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Author : Zhuangzhi Wang
Publisher :
ISBN 13 :
Total Pages : 380 pages
Book Rating : 4.3/5 (121 download)
Download or read book High-throughput Study of Biospecific Interactions with Surface Plasmon Resonance Imaging written by Zhuangzhi Wang and published by . This book was released on 2007 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yi Chen
Publisher : Springer Nature
ISBN 13 : 9819931185
Total Pages : 391 pages
Book Rating : 4.8/5 (199 download)
Download or read book Surface Plasmon Resonance Imaging written by Yi Chen and published by Springer Nature. This book was released on 2023-07-01 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the fundamentals, instruments, methodology, and applications of surface plasmon resonance imaging (SPRi) and related techniques. It provides an overview of SPRi development and an easy-to-understand interpretation of theory and operation principles. Some unique ideas proposed by the authors to design and set up SPRi devices and methods are disclosed for the first time. Crucial manipulation experiences are also summarized here, including chip surface functionalization, sensitivity enhancement and coupling of SPRi with other analytical techniques. The application of SPRi for molecular interaction study, featuring high throughput, label-freeness, and physiologically compatible analysis, is discussed in detail. This book is of interest and useful to a wide readership in bioanalytical chemistry, molecular biology, and many related interdisciplinary fields.
Author :
Publisher : Elsevier
ISBN 13 : 0323853102
Total Pages : 424 pages
Book Rating : 4.3/5 (238 download)
Download or read book Surface Plasmon Resonance in Bioanalysis written by and published by Elsevier. This book was released on 2021-11-11 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface Plasmon Resonance in Bioanalysis, Volume 95 in the Comprehensive Analytical Chemistry series, contains a wide range of topics on the applications and new advances of surface plasmon resonance (SPR) in bioanalysis, including Surface plasmon resonance microscopy for single-cell based drug screening, Phase-Sensitive Surface Plasmon Resonance Sensors for Highly Sensitive Bioanalysis, SPR coupled to ambient mass spectrometry, Surface Plasmon Resonance Microscopy for activity detection and imaging of single cells, SPR for water pollutant detection and biofouling control, SPR imaging for cellular analysis and detection, Progress in detection of surface palsmon resonance for biorefinery technology, and more. Additional chapters cover Long-range surface plasmon resonance and its biological sensing applications and Critical issues in clinical and biomedical applications of Surface Plasmon Resonance sensing. Provides updates on the latest applications of SPR microscopy in cell analysis Covers the latest design in SPR sensing for highly sensitive bioanalysis Presents the critical issues in clinical and biomedical applications of SPR
Author : Richard B. M. Schasfoort
Publisher : Royal Society of Chemistry
ISBN 13 : 1782627308
Total Pages : 555 pages
Book Rating : 4.7/5 (826 download)
Download or read book Handbook of Surface Plasmon Resonance written by Richard B. M. Schasfoort and published by Royal Society of Chemistry. This book was released on 2017-05-30 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface plasmon resonance (SPR) plays a dominant role in real-time interaction sensing of biomolecular binding events, this book provides a total system description including optics, fluidics and sensor surfaces for a wide researcher audience.
Author : Sameer Mahmood Zaheer
Publisher : Springer Nature
ISBN 13 : 9811615365
Total Pages : 116 pages
Book Rating : 4.8/5 (116 download)
Download or read book Methods for Fragments Screening Using Surface Plasmon Resonance written by Sameer Mahmood Zaheer and published by Springer Nature. This book was released on 2021-09-15 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes methods and protocols for the fragment-based screening of proteins using Surface Plasmon Resonance (SPR). The initial chapter of the book discusses the principle of SPR for the identification of biomolecular interactions, while the subsequent chapters introduce methods for labelling proteins with different tags including, histidine and biotin tags. It also discusses techniques and factors that affect the amine and biotin-streptavidin coupling and methods to optimize the interactions. Next, it describes fragment preparation for screening in SPR and presents methods to calculate equilibrium dissociation constant (KD) and ligand efficiency (LE). It reviews techniques of next-generation injections that improve the efficiency of the characterization process over traditional SPR by determining the kinetics and affinity in a single step. Finally, the book elucidates a comprehensive yet representative description of challenges associated with the molecular interaction of proteins using SPR.
