High Throughput Molecular Char

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Optimal High-Throughput Screening

Author : Xiaohua Douglas Zhang
Publisher : Cambridge University Press
ISBN 13 : 1139498371
Total Pages : 223 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Optimal High-Throughput Screening by : Xiaohua Douglas Zhang

Download or read book Optimal High-Throughput Screening written by Xiaohua Douglas Zhang and published by Cambridge University Press. This book was released on 2011-02-21 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments.

Plant Speed Breeding and High-throughput Technologies

Author : Jen-Tsung Chen
Publisher : CRC Press
ISBN 13 : 1040091229
Total Pages : 410 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Plant Speed Breeding and High-throughput Technologies by : Jen-Tsung Chen

Download or read book Plant Speed Breeding and High-throughput Technologies written by Jen-Tsung Chen and published by CRC Press. This book was released on 2024-08-26 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: The research field of “plant speed breeding" is promising to meet the future demand for crop improvement in an efficient and effective manner. The process accelerates breeding and research programs through the shortening of the generation time of crops. Plant Speed Breeding and High-Throughput Technologies explores and analyzes a range of innovations from CRISPR/Cas9-based genome editing to state-of-the-art controlled-environment growth chambers. The book integrates achievements of plant speed breeding technologies with an emphasis on the fundamental and advanced systems for genome editing, functional genomics, controlled-environment growth chambers, genomic and phenotypic selection methods, and high-throughput technologies. It examines the applications of technologies across major model plants and key crops such as cereals, vegetables, and fruit trees. The book explores high-throughput genotyping using next-generation sequencing systems, enabling precise single nucleotide polymorphism markers, quantitative trait loci mapping, and genome-wide association studies . These tools are used in identifying candidate genes that will revolutionize crop breeding, as they are capable of tolerating complex abiotic and biotic stresses induced by global climate change. Serving as an ideal reference on plant speed breeding technologies, this book is for graduate students, teachers, researchers, and experts in the fields of plant sciences and plant breeding as well as agronomy and agriculture.

The Molecular Basis of Human Cancer

Author : William B. Coleman
Publisher : Humana Press
ISBN 13 : 1597454583
Total Pages : 868 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis The Molecular Basis of Human Cancer by : William B. Coleman

Download or read book The Molecular Basis of Human Cancer written by William B. Coleman and published by Humana Press. This book was released on 2016-11-11 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care. The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.

Structural Biology in Drug Discovery

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
ISBN 13 : 1118900502
Total Pages : 1437 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud

Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1437 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Free Energy Calculations

Author : Christophe Chipot
Publisher : Springer Science & Business Media
ISBN 13 : 3540384472
Total Pages : 528 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Free Energy Calculations by : Christophe Chipot

Download or read book Free Energy Calculations written by Christophe Chipot and published by Springer Science & Business Media. This book was released on 2007-01-08 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free energy constitutes the most important thermodynamic quantity to understand how chemical species recognize each other, associate or react. Examples of problems in which knowledge of the underlying free energy behaviour is required, include conformational equilibria and molecular association, partitioning between immiscible liquids, receptor-drug interaction, protein-protein and protein-DNA association, and protein stability. This volume sets out to present a coherent and comprehensive account of the concepts that underlie different approaches devised for the determination of free energies. The reader will gain the necessary insight into the theoretical and computational foundations of the subject and will be presented with relevant applications from molecular-level modelling and simulations of chemical and biological systems. Both formally accurate and approximate methods are covered using both classical and quantum mechanical descriptions. A central theme of the book is that the wide variety of free energy calculation techniques available today can be understood as different implementations of a few basic principles. The book is aimed at a broad readership of graduate students and researchers having a background in chemistry, physics, engineering and physical biology.

