Human Prion Diseases

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Human Prion Diseases

Author :
Publisher : Elsevier
ISBN 13 : 0444639535
Total Pages : 520 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Human Prion Diseases by :

Download or read book Human Prion Diseases written by and published by Elsevier. This book was released on 2018-06-07 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. - Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms - Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans - Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms

Neuropathology of Neurodegenerative Diseases

Author : Gabor G. Kovacs
Publisher : Cambridge University Press
ISBN 13 : 1316337650
Total Pages : 320 pages
Book Rating : 4.3/5 (163 download)

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Book Synopsis Neuropathology of Neurodegenerative Diseases by : Gabor G. Kovacs

Download or read book Neuropathology of Neurodegenerative Diseases written by Gabor G. Kovacs and published by Cambridge University Press. This book was released on 2017-12-13 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases.

Advancing Prion Science

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309087449
Total Pages : 125 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Advancing Prion Science by : Institute of Medicine

Download or read book Advancing Prion Science written by Institute of Medicine and published by National Academies Press. This book was released on 2003-04-20 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs' from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment. This report summarizes the progress thus far.

Neurogenetics, Part II

Author :
Publisher : Elsevier
ISBN 13 : 0444640770
Total Pages : 480 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Neurogenetics, Part II by :

Download or read book Neurogenetics, Part II written by and published by Elsevier. This book was released on 2018-01-29 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurogenetics, Part II, Volume 148, the latest release in the Handbook of Clinical Neurology, provides the latest information on the genetic methodologies that are having a significant impact on the study of neurological and psychiatric disorders. Using genetic science, researchers have identified over 200 genes that cause or contribute to neurological disorders. Still an evolving field of study, defining the relationship between genes and neurological and psychiatric disorders is expected to dramatically grow in scope. Part II builds on the foundation of Part I, expanding the coverage to dementias, paroxysmal disorders, neuromuscular disorders, white matter and demyelination diseases, cerebrovascular diseases, adult psychiatric disorders and cancer and phacomatoses. - Contains comprehensive coverage of neurogenetics - Details the latest science and its impact on our understanding of neurological, psychiatric disorders - Presents a focused reference for clinical practitioners and the neuroscience/neurogenetics research community

The Prion Protein

Author : Jorg Tatzelt
Publisher :
ISBN 13 : 9780954333522
Total Pages : 80 pages
Book Rating : 4.3/5 (335 download)

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Book Synopsis The Prion Protein by : Jorg Tatzelt

Download or read book The Prion Protein written by Jorg Tatzelt and published by . This book was released on 2010 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: A conformational transition of the cellular prion protein (PrPC) into an aberrantly folded isoform designated scrapie prion protein (PrPSc) is the hallmark of a variety of neurodegenerative disorders collectively called prion diseases. They include Creutzfeldt-Jakob disease and Gerstmann-Stäussler-Scheinker syndrome in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and chronic wasting disease (CWD) in free-ranging deer. In contrast to the deadly properties of misfolded PrP, PrPC seems to possess a neuroprotective activity. More-over, animal models indicated that the stress-protective activity of PrPC and the neurotoxic effects of PrPSc are somehow interconnected. In this timely book, leading scientists in the field have come together to highlight the apparently incongruous activities of different PrP conformers. The articles outline current research on celluar pathways implicated in the formation and signaling of neurotoxic and physiological PrP isoforms and delineate future research direction. Topics covered include the physiologcial activity of PrPC and its possible role as a neurotrophic factor, the finding that aberrant PrP conformers can cause neurodegeneration in the absence of infectious prion propagation, the requirement of the GPI anchor of PrPC for the neurotoxic effects of scrapie prions, the pathways implicated in the formation and neurotoxic properties of cytosolically localized PrP, the impact of metal ions on the processing of PrP, and the role of autophagy in the propagation and clearance of PrPSc. The book is fully illustrated and chapters include comprehensive reference sections. Essential reading for scientists involved in prion research.

Prions

Author : Stanley B. Prusiner
Publisher :
ISBN 13 :
Total Pages : 568 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Prions by : Stanley B. Prusiner

Download or read book Prions written by Stanley B. Prusiner and published by . This book was released on 1987 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Prion Diseases

Author : John Collinge (MD.)
Publisher :
ISBN 13 :
Total Pages : 226 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Prion Diseases by : John Collinge (MD.)

Download or read book Prion Diseases written by John Collinge (MD.) and published by . This book was released on 1997 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: The number of neurological conditions associated with the mutant "prion" protein continues to grow. The list includes BSE and scrapie, which affect cattle and sheep respectively, and Creutzfeldt-Jacob Disease, which affects humans. This is an area of intense interest to neuroscientists,veterinary scientists, and clinicians. It has also attracted significant media attention because of the potential risks to humans. This book brings together leading researchers in the field to provide the most up-to-date and authoritative summary available of the field. Contents include human and animal prion diseases; pathology and cell biology of prion diseases; and prion protein structure.

