Homocysteine In Protein Structure Function And Human Disease

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Homocysteine in Protein Structure/Function and Human Disease

Author : Hieronim Jakubowski
Publisher : Springer Science & Business Media
ISBN 13 : 3709114101
Total Pages : 175 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Homocysteine in Protein Structure/Function and Human Disease by : Hieronim Jakubowski

Download or read book Homocysteine in Protein Structure/Function and Human Disease written by Hieronim Jakubowski and published by Springer Science & Business Media. This book was released on 2013-06-20 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease.

Homocysteine in Health and Disease

Author : Ralph Carmel
Publisher : Cambridge University Press
ISBN 13 : 9780521653190
Total Pages : 558 pages
Book Rating : 4.6/5 (531 download)

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Book Synopsis Homocysteine in Health and Disease by : Ralph Carmel

Download or read book Homocysteine in Health and Disease written by Ralph Carmel and published by Cambridge University Press. This book was released on 2001-07-19 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an unusually comprehensive 2001 account of the broad range of medical implications of homocysteine.

Protein Modificomics

Author : Tanveer Ali Dar
Publisher : Academic Press
ISBN 13 : 9780128119136
Total Pages : 0 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Protein Modificomics by : Tanveer Ali Dar

Download or read book Protein Modificomics written by Tanveer Ali Dar and published by Academic Press. This book was released on 2019-05-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins, including discussions on diseases involving PTMs, such as Alzheimer's, Huntington's, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome and OFC10. The book also discusses the role PTMs play in plant physiology and the production of medicinally important primary and secondary metabolites. The understanding of PTMs in plants helps us enhance the production of these metabolites without greatly altering the genome, providing robust eukaryotic systems for the production and isolation of desired products without considerable downstream and isolation processes.

Homocysteine and Vascular Disease

Author : K. Robinson
Publisher : Springer Science & Business Media
ISBN 13 : 9780792362487
Total Pages : 480 pages
Book Rating : 4.3/5 (624 download)

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Book Synopsis Homocysteine and Vascular Disease by : K. Robinson

Download or read book Homocysteine and Vascular Disease written by K. Robinson and published by Springer Science & Business Media. This book was released on 2000-04-30 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This state-of-the-art review provides an in-depth and critical summary of homocysteine from its molecular basis to clinical relevance and current clinical trials of folic acid and vitamin B6. Written by leading workers in the field, the book provides an authoritative, comprehensive and thoroughly up-to-date overview for scientists and clinicians and any others engaged in the field. It will also be useful to anyone involved in managing vascular patients or cardiac risk factors, as well as biochemists, pharmacologists, general physicians, cardiologists and clinical and basic researchers with an interest in preventive medicine.

Biomarkers for Stroke Recovery

Author : Pradeep Kumar
Publisher : Frontiers Media SA
ISBN 13 : 2832519741
Total Pages : 221 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Biomarkers for Stroke Recovery by : Pradeep Kumar

Download or read book Biomarkers for Stroke Recovery written by Pradeep Kumar and published by Frontiers Media SA. This book was released on 2023-04-03 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt:

S-adenosylmethionine-dependent Methyltransferases: Structures And Functions

Author : Robert M Blumenthal
Publisher : World Scientific
ISBN 13 : 9814494976
Total Pages : 419 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis S-adenosylmethionine-dependent Methyltransferases: Structures And Functions by : Robert M Blumenthal

Download or read book S-adenosylmethionine-dependent Methyltransferases: Structures And Functions written by Robert M Blumenthal and published by World Scientific. This book was released on 1999-07-23 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: This invaluable volume, written by an international group of scientists, presents an overview of the AdoMet-dependent methyltransferases, with special emphasis on structure-function relationships.S-adenosyl-L-methionine (AdoMet) is the second most commonly used enzyme cofactor after ATP. The AdoMet-dependent methyltransferases act on a wide variety of target molecules, including DNA, RNA, protein, polysaccharides, lipids and a range of small molecules.The well-conserved architecture of these enzymes, and the implications of this conservation for their evolutionary history, are major themes of this book. The thirteen chapters describe in detail the structures, enzyme kinetics and biological roles of the AdoMet-dependent methyltransferases from a wide range of cell types: plant, animal, bacterial and archaeal.