Comparative Genomics

Author : James R. Brown
Publisher : CRC Press
ISBN 13 : 1420008870
Total Pages : 409 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Comparative Genomics by : James R. Brown

Download or read book Comparative Genomics written by James R. Brown and published by CRC Press. This book was released on 2007-12-03 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: Through comparative analysis, the genomes of a number of species are providing a deeper understanding of the human genome. This is highly useful in drug research, especially in the treatment of otherwise intractable conditions. Compiling first-hand descriptions of the pioneering achievements of prominent researchers, this text focuses on revolutionary advances in DNA-sequencing technology, new approaches to the organization and analysis of large phylogenetic data sets, new perspectives on evolution, and the development of novel antimicrobial drugs. This seminal volume demonstrates both the means and the fruits of cooperation across a number of fields, and in doing so lays the groundwork for continued progress.

Quantum Chemistry in the Age of Machine Learning

Author : Pavlo O. Dral
Publisher : Elsevier
ISBN 13 : 0323886043
Total Pages : 702 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Quantum Chemistry in the Age of Machine Learning by : Pavlo O. Dral

Download or read book Quantum Chemistry in the Age of Machine Learning written by Pavlo O. Dral and published by Elsevier. This book was released on 2022-09-16 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantum chemistry is simulating atomistic systems according to the laws of quantum mechanics, and such simulations are essential for our understanding of the world and for technological progress. Machine learning revolutionizes quantum chemistry by increasing simulation speed and accuracy and obtaining new insights. However, for nonspecialists, learning about this vast field is a formidable challenge. Quantum Chemistry in the Age of Machine Learning covers this exciting field in detail, ranging from basic concepts to comprehensive methodological details to providing detailed codes and hands-on tutorials. Such an approach helps readers get a quick overview of existing techniques and provides an opportunity to learn the intricacies and inner workings of state-of-the-art methods. The book describes the underlying concepts of machine learning and quantum chemistry, machine learning potentials and learning of other quantum chemical properties, machine learning-improved quantum chemical methods, analysis of Big Data from simulations, and materials design with machine learning. Drawing on the expertise of a team of specialist contributors, this book serves as a valuable guide for both aspiring beginners and specialists in this exciting field. - Compiles advances of machine learning in quantum chemistry across different areas into a single resource - Provides insights into the underlying concepts of machine learning techniques that are relevant to quantum chemistry - Describes, in detail, the current state-of-the-art machine learning-based methods in quantum chemistry

Integrative Advances in Rice Research

Author : Min Huang
Publisher : BoD – Books on Demand
ISBN 13 : 1839695994
Total Pages : 344 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Integrative Advances in Rice Research by : Min Huang

Download or read book Integrative Advances in Rice Research written by Min Huang and published by BoD – Books on Demand. This book was released on 2022-01-26 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes some recent advances in rice research in terms of crop breeding and improvement (Section 1), crop production and protection (Section 2), and crop quality control and food processing (Section 3). It contains fourteen chapters that cover such topics as two-line rice breeding in India, the different aspects of aromatic rice, bacterial diseases of rice, quality control and breeding strategies, and much more. This volume is a useful reference for professionals and graduate students working in all areas of rice science and technology.

Targeting Ion Channels for Drug Discovery: Emerging Challenges for High Throughput Screening Technologies

Author : Ciria Hernandez
Publisher : Frontiers Media SA
ISBN 13 : 2832550169
Total Pages : 153 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Targeting Ion Channels for Drug Discovery: Emerging Challenges for High Throughput Screening Technologies by : Ciria Hernandez

Download or read book Targeting Ion Channels for Drug Discovery: Emerging Challenges for High Throughput Screening Technologies written by Ciria Hernandez and published by Frontiers Media SA. This book was released on 2024-06-07 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ligand and voltage-gated ion channels are highly regulated protein molecules that cross the cell membrane allowing ion flow from one side of the membrane to the other. They are ubiquitously expressed in human tissues and consist of one of the largest and best understood functional groups of proteins, with more than 400 members spanning nearly 1% of the human genome. They are involved in a variety of fundamental physiological processes, and their malfunction causes numerous diseases. In terms of the challenges faced in the effort to discover specific drugs in ancient and emerging diseases, ion channels are the third-largest class of target proteins after G-protein-coupled receptors (GPCRs) and kinases. 15% of small molecule drug targets have been reported to be voltage- or ligand-gated ion channels, resulting in approximately 150 new drug candidates in preclinical and clinical studies. Of the ion channel targeting drugs found on the market, these were identified more than a decade ago, and many of the current studies are at various stages of scientific approval. Overcoming these challenges has led the field of ion channel drug discovery to transform over the past 15 years through major advancements in genetic target detection, validation, structure-based drug design, and drug modeling of cell-based diseases.