Mad Cow Disease and Related Spongiform Encephalopathies

Author : David A. Harris
Publisher : Springer Science & Business Media
ISBN 13 : 9783540201076
Total Pages : 236 pages
Book Rating : 4.2/5 (1 download)

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Book Synopsis Mad Cow Disease and Related Spongiform Encephalopathies by : David A. Harris

Download or read book Mad Cow Disease and Related Spongiform Encephalopathies written by David A. Harris and published by Springer Science & Business Media. This book was released on 2004-03-18 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bovine spongiform encephalopathy (BSE) has become the most publicly recognizable example of a group of fatal neurodegenerative diseases caused by proteinaceous infectious particles called prions. The contributors to this volume, all internationally recognized experts in their fields, provide an introduction to prion biology, followed by reviews of the latest information on BSE, vCJD, and chronic wasting disease, an animal prion disease that has recently emerged in North America.

Madness and Memory

Author : Stanley B. Prusiner
Publisher : Yale University Press
ISBN 13 : 0300191146
Total Pages : 344 pages
Book Rating : 4.3/5 (1 download)

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Book Synopsis Madness and Memory by : Stanley B. Prusiner

Download or read book Madness and Memory written by Stanley B. Prusiner and published by Yale University Press. This book was released on 2014-04-29 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author, a 1997 recipient of the Noble Prize in medicine, describes the years he spent researching and demonstrating how the infectious proteins known as prions were responsible for brain diseases and how his theory has now become widely accepted in the science establishment.

Prions

Author : Claudio Soto
Publisher : CRC Press
ISBN 13 : 142004012X
Total Pages : 191 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Prions by : Claudio Soto

Download or read book Prions written by Claudio Soto and published by CRC Press. This book was released on 2005-12-20 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prion-related diseases, known as transmissible spongiform encephalopathies (TSEs), are infectious, fatal neurodegenerative disorders for which there is no cure, treatment, nor even a means for early diagnosis. The horrific advent of Mad Cow Disease -- transmitted to humans through eating meat from steers sickened by bovine spongiform encephalopathy

Infectious Diseases from Nature: Mechanisms of Viral Emergence and Persistence

Author : C.J. Peters
Publisher : Springer
ISBN 13 : 9783211243350
Total Pages : 216 pages
Book Rating : 4.2/5 (433 download)

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Book Synopsis Infectious Diseases from Nature: Mechanisms of Viral Emergence and Persistence by : C.J. Peters

Download or read book Infectious Diseases from Nature: Mechanisms of Viral Emergence and Persistence written by C.J. Peters and published by Springer. This book was released on 2005-09-27 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant zoonotic diseases have appeared with increasing frequency in recent years. At a symposium held in Galveston, Texas, in March 2004, many outstanding virologists and others presented papers under the broad theme of "emergence". The intent was to elucidate the diseases themselves, the mechanisms by which they have emerged, the publication perception and response to the diseases, and the possibility of prevention or prediction. The papers in this book summarize the talks of this meeting. Among the many timely papers are those by Nobel Prize winner Peter Doherty, influenza epidemiologists Robert Webster and Jeffery Taubenberger, and important contributions by Neal Nathanson, Esteban Domingo, Barry Beaty, David Walker, James Hughes, and others of world expertise.

Prions

Author : Akikazu Sakudo
Publisher :
ISBN 13 : 9781910190951
Total Pages : 160 pages
Book Rating : 4.1/5 (99 download)

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Book Synopsis Prions by : Akikazu Sakudo

Download or read book Prions written by Akikazu Sakudo and published by . This book was released on 2019-03-12 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential reading for everyone working with prions from the PhD student to the experienced scientist.

Prions Prions Prions

Author : Stanley B. Prusiner
Publisher : Springer
ISBN 13 : 9783540593430
Total Pages : 163 pages
Book Rating : 4.5/5 (934 download)

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Book Synopsis Prions Prions Prions by : Stanley B. Prusiner

Download or read book Prions Prions Prions written by Stanley B. Prusiner and published by Springer. This book was released on 1995-12-12 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: A series of remarkable discoveries in the past three decades have led to the molecular and genetic characterization of the transmissible pathogen causing scrapie in animals and a quartet of human illnesses: kuru, Jakob-Creutzfeld disease, Gerstmann-Sträussler-Scheinker disease, and fatal familial insomnia. To distinguish this pathogen from viruses and viroids, the term "prion" was introduced to emphasize its proteinaceous and infectious nature. Stanley B. Prusiner, editor of this volume, was awarded the 1997 Nobel Prize in Physiology and Medicine for his pioneering discovery of prions. The book reviews advances in studies of prions, which - as considereable evidence indicates - are novel pathogens composed only of protein.

