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The Hsp70 Molecular Chaperone Machines

Author : Matthias P. Mayer
Publisher : Frontiers Media SA
ISBN 13 : 2889451259
Total Pages : 71 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis The Hsp70 Molecular Chaperone Machines by : Matthias P. Mayer

Download or read book The Hsp70 Molecular Chaperone Machines written by Matthias P. Mayer and published by Frontiers Media SA. This book was released on 2017-03-24 with total page 71 pages. Available in PDF, EPUB and Kindle. Book excerpt: Members of the HSP70 family form a central hub of the molecular chaperone network, controlling protein homeostasis in prokaryotes and in the ATP-containing compartments of the eukaryotic cells. The heat-inducible form HSPA1A (HSP70), its constitutive cytosolic cognate HSPA8 (Hsc70), its endoplasmic reticulum form HSPA5 (BiP), and its mitochondrial form HSPA9 (Mortalin), as well as the more distantly related HSPHs (HSP110s), make up 1-2 % of the total mass of proteins in human cells. They use the energy of ATP-hydrolysis to prevent and forcefully revert the process of protein misfolding and aggregation during and following various stresses, presumably by working as unfoldases to lift aberrant conformers out of kinetic traps. As such, HSP70s, in cooperation with their J-domain co-chaperones and nucleotide exchange factors (NEFs) and co-disaggregases, form an efficient network of cellular defenses against the accumulation of cytotoxic misfolded protein conformers, which may cause degenerative diseases such as Parkinson's and Alzheimer's disease, diabetes, and aging in general. In addition to their function in repair of stress-induced damage, HSP70s fulfill many housekeeping functions, including assisting the de novo folding and maturation of proteins, driving the translocation of protein precursors across narrow membrane pores into organelles, and by controlling the oligomeric state of key regulator protein complexes involved in signal transduction and vesicular trafficking. For reasons not well understood, HSP70s are also found on the surface of some animal cells, in particular cancer cells where they may serve as specific targets for cancer immunotherapy. Here, we gathered seven mini reviews, each presenting a complementary aspect of HSP70’s structure and function in bacteria and eukaryotes, under physiological and stressful conditions. These articles highlight how, the various members of this conserved family of molecular chaperones, assisted by their various J-domain and NEF cochaperones and co-disaggregases, harness ATP hydrolysis to perform a great diversity of life-sustaining cellular functions using a similar molecular mechanism.

HSP70 in Human Diseases and Disorders

Author : Alexzander A. A. Asea
Publisher : Springer
ISBN 13 : 3319895516
Total Pages : 403 pages
Book Rating : 4.3/5 (198 download)

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Book Synopsis HSP70 in Human Diseases and Disorders by : Alexzander A. A. Asea

Download or read book HSP70 in Human Diseases and Disorders written by Alexzander A. A. Asea and published by Springer. This book was released on 2018-06-26 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book HSP70 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP70 family - one of the most studied HSP - in human diseases and disorders. Using an integrative approach to expand our current understanding of HSP70 functions, the contributors provide a synopsis of novel mechanisms by which HSP70 is involved in the regulation of human diseases and disorders. Key basic and clinical research laboratories from major universities and academic medical hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for medical students and residents, clinical and basic science researchers, postdoctoral fellows and graduate students in the fields of Medicine, Physiology, Clinical Trials, Biotechnology, Molecular Medicine and Pathology.

Molecular Chaperones in the Cell

Author : Peter A. Lund
Publisher : Oxford University Press, USA
ISBN 13 : 9780199638673
Total Pages : 308 pages
Book Rating : 4.6/5 (386 download)

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Book Synopsis Molecular Chaperones in the Cell by : Peter A. Lund

Download or read book Molecular Chaperones in the Cell written by Peter A. Lund and published by Oxford University Press, USA. This book was released on 2001 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this text, leading experts synthesise our body of knowledge , and the reader gains not only a fuller understanding of the roles of chaperones in the context of cellular processes, but also an insight into the nature of these proteins.

HSF1 and Molecular Chaperones in Biology and Cancer

Author : Marc Laurence Mendillo
Publisher : Springer Nature
ISBN 13 : 3030402045
Total Pages : 185 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis HSF1 and Molecular Chaperones in Biology and Cancer by : Marc Laurence Mendillo

Download or read book HSF1 and Molecular Chaperones in Biology and Cancer written by Marc Laurence Mendillo and published by Springer Nature. This book was released on 2020-04-15 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Guidebook to Molecular Chaperones and Protein-Folding Catalysts

Author : Mary-Jane Gething
Publisher : OUP Oxford
ISBN 13 : 0191547271
Total Pages : 586 pages
Book Rating : 4.1/5 (915 download)

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Book Synopsis Guidebook to Molecular Chaperones and Protein-Folding Catalysts by : Mary-Jane Gething

Download or read book Guidebook to Molecular Chaperones and Protein-Folding Catalysts written by Mary-Jane Gething and published by OUP Oxford. This book was released on 1997-11-27 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: The precise shape of a protein is a crucial factor in its function. How do proteins become folded into the right conformation? Molecular chaperones and protein folding catalysts bind to developing polypeptides in the cytoplasm and ensure correct folding and transport. This Guidebook catalogues the latest information on nearly 200 of these molecules, including the important class of heat shock proteins; each entry is written by leading researchers in the field.