Author : Greta J. Wegner
Publisher :
ISBN 13 :
Total Pages : 120 pages
Book Rating : 4.:/5 (89 download)
Download or read book Surface Plasmon Resonance Imaging Studies of Protein Interactions Onto Peptide and Protein Microarrays written by Greta J. Wegner and published by . This book was released on 2004 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 1006 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 1006 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jennifer Betsy Fasoli
Publisher :
ISBN 13 : 9781321846140
Total Pages : 67 pages
Book Rating : 4.8/5 (461 download)
Download or read book Surface Functionalization for Enhanced Fluorescence Detection, Surface Plasmon Resonance Imaging and Microscopy written by Jennifer Betsy Fasoli and published by . This book was released on 2015 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents several high throughput imaging and analysis techniques performed by fluorescence detection and surface plasmon resonance biosensing. The microarray fabrication methods introduced in this thesis, as well as the DNA functionalization on planar and nanoparticle surfaces, enable and facilitate the real-time study of adsorption events via DNA- DNA hybridization and protein-DNA interaction. Silica deposited on polyolefin film serves as the base for the development of DNA microarray. Fabrication process involves poly(L-glutamic acid) monolayer to react with amine functional groups functionalized on both the silica surface and the probe DNA strands. Covalently surface-bound probes then hybridize with fluorophore-labeled target DNA. Shrinking the microarray with heat significantly enhances the sensitivity of detection via fluorescence signal amplification. Polydopamine, a biomimetic polymer, easily and rapidly grows an adhesive layer to link amine-terminated, single-stranded DNA to gold surface. Self-polymerization of polydopamine simply requires mild reagents and reaction condition. The microarray formed with polydopamine attachment technique reserves its stability and specificity to detect DNA and protein targets by surface plasmon resonance imaging. This one-step microarray fabrication approach, when coupled with signal amplification from DNA-modified gold nanoparticles, empowers the detection limit capable of seeing down to 10 pM target concentration. Electrochemical deposition of polydopamine demonstrates strong control over film localization and thickness. This meticulous polymerization on gold surface at the microscale proves the high toposelectivity of this deposition technique. Amine-modified DNA bound on this polydopamine thin flim hybridizes with fluorophore-tagged DNA to generate fluorescent DNA micropatterns. This electordeposition also forms DNA microarrays used in surface plasmon resonance imaging for DNA-DNA hybridization and DNA-coated gold nanoparticle adsorption measurements. A 814 nm, near-infrared surface plasmon resonance microscope exemplifies a novel, objective-coupled sensing and imaging system at single-nanoparticle scale. This microscope visualizes individual binding occurrence of gold nanoparticles and polystyrene beads. Adsorption analysis presents the calculated surface plasmon resonance signal ([delta]%R) as it varies with particle size. For initial biosensing measurements, the surface plasmon resonance microscopy examines each hybridization-adsorption of DNA-decorated gold nanoparticle on gold surface functionalized with either completely or partially complementary DNA monolayer.
Author : Manfred Schwab
Publisher : Springer Science & Business Media
ISBN 13 : 3540368477
Total Pages : 3307 pages
Book Rating : 4.5/5 (43 download)
Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
Author : Peng Yu
Publisher : Springer Nature
ISBN 13 : 303087544X
Total Pages : 348 pages
Book Rating : 4.0/5 (38 download)
Download or read book Plasmon-enhanced light-matter interactions written by Peng Yu and published by Springer Nature. This book was released on 2022-03-01 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights cutting-edge research in surface plasmons, discussing the different types and providing a comprehensive overview of their applications. Surface plasmons (SPs) receive special attention in nanoscience and nanotechnology due to their unique optical, electrical, magnetic, and catalytic properties when operating at the nanoscale. The excitation of SPs in metal nanostructures enables the manipulation of light beyond the diffraction limit, which can be utilized for enhancing and tailoring light-matter interactions and developing ultra-compact high-performance nanophotonic devices for various applications. With clear and understandable illustrations, tables, and descriptions, this book provides physicists, materials scientists, chemists, engineers, and their students with a fundamental understanding of surface plasmons and device applications as a basis for future developments.