Harrison's Neurology in Clinical Medicine, 3E

Author : Stephen Hauser
Publisher : McGraw Hill Professional
ISBN 13 : 0071815007
Total Pages : 897 pages
Book Rating : 4.0/5 (718 download)

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Book Synopsis Harrison's Neurology in Clinical Medicine, 3E by : Stephen Hauser

Download or read book Harrison's Neurology in Clinical Medicine, 3E written by Stephen Hauser and published by McGraw Hill Professional. This book was released on 2013-04-08 with total page 897 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurology – as only Harrison’s can cover it Featuring a superb compilation of chapters related to neurology that appear in Harrison’s Principles of Internal Medicine, Eighteenth Edition, this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison’s. You will find content from renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation. Features Current, complete coverage of clinically important topics in neurology, including Clinical Manifestations of Neurologic Diseases, Diseases of the Nervous System, Chronic Fatigue Syndrome, Psychiatric Disorders, and Alcoholism and Drug Dependency NEW CHAPTERS discuss the pathogenesis and treatment and syncope; dizziness and vertigo; peripheral neuropathy; neuropsychiatric problems among war veterans; and advances in deciphering the pathogenesis of common psychiatric disorders Integration of pathophysiology with clinical management 118 high-yield questions and answers drawn from Harrison’s Principles of Internal Medicine Self-Assessment and Board Review, 18e Content updates and new developments since the publication of Harrison’s Principles of Internal Medicine, 18e 58 chapters written by physicians who are recognized experts in the field of clinical neurology Helpful appendix of laboratory values of clinical importance

How the Cows Turned Mad

Author : Maxime Schwartz
Publisher : Univ of California Press
ISBN 13 : 0520243374
Total Pages : 264 pages
Book Rating : 4.5/5 (22 download)

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Book Synopsis How the Cows Turned Mad by : Maxime Schwartz

Download or read book How the Cows Turned Mad written by Maxime Schwartz and published by Univ of California Press. This book was released on 2004-09-13 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: "How the Cows Turned Mad tells the story of a disease that continues to elude on many levels. Yet science has come far in understanding its origins, incubation, and transmission. This book is a case history that illuminates the remarkable progression of science."--BOOK JACKET.

Prion Biology

Author : Stanley B. Prusiner
Publisher :
ISBN 13 : 9781621820932
Total Pages : 0 pages
Book Rating : 4.8/5 (29 download)

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Book Synopsis Prion Biology by : Stanley B. Prusiner

Download or read book Prion Biology written by Stanley B. Prusiner and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prions are infectious proteins responsible for diseases such as Creutzfeldt-Jakob disease and "mad cow" disease. They are misfolded versions of normal proteins that replicate by converting their normal cellular counterparts into abnormal prion proteins that disrupt cell function and can be transmitted to other cells and individuals. This book examines our under-standing of their structure, biochemistry, and pathophysiology.

Prions in Humans and Animals

Author : Beat Hörnlimann
Publisher : Walter de Gruyter
ISBN 13 : 3110200171
Total Pages : 743 pages
Book Rating : 4.1/5 (12 download)

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Book Synopsis Prions in Humans and Animals by : Beat Hörnlimann

Download or read book Prions in Humans and Animals written by Beat Hörnlimann and published by Walter de Gruyter. This book was released on 2009-05-08 with total page 743 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive work, aimed at both students and researchers alike, systematically covers all aspects of prion diseases (transmissible spongiform encephalopathies), from their history, microbiology and pathology to their transmissibility and prevention. The book describes diseases such as Creutzfeldt-Jakob disease, kuru, mad cow disease (BSE), chronic wasting disease and scrapie, highlighting their biochemical, molecular biological, genetic, and clinical aspects. A detailed presentation of the impact of prion diseases in fields such as pharmaceutics, blood products, disinfection, surgical instruments and epidemiology concludes with a discussion of preventive measures. A renowned editorial team, representing the fields of medicine, veterinary medicine and molecular biology, brought together 80 internationally respected authors for this translation and new edition of the successful German publication, not only from relevant research fields, but also from industry and public health institutions. The book includes chapters by, among many other notable scientists, William J. Hadlow, who discovered the relationship between the human and animal forms of prion diseases and Michael P. Alpers, with 45 years of experience in Papua New Guinea investigating the first known human epidemic form, kuru, transmitted by endocannibalism. Further contributions from Gerald A. H. Wells, a veterinary pathologist who described BSE and recognised its similarity to scrapie, thus recording the first cases in 1986 of the most important animal epidemic of modern times, and Robert G. Will, a medical neurologist and epidemiologist who discovered the emergence of the variant form of Creutzfeldt-Jakob disease in 1996, underscore the strength of this author team. Carefully edited with numerous illustrations, this work offers a systematic approach committed to a clear presentation of the current knowledge of prion diseases. It aims to inspire and stimulate interdisciplinary cooperation, innovative research ideas and effective prevention.