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Author : Frank Stanley Czerwiec
Publisher :
ISBN 13 :
Total Pages : 362 pages
Book Rating : 4.:/5 (261 download)
Download or read book Hormonal Influences on Gene Expression written by Frank Stanley Czerwiec and published by . This book was released on 1990 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309072964
Total Pages : 225 pages
Book Rating : 4.3/5 (9 download)
Download or read book New Horizons in Health written by National Research Council and published by National Academies Press. This book was released on 2001-03-09 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Horizons in Health discusses how the National Institutes of Health (NIH) can integrate research in the social, behavioral, and biomedical sciences to better understand the causes of disease as well as interventions that promote health. It outlines a set of research priorities for consideration by the Office of Behavioral and Social Sciences Research (OBSSR), with particular attention to research that can support and complement the work of the National Institutes of Health. By addressing the range of interactions among social settings, behavioral patterns, and important health concerns, it highlights areas of scientific opportunity where significant investment is most likely to improve nationalâ€"and globalâ€"health outcomes. These opportunities will apply the knowledge and methods of the behavioral and social sciences to contemporary health needs, and give attention to the chief health concerns of the general public.
Author : A.K. Roy
Publisher : Springer Science & Business Media
ISBN 13 : 1461254825
Total Pages : 345 pages
Book Rating : 4.4/5 (612 download)
Download or read book Gene Regulation by Steroid Hormones II written by A.K. Roy and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Receptors and Gene Expression It is now more than three years since the last Meadow Brook Conference on Hormones, and a great deal has happened in the meantime. We have become comfortable with the totally unanticipated fact that the coding sequences of genes are in discontinuous arrangements and that the RNA transcribed from them must be extensively processed to form messenger RNA. We have also learned about the strategy of "mixing and matching" of genetic segments so that a small amount of DNA can go a long way in producing a huge variety of different proteins, as in the immunoglobulin system. The explosive effort directed toward DNA sequence analysis has led us to the conclusion that there are signals within the DNA that specify sites of transcription initiation and possibly sites for interacting with regulatory molecules such as hor mones and their receptors. The current intense interest in the structure of chromatin beyond the nucleosome-that is, the superstructural characteris tics of the genetic material-is finally yielding meaningful results that give promise for understanding the regulation of gene activity. ROBERT F. GOLDBERGER Preface Research on the molecular mechanism of steroid hormone action continues at an extraordinary pace and a great deal of progress has been made. Steroid hormones have been localized on target genes providing the long awaited evidence for the concept of a direct effect of the steroid-receptor complex on gene regulation. Purified steroid receptors have been dissected to identify different functional domains.
Author : Kenneth McKerns
Publisher : Springer Science & Business Media
ISBN 13 : 1468444182
Total Pages : 350 pages
Book Rating : 4.4/5 (684 download)
Download or read book Regulation of Gene Expression by Hormones written by Kenneth McKerns and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Foundation for Biochemical Endocrinology is incorporated as a nonprofit research and educational organization. It is dedicated to the dissemination of knowledge, cooperative research programs, and cultural interaction on an international basis. The Foundation is concerned with both basic research and practical applications of biological knowledge to the betterment of humanity. Among our interests are global resource management, human reproduction, hormonal regulation of normal and cancer cells, study of aging and degenerative diseases, brain peptides, peptide neurotransmitter compounds, mechanism of action of hormones, peptide hormone synthesis, and recombinant DNA techniques. This monograph is the ninth sponsored by the Foundation in the Biochemical Endocrinology series. The previous four have been: Hormonally Active Brain Peptides: Structure and Function (1982), K. W. McKerns and V. Pantie, eds.; Reproductive Processes and Contraception (1981), K. W. McKerns, ed.; Synthesis and Release of Adenohypophyseal Hormones (1980), M. Jutisz and K. W. McKerns, eds.; and Structure and Function of the Gonadotropins (1978), K. W. McKerns, ed. These have all been published by Plenum Press.