Implications of lipids and modified lipoproteins in atherogenesis: From mechanisms towards novel diagnostic and therapeutic targets

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Author : Alexander Akhmedov
Publisher : Frontiers Media SA
ISBN 13 : 2832529739
Total Pages : 175 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Implications of lipids and modified lipoproteins in atherogenesis: From mechanisms towards novel diagnostic and therapeutic targets by : Alexander Akhmedov

Download or read book Implications of lipids and modified lipoproteins in atherogenesis: From mechanisms towards novel diagnostic and therapeutic targets written by Alexander Akhmedov and published by Frontiers Media SA. This book was released on 2023-08-01 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Fibrinolysis and Thrombolysis

Author : Krasimir Kolev
Publisher : BoD – Books on Demand
ISBN 13 : 9535112651
Total Pages : 210 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Fibrinolysis and Thrombolysis by : Krasimir Kolev

Download or read book Fibrinolysis and Thrombolysis written by Krasimir Kolev and published by BoD – Books on Demand. This book was released on 2014-05-07 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book familiarizes the reader with some recent trends in the theory and practice of thrombolysis. It covers the field of fibrinolysis from the standpoint of basic scientists and clinicians and delivers the state-of-the-art information on the biochemistry and pharmacology of fibrinolysis, as well as related novel methodological and diagnostic tools in the field. An introductory chapter summarizes the basic molecular mechanisms in fibrinolysis (plasminogen, its endogenous activators and their inhibitors, plasmin and its inhibitors). Recent developments in our understanding of fibrin formation are described in the context of its impact on fibrinolysis. The discussion of neutrophil extracellular traps in the modulation of fibrin assembly and the consequences regarding plasminogen activation and plasmin action addresses a novel aspect of fibrinolysis.

Feed Additives

Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1837690812
Total Pages : 206 pages
Book Rating : 4.8/5 (376 download)

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Book Synopsis Feed Additives by :

Download or read book Feed Additives written by and published by BoD – Books on Demand. This book was released on 2024-07-31 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Protein Sensors and Reactive Oxygen Species

Author : Helmut Sies
Publisher : Academic Press
ISBN 13 : 0121822486
Total Pages : 550 pages
Book Rating : 4.1/5 (218 download)

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Book Synopsis Protein Sensors and Reactive Oxygen Species by : Helmut Sies

Download or read book Protein Sensors and Reactive Oxygen Species written by Helmut Sies and published by Academic Press. This book was released on 2002 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Methods in Enzymology is concerned with the rapidly developing field of selenoprotein synthesis and its related molecular genetics. Progressive information on the topics of proteins as redox sensors, selenoproteins, and the thioredoxin system is studied using methods such as bioinformatics, DNA chip technology, cell biology, molecular genetics, and enzymology. The information on novel selenoproteins identified from genomic sequence data, as well as current knowledge on glutathione peroxidases, selenoprotein P, iodothyronine deiodinases, and thioredoxin reductases, is presented in a method-based approach.

