Human Microbiome in Health, Disease, and Therapy

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Publisher : Springer Nature
ISBN 13 : 9819951143
Total Pages : 330 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Human Microbiome in Health, Disease, and Therapy by : Pallaval Veera Bramhachari

Download or read book Human Microbiome in Health, Disease, and Therapy written by Pallaval Veera Bramhachari and published by Springer Nature. This book was released on 2024-01-15 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the role of the human microbiome in health and diseases. It discusses the association of an imbalanced human microbiome with different human diseases, including inflammatory, metabolic conditions, neurological, cardiovascular, and respiratory diseases. The book further reviews the association between intestinal microbiota and immune defense systems. The book provides evolving knowledge of the development, complexity, and functionality of the healthy gut microbiota and covers interventions that modulate and stabilize the gut microbiota. Further, it introduces the human microbiome as a reservoir of AMR genes, the current knowledge on the resistome, and the recent and upcoming advances in molecular diagnostic approaches to unravel this reservoir. Toward the end, the book reviews the advances in understanding the human urinary microbiome and its potential role in urinary tract infection. The chapter also presents the dynamics of the skin microbiome and the association of microbiota with skin disorders and therapeutic interventions. This book is an invaluable read for health professionals, medical students, microbiologists, and scientific research communities who are eager to update themselves with recent trends in microbiome research.

Human Microbiota in Health and Disease

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Publisher : Academic Press
ISBN 13 : 0128146508
Total Pages : 674 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Human Microbiota in Health and Disease by : Bryan Tungland

Download or read book Human Microbiota in Health and Disease written by Bryan Tungland and published by Academic Press. This book was released on 2018-05-25 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Gut Microbiota in Health and Disease: From Pathogenesis to Therapy is a comprehensive discussion of all the aspects associated with gut microbiota early colonization, its development and maintenance, and its symbiotic relationship with the host to promote health. Chapters illustrate the complex mechanisms and metabolic signalling pathways related to how the gut microbiota maintain proper regulation of glucose, lipid and energy homeostasis and immune response, while mediating inflammatory processes involved in the etiology of many chronic disease conditions. Details are provided on the primary etiological factors of chronic disease, the effects of gut dysbiosis and its associated disease conditions, while providing an overview of therapeutic strategies involving dietary fiber and prebiotics, fecal microbiota transplantation therapy and probiotics. Throughout the chapters, a comprehensive review of peer-reviewed animal and human studies is provided as evidence related to the history of human exposure, safety, tolerance, toxicity, nomenclature, and clinical efficacy of utilizing prebiotic fructans, s, as well as probiotic intervention, and dietary modification in the prevention and intervention of chronic disease conditions. With common use today of pharmaceutical medicine in treating symptoms, and frequent overuse of antibiotics in chronic disease within mainstream medical practice, understanding the etiological mechanisms of dysbiosis-induced chronic disease, and natural approaches that offer prevention and potential cures for these diseases is of vital importance to overall human health. Details the complex relationship between human microbiota in the gut, oral cavity, urogenital tract and skin as well as their colonization, development and impact of factors that influence the relationship Illustrates the mechanisms associated with dysbiosis-associated inflammation and its role in the onset and progression in chronic disease Provides the primary mechanisms and comprehensive scientific evidence for the use of dietary modification, and pro- and pre-biotics in preventing and intervening in chronic disease

The Chemistry of Microbiomes

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Publisher : National Academies Press
ISBN 13 : 0309458390
Total Pages : 133 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis The Chemistry of Microbiomes by : National Academies of Sciences, Engineering, and Medicine

Download or read book The Chemistry of Microbiomes written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-07-19 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 21st century has witnessed a complete revolution in the understanding and description of bacteria in eco- systems and microbial assemblages, and how they are regulated by complex interactions among microbes, hosts, and environments. The human organism is no longer considered a monolithic assembly of tissues, but is instead a true ecosystem composed of human cells, bacteria, fungi, algae, and viruses. As such, humans are not unlike other complex ecosystems containing microbial assemblages observed in the marine and earth environments. They all share a basic functional principle: Chemical communication is the universal language that allows such groups to properly function together. These chemical networks regulate interactions like metabolic exchange, antibiosis and symbiosis, and communication. The National Academies of Sciences, Engineering, and Medicine's Chemical Sciences Roundtable organized a series of four seminars in the autumn of 2016 to explore the current advances, opportunities, and challenges toward unveiling this "chemical dark matter" and its role in the regulation and function of different ecosystems. The first three focused on specific ecosystemsâ€"earth, marine, and humanâ€"and the last on all microbiome systems. This publication summarizes the presentations and discussions from the seminars.