Author : Subhrangsu S. Mandal
Publisher : John Wiley & Sons
ISBN 13 : 3527697241
Total Pages : 688 pages
Book Rating : 4.5/5 (276 download)
Download or read book Gene Regulation, Epigenetics and Hormone Signaling written by Subhrangsu S. Mandal and published by John Wiley & Sons. This book was released on 2017-05-09 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Das erste Referenzwerk dieser Art mit einer umfassenden und dennoch prägnanten Einführung in die Epigenetik beschäftigt sich mit den unzähligen Interaktionen zwischen Hormonregulation und Epigenetik. Die Inhalte sind gut strukturiert. Es gibt keine Überschneidungen zwischen den Kapiteln und jedes Kapitel beinhaltet Zusatzmaterialien für Präsentationen. Der Schwerpunkt liegt durchgängig auf Erkrankungen. Zielgruppe sind die vielen Physiologen und Entwicklungsbiologen, die zwar mit der Bedeutung und den Mechanismen der Hormonregulation vertraut sind, aber über unzureichendes Hintergrundwissen im Bereich Epigenetik verfügen.
Author : Bert W. O'Malley
Publisher : Elsevier
ISBN 13 : 9780123124111
Total Pages : 364 pages
Book Rating : 4.1/5 (241 download)
Download or read book Hormones and Signaling written by Bert W. O'Malley and published by Elsevier. This book was released on 1998 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormones and Signaling focuses on the mechanism of gene regulation at the cellular level. It also covers the way hormones act to modulate gene regulation and animal development. Key Features * Includes information on: * Nuclear receptors, coactivators, and corepressors * Membrane receptors, kinases, and phosphorylation on cascades * Hormonal regulation of development * Calcium channels and neurotransmitters * Chromatin, transcription factors, and regulation of gene expression * JAK/STAT pathways * Hormone-regulated development and gene "knock-out"
Author : A.K. Roy
Publisher : Springer Science & Business Media
ISBN 13 : 146126054X
Total Pages : 325 pages
Book Rating : 4.4/5 (612 download)
Download or read book Gene Regulation by Steroid Hormones written by A.K. Roy and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the last two decades endocrinological research has taken a definite tum toward biochemistry and molecular biology. This has resulted in a new discipline called' 'molecular endocrinology. " Studies on the mechanism of hormone action have continued to make headlines with fundamental discov eries in receptor action and gene regulation. Recently the insect endocrino logists have also begun to explore the molecular mechanism of steroid hor mone action taking advantage of the vast number of Drosophila mutants, the library of Drosophila gene, and several well-characterized cell-lines. The availability ofthe recombinant DNA technology has provided a truly revolu tionary tool in the hands of the molecular endocrinologists. "Gene Regula tion by Steroid Hormones" is compiled and presented in this frontier spirit, and we hope that this volume will serve not only the active investigators in the field but will also be very useful to students and researchers with a gen eral interest in regulatory biology. The book is an offshoot of the Conference on Molecular Mechanism of Steroid Hormone Action held at the Meadow Brook Mansion of Oakland University in the fall of 1978. We wish to acknowledge the financial assist ance from the National Science Foundation and Oakland University. The conferees will never forget the warmest hospitality of Dr. LOWELL EKLUND and his staff at the Meadow Brook center and we also wish to express per sonal gratitude to many of our students and colleagues for helping us to make the conference a great success.
Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Philip Cohen
Publisher : North Holland
ISBN 13 :
Total Pages : 524 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Hormonal Control of Gene Transcription written by Philip Cohen and published by North Holland. This book was released on 1991 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Brian E. Henderson
Publisher : Oxford University Press
ISBN 13 : 0199771588
Total Pages : 467 pages
Book Rating : 4.1/5 (997 download)
Download or read book Hormones, Genes, and Cancer written by Brian E. Henderson and published by Oxford University Press. This book was released on 2003-03-13 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormonal carcinogenesis is an important and controversial area of current research. In addition to accelerating existing cancers, can hormones play the role of primary carcinogens? How do genetic factors influence hormone-related cancer risk? Hormones, Genes, and Cancer addresses these questions. Over the past few decades, cancer research has focused on external environmental causes(e.g., tobacco smoke, viruses, asbestos). With the advent of new genetic sequencing techniques, we are just now beginning to understand how the body's internal environment(i.e., the hormones and growth factors that determine normal development) influences cancer etiology and prevention. From molecular insights to clinical analyses, this volume provides state-of-the-art information on the complex interactions between hormones and genes and cancer. The epidemiology and molecular endocrinology of prostate, breast, uterine, ovarian and testicular cancer are detailed in this timely treatise.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309064198
Total Pages : 453 pages
Book Rating : 4.3/5 (9 download)
Download or read book Hormonally Active Agents in the Environment written by National Research Council and published by National Academies Press. This book was released on 2000-02-03 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.
Author : Gerald Litwack
Publisher : Elsevier
ISBN 13 : 0443158185
Total Pages : 394 pages
Book Rating : 4.4/5 (431 download)
Download or read book Hormones and Epigenetics written by Gerald Litwack and published by Elsevier. This book was released on 2023-03 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormones and Epigenetics, Volume 122, the latest release in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting timely, interesting chapters written by an international board of authors.
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309132975
Total Pages : 287 pages
Book Rating : 4.3/5 (91 download)
Download or read book Exploring the Biological Contributions to Human Health written by Institute of Medicine and published by National Academies Press. This book was released on 2001-07-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.
Author : Malcolm G. Parker
Publisher :
ISBN 13 :
Total Pages : 434 pages
Book Rating : 4.3/5 (91 download)
Download or read book Nuclear Hormone Receptors written by Malcolm G. Parker and published by . This book was released on 1991 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the supergene family made up of those nuclear hormone receptors which recognize thyroid and steroid hormones, vitamen D and retinoic acid and which are characterized by their ability to bind both ligands and the genes which respond to them.
Author : Mara H. Feld
Publisher :
ISBN 13 :
Total Pages : 216 pages
Book Rating : 4.:/5 (891 download)
Download or read book Effects of Sex Hormones on Hepatic Gene Expression and Hepatocarcinogenesis in the Mouse written by Mara H. Feld and published by . This book was released on 2008 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J. T. Cunningham
Publisher : DigiCat
ISBN 13 :
Total Pages : 194 pages
Book Rating : 4.8/5 (596 download)
Download or read book Hormones and Heredity written by J. T. Cunningham and published by DigiCat. This book was released on 2022-09-15 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormones and Heredity by J. T. Cunningham is a wonderful book all about the wonders of human hormones, and how they are impacted by genetic inheritance. Excerpt: "Weismann, strongly as he denied the possibility of the transmission of somatic modifications, admitted the possibility or even the fact of the simultaneous modification of soma and germ by external conditions such as temperature."
Author : Matthew Scott Bramble
Publisher :
ISBN 13 :
Total Pages : 149 pages
Book Rating : 4.:/5 (17 download)
Download or read book The Effects of Chromosomal Composition and Hormonal Influences on Shaping Sex Differences in the Developing Mammalian Brain written by Matthew Scott Bramble and published by . This book was released on 2017 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mechanisms by which sex differences in the mammalian brain arise are poorly understood, but are influenced by a combination of underlying genetic differences and gonadal hormone exposure. Using a mouse embryonic neural stem cell (eNSC) model to understand early events contributing to sexually dimorphic brain development, we identified novel interactions between chromosomal sex and hormonal exposure that are instrumental to early brain sex differences. RNA-sequencing identified 103 transcripts that were differentially expressed between XX and XY eNSCs at baseline (FDR=0.10). Treatment with testosterone-propionate (TP) reveals sex-specific gene expression changes, causing 2854 and 792 transcripts to become differentially expressed on XX and XY genetic backgrounds respectively. These findings indicate that testosterone exposure on XX cells have a more robust effect with regards to altering gene expression. It was also found that by exposing XX eNSCs to TP, 42% (43/103) of the original 103 basal sex differences that existed became masculinized and shifted towards a XY typical gene expression pattern. We also determined that 25% (26/103) of basal sex differences were actually feminized in an XY background post-TP. These alteration in gene expression post-TP exposure were determine to require functional androgen receptor (AR), as AR knockout (ARKO) eNSCs did not show differential expression of select genes in the presence of TP. Within the TP responsive transcripts, there was enrichment for genes which function as epigenetic regulators that affect both histone modifications and DNA methylation patterning, specifically Tet proteins, known to function as a DNA demethylases. We observed that TP caused a global decrease in 5-methylcytosine abundance in both sexes, a transmissible effect that was maintained in cellular progeny. Like gene expression, alteration in DNA methylation function downstream of AR activation, with ARKO lines showing no significant androgen induced DNA de-methylation. Additionally, we determined that TP was associated with residue-specific alterations in acetylation of histone tails. Collectively, these findings highlight an unknown component of androgen action on cells within the developmental CNS, and contribute to a novel mechanism of action by which early hormonal organization is initiated and maintained.
