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Hormone Replacement Therapy And Breast Cancer
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Book Synopsis The Controversy over Hormone Replacement Therapy: Evaluating Related Risk of Breast Cancer and Other Diseases by :
Download or read book The Controversy over Hormone Replacement Therapy: Evaluating Related Risk of Breast Cancer and Other Diseases written by and published by Am Cncl on Science, Health. This book was released on with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Hormone Replacement: Therapy and Breast Cancer Risk by : R.D. Mann
Download or read book Hormone Replacement: Therapy and Breast Cancer Risk written by R.D. Mann and published by CRC Press. This book was released on 1992-07-15 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers a topic of considerable current interest and presents many of the most significant research findings available to date. Workers at the forefront of research on hormone replacement therapy and the implications for the risk of breast cancer were invited to attend a special Conference at the Royal Society of Medicine in London in September, 1991, where the latest data were presented to a distinguished audience and the implications of this research were discussed. The volume reviews various aspects of HRT and breast cancer, the physiology of the menopause, the current use of HRT in practice, osteoporosis and epidemiology and presents results from a range of European, American and Australian studies on the role of breast cancer and HRT, finishing with an overview of benefits, use and cost-effectiveness and a general summary. The book represents a definitive statement of current knowledge in this field and an informative update on the implications of recent research. It will be a valuable addition of special significance to the libraries of all those concerned with hormone replacement therapy and the study of breast cancer.
Download or read book Estrogen Matters written by Carol Tavris and published by Hachette UK. This book was released on 2018-09-04 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: A compelling, “fascinating” (Robert Cialdini) defense of hormone replacement therapy, exposing the faulty science behind its fall from prominence and giving women the evidence they need to make informed decisions about their health. Now fully revised and updated. "Estrogen Matters was my antidote to the misinformation surrounding menopause. This book should be the bible for every single person going through menopause.”―Naomi Watts For years, hormone replacement therapy (HRT) was the medically approved way to alleviate menopausal symptoms (ranging from hot flushes to brain fog) and reduce the risk of heart disease, Alzheimer's, and osteoporosis. But when a large study by the Women's Health Initiative (WHI) announced, with national fanfare, that women taking HRT had an increased risk of breast cancer, women were scared off, and the treatment was abandoned. Now, Dr. Bluming, a medical oncologist, and Dr. Tavris, a social psychologist, reveal the true story of the WHI’s efforts to distort their data to exaggerate unsupported claims of estrogen’s harms. Important updates in this edition include: Evidence that demolishes the WHI’s claim that HRT causes breast cancer. A list of the WHI’s retractions of their original scare stories. Updated findings on estrogen’s benefits on heart, brain, bones, and longevity. A critical review of the alternative products and medications being marketed to treat symptoms of menopause. A sobering and revelatory read, Estrogen Matters sets the record straight on estrogen’s benefits, providing a light to guide women through this inevitable phase of life.
Book Synopsis The Controversy over Hormone Replacement Therapy by :
Download or read book The Controversy over Hormone Replacement Therapy written by and published by Am Cncl on Science, Health. This book was released on with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis International Differences in Mortality at Older Ages by : National Research Council
Download or read book International Differences in Mortality at Older Ages written by National Research Council and published by National Academies Press. This book was released on 2011-02-27 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1950 men and women in the United States had a combined life expectancy of 68.9 years, the 12th highest life expectancy at birth in the world. Today, life expectancy is up to 79.2 years, yet the country is now 28th on the list, behind the United Kingdom, Korea, Canada, and France, among others. The United States does have higher rates of infant mortality and violent deaths than in other developed countries, but these factors do not fully account for the country's relatively poor ranking in life expectancy. International Differences in Mortality at Older Ages: Dimensions and Sources examines patterns in international differences in life expectancy above age 50 and assesses the evidence and arguments that have been advanced to explain the poor position of the United States relative to other countries. The papers in this deeply researched volume identify gaps in measurement, data, theory, and research design and pinpoint areas for future high-priority research in this area. In addition to examining the differences in mortality around the world, the papers in International Differences in Mortality at Older Ages look at health factors and life-style choices commonly believed to contribute to the observed international differences in life expectancy. They also identify strategic opportunities for health-related interventions. This book offers a wide variety of disciplinary and scholarly perspectives to the study of mortality, and it offers in-depth analyses that can serve health professionals, policy makers, statisticians, and researchers.