Reproductive Toxicology

Author : Jesús del Mazo
Publisher : Springer Science & Business Media
ISBN 13 : 1489900896
Total Pages : 221 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Reproductive Toxicology by : Jesús del Mazo

Download or read book Reproductive Toxicology written by Jesús del Mazo and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous reports demonstrate that the reproductive system could be affected by multiple potential toxicological agents. The volume includes different aspects of the development of new approaches to in vitro testing using sperm cells and systems involved on reproduction in mammals. Comparative analysis of in vivo and in vitro methods has been included to take steps towards the further development of and applications of new systems for germline toxicology.

Molecular Mechanisms and Genetics of Plant Resistance to Abiotic Stress

Author : Jill M. Farrant
Publisher : MDPI
ISBN 13 : 3039281224
Total Pages : 152 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Molecular Mechanisms and Genetics of Plant Resistance to Abiotic Stress by : Jill M. Farrant

Download or read book Molecular Mechanisms and Genetics of Plant Resistance to Abiotic Stress written by Jill M. Farrant and published by MDPI. This book was released on 2020-03-05 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: We are currently experiencing a climate crisis that is associated with extreme weather events worldwide. Some of its most noticeable effects are increases in temperatures, droughts, and desertification. These effects are already making whole regions unsuitable for agriculture. Therefore, we urgently need global measures to mitigate the effects of climate breakdown as well as crop alternatives that are more stress-resilient. These crop alternatives can come from breeding new varieties of well-established crops, such as wheat and barley. They can also come from promoting underutilized crop species that are naturally tolerant to some stresses, such as quinoa. Either way, we need to gather more knowledge on how plants respond to stresses related to climate breakdown, such as heat, water-deficit, flooding high salinity, nitrogen, and heavy metal stress. This Special Issue provides a timely collection of recent advances in the understanding of plant responses to these stresses. This information will definitely be useful to the design of new strategies to prevent the loss of more cultivable land and to reclaim the land that has already been declared unsuitable.

International Review of Cell and Molecular Biology

Author : Kwang W. Jeon
Publisher : Academic Press
ISBN 13 : 0123812518
Total Pages : 205 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis International Review of Cell and Molecular Biology by : Kwang W. Jeon

Download or read book International Review of Cell and Molecular Biology written by Kwang W. Jeon and published by Academic Press. This book was released on 2010-10-27 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Impact factor for 2008: 4.935. Authored by some of the foremost scientists in the field Provides up-to-date information and directions for future research Valuable reference material for advanced undergraduates, graduate students and professional scientists

International Review of Cytology

Author :
Publisher : Academic Press
ISBN 13 : 9780080857176
Total Pages : 337 pages
Book Rating : 4.8/5 (571 download)

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Book Synopsis International Review of Cytology by :

Download or read book International Review of Cytology written by and published by Academic Press. This book was released on 1997-11-17 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Karyotypic Evolution of Cells in Culture Sucrose Transport in Higher Plants Interaction of Cytoskeletal Proteins with membrane Lipids The Cell Biology of Autoimmune Diseases Multiple Forms of Tubulin: Different Gene Products and Covalent Modifications Translocation of Proteins across the ER Membrane

Advances in Plant Defense Mechanisms

Author : Josphert N. Kimatu
Publisher : BoD – Books on Demand
ISBN 13 : 1803558016
Total Pages : 372 pages
Book Rating : 4.8/5 (35 download)

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Book Synopsis Advances in Plant Defense Mechanisms by : Josphert N. Kimatu

Download or read book Advances in Plant Defense Mechanisms written by Josphert N. Kimatu and published by BoD – Books on Demand. This book was released on 2022-12-14 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Increasing human migrations, technological advances, agricultural activities, and climate change are forcing plants to adapt to new environments. This book highlights current morphological, anatomical, physiological, molecular, and genomic advances in plant defense mechanisms. These advances, including epigenetic mechanisms, have been linked to observed phenotypic plant plasticity. The book also outlines next-generation food systems, considering the resilience and sustainability of plant genomes and epigenomes.

Heat Shock Proteins in Signaling Pathways

Author : Alexzander A. A. Asea
Publisher : Springer
ISBN 13 : 3030039528
Total Pages : 482 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Heat Shock Proteins in Signaling Pathways by : Alexzander A. A. Asea

Download or read book Heat Shock Proteins in Signaling Pathways written by Alexzander A. A. Asea and published by Springer. This book was released on 2019-07-09 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signaling pathways is a comprehensive mechanism by which all cellular organisms communicate internally and externally with their microenvironment. This is a highly complex and exact process. Errors in signaling pathways and in the processing of cellular information are known to be responsible for the majority of diseases including cancer, inflammatory and neurological disorders. Knowledge gained from the better understanding of signaling pathways will help in elucidating disease processes and will assist in development and design of novel targeted treatment therapies to combat human diseases and disorders. Heat shock proteins (HSP) are uniquely involved in a number of critical signaling pathways. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Ferroptosis in Health and Disease