Download or read book Combinational Chemistry & High Throughput Screening written by and published by . This book was released on 1998-12 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Manashi Bagchi
Publisher : John Wiley & Sons
ISBN 13 : 1118451937
Total Pages : 1118 pages
Book Rating : 4.1/5 (184 download)
Download or read book Bio-Nanotechnology written by Manashi Bagchi and published by John Wiley & Sons. This book was released on 2012-11-26 with total page 1118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bio-nanotechnology is the key functional technology of the 21st century. It is a fusion of biology and nanotechnology based on the principles and chemical pathways of living organisms, and refers to the functional applications of biomolecules in nanotechnology. It encompasses the study, creation, and illumination of the connections between structural molecular biology, nutrition and nanotechnology, since the development of techniques of nanotechnology might be guided by studying the structure and function of the natural nano-molecules found in living cells. Biology offers a window into the most sophisticated collection of functional nanostructures that exists. This book is a comprehensive review of the state of the art in bio-nanotechnology with an emphasis on the diverse applications in food and nutrition sciences, biomedicine, agriculture and other fields. It describes in detail the currently available methods and contains numerous references to the primary literature, making this the perfect “field guide” for scientists who want to explore the fascinating world of bio-nanotechnology. Safety issues regarding these new technologies are examined in detail. The book is divided into nine sections – an introductory section, plus: Nanotechnology in nutrition and medicine Nanotechnology, health and food technology applications Nanotechnology and other versatile applications Nanomaterial manufacturing Applications of microscopy and magnetic resonance in nanotechnology Applications in enhancing bioavailability and controlling pathogens Safety, toxicology and regulatory aspects Future directions of bio-nanotechnology The book will be of interest to a diverse range of readers in industry, research and academia, including biologists, biochemists, food scientists, nutritionists and health professionals.
Author : Richard B M Schasfoort
Publisher : Royal Society of Chemistry
ISBN 13 : 1788011392
Total Pages : 555 pages
Book Rating : 4.7/5 (88 download)
Download or read book Handbook of Surface Plasmon Resonance written by Richard B M Schasfoort and published by Royal Society of Chemistry. This book was released on 2017-05-24 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface plasmon resonance (SPR) plays a dominant role in real-time interaction sensing of biomolecular binding events and with the biosensor field expanding more applications are being found. In response to the market, an update to the original title which was published in 2008 is now appropriate. With over fifty percent of the material being updated, this book provides a total system description including optics, fluidics and sensor surfaces. Spanning theory, instrumentation and applications, it covers all the relevant issues for the practicing researcher. Unlocking the potential for SPR by showing highly exciting and unique opportunities for unraveling the functional relationships of complex biological processes, it is intended for a wide audience. A comprehensive and accessible source it contains expanded tutorial details to inspire students and guide them in this technology.
Author : Kevin Healy
Publisher : Elsevier
ISBN 13 : 0081006926
Total Pages : 4865 pages
Book Rating : 4.0/5 (81 download)
Download or read book Comprehensive Biomaterials II written by Kevin Healy and published by Elsevier. This book was released on 2017-05-18 with total page 4865 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications
Author : Mohammed Zourob
Publisher : Springer Science & Business Media
ISBN 13 : 3540882421
Total Pages : 241 pages
Book Rating : 4.5/5 (48 download)
Download or read book Optical Guided-wave Chemical and Biosensors I written by Mohammed Zourob and published by Springer Science & Business Media. This book was released on 2010-03-18 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time, distinguished scientists from key institutions worldwide provide a comprehensive approach to optical sensing techniques employing the phenomenon of guided wave propagation for chemical and biosensors. This includes both state-of the-art fundamentals and innovative applications of these techniques. The authors present a deep analysis of their particular subjects in a way to address the needs of novice researchers such as graduate students and post-doctoral scholars as well as of established researchers seeking new avenues. Researchers and practitioners who need a solid foundation or reference will find this work invaluable. This first of two volumes contains eight chapters covering planar waveguides for sensing, as well as sensing techniques based on plasmonic waveguides.