DOE Genomics

Author :
Publisher :
ISBN 13 :
Total Pages : 320 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis DOE Genomics by :

Download or read book DOE Genomics written by and published by . This book was released on 2005 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biocatalysis and Agricultural Biotechnology

Author : Ching T. Hou
Publisher : CRC Press
ISBN 13 : 1420077074
Total Pages : 428 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Biocatalysis and Agricultural Biotechnology by : Ching T. Hou

Download or read book Biocatalysis and Agricultural Biotechnology written by Ching T. Hou and published by CRC Press. This book was released on 2009-04-27 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Worldwide energy and food crises are spotlighting the importance of bio-based products - an area many are calling on for solutions to these shortages. Biocatalysis and Agricultural Biotechnology encapsulates the cutting-edge advances in the field with contributions from more than 50 international experts comprising sectors of academia, industry, an

Review

Author : Oak Ridge National Laboratory
Publisher :
ISBN 13 :
Total Pages : 70 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Review by : Oak Ridge National Laboratory

Download or read book Review written by Oak Ridge National Laboratory and published by . This book was released on 2003 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Drug-like Properties: Concepts, Structure Design and Methods

Author : Li Di
Publisher : Elsevier
ISBN 13 : 0080557619
Total Pages : 549 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Drug-like Properties: Concepts, Structure Design and Methods by : Li Di

Download or read book Drug-like Properties: Concepts, Structure Design and Methods written by Li Di and published by Elsevier. This book was released on 2010-07-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. - Serves as an essential working handbook aimed at scientists and students in medicinal chemistry - Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies - Discusses improvements in pharmacokinetics from a practical chemist's standpoint

Molecular Plant Breeding

Author : Yunbi Xu
Publisher : CABI
ISBN 13 : 1845933923
Total Pages : 754 pages
Book Rating : 4.8/5 (459 download)

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Book Synopsis Molecular Plant Breeding by : Yunbi Xu

Download or read book Molecular Plant Breeding written by Yunbi Xu and published by CABI. This book was released on 2010 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in plant genomics and molecular biology have revolutionized our understanding of plant genetics, providing new opportunities for more efficient and controllable plant breeding. Successful techniques require a solid understanding of the underlying molecular biology as well as experience in applied plant breeding. Bridging the gap between developments in biotechnology and its applications in plant improvement, Molecular Plant Breeding provides an integrative overview of issues from basic theories to their applications to crop improvement including molecular marker technology, gene mapping, genetic transformation, quantitative genetics, and breeding methodology.

Genomics of Plant Genetic Resources

Author : Roberto Tuberosa
Publisher : Springer Science & Business Media
ISBN 13 : 940077575X
Total Pages : 517 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Genomics of Plant Genetic Resources by : Roberto Tuberosa

Download or read book Genomics of Plant Genetic Resources written by Roberto Tuberosa and published by Springer Science & Business Media. This book was released on 2013-12-23 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our lives and well being intimately depend on the exploitation of the plant genetic resources available to our breeding programs. Therefore, more extensive exploration and effective exploitation of plant genetic resources are essential prerequisites for the release of improved cultivars. Accordingly, the remarkable progress in genomics approaches and more recently in sequencing and bioinformatics offers unprecedented opportunities for mining germplasm collections, mapping and cloning loci of interest, identifying novel alleles and deploying them for breeding purposes. This book collects 48 highly interdisciplinary articles describing how genomics improves our capacity to characterize and harness natural and artificially induced variation in order to boost crop productivity and provide consumers with high-quality food. This book will be an invaluable reference for all those interested in managing, mining and harnessing the genetic richness of plant genetic resources.

Glossary of Biotechnology Terms

Author : Kimball Nill
Publisher : CRC Press
ISBN 13 : 9781420048926
Total Pages : 308 pages
Book Rating : 4.0/5 (489 download)

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Book Synopsis Glossary of Biotechnology Terms by : Kimball Nill

Download or read book Glossary of Biotechnology Terms written by Kimball Nill and published by CRC Press. This book was released on 2010-12-12 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a result of biotechnology becoming such a highly prolific area, non-technical people, such as lobbyists, attorneys, marketing, and public relations people, have had to quickly become conversant about a topic that is highly technical. In addition, various specialists working in the field of biotechnology, including chemists, geneticists, and biologists, occasionally have difficulty in understanding the terms utilized by each other in their respective specialties. It is, therefore, necessary to have a book to which you can refer so everyone can clearly discuss the topics in biotechnology. This text provides concise definitions of terms for persons unfamiliar with biotechnology, and clarifies new terms and how they are being used for those who are already somewhat conversant in the area. The Glossary of Biotechnology Terms is a handy reference for people with little or no training in the biological and chemical sciences because it has been written in non-technical language and serves to bring you up to date on biotechnology terminology to provide for more effective communication. The definitions are written utilizing words that enable you to conceptualize the idea embodied in the term and explanations are based on analogy whenever possible. Written to assist those individuals who seek to gain an understanding of the terminology as it is currently used, the Glossary of Biotechnology Terms, Third Edition is compulsory for anyone involved in the biotechnology field or anyone who deals with professionals in biotechnology.

Henry's Clinical Diagnosis and Management by Laboratory Methods E-Book

Author : Richard A. McPherson
Publisher : Elsevier Health Sciences
ISBN 13 : 1455726842
Total Pages : 1769 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Henry's Clinical Diagnosis and Management by Laboratory Methods E-Book by : Richard A. McPherson

Download or read book Henry's Clinical Diagnosis and Management by Laboratory Methods E-Book written by Richard A. McPherson and published by Elsevier Health Sciences. This book was released on 2011-09-06 with total page 1769 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognized as the definitive book in laboratory medicine since 1908, Henry’s Clinical Diagnosis and Management by Laboratory Methods, edited by Richard A. McPherson, MD and Matthew R. Pincus, MD, PhD, is a comprehensive, multidisciplinary pathology reference that gives you state-of-the-art guidance on lab test selection and interpretation of results. Revisions throughout keep you current on the latest topics in the field, such as biochemical markers of bone metabolism, clinical enzymology, pharmacogenomics, and more! A user-friendly full-color layout puts all the latest, most essential knowledge at your fingertips. Update your understanding of the scientific foundation and clinical application of today's complete range of laboratory tests. Get optimal test results with guidance on error detection, correction, and prevention as well as cost-effective test selection. Reference the information you need quickly and easily thanks to a full-color layout, many new color illustrations and visual aids, and an organization by organ system. Master all the latest approaches in clinical laboratory medicine with new and updated coverage of: the chemical basis for analyte assays and common interferences; lipids and dyslipoproteinemia; markers in the blood for cardiac injury evaluation and related stroke disorders; coagulation testing for antiplatelet drugs such as aspirin and clopidogrel; biochemical markers of bone metabolism; clinical enzymology; hematology and transfusion medicine; medical microbiology; body fluid analysis; and many other rapidly evolving frontiers in the field. Effectively monitor the pace of drug clearing in patients undergoing pharmacogenomic treatments with a new chapter on this groundbreaking new area. Apply the latest best practices in clinical laboratory management with special chapters on organization, work flow, quality control, interpretation of results, informatics, financial management, and establishing a molecular diagnostics laboratory. Confidently prepare for the upcoming recertification exams for clinical pathologists set to begin in 2016.