The Human Microbiota and Chronic Disease

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Publisher : John Wiley & Sons
ISBN 13 : 1118982878
Total Pages : 564 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis The Human Microbiota and Chronic Disease by : Luigi Nibali

Download or read book The Human Microbiota and Chronic Disease written by Luigi Nibali and published by John Wiley & Sons. This book was released on 2016-10-03 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease. The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states. Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section. The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position. Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition Explores the relationship humans have with their microbiota, and its significance in human health and disease Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.

Human Microbiome

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Author :
Publisher : Springer Nature
ISBN 13 : 9811676720
Total Pages : 269 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Human Microbiome by : Sabu Thomas

Download or read book Human Microbiome written by Sabu Thomas and published by Springer Nature. This book was released on 2022-02-02 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human microbiome refers to the complete microorganisms inhabiting the human body sites including skin, ear, nose, oral cavity, the genital, gastrointestinal and respiratory tracts, and body fluids such as breast milk, saliva, and urine. It is a significant and essential organ recognized for the body and has an established involvement in the host wellbeing, in terms of nutritional requirements and immunomodulation. This book talks about how alteration and imbalance in the same can have clinical implications associated with a multitude of gastrointestinal, lifestyle-associated, and neurodegenerative disorders. How the proliferation of specific groups of bacteria and their metabolic activities, as a result of intestinal dysbiosis leads to the 'leaky gut' condition thereby influences brain activity via the bidirectional gut-brain axis. It also coves the importance of microbial seeding and how it can be influenced by the mode of delivery, nutrition, and medication. This book also provides various therapeutic interventions such as the establishment of stool banks and Faecal microbiota transplantation (FMT) that have recently proved promising in the treatment of ASD, Inflammatory Bowel Disease, and Ulcerative Colitis. This book provides a deeper understanding of the development of the human gut microbiome and the factors driving its dysbiosis. This book is a valuable read for health professionals, medical students, nutritionists, and scientific research communities who are eager to update themselves with recent trends in microbiome research. It will also aid gastroenterologists and nutritionists to make well-informed choices regarding therapeutic regimes.

Microbiome in Human Health and Disease

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Publisher : Springer Nature
ISBN 13 : 9811631565
Total Pages : 306 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Microbiome in Human Health and Disease by : Pallaval Veera Bramhachari

Download or read book Microbiome in Human Health and Disease written by Pallaval Veera Bramhachari and published by Springer Nature. This book was released on 2021-10-18 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an overview on how the microbiome contributes to human health and disease. The microbiome has also become a burgeoning field of research in medicine, agriculture & environment. The readers will obtain profound knowledge on the connection between intestinal microbiota and immune defense systems, medicine, agriculture & environment. The book may address several researchers, clinicians and scholars working in biomedicine, microbiology and immunology. The application of new technologies has no doubt revolutionized the research initiatives providing new insights into the dynamics of these complex microbial communities and their role in medicine, agriculture & environment shall be more emphasized. Drawing on broad range concepts of disciplines and model systems, this book primarily provides a conceptual framework for understanding these human-microbe, animal-microbe & plant-microbe, interactions while shedding critical light on the scientific challenges that lie ahead. Furthermore this book explains why microbiome research demands a creative and interdisciplinary thinking—the capacity to combine microbiology with human, animal and plant physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science.This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet in a typical immune system, and have contributed to animal and plant diversification over long evolutionary timescales. Also this book explains why microbiome research presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for human health and new strategies.