Author : Tuan Vo-Dinh
Publisher : CRC Press
ISBN 13 : 1439893799
Total Pages : 740 pages
Book Rating : 4.4/5 (398 download)
Download or read book Nanotechnology in Biology and Medicine written by Tuan Vo-Dinh and published by CRC Press. This book was released on 2017-10-03 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Nanotechnology in Biology and Medicine is intended to serve as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of nanotechnology in life sciences. This technology, which is on the scale of molecules, has enabled the development of devices smaller and more efficient than anything currently available. To understand complex biological nanosystems at the cellular level, we urgently need to develop a next-generation nanotechnology tool kit. It is believed that the new advances in genetic engineering, genomics, proteomics, medicine, and biotechnology will depend on our mastering of nanotechnology in the coming decades. The integration of nanotechnology, material sciences, molecular biology, and medicine opens the possibility of detecting and manipulating atoms and molecules using nanodevices, which have the potential for a wide variety of biological research topics and medical uses at the cellular level. This book presents the most recent scientific and technological advances of nanotechnology for use in biology and medicine. Each chapter provides introductory material with an overview of the topic of interest; a description of methods, protocols, instrumentation, and applications; and a collection of published data with an extensive list of references for further details. The goal of this book is to provide a comprehensive overview of the most recent advances in instrumentation, methods, and applications in areas of nanobiotechnology, integrating interdisciplinary research and development of interest to scientists, engineers, manufacturers, teachers, and students.
Author : Amrita Yadav
Publisher :
ISBN 13 :
Total Pages : 215 pages
Book Rating : 4.:/5 (894 download)
Download or read book Development of Arrayed Imaging Reflectometry as a Biomolecular Interaction Analysis Platform written by Amrita Yadav and published by . This book was released on 2012 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The characterization of biomolecular interactions is an important step towards understanding the basic biochemical processes that govern cellular function, the aberrations that cause disease and potential therapeutic candidates. The goal of my thesis research has been to develop Arrayed Imaging Reflectometry (AIR) as a technique to characterize biomolecular interactions in terms of their binding affinity and binding kinetics. AIR is an interferometric biosensing technique that relies on the creation of a total destructive interference condition on a silicon chip coated with a thin layer of probe-functionalized silicon dioxide. Specific binding of target molecules results in an increase in the local thickness of the probe layer and a concomitant destruction of this total destructive interference condition, resulting in an increased reflectance that corresponds to the amount of bound target. Initial studies towards this goal focused on the optimization of surface functionalization chemistry for AIR experiments. Next, experiments were carried out to confirm the quantitative performance of AIR across a range of probe-analyte affinities. We combined biomolecular binding models with data obtained from spectroscopic ellipsometry and surface plasmon resonance experiments to model AIR response for two probe-analyte pairs and compared it to experimental observations. This study confirmed that AIR response is a predictable function of probe and analyte properties and thus could be used to determine binding parameters for biomolecular interactions. A modified substrate consisting of a silicon nitride/ silicon dioxide bilayer on a silicon chip was introduced to enable AIR detection under aqueous media. The thickness sensitivity of this substrate was experimentally determined to be 1 Å. We used the new substrate to measure the binding kinetics of Muscleblind-like 1 (MBNL1), a splicing regulator protein that is implicated in the pathology of the Myotonic Dystrophies and Huntington Disease, to several of its 'normal' and 'pathogenic' RNA targets microarrayed on an AIR chip. The binding kinetics of 'normal' and 'pathogenic' RNA sequences were observed to be distinctly different even though their steady state binding constants were similar. These results suggest that AIR can be a powerful technique for the label-free real-time analysis of biomolecular interactions in a high-throughput format"--Pages viii-ix.