Book Synopsis Menopause and Hormone Replacement by : Hilary O. D. Critchley
Download or read book Menopause and Hormone Replacement written by Hilary O. D. Critchley and published by . This book was released on 2004 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The New Testosterone Treatment by : Edward Friedman
Download or read book The New Testosterone Treatment written by Edward Friedman and published by Rowman & Littlefield. This book was released on 2023-12-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the leading authority on hormone receptors and prostate cancer, this book reveals the surprising truth about how you can prevent and treat breast cancer, prostate cancer, and Alzheimer's with testosterone and other FDA-approved drugs.For decades, doctors have sought to combat prostate cancer under the mistaken assumption that testosterone fueled its growth. But the latest research into the nature of hormone receptors and therapies using bioidentical instead of synthetic hormones have caused a shift in thinking and new hope for treating this cancer with testosterone. Today the medical profession equates a diagnosis of Alzheimer's with a death sentence. In fact, the only thing doctors do is throw ineffective drugs at it and resign themselves to failure. For the first time, this book explains how testosterone can halt the disease and cure early-stage Alzheimer's. Similar breakthroughs for fighting breast cancer follow close on the heels of these revelations, outlining how the avoidance of synthetic progestins and the use of aromatase inhibitors are crucial tools in prevention and treatment. At the core of this book is the remarkable observation that we experience our highest hormone levels during our teen years--a time of life when there is no breast cancer, prostate cancer, or Alzheimer's. Could bringing hormones back to teen levels be the key to vibrant good health? The answer is a resounding yes. This thoroughly researched guide to the latest biomedical research is must-reading for medical professionals and anyone concerned about their health.
Book Synopsis Hormone Replacement Therapy and Cancer by : Andrea R. Genazzani
Download or read book Hormone Replacement Therapy and Cancer written by Andrea R. Genazzani and published by CRC Press. This book was released on 2020-07-26 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The clinical benefits of hormone replacement therapy in women have to be carefully balanced against the possible risks, and a particular theoretical concern relates to risks associated with various forms of female oncology. Because of conflicting reports, gynecologists and oncologists especially need a single, authoritative resource of up-to-date information. Hormone Replacement Therapy and Cancer, published in association with the International Menopause Society, provides the very consensus statement that clinicians need in this difficult and complex area. Many of the world's leading specialists have contributed important chapters that provide state-of-the-art knowledge about the effects of hormones on women and possible cancer risks. The introductory section deals with carcinogenesis, and the other main sections cover HRT and breast cancer, endometrial cancer, colon cancer, melanoma and epithelial ovarian cancer. The concluding chapters discuss the benefits and risks of sp ecific therapies. An authoritative clinical reference with extensive bibliographic references and index, Hormone Replacement Therapy and Cancer covers all aspects of HRT and cancer based on the research available up to June 2001.
