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Hla Typing Methodology Clinical Aspects
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Download or read book HLA Typing written by Soldano Ferrone and published by CRC Press. This book was released on 2019-06-04 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1982, this two-volume set provides the reader with insightful knowledge of HLA Typing and the different methods in which this can be undertaken. In this volume, we are presented with inside knowledge of the variety of HLA typing methods and the circumstances in which they are necessary.
Book Synopsis HLA TYPING METHODOLOGY & CLINICAL ASPECTS by : Ferrone
Download or read book HLA TYPING METHODOLOGY & CLINICAL ASPECTS written by Ferrone and published by CRC-Press. This book was released on 1982-07-07 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book HLA Typing written by Sebastian Boegel and published by Springer Nature. This book was released on with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of HLA Typing Techniques by : Kam M. Hui
Download or read book Handbook of HLA Typing Techniques written by Kam M. Hui and published by CRC Press. This book was released on 2020-10-07 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an authoritative collection of HLA phenotyping and genotyping techniques to be used at the bench level and as a reference. It includes detailed methodologies, notes on the interpretation of tests, reference material, and appendices.
Download or read book HLA Typyng written by Soldano Ferrone and published by . This book was released on 1982 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis HLA TYPING FROM NEXT GENERATIO by : Yazhi Huang
Download or read book HLA TYPING FROM NEXT GENERATIO written by Yazhi Huang and published by Open Dissertation Press. This book was released on 2017-01-26 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "HLA Typing From Next Generation Sequencing Data: Strategies, Methods, and Applications" by Yazhi, Huang, 黄亚志, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: HLA genes play a key role in the human immune system. As a result, HLA typing is very important for both clinical laboratories and biomedical research. However, HLA typing has always been challenging due to the complexity of this group of genes, including existence of large number of alleles for most HLA genes, major sequence difference between these alleles, sequence similarity among the paralogous HLA genes, and long range linkage disequilibrium (LD) in this region. With the development of NGS, large amount of sequencing data are becoming widely available. Although most of them were not generated for this purpose, they still provide valuable resources for HLA typing. NGS data might be useful in many aspects such as preliminary screening for potential organ donors, for individuals that are potentially susceptible to adverse drug responses, risk prediction for complex diseases, and population genetic studies. However, due to the complexity of the HLA loci, the large amount of NGS data has not been made informative on HLA genotypes. Many efforts have been made on HLA typing by mining NGS data, including the alignment-based method that relies on counting the number of short reads aligned to each specific allele, the assembly- and scoring-based method that takes into account of good quality contigs and their scores for each candidate HLA allele. These methods capitalize on the increasing accessibility and affordability of NGS sequencing and have greatly reduced the time and cost required to make an HLA call comparing to traditional standard PCR-based solutions. Unfortunately, these methods are only capable of achieving low-digit resolution and perform poorly at higher-digit resolution, which is required for clinical applications. In this study, I introduce a novel approach for accurate HLA typing at high-digit resolution based on a strategy of comparing sequence reads to a comprehensive reference panel containing all the known HLA alleles for high efficiency mapping, followed by assembly of the mapped reads to contigs, stepwise matching and designation of the contigs to HLA alleles and decision on HLA allele calling. Testing of the method on a set of public and internal whole exome sequencing (WES) data demonstrated that this new method is capable of reporting HLA alleles at a high-digit resolution with great accuracy. I also conducted a preliminary analysis of WES data from a set of NGS samples generated in-house. HLA calling results demonstrated consistent allele frequencies to those recorded in the Allele Frequency Net Database (AFND) of the same population. In addition, I also used the typing results from the NGS samples to design population-specific primers and probes. Finally, two set of samples with Crohn's disease and tuberculosis were studied using this method. Results showed that the previous findings related to HLA and these diseases were effectively replicated in our dataset using the proposed method. Certain interesting results that were not yet reported were also observed in our dataset. These preliminary results highlighted the potential applications of this method for HLA calling from NGS data. DOI: 10.5353/th_b5736651 Subjects: HLA histocompatibility antigens Nucleotide sequence
Download or read book The HLA System written by John Lee and published by Springer. This book was released on 2011-09-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume documents our growing understanding of the human major histocompatibility complex. The application of this information is ever more important as the limits of transplantation continue to be reduced, including the recent success of bone marrow transplantation between unrelated but closely matched individuals. In addition, the need to transfuse platelets in the face of immunologic barriers continues to challenge transfusion services. Thus, the serologic information summarized in this volume is essential for optimal patient care. At the same time, recombinant DNA technology has led to a revolution in our understanding of many aspects of basic biology. Among the advances has been the initial characterization of the structure of some HLA loci. While this will ultimately improve clinical services, constant reference to serologic data is essential so that the powerful new techniques can be applied in the most effective ways. The timing of the First Red Cross International Histocompatibility Workshop is fortunate as it brings together experts from around the world to address the state of the art. We are all grateful to Dr. John Lee and his colleagues for organizing the workshop, and for bringing together in this volume the material to be presented in Beijing during October 17-23, 1990. Leon W. Hoyer, M.D.