Non-Proteinogenic Amino Acids

Author :
Publisher :
ISBN 13 : 9781838815974
Total Pages : pages
Book Rating : 4.8/5 (159 download)

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Book Synopsis Non-Proteinogenic Amino Acids by :

Download or read book Non-Proteinogenic Amino Acids written by and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Essential and Toxic Trace Elements and Vitamins in Human Health

Author : George J. Brewer
Publisher : Academic Press
ISBN 13 : 0128093013
Total Pages : 328 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Essential and Toxic Trace Elements and Vitamins in Human Health by : George J. Brewer

Download or read book Essential and Toxic Trace Elements and Vitamins in Human Health written by George J. Brewer and published by Academic Press. This book was released on 2020-06-14 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential and Toxic Trace Elements and Vitamins in Human Health is a comprehensive guide to the wide variety of micronutrients that affect human health, including fat-soluble and water-soluble vitamins that support diverse biochemical functions, trace elements with established and suggested links to health maintenance, and elements with known human toxicity such as arsenic, cadmium, and lead. An essential reference text for nutritionists working in academia and functional food and supplement industries, dieticians, and clinicians, Essential and Toxic Trace Elements and Vitamins in Human Health provides an in-depth look at toxic trace elements and essential vitamins and minerals and their direct influence on the body's overall health with expert research from renowned scientists. - Presents a balanced scientific view of essential and nonessential micronutrients with an in-depth analysis of the biochemical functions each plays in human health - Examines particular micronutrients in detail with coverage of clinical aspects, interaction with other micronutrients, immunological effects, cognitive functions and epigenetics - Focuses on effective management of micronutrient deficiencies and on toxicity implications of overexposure

Hematology E-Book

Author : Ronald Hoffman
Publisher : Elsevier Health Sciences
ISBN 13 : 0323733891
Total Pages : 2886 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Hematology E-Book by : Ronald Hoffman

Download or read book Hematology E-Book written by Ronald Hoffman and published by Elsevier Health Sciences. This book was released on 2022-10-27 with total page 2886 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively revised, comprehensive content from leading global contributors ensures that Hematology, 8th Edition, remains your #1 choice for expert guidance in all areas of this rapidly advancing subspecialty. This edition reflects the numerous advances that are redefining the field and dramatically influencing new approaches to diagnosis, treatment, and outcomes. Well-illustrated and clinically focused, it details the basic science and clinical practice of hematology and hematopoietic cellular therapy—covering virtually all aspects of hematology in one definitive resource. - Covers all hematologic disorders, including comprehensive discussions of hematologic malignancies, individualized patient care, cell-based therapies, transplantation, transfusion medicine, hemostasis, thrombosis, and consultative hematology—in one convenient volume. - Provides state-of-the-art guidance from global experts at the forefront of the latest research and clinical practice. - Provides extensive updates throughout on basic science research, advances in molecular diagnostics, new drugs, immunotherapies, personalized medicine, laboratory medicine, transfusion medicine, stem cell transplantation, and clinical treatment for all hematologic malignancies and non-malignancies - Contains new chapters on gene editing; the impact of mitochondria on hematopoiesis; myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes; immunotherapy and management of its toxicities; transfusion medicine in sickle cell disease; principles of radiation therapy; and COVID-19, including complications of vaccination and its impact on the hematologic system. - Discusses many new advances in the field, including details and the future of gene therapy for hemophilia, gene editing for sickle cell disease and thalassemia, the evolution of cellular therapy, use of cells, transfusion medicine vs. protein therapy, gene sequencing, immunotherapy, and new targeted drugs. - Includes more decision-making algorithms for formulating diagnoses and personalized treatment plans for those highly complex disorders that require individualized approaches. - Addresses the effects of aging on hematopoiesis and on the manifestations of a variety of hematologic disorders. - Discusses cardio-oncology and its impact on the treatment of patients with hematologic disorders. - Presents relevant basic science as background for clinical application in later sections. - An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

Laboratory Assessment of Vitamin Status

Author : Dominic J. Harrington
Publisher : Academic Press
ISBN 13 : 0128130512
Total Pages : 342 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Laboratory Assessment of Vitamin Status by : Dominic J. Harrington