Book Synopsis Hormone Replacement Therapy and Breast Cancer by : Linda L. Humphrey
Download or read book Hormone Replacement Therapy and Breast Cancer written by Linda L. Humphrey and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: OBJECTIVE: To evaluate and update the prior review evaluating the risk of breast cancer and breast cancer (BCA) death associated with the use of postmenopausal hormone replacement therapy (HRT) by reviewing the medical literature which has been published since the last US Preventive Services Task Force update. DATA SOURCE: All English language studies identified in the Medline database from 1992-2000 and all previously published meta-analyses. In addition, reference lists of key articles, letters, and editorials were reviewed for all related studies, including those pre-dating the database search. STUDY SELECTION: All studies that evaluated breast cancer incidence or mortality as a primary or secondary outcome in association with hormone replacement therapy published between 1992-2000. Studies evaluating the effect of hormone replacement therapy on breast density were also reviewed. DATA EXTRACTION: The following studies met inclusion criteria: 8 meta-analyses from the years 1988-1997, 1 nested case-control study, 14 case-control studies, and 15 cohort studies all evaluating breast cancer incidence, mortality, or both. Of the 15 cohort studies, 10 represented unique cohorts and of the 14 case control studies, 2 involved updates of the same case set. Data from each study were abstracted to prepared forms. When more than one study from the same population was reported, data from the most recent publication were reviewed. If data from the same population were analyzed by cohort and by case-control analysis, both results were reported if they evaluated different outcomes. In addition, several studies evaluating breast density and HRT were reviewed, and the best studies summarized. DATA SYNTHESIS: For ever or short-term use of estrogen, 7 of the 8 meta-analyses, 8 of the 11 case-control studies, and 6 of the 7 cohort studies evaluating incidence showed no increase in breast cancer with hormone replacement therapy. Of the original studies reviewed evaluating incidence, 12 of 19 showed no increased risk of breast cancer with long duration ERT or HRT use. However, 5 of the meta-analyses showed increased risk with duration over 5 years and 2 important cohort studies showed increased risk with longer duration use. Eleven original studies evaluated combined estrogen and progestin, and one showed increased risk of BCA with short-term use; 3 of the 5 evaluating duration with combined therapy showed increased risk that was statistically significant. Current use of ERT was associated with significantly increased risk of breast cancer in two of the best cohort studies; use of combined therapy was associated with increased risk in 3 studies. Six recent cohort studies (1992-2000) evaluated breast cancer mortality in association with hormone use: 1 showed increased risk of death, 4 showed decreased risk of death, and one showed no association. Several recent studies show that post-menopausal estrogen therapy is associated with increased breast density by mammography and that adding progesterone to estrogen results in even greater increases in breast density. Finally, there is evidence suggesting an important interaction between HRT and alcohol use and HRT and lower body weight. CONCLUSIONS: The association of short-term hormone replacement therapy with the development of breast cancer is uncertain based on multiple studies with inconsistent findings. Among studies indicating increased risk, the risk is largely confined to current and long-term use (>5-10 years), and the risk is relatively small (RR 1.2-1.5). Reduced mortality is a fairly consistent finding among the studies evaluating breast cancer mortality and HRT use. The addition of progesterone to estrogen and current, as well as long-term, use may be associated with breast cancer risk above that of estrogen itself. Although the biological plausibility of an association between postmenopausal hormone use and breast cancer is high, the studies showing risk or benefit from the use of post-menopausal hormones are limited by the observational nature of the epidemiologic data existing to date. Data from randomized controlled trials are needed to validly evaluate the relationship.
Book Synopsis Estrogen and Breast Cancer by : Carol Ann Rinzler
Download or read book Estrogen and Breast Cancer written by Carol Ann Rinzler and published by Hunter House. This book was released on 1996 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: A cautionary tale about American medicine's experimentation with female hormones, this balanced book chronicles the 60-year attempt to "cure" menopause with estrogen and the 40-year history of chemical contraception, weighing the pros and cons of estrogen use and allowing women to make informed decisions about their bodies.
Author :U. S. Department of Health and Human Services Publisher :CreateSpace ISBN 13 :9781490565552 Total Pages :132 pages Book Rating :4.5/5 (655 download)
Book Synopsis Hormone Replacement Therapy and Breast Cancer by : U. S. Department of Health and Human Services