Book Synopsis Applied Bioinformatics by : Paul Maria Selzer
Download or read book Applied Bioinformatics written by Paul Maria Selzer and published by Springer Science & Business Media. This book was released on 2008-01-18 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: At last, here is a baseline book for anyone who is confused by cryptic computer programs, algorithms and formulae, but wants to learn about applied bioinformatics. Now, anyone who can operate a PC, standard software and the internet can also learn to understand the biological basis of bioinformatics, of the existence as well as the source and availability of bioinformatics software, and how to apply these tools and interpret results with confidence. This process is aided by chapters that introduce important aspects of bioinformatics, detailed bioinformatics exercises (including solutions), and to cap it all, a glossary of definitions and terminology relating to bioinformatics.
Book Synopsis Molecular Diagnostics by : William B. Coleman
Download or read book Molecular Diagnostics written by William B. Coleman and published by Springer Science & Business Media. This book was released on 2007-10-28 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying CD-ROM contains ... "a companion eBook version of Molecular diagnostics : for the clinical laboratorian, Second edition ... for downloading and use in the reader's PC or PDA."--Page 4 of cover.
Book Synopsis HLA in Health and Disease by : Robert Lechler
Download or read book HLA in Health and Disease written by Robert Lechler and published by Academic Press. This book was released on 2000-05-09 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive and definitive work succeeds and expands on the highly successful HLA and Disease published in 1994. This new edition has been updated, redesigned and reorganised into three sections making it an invaluable reference. The introductory section summarises current knowledge on the structure, function, genetics and evolution of the HLA system. It clarifies its complex and ever changing nomenclature and discusses the mechanisms underlying disease associations with HLA alleles. The second section deals with the importance of HLA in the context of different clinical specialities. Individual chapters describe the association between HLA polymorphism and each disease. The final section features chapters on current laboratory practice in histocompatibility and tissue typing. HLA in Health and Disease is essential reading for basic and clinical researchers working in immunology and immunogenetics, transplantation medicine and autoimmunity. It will also be of interest to anyone in the fields of rheumatology, diabetology, nephrology, allergy, dermatology, neurology, endocrinology, cancer biology, respiratory medicine, haematology, molecular biology and biochemistry. Key Features Structure, function and genetics of HLA HLA nomenclature Evolution of HLA polymorphisms HLA associations in arthritis and rheumatology, renal disease, neurology, diabetes and endocrinology, gastroenterology, respiratory disease, ophthalmology, infections, dermatology and psychiatry HLA and organ transplantation Serological and PCR-based methods in HLA typing Cellular techniques in testing histocompatibility Edited and written by an international panel of experts in the field
Download or read book Immunogenetics written by and published by Springer. This book was released on 2012-08-31 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The HLA FactsBook by : Steven G.E. Marsh
Download or read book The HLA FactsBook written by Steven G.E. Marsh and published by Elsevier. This book was released on 1999-12-13 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The HLA FactsBook presents up-to-date and comprehensive information on the HLA genes in a manner that is accessible to both beginner and expert alike. The focus of the book is on the polymorphic HLA genes (HLA-A, B, C, DP, DQ, and DR) that are typed for in clinical HLA laboratories. Each gene has a dedicated section in which individual entries describe the structure, functions, and population distribution of groups of related allotypes. Fourteen introductory chapters provide a beginner's guide to the basic structure, function, and genetics of the HLA genes, as well as to the nomenclature and methods used for HLA typing. This book will be an invaluable reference for researchers studying the human immune response, for clinicians and laboratory personnel involved in clinical and forensic HLA typing, and for human geneticists, population biologists, and evolutionary biologists interested in HLA genes as markers of human diversity. Introductory chapters provide good general overview of HLA field for novice immunologists and geneticists Up-to-date, complete listing of HLA alleles Invaluable reference resource for immunologists, geneticists, and cell biologists Combines both structural and functional information, which has never been compiled in a single reference book previously Serological specificity of allotypes Identity of material sequenced including ethnic origin Database accession numbers Population distribution Peptide binding specificities T cell epitopes Amino acid sequences of allotypes Key references
Book Synopsis Primary Immunodeficiency Diseases by : Hans D. Ochs
Download or read book Primary Immunodeficiency Diseases written by Hans D. Ochs and published by . This book was released on 2007 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders--disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.