The Gut Microbiome in Health and Disease

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Author :
Publisher : Springer
ISBN 13 : 3319905457
Total Pages : 355 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis The Gut Microbiome in Health and Disease by : Dirk Haller

Download or read book The Gut Microbiome in Health and Disease written by Dirk Haller and published by Springer. This book was released on 2018-07-27 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an overview on how the gut microbiome contributes to human health. The readers will get profound knowledge on the connection between intestinal microbiota and immune defense systems. The tools of choice to study the ecology of these highly-specialized microorganism communities such as high-throughput sequencing and metagenomic mining will be presented. In addition the most common diseases associated to the composition of the gut flora are discussed in detail. The book will address researchers, clinicians and advanced students working in biomedicine, microbiology and immunology.

Diet, Microbiome and Health

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Publisher : Academic Press
ISBN 13 : 0128114924
Total Pages : 526 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Diet, Microbiome and Health by : Alexandru Mihai Grumezescu

Download or read book Diet, Microbiome and Health written by Alexandru Mihai Grumezescu and published by Academic Press. This book was released on 2018-01-02 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diet, Microbiome and Health, Volume 11, in the Handbook of Food Bioengineering series, presents the most up-to-date research to help scientists, researchers and students in the field of food engineering understand the different microbial species we have in our guts, why they are important to human development, immunity and health, and how to use that understanding to further promote research to create healthy food products. In addition, the book provides studies that clearly demonstrate how dietary preferences and social behavior significantly impact the diversity of microbial species in the gut and their numeric values, which may balance health and disease. Highlights research discoveries on how gut microbiota influence and are impacted by health and disease Includes information on and examples of healthy foods Discusses gut microbiota in autism, GI disease, neuropsychiatric disorders, obesity and metabolic disease Explores the barrier function of the gut Examines how food preferences impact gut microbiota

Gut Microbiome-Related Diseases and Therapies

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Publisher : Springer Nature
ISBN 13 : 3030596427
Total Pages : 328 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Gut Microbiome-Related Diseases and Therapies by : Maria Gazouli

Download or read book Gut Microbiome-Related Diseases and Therapies written by Maria Gazouli and published by Springer Nature. This book was released on 2021-04-24 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews recent knowledge of the role of gut microbiome in health and disease. It covers extensive topics for several diseases, including metabolic-related diseases, allergies, gastrointestinal diseases, psychiatric diseases, and cancer, while also discussing therapeutic approaches by microbiota modification. Comprehensive and cutting-edge, Gut Microbiome-Related Diseases and Therapies deepens a reader’s theoretical expertise in gut microbiome. Graduate and postdoctoral students, medical doctors, and biomedical researchers will benefit from this book.

Environmental Chemicals, the Human Microbiome, and Health Risk

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Publisher : National Academies Press
ISBN 13 : 0309468698
Total Pages : 123 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Environmental Chemicals, the Human Microbiome, and Health Risk by : National Academies of Sciences, Engineering, and Medicine

Download or read book Environmental Chemicals, the Human Microbiome, and Health Risk written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-03-01 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: A great number of diverse microorganisms inhabit the human body and are collectively referred to as the human microbiome. Until recently, the role of the human microbiome in maintaining human health was not fully appreciated. Today, however, research is beginning to elucidate associations between perturbations in the human microbiome and human disease and the factors that might be responsible for the perturbations. Studies have indicated that the human microbiome could be affected by environmental chemicals or could modulate exposure to environmental chemicals. Environmental Chemicals, the Human Microbiome, and Health Risk presents a research strategy to improve our understanding of the interactions between environmental chemicals and the human microbiome and the implications of those interactions for human health risk. This report identifies barriers to such research and opportunities for collaboration, highlights key aspects of the human microbiome and its relation to health, describes potential interactions between environmental chemicals and the human microbiome, reviews the risk-assessment framework and reasons for incorporating chemicalâ€"microbiome interactions.

