoelastic properties. The authors provide chemical modification approaches to hyaluronic acid, as well as address the magnitude of applications of hyaluronic acid-based targeted drug vectors and patents. The closing study discusses glycosaminoglycans, a specialized group of unbranched, anionic disaccharide polymers attached by a covalent linkage to the membrane proteins via sulphate groups in their sugar moieties.