Download or read book Hormone Replacement Therapy and Breast Cancer written by U. S. Department of Health and Human Services and published by CreateSpace. This book was released on 2013-06-28 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this systematic evidence review, we evaluate data on the relationship between the use of postmenopausal hormone replacement therapy (HRT) and the risk of breast cancer (BCA). The context of this review is in the overall evaluation of postmenopausal hormone replacement therapy as chemoprophylaxis for chronic conditions. The results from this report will be used as part of an overall report on the risks and benefits of hormone replacement therapy for postmenopausal women. Hormone replacement therapy is used in the United States and worldwide to treat symptoms of menopause and to prevent chronic conditions such as osteoporosis. It is one of the most commonly prescribed drugs in the U.S.; a recent survey in the U.S. of postmenopausal women ages 50 to 75 showed that nearly 38% of women were currently using estrogen or hormone replacement therapy (58.7% of those with prior hysterectomy and 19.6% without hysterectomy). A major and as yet unanswered clinical question is whether hormone replacement therapy increases a woman's risk of breast cancer. This issue is a critical one because the use of HRT is prevalent and because breast cancer is a relatively common disease, so that even a small increase in breast cancer in association with hormone use could significantly influence public health. The importance of endogenous estrogen in the development of breast cancer has been evaluated and confirmed in multiple studies of differing methodologies. Studies in animals have shown that breast cancer can be induced by the administration of estrogen. Among humans, some studies have shown that women with increased levels of circulating estrogen are at higher risk for the subsequent development of breast cancer. Other studies have had conflicting findings, and some have shown this relationship in postmenopausal women only. Reproductive events are important risk factors for breast cancer. Those shown to increase risk include early menarche and late menopause, both of which prolong exposure to higher levels of estrogen as well as other reproductive hormones. Other reproductive experiences, such as late age at first pregnancy and nulliparity, increase breast cancer risk. Oopherectomy among premenopausal women is protective against breast cancer, possibly because of reduced exposure to estrogen. Other risk factors also suggest an important role for estrogen in BCA development. In postmenopausal women, obesity, which correlates with increased estrogen levels, is also associated with an increased risk of BCA. Recent studies have also shown that increased bone density, possibly a reflection of lifetime estrogen exposure, is associated with increased rates of breast cancer. Finally, age-adjusted rates of increase in breast cancer incidence slow at menopause when estrogen levels fall. There are several critical key questions to consider when evaluating the research describing the role of exogenous estrogen or estrogen/progesterone in breast cancer development and prognosis. First, is either estrogen alone or estrogen with progesterone associated with a change in breast cancer mortality? Second, does short-term estrogen use increase the risk of breast cancer? The third question, which is most relevant to the use of estrogen to prevent chronic conditions, is whether long-term estrogen increases breast cancer risk. The fourth question, which reflects the current standard of practice, is whether the combination of estrogen and progesterone, either short-term or long-term, increases the risk of breast cancer. Fifth, is current use of estrogen or hormone replacement therapy associated with increased risk of breast cancer? Sixth, are there subpopulations of women who might be at increased risk of breast cancer when using HRT? Finally, because increased breast mammographic density is independently associated with an increase in breast cancer risk, as well as with decreased accuracy of mammography, does estrogen or estrogen/progestins change breast density?
Book Synopsis HRT (hormone Replacement Therapy) and Breast Cancer by : Action Breast Cancer
Download or read book HRT (hormone Replacement Therapy) and Breast Cancer written by Action Breast Cancer and published by . This book was released on 2004 with total page 4 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :IARC Working Group on the Evaluation of Carcinogenic Risks to Humans Publisher :World Health Organization ISBN 13 : Total Pages :692 pages Book Rating :4.3/5 (91 download)
Book Synopsis Hormonal Contraception and Post-menopausal Hormonal Therapy by : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Download or read book Hormonal Contraception and Post-menopausal Hormonal Therapy written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by World Health Organization. This book was released on 1999 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evaluates evidence for an increased risk of cancer in women using combined oral contraceptives, progestogen-only hormonal contraceptives, post-menopausal estrogen therapy, and post-menopausal estrogen-progestogen therapy. Although the carcinogenicity of these preparations has been extensively investigated, the book stresses the many complex methodological issues that must be considered when interpreting findings and weighing results. Evidence of an association between use of these preparations and positive effects on health, including a reduced risk of some cancers, is also critically assessed. The first and most extensive monograph evaluates evidence of an association between the use of combined oral contraceptives and cancer at nine sites. Concerning breast cancer, the evaluation concludes that, even if the association is causal, the excess risk for breast cancer associated with patterns of use that are typical today is very small. Studies of predominantly high-dose preparations found an increased risk of hepatocellular carcinoma in the absence of hepatitis viruses. Citing these findings, the evaluation concludes that there is sufficient evidence in humans for the carcinogenicity of combined oral contraceptives. The evaluation also found sufficient evidence for the carcinogenicity of some, but not all, combined preparations in animals. Combined oral contraceptives were classified as carcinogenic to humans. The evaluation also cites conclusive evidence that these agents have a protective effect against cancers of the ovary and endometrium. Progestogen-only contraceptives are evaluated in the second monograph, which considers the association with cancer at six sites. The evaluation found no evidence of an increased risk for breast cancer. Although the evaluation found sufficient evidence in animals for the carcinogenicity of medroxyprogesterone acetate, evidence for the carcinogenicity of progestogen-only contraceptives in humans was judged inadequate. Progestogen-only contraceptives were classified as possibly carcinogenic to humans. The third monograph, on post-menopausal estrogen therapy, considers evidence of an association with cancer at eight sites. Findings from a large number of epidemiological studies indicate a small increase in the risk of breast cancer in women who have used these preparations for five years or more. Studies consistently show an association between use of post-menopausal estrogen therapy and an increased risk for endometrial cancer. Data on the association with other cancers were either inconclusive or suggested no effect on risk. The evaluation concludes that post-menopausal estrogen therapy is carcinogenic to humans. The final monograph evaluates the association between the use of post-menopausal estrogen-progestogen therapy and cancer at four sites. The evaluation of limited data on breast cancer found an increased relative risk observed with long-term use. Data were judged insufficient to assess the effects of past use and of different progestogen compounds, doses, and treatment schedules. For endometrial cancer, the evaluation found an increase in risk relative to non-users when the progestogen was added to the cycle for 10 days or fewer. Post-menopausal estrogen-progestogen therapy was classified as possibly carcinogenic to humans. Concerning post-menopausal therapy in general, the book notes that evidence of carcinogenic risks must be placed in perspective of potential benefits. The prevention of osteoporotic fractures is cited as the best-established benefit. Evidence also suggests that estrogen prevents heart disease and may prevent memory loss and dementia.
Book Synopsis Hormone Therapy and Replacement in Cancer and Aging-related Diseases by : Letícia Rangel
Download or read book Hormone Therapy and Replacement in Cancer and Aging-related Diseases written by Letícia Rangel and published by BoD – Books on Demand. This book was released on 2020-07-22 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume, Hormone Therapy and Replacement in Cancer and Aging-related Diseases, is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of hormone replacement therapy. The book comprises single chapters authored by various researchers and edited by experts active in the hormone replacement therapy research area. All chapters are complete in themselves but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on hormone replacement therapy, and opens new possible research paths for further novel developments.
Book Synopsis Hormone Replacement Therapy and Breast Cancer by : Farhana Zaman
Download or read book Hormone Replacement Therapy and Breast Cancer written by Farhana Zaman and published by LAP Lambert Academic Publishing. This book was released on 2012 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: Worldwide, breast cancer is the fifth most common cause of cancer death Among women in the USA breast cancer is the second-most common cause of cancer death. In Bangladesh breast cancer causes death to over 22,000 women every year and out of them 15,000 without any treatment. In Bangladesh, it is difficult to know the actual number of women who died of breast cancer. It is estimated that, about 17% of the women suffering from cancer are breast cancer suffers. WHO warned that cancer cases would be doubled in the developing countries and bound to jump by 40% in the developed countries by 2020. There is good evidence that use of estrogen and progesterone (HRT) increase the risk of breast cancer. Mostly, it is prescribed to women who have lost their uterus, due to surgical menopause or menopause to prevent the overgrowth of uterine lining. HRT can stimulate breast cell to proliferate . Proliferating cells are more likely to develop the genetic damage that leads to breast cancer. Regular breast cancer screening is essential for all women, especially those who decide to use HRT. Screening includes a combination of breast self exam, annual breast exam and annual mammogram.
Book Synopsis Feminine Forever by : Robert A. Wilson
Download or read book Feminine Forever written by Robert A. Wilson and published by . This book was released on 2000-07 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis An Assessment of the NIH Women's Health Initiative by : Institute of Medicine
Download or read book An Assessment of the NIH Women's Health Initiative written by Institute of Medicine and published by National Academies Press. This book was released on 1993-02-01 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Institutes of Health Women's Health Initiative (WHI) is the largest research study ever funded by NIH ($625 million over 14 years) and is designed to test strategies to prevent cardiovascular disease, breast cancer, and osteoporotic fracturesâ€"leading causes of death, disability, and decreased quality of life for older women. Although the WHI has already begun, serious questions remain about its design, cost, and the likelihood that it can answer the questions it asks. This book evaluates whether the effort can be justified scientifically.