Download or read book Laboratory Assessment of Vitamin Status written by Dominic J. Harrington and published by Academic Press. This book was released on 2018-11-28 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Laboratory Assessment of Vitamin Status provides a comprehensive understanding of the limitations of commonly used approaches used for the evaluation of vitamin status, reducing harm in the general health setting. It outlines the application of 'Best Practice' approaches to the evaluation of vitamin status, giving physicians and other healthcare professionals the opportunity to make evidence-based interventions. Nearly every metabolic and developmental pathway in the human body has a dependency on at least one micronutrient. Currently, the clinical utility of approaches taken by laboratories for the assessment of vitamin status is generally poorly understood, missing the opportunity to diagnosis vitamin deficiencies. This essential reference gives clinical and biomedical scientists an understanding of the limitations of commonly used approaches to the evaluation of vitamin status in the general health setting through change in practice. Nutritionists and dietitians gain an understanding of more sophisticated markers of vitamin status. - Describes specialist assays in sufficient detail to enable laboratories to replicate what is being performed by expert groups - Provides detailed information that supports laboratories in the setting up of methods for the evaluation of vitamin status - Informs laboratories looking for third party providers of specialist investigations - Provides an essential overview of reference ranges for each vitamin

Subcortical Vascular Dementia

Author : Rita Moretti
Publisher : Nova Publishers
ISBN 13 : 9781594549960
Total Pages : 192 pages
Book Rating : 4.5/5 (499 download)

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Book Synopsis Subcortical Vascular Dementia by : Rita Moretti

Download or read book Subcortical Vascular Dementia written by Rita Moretti and published by Nova Publishers. This book was released on 2006 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular dementia is one of the most common forms of mental deterioration for the elderly, second only to Alzheimer's disease. It should not be defined as a single disease, but rather as a group of syndromes that relate to different vascular mechanisms. This is one of the first books to be solely dedicated to the specific class of vascular dementia known as subcortical vascular dementia. The strict focus of the chapters give an depth review that will clarify many different aspects and give an unprecedented amount of detail about this clinical problem. Considering that vascular dementia can be prevented with early diagnosis, the research presented in this book will be important for both students and specialists of this important field.

Amino Acids

Author : Guoyao Wu
Publisher : CRC Press
ISBN 13 : 1000412032
Total Pages : 1145 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Amino Acids by : Guoyao Wu

Download or read book Amino Acids written by Guoyao Wu and published by CRC Press. This book was released on 2021-09-26 with total page 1145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following its predecessor, the second edition of Amino Acids: Biochemistry and Nutrition presents exhaustive coverage of amino acids in the nutrition, metabolism and health of humans and other animals. Substantially revised, expanded and updated to reflect scientific advances, this book introduces the basic principles of amino acid biochemistry and nutrition, while highlighting the current knowledge of the field and its future possibilities. The book begins with the basic chemical concepts of amnio acids, peptides and proteins, and their digestion and absorption. Subsequent chapters cover cell-, tissue-, and species-specific synthesis and catabolism of amino acids and related bioactive metabolites, and the use of isotopes to study amino acids metabolism in cells and the body. The book details protein turnover, physiological functions of amino acids, as well as both the regulation and inborn errors of amino acid metabolism. The book concludes with a presentation on human and animal dietary requirements of amino acids and evaluates dietary protein quality. Features: Encompasses a comprehensive coverage of basic to applied concepts in amino acid metabolism in humans and other animals. Highlights important roles of dietary amino acids and protein intake in growth, physical performance and health, including sarcopenia mitigation and immunity. Discusses concerns over the excess intakes of amino acids or protein in the development of diseases, including cardiovascular disorders, diabetes and cancers, as well as bone integrity Each chapter contains select references to provide comprehensive reviews and original experimental data on the topics discussed. Each chapter is backed by original experimental data on various topics discussed and contains select references to aid the reader further in research. Written by Distinguished Professor of Animal Nutrition, Guoyao Wu, Ph.D., this book is an authoritative reference for students and researchers in both biomedicine and agriculture.

The Endothelium

Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041230
Total Pages : 309 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis The Endothelium by : Michel Félétou

Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References