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Author : