Human Aging And Chronic Disease

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Advances in Geroscience

Author : Felipe Sierra
Publisher : Springer
ISBN 13 : 3319232460
Total Pages : 637 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Advances in Geroscience by : Felipe Sierra

Download or read book Advances in Geroscience written by Felipe Sierra and published by Springer. This book was released on 2015-11-10 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a critical malleable risk factor in most chronic diseases, which, in turn, could lead to interventions that can help increase a healthy lifespan, or ‘healthspan.’ The book begins with an analysis of the Geroscience hypothesis, as well as the epidemiological underpinnings that define aging as a candidate main risk factor for most chronic diseases. Next, each chapter focuses on one particular disease, or group of diseases, with an emphasis on how basic molecular and cellular biology might explain why aging is a major risk factor for it. Coverage in the book includes: cancer, cardiovascular disease, dementias, stroke, Parkinson's and Alzheimer’s diseases, osteoporosis, arthritis, diabetes asthma, emphysema, kidney disease, vision impairment, and AIDS/HIV. It finishes with a chapter on pain in the elderly and an overview of future steps needed to bring the newly acquired knowledge into the clinic and the public at large.

Human Aging

Author : Calogero Caruso
Publisher : Elsevier
ISBN 13 : 0128225696
Total Pages : 382 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Human Aging by : Calogero Caruso

Download or read book Human Aging written by Calogero Caruso and published by Elsevier. This book was released on 2021-05-13 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intro -- Human Aging: From Cellular Mechanisms to Therapeutic Strategies -- Copyright -- Contents -- Contributors -- About the editors -- Preface -- Chapter 1: Aging and longevity: An evolutionary approach -- 1.1. Introduction -- 1.2. Why does aging occur? -- 1.3. Mechanisms of aging -- 1.4. Causality and chance in aging and longevity -- 1.5. Conclusions and future perspectives -- References -- Chapter 2: Demographic aspects of aging -- 2.1. Introduction -- 2.2. Understanding the process: Browsing around the demographic transition theories -- 2.3. Aging inequalities -- 2.3.1. Differences by gender, education, and cause of death -- 2.3.2. Does having a longer life also mean having a better life? -- 2.3.3. Economics of population aging -- 2.4. Conclusions and perspectives -- References -- Chapter 3: Pathobiology of aging: An introduction to age-related diseases -- 3.1. Introduction -- 3.2. Complexity -- 3.3. Hallmarks of aging -- 3.4. Genomic instability -- 3.5. Epigenetic alteration -- 3.6. Deregulated nutrient sensing pathways -- 3.6.1. FOXO3 -- 3.6.2. Insulin/IGF-1 pathway -- 3.6.3. mTOR pathway -- 3.6.4. Sirtuin pathway -- 3.6.5. Autophagy -- 3.7. Loss of proteostasis -- 3.8. Mitochondrial dysfunction -- 3.9. Telomere attrition -- 3.10. Cellular senescence -- 3.11. Stem cell exhaustion -- 3.12. Altered intercellular communication -- 3.13. Cancer and aging -- 3.14. Conclusion and future perspectives -- References -- Chapter 4: Cellular senescence and senescence-associated secretory phenotype (SASP) in aging process -- 4.1. Introduction -- 4.2. Signaling pathway stimulating the appearance of SASP -- 4.3. SASP components -- 4.4. MiRNA and extracellular vesicles as new regulators and components of SASP -- 4.5. SASP profile in different cell types -- 4.6. Cellular senescence, SASP, and aging -- 4.7. Conclusions and future perspectives -- References.

Changing Mortality Patterns, Health Services Utilization, and Health Care Expenditures

Author : Dorothy P. Rice
Publisher :
ISBN 13 :
Total Pages : 48 pages
Book Rating : 4.3/5 (2 download)

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Book Synopsis Changing Mortality Patterns, Health Services Utilization, and Health Care Expenditures by : Dorothy P. Rice

Download or read book Changing Mortality Patterns, Health Services Utilization, and Health Care Expenditures written by Dorothy P. Rice and published by . This book was released on 1983 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Inflammation, Aging and Cancer

Author : Mahin Khatami
Publisher : Springer
ISBN 13 : 3319664751
Total Pages : 402 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Inflammation, Aging and Cancer by : Mahin Khatami

Download or read book Inflammation, Aging and Cancer written by Mahin Khatami and published by Springer. This book was released on 2018-01-17 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was prepared as extension of author’s accidental discoveries on experimental models of acute and chronic ocular inflammatory diseases that were established at the University of Pennsylvania in 1980’s. Analyses of original data suggest a series of first evidence for direct link between inflammation and developmental phases of immune dysfunction in multistep tumorigenesis and angiogenesis. The only evidence presented on initial events for interactions and synergies between activated host and recruiting cells toward tumorigenesis. Effective immunity was defined as balance between two highly regulated and biologically opposing arms, Yin and Yang of acute inflammation, an amazingly precise signal communications between immune and non-immune systems requiring differential bioenergetics. Unresolved inflammation is a common denominator mapping aging process and induction of ‘mild’, ‘moderate’ or ‘severe’ immune disorders including cancers. Our knowledge of the fascinating biology of immunity in health or chronic diseases is fragmentary, chaotic and confusing, particularly for cancer science. Lack of progress in curing majority of chronic diseases or cancer is primarily due to the fact that scientists work on isolated molecules/cells or topics that are funded and promoted by decision makers in medical/cancer establishment. Despite existence of over 25 million articles on cancer-related topics, cancer biology and cure remain mysteries to be solved. After a century of cancer research, the failure rates of therapies for solid tumors are 90% (+/-5). Current reductionist views on cancer science are irresponsible, shut-gun approaches and create chaos. Outcomes are loss of millions of precious lives and economic drain to society. Very little is known about initial events that disturb effective immunity whose function is to monitor and arrest growth of cancerous cells or defend against other external or internal hazardous agents that threaten body’s survival. The author demonstrates the serious need for systematic understanding of how immune disruptors and aging process would alter effective immunity. Outcomes of proposed orderly studies are expected to provide logical foundations for cost-effective strategies to promote immunity toward a healthier society. The policy makers and medical/cancer establishment are urged to return to the common sense that our Forefathers used to serve the public.

Retooling for an Aging America

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309131952
Total Pages : 316 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Retooling for an Aging America by : Institute of Medicine

Download or read book Retooling for an Aging America written by Institute of Medicine and published by National Academies Press. This book was released on 2008-08-27 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the first of the nation's 78 million baby boomers begin reaching age 65 in 2011, they will face a health care workforce that is too small and woefully unprepared to meet their specific health needs. Retooling for an Aging America calls for bold initiatives starting immediately to train all health care providers in the basics of geriatric care and to prepare family members and other informal caregivers, who currently receive little or no training in how to tend to their aging loved ones. The book also recommends that Medicare, Medicaid, and other health plans pay higher rates to boost recruitment and retention of geriatric specialists and care aides. Educators and health professional groups can use Retooling for an Aging America to institute or increase formal education and training in geriatrics. Consumer groups can use the book to advocate for improving the care for older adults. Health care professional and occupational groups can use it to improve the quality of health care jobs.

Successful Aging

Author : John Wallis Rowe
Publisher : Random House Large Print Publishing
ISBN 13 : 9780375701795
Total Pages : 0 pages
Book Rating : 4.7/5 (17 download)

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Book Synopsis Successful Aging by : John Wallis Rowe

Download or read book Successful Aging written by John Wallis Rowe and published by Random House Large Print Publishing. This book was released on 1998 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the results of the MacArthur Foundation Study of Aging in America, which show how to maintain optimum physical and mental strength throughout later life.

Social Isolation and Loneliness in Older Adults

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309671035
Total Pages : 317 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Social Isolation and Loneliness in Older Adults by : National Academies of Sciences, Engineering, and Medicine

Download or read book Social Isolation and Loneliness in Older Adults written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-05-14 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Social isolation and loneliness are serious yet underappreciated public health risks that affect a significant portion of the older adult population. Approximately one-quarter of community-dwelling Americans aged 65 and older are considered to be socially isolated, and a significant proportion of adults in the United States report feeling lonely. People who are 50 years of age or older are more likely to experience many of the risk factors that can cause or exacerbate social isolation or loneliness, such as living alone, the loss of family or friends, chronic illness, and sensory impairments. Over a life course, social isolation and loneliness may be episodic or chronic, depending upon an individual's circumstances and perceptions. A substantial body of evidence demonstrates that social isolation presents a major risk for premature mortality, comparable to other risk factors such as high blood pressure, smoking, or obesity. As older adults are particularly high-volume and high-frequency users of the health care system, there is an opportunity for health care professionals to identify, prevent, and mitigate the adverse health impacts of social isolation and loneliness in older adults. Social Isolation and Loneliness in Older Adults summarizes the evidence base and explores how social isolation and loneliness affect health and quality of life in adults aged 50 and older, particularly among low income, underserved, and vulnerable populations. This report makes recommendations specifically for clinical settings of health care to identify those who suffer the resultant negative health impacts of social isolation and loneliness and target interventions to improve their social conditions. Social Isolation and Loneliness in Older Adults considers clinical tools and methodologies, better education and training for the health care workforce, and dissemination and implementation that will be important for translating research into practice, especially as the evidence base for effective interventions continues to flourish.

Mitochondria and the Future of Medicine

Author : Lee Know
Publisher : Chelsea Green Publishing
ISBN 13 : 1603587675
Total Pages : 274 pages
Book Rating : 4.6/5 (35 download)

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Book Synopsis Mitochondria and the Future of Medicine by : Lee Know

Download or read book Mitochondria and the Future of Medicine written by Lee Know and published by Chelsea Green Publishing. This book was released on 2018 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: With information for patients and practitioners on optimizing mitochondrial function for greater health and longevity Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion: mitochondria and bioenergetics. In Mitochondria and the Future of Medicine, Naturopathic Doctor Lee Know tells the epic story of mitochondria, the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy. By understanding how our mitochondria work, in fact, it is possible to add years to our lives, and life to our years. Current research, however, has revealed a dark side: many seemingly disconnected degenerative diseases have tangled roots in dysfunctional mitochondria. However, modern research has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. Lee Know offers cutting-edge information on supplementation and lifestyle changes for mitochondrial optimization, such as CoQ10, D-Ribose, cannabinoids, and ketogenic dietary therapy, and how to implement their use successfully. Mitochondria and the Future of Medicine is an invaluable resource for practitioners interested in mitochondrial medicine and the true roots of chronic illness and disease, as well as anyone interested in optimizing their health.

Providing Healthy and Safe Foods As We Age

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309158834
Total Pages : 192 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Providing Healthy and Safe Foods As We Age by : Institute of Medicine

Download or read book Providing Healthy and Safe Foods As We Age written by Institute of Medicine and published by National Academies Press. This book was released on 2010-11-29 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Does a longer life mean a healthier life? The number of adults over 65 in the United States is growing, but many may not be aware that they are at greater risk from foodborne diseases and their nutritional needs change as they age. The IOM's Food Forum held a workshop October 29-30, 2009, to discuss food safety and nutrition concerns for older adults.

Families Caring for an Aging America

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309448093
Total Pages : 367 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Families Caring for an Aging America by : National Academies of Sciences, Engineering, and Medicine

Download or read book Families Caring for an Aging America written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-11-08 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Family caregiving affects millions of Americans every day, in all walks of life. At least 17.7 million individuals in the United States are caregivers of an older adult with a health or functional limitation. The nation's family caregivers provide the lion's share of long-term care for our older adult population. They are also central to older adults' access to and receipt of health care and community-based social services. Yet the need to recognize and support caregivers is among the least appreciated challenges facing the aging U.S. population. Families Caring for an Aging America examines the prevalence and nature of family caregiving of older adults and the available evidence on the effectiveness of programs, supports, and other interventions designed to support family caregivers. This report also assesses and recommends policies to address the needs of family caregivers and to minimize the barriers that they encounter in trying to meet the needs of older adults.

Aging, Technology and Health

Author : Richard Pak
Publisher : Academic Press
ISBN 13 : 0128112735
Total Pages : 318 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Aging, Technology and Health by : Richard Pak

Download or read book Aging, Technology and Health written by Richard Pak and published by Academic Press. This book was released on 2018-03-15 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging, Health and Technology takes a problem-centered approach to examine how older adults use technology for health. It examines the many ways in which technology is being used by older adults, focusing on challenges, solutions and perspectives of the older user. Using aging-health technology as a lens, the book examines issues of technology adoption, basic human factors, cognitive aging, mental health, aging and usability, privacy, trust and automation. Each chapter takes a case study approach to summarize lessons learned from unique examples that can be applied to similar projects, while also providing general information about older adults and technology. - Discusses human factors design challenges specific to older adults - Covers the wide range of health-related uses for technology—from fitness to leading a more engaged life - Utilizes a case study approach for practical application - Envisions what the future will hold for technology and older adults - Employs a roster of interdisciplinary contributors

Chronic Medical Disease and Cognitive Aging

Author : Kristine Yaffe
Publisher : Oxford University Press
ISBN 13 : 0199396221
Total Pages : 317 pages
Book Rating : 4.1/5 (993 download)

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Book Synopsis Chronic Medical Disease and Cognitive Aging by : Kristine Yaffe

Download or read book Chronic Medical Disease and Cognitive Aging written by Kristine Yaffe and published by Oxford University Press. This book was released on 2013-03-11 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic Medical Disease and Cognitive Aging: Toward a Healthy Body and Brain explores the important and often overlooked connection between how chronic medical diseases of the body can affect cognitive function and brain health. As population demographics shift to that of an aging population it has become more important to understand and improve cognitive function in late life. Chronic medical diseases often increase the risk of cognitive impairment, and those with cognitive impairment may be less able to effectively manage their medical conditions, suggesting a reciprocal relationship may exist where medical disease impacts cognition that in turn may exacerbate physical health. Chronic Medical Disease and Cognitive Aging discusses current research on the association between a variety of chronic medical diseases and cognition and, where appropriate, promising interventions or accepted treatment strategies. While a cure for many diseases continues to be elusive, insights garnered from the interplay between diseases of the body and mind may help point the way to novel therapeutic strategies to improve cognitive function in late life.

Human Aging and Chronic Disease

Author : Cary Steven Kart
Publisher : Jones & Bartlett Learning
ISBN 13 : 9780867203158
Total Pages : 354 pages
Book Rating : 4.2/5 (31 download)

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Book Synopsis Human Aging and Chronic Disease by : Cary Steven Kart

Download or read book Human Aging and Chronic Disease written by Cary Steven Kart and published by Jones & Bartlett Learning. This book was released on 1992 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Guiding Principles for Developing Dietary Reference Intakes Based on Chronic Disease

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309462568
Total Pages : 335 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Guiding Principles for Developing Dietary Reference Intakes Based on Chronic Disease by : National Academies of Sciences, Engineering, and Medicine

Download or read book Guiding Principles for Developing Dietary Reference Intakes Based on Chronic Disease written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-12-21 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 1938 and 1941, nutrient intake recommendations have been issued to the public in Canada and the United States, respectively. Currently defined as the Dietary Reference Intakes (DRIs), these values are a set of standards established by consensus committees under the National Academies of Sciences, Engineering, and Medicine and used for planning and assessing diets of apparently healthy individuals and groups. In 2015, a multidisciplinary working group sponsored by the Canadian and U.S. government DRI steering committees convened to identify key scientific challenges encountered in the use of chronic disease endpoints to establish DRI values. Their report, Options for Basing Dietary Reference Intakes (DRIs) on Chronic Disease: Report from a Joint US-/Canadian-Sponsored Working Group, outlined and proposed ways to address conceptual and methodological challenges related to the work of future DRI Committees. This report assesses the options presented in the previous report and determines guiding principles for including chronic disease endpoints for food substances that will be used by future National Academies committees in establishing DRIs.