Author : Daolin Tang
Publisher : Springer Nature
ISBN 13 : 3030267806
Total Pages : 320 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Ferroptosis in Health and Disease by : Daolin Tang

Download or read book Ferroptosis in Health and Disease written by Daolin Tang and published by Springer Nature. This book was released on 2019-10-10 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book sheds new light on ferroptosis, as an only recently recognised form of regulated cell death. Its respective chapters address the numerous implications that ferroptosis can have for virtually all aspects of metabolism. They also share insights on the morphological characterisation of ferroptosis and highlight the different pathways of induction. Accordingly, the book offers a unique perspective on a mechanism that is involved in a multitude of pathologies, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, tissue ischemia/reperfusion injury, and T cell immunity. Readers will learn in which cell types this form of regulated cell death is likely to occur, and how it can be pharmacologically influenced, making the book a fascinating and informative read not only for scientists working in cell biology, but also for clinicians in the field of cancer research.

Changing Views on Living Organisms

Author : Christian Neri
Publisher : Bentham Science Publishers
ISBN 13 : 1608051293
Total Pages : 541 pages
Book Rating : 4.6/5 (8 download)

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Book Synopsis Changing Views on Living Organisms by : Christian Neri

Download or read book Changing Views on Living Organisms written by Christian Neri and published by Bentham Science Publishers. This book was released on 2013-04-03 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome science or genomics is essential to advancing knowledge in the fields of biology and medicine. Specifically, researchers learn about the molecular biology behind genetic expression in living organisms and related methods of treating human genetic diseases (including gene therapy). Advances in Genome Science is an e-book series which provides a multi-disciplinary view of some of the latest developments in genome research, allowing readers to capture the essentiality and diversity of genomics in contemporary science.

Reviews of Physiology, Biochemistry and Pharmacology 153

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3540273638
Total Pages : 115 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis Reviews of Physiology, Biochemistry and Pharmacology 153 by :

Download or read book Reviews of Physiology, Biochemistry and Pharmacology 153 written by and published by Springer Science & Business Media. This book was released on 2007-05-02 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers individual discussions of cell functions as they relate to physiology, biochemistry, or pharmacology. Topics covered include molecular mechanisms in membrane polarity, pharmacological properties of cerium compounds, and recruitment of Hsp70 chaperones.

Cellular Trafficking of Cell Stress Proteins in Health and Disease

Author : Brian Henderson
Publisher : Springer Science & Business Media
ISBN 13 : 9400747403
Total Pages : 300 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Cellular Trafficking of Cell Stress Proteins in Health and Disease by : Brian Henderson

Download or read book Cellular Trafficking of Cell Stress Proteins in Health and Disease written by Brian Henderson and published by Springer Science & Business Media. This book was released on 2012-11-19 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular chaperones from cells. In bacteria, molecular chaperones are involved in the trafficking of other proteins and are themselves released into the external milieu. The increasing appreciation of the role of molecular chaperones and Protein-Folding Catalysts in the interplay between bacteria and the cells of their hosts is now an important area of research for understanding the mechanisms of infectious diseases. This volume brings together experts in the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts with a focus on the mechanisms of cellular trafficking of these proteins and the role of these variegated trafficking mechanisms in both human and animal health and disease.

Inhibitors of Molecular Chaperones as Therapeutic Agents

Author : Timothy D. Machajewski
Publisher : Royal Society of Chemistry
ISBN 13 : 1849736669
Total Pages : 443 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Inhibitors of Molecular Chaperones as Therapeutic Agents by : Timothy D. Machajewski

Download or read book Inhibitors of Molecular Chaperones as Therapeutic Agents written by Timothy D. Machajewski and published by Royal Society of Chemistry. This book was released on 2014 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad interest among researchers in the field of molecular chaperone pharmaceutical research, oncology research, and medicinal chemistry. Arranged into three main sections the book covers structure and function, small molecule inhibitors and concludes with a section discussing clinical perspectives. With specific chapters covering the discovery of key molecules such as, BIIB028, STA-9090, Serenex Hsp90 inhibitor, NVP-AUY922 and NVP-HSP990, this comprehensive text will be an essential treatise for researchers working in academia and industry.

Regulation of Heat Shock Protein Responses

Author : Alexzander A A Asea
Publisher : Springer
ISBN 13 : 3319747150
Total Pages : 472 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Regulation of Heat Shock Protein Responses by : Alexzander A A Asea

Download or read book Regulation of Heat Shock Protein Responses written by Alexzander A A Asea and published by Springer. This book was released on 2018-05-01 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This books provides the most up-to-date reviews on current advances in our understanding of the regulation of heat shock protein responses. Key basic scientists and clinical research laboratories from major universities, academic medical centers and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into four sections, including, Section I - HSP and Stress Responses; Section II - Chaperone Functions of HSP; Section III - HSP in Human Diseases; Section IV - Prognosis & Diagnosis of HSP. The book is a must read for researchers involved in biomedical research, drug discovery and design to improve human health.