The Human Microbiome in Early Life

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Publisher : Academic Press
ISBN 13 : 0128180986
Total Pages : 327 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Human Microbiome in Early Life by : Omry Koren

Download or read book The Human Microbiome in Early Life written by Omry Koren and published by Academic Press. This book was released on 2020-09-18 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Human Microbiome in Early Life: Implications to Health and Disease presents recent research advances that have highlighted the significance of early life, possibly beginning before birth, in the establishment of both the microbiome and its role in health and disease. The book reviews current knowledge on the origins of the human microbiota in early life, presents exposures which may disturb normal microbial colonization, and covers their implications to the risk of disease. Finally, emerging means to modify the early human microbiome to improve health are discussed. Examines the timeline of the human microbiome, from before conception to infancy, with an emphasis on clinical implications Evaluates the effort to understand not only the composition but also the origin of the microbiome Proves the emerging means to modify the human microbiome and particularly ‘the first 1000 days of life’ improve human health and prevent disease Generates resources to facilitate characterization of the human microbiota to further our understanding of how the microbiome impacts human health and disease

Role of Microbes in Human Health and Diseases

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1838802339
Total Pages : 84 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Role of Microbes in Human Health and Diseases by : Nar Singh Chauhan

Download or read book Role of Microbes in Human Health and Diseases written by Nar Singh Chauhan and published by BoD – Books on Demand. This book was released on 2019-06-05 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbes are ubiquitous and have ecological interactions with almost all life forms. Likewise, humans invariably engage in host-microbial interactions that could induce short-term or long-term effects. Some of these long-term crossover interactions have allowed successful colonization of microbes within or on the human body, collectively known as the human microbiome or human microbiota. The human microbiome is identified as playing a key role in various physiological processes like digestion, immunity, defense, growth, and development. Any dysbiosis in the human microbiome structure could induce the onset of various metabolic or physiological disorders. Cumulatively, the human microbiome is considered as a virtual human organ that is essential for host survival. Additionally, short-term biological interactions of the host and microbes have exposed microbes to the human cellular system. This exposure could have allowed the microbes to invade human cells for their growth and reproduction-induced onset of various infectious diseases. This book incorporates a number of studies highlighting the role of microbes in human health and diseases.

Human Microbiome in Health and Disease - Part B

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Publisher : Academic Press
ISBN 13 : 0323913210
Total Pages : 356 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Human Microbiome in Health and Disease - Part B by :

Download or read book Human Microbiome in Health and Disease - Part B written by and published by Academic Press. This book was released on 2022-10-22 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Microbiome in Health and Disease, Volume 192, Part B includes chapters surrounding the role of human microbiome in different diseases. Chapters in this comprehensive new volume include The microbiome and communicable diseases, Gut Microbiome and Antimicrobial Resistance in bacterial pathogens, Dysbiosis of human microbiome and infectious disease, Gastrointestinal microbiome in the context of infection in stomach and gastroduodenal diseases, Respiratory tract microbiome and pneumonia, Gut microbiome and neonatal sepsis, Diarrheal disease and gut microbiome, The microbiome and non-communicable diseases, Gut microbiome and inflammatory bowel disease, Gut microbiome and undernutrition, Human microbiome and cardiovascular disease, and much more. Covers dysbiosis of microbiome in communicable and non-communicable diseases Discusses the emergence and spread of antimicrobial resistance in gut microbiome Presents the latest information on reproductive tract microbiome and birth outcomes

Human Microbes - The Power Within

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Publisher : Springer
ISBN 13 : 9811076847
Total Pages : 183 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Human Microbes - The Power Within by : Vasu D. Appanna

Download or read book Human Microbes - The Power Within written by Vasu D. Appanna and published by Springer. This book was released on 2018-02-05 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a unique perspective on the invisible organ, a body part that has been visualized only recently. It guides the readers into the world of the microbial constituents that make humans the way they are. The vitamins they produce, the smell they generate, the signals they create, and the molecular guards they elaborate are some of the benefits they bestow on humans. After introducing the notion as to why microbes are an integral component in the development of humans, the book examines the genesis of the microbiome and describes how the resident bacteria work in partnership with the skin, digestive tract, sexual organs, mouth and lungs to execute vital physiological functions. It then discusses the diseases that are triggered by the disruption of the harmonious relationships amongst these diverse systems and provides microbial cures to ailments such as obesity and digestive complications. Finally, the book focuses on the future when the workings of the human microbes will be fully unravelled. Societal changes in health education, the establishment of the microbiome bank, the fight against hunger, space travel, designer traits and enhanced security are explained. Each chapter is accompanied by captivating illustrations and ends with a visual summary. Dr. Appanna has been researching for over 30 years on various aspects of microbial and human cellular systems. He is a professor of biochemistry and has also served as Department Chair and Dean of the Faculty at Laurentian University, Sudbury, Canada. The book is aimed at readers enrolled in medical, chiropractic, nursing, pharmacy, and health science programs. Practicing health-care professionals and continuing education learners will also find the content beneficial.

The Human Microbiome

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Publisher : Oxford University Press
ISBN 13 : 019982942X
Total Pages : 281 pages
Book Rating : 4.1/5 (998 download)

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Book Synopsis The Human Microbiome by : Rosamond Rhodes

Download or read book The Human Microbiome written by Rosamond Rhodes and published by Oxford University Press. This book was released on 2013-08-15 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human microbiome is the bacteria, viruses, and fungi that cover our skin, line our intestines, and flourish in our body cavities. Work on the human microbiome is new, but it is quickly becoming a leading area of biomedical research. What scientists are learning about humans and our microbiomes could change medical practice by introducing new treatment modalities. This new knowledge redefines us as superorganisms comprised of the human body and the collection of microbes that inhabit it and reveals how much we are a part of our environment. The understanding that microbes are not only beneficial but sometimes necessary for survival recasts our interaction with microbes from adversarial to neighborly. This volume explores some of the science that makes human microbiome research possible. It then considers ethical, legal, and social concerns raised by microbiome research. Chapters explore issues related to personal identity, property rights, and privacy. The authors reflect on how human microbiome research challenges reigning views on public health and research ethics. They also address the need for thoughtful policies and procedures to guide the use of the biobanked human samples required for advancing this new domain of research. In the course of these explorations, they introduce examples from the history of biomedical science and recent legal cases that shed light on the issues and inform the policy recommendations they offer at the end of each topic's discussion. This volume is the product of an NIH Human Microbiome Project grant. It represents three years of conversations focused on consensus formation by the twenty-seven members of the interdisciplinary Microbiome Working Group. "The microbiome is a relatively new area of medical attention. Ethical issues related to the microbiome have barely been identified, much less carefully analyzed. This volume is an excellent start toward that ethical analysis. Many of the arguments are persuasive and provocative. In particular, some contributors challenge the ethical need for anonymizing microbiome specimens as well as the need for individual informed consent for specific uses of these specimens. I highly recommend this volume for all those interested in the microbiome and in new frontiers in medical ethics." -Leonard M. Fleck, Michigan State University

Predictive Modeling of Human Microbiota and their Role in Health and Disease

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889740919
Total Pages : 145 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Predictive Modeling of Human Microbiota and their Role in Health and Disease by : Hyun-Seob Song

Download or read book Predictive Modeling of Human Microbiota and their Role in Health and Disease written by Hyun-Seob Song and published by Frontiers Media SA. This book was released on 2022-01-19 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Gut-brain Connection, Myth Or Reality?: Role Of The Microbiome In Health And Diseases

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Author :
Publisher : World Scientific
ISBN 13 : 9811221162
Total Pages : 396 pages
Book Rating : 4.8/5 (112 download)

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Book Synopsis Gut-brain Connection, Myth Or Reality?: Role Of The Microbiome In Health And Diseases by : Adrien A Eshraghi

Download or read book Gut-brain Connection, Myth Or Reality?: Role Of The Microbiome In Health And Diseases written by Adrien A Eshraghi and published by World Scientific. This book was released on 2021-11-03 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book the recent advancements in understanding the gut-brain interaction as well as gut microbiome and how this interaction plays a vital role in human health and disease are discussed. Each chapter gives an analysis of questions, research directions, and methods within the field of gut-brain axis. The readers will benefit from the latest knowledge about our understanding about how gut-brain axis and modulation of gut microbiome determines predisposition to neurological disorders. The multidisciplinary book is essential reading for anyone interested in the field of gut-brain axis and gut microbiome: from undergraduates to graduate students as well as scientists and physicians having an interest in the new exciting field of gut microbiome and its relationship with brain function.