Book Synopsis Hematopoietic Stem Cell Transplantation in Clinical Practice by : Jennifer G. Treleaven
Download or read book Hematopoietic Stem Cell Transplantation in Clinical Practice written by Jennifer G. Treleaven and published by Elsevier Health Sciences. This book was released on 2008-09-02 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the practice of stem cell transplantation, its status in the treatment of various disorders and the problems that arise after transplantation, aimed at the whole transplant team. - An up to date guide to best practice in the use of stem cell transplantation, covering current status in the treatment of malignant and non-malignant conditions, practical aspects and problems such as infection and graft versus host disease. - Has a practical, accessible approach with free use of algorithms, list tables. - Aimed at the whole transplant team - this is an interdisciplinary field. - International contributor team with editors in the UK and USA. - Illustrated in colour throughout.
Book Synopsis HLA Class II Antigens by : Bjarte G. Solheim
Download or read book HLA Class II Antigens written by Bjarte G. Solheim and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume deals with the structure and function of molecules that have, during the last decade, turned out to have a central role in immune responses. Trans plantation antigens were discovered and characterized by Gorer about 50 years ago, and the biological basis for the unequalled complexity of their variability between individuals within a species, in spite of extreme conservation between species, was the subject of intense research and discussion for many years. During the days of belief in "immune surveillance" against spontaneously developing tumors, it was suggested that histoincompatibility between members of one species would prevent cancer from being a contagious disease and thus a threat to the species. Immunologists involved in human transplantation had to learn and care about the complexity, especially after 1967, when it was found that HLA antigens were the products of the human MHC. Rejection of HLA-identical sib kidney grafts was so rare, even in those days, that cases of rejection were described in scientific papers.
Book Synopsis Histocompatibility Testing 1984 by : E.D. Albert
Download or read book Histocompatibility Testing 1984 written by E.D. Albert and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 785 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Leukocyte Typing II by : Ellis L. Reinherz
Download or read book Leukocyte Typing II written by Ellis L. Reinherz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second International Workshop on Human Leukocyte Differentia- tion Antigens was held in Boston, September 17-20, 1984. More than 350 people interested in leukocyte differentiation agreed to exchange reagents and participate in this joint venture. All in all, in excess of 400 antibodies directed against surface structures on T lymphocytes, B lymphocytes, and myeloid-hematopoietic stem cells were characterized. Because of the enormous quantity of serologic, biochemical, and functional data, Leuko- cyte Typing II has been divided into three volumes. These books represent the written results of workshop participants. They should be helpful to both researchers and clinicians involved in scientific endeavors dealing with these broad fields of immunobiology. To those who delve into the various sections of the volumes, it will become evident that the work speaks for itself. I am deeply indebted to the section editors, Barton F. Haynes, Volume 1, Human T Lymphocytes, Lee M. Nadler, Volume 2, Human B Lympho- cytes, and Irwin D.Bernstein, Volume 3, Human Myeloid and Hemato- poietic Cells for their major contributions in planning, executing, and summarizing the workshop, as well as council members John Hansen, Alain Bernard, Laurence Boumsell, Walter Knapp, Andrew McMichael, Cesar Milstein, and Stuart F. Schlossman. I would also like to thank the National Institutes of Health, World Health Organization, and Interna- tional Union of Immunological Societies for making this meeting possible.