World Report on Ageing and Health

Author : World Health Organization
Publisher : World Health Organization
ISBN 13 : 9241565047
Total Pages : 260 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis World Report on Ageing and Health by : World Health Organization

Download or read book World Report on Ageing and Health written by World Health Organization and published by World Health Organization. This book was released on 2015-10-22 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The WHO World report on ageing and health is not for the book shelf it is a living breathing testament to all older people who have fought for their voice to be heard at all levels of government across disciplines and sectors. - Mr Bjarne Hastrup President International Federation on Ageing and CEO DaneAge This report outlines a framework for action to foster Healthy Ageing built around the new concept of functional ability. This will require a transformation of health systems away from disease based curative models and towards the provision of older-person-centred and integrated care. It will require the development sometimes from nothing of comprehensive systems of long term care. It will require a coordinated response from many other sectors and multiple levels of government. And it will need to draw on better ways of measuring and monitoring the health and functioning of older populations. These actions are likely to be a sound investment in society's future. A future that gives older people the freedom to live lives that previous generations might never have imagined. The World report on ageing and health responds to these challenges by recommending equally profound changes in the way health policies for ageing populations are formulated and services are provided. As the foundation for its recommendations the report looks at what the latest evidence has to say about the ageing process noting that many common perceptions and assumptions about older people are based on outdated stereotypes. The report's recommendations are anchored in the evidence comprehensive and forward-looking yet eminently practical. Throughout examples of experiences from different countries are used to illustrate how specific problems can be addressed through innovation solutions. Topics explored range from strategies to deliver comprehensive and person-centred services to older populations to policies that enable older people to live in comfort and safety to ways to correct the problems and injustices inherent in current systems for long-term care.

Chronic Disease in the Twentieth Century

Author : George Weisz
Publisher : JHU Press
ISBN 13 : 1421413027
Total Pages : 326 pages
Book Rating : 4.4/5 (214 download)

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Book Synopsis Chronic Disease in the Twentieth Century by : George Weisz

Download or read book Chronic Disease in the Twentieth Century written by George Weisz and published by JHU Press. This book was released on 2014-05 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic Disease in the Twentieth Century challenges the conventional wisdom that the concept of chronic disease emerged because medicine's ability to cure infectious disease led to changing patterns of disease. Instead, it suggests, the concept was constructed and has evolved to serve a variety of political and social purposes. How and why the concept developed differently in the United States, an United Kingdom, and France are central concerns of this work. While an international consensus now exists, the different paths taken by these three countries continue to exert profound influence. This book seeks to explain why, among the innumerable problems faced by societies, some problems in some places become viewed as critical public issues that shape health policy. -- from back cover.

Early Vascular Aging (EVA)

Author : Pedro Guimarães Cunha
Publisher : Elsevier
ISBN 13 : 0443155135
Total Pages : 772 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Early Vascular Aging (EVA) by : Pedro Guimarães Cunha

Download or read book Early Vascular Aging (EVA) written by Pedro Guimarães Cunha and published by Elsevier. This book was released on 2024-02-29 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early Vascular Aging (EVA): New Directions in Cardiovascular Protection, Second Edition continues to be the most comprehensive and authoritative resource on premature alterations in artery structure and function. The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. This second edition contains completely updated content with expanded coverage of basic and translational research, systematic reviews of the most prominent literature, discussion of applicability of new evidence and more. Written by an international team of clinicians and researchers, this is a valuable resource to basic and translational scientists, clinical researchers and clinicians in the cardiovascular field interested in prevention, diagnosis and treatment of EVA. - Contains all the relevant information available on the main paradigm shifts in vascular aging research, from different fields of knowledge (from basic biology to epidemiology) - Reviews the most prominent evidence produced on early vascular aging (EVA), highlighting recent research advances, clinical applications, and research opportunities - Formulates, in each chapter, a set of research questions that need to be addressed, challenging the vast research community to take on new directions and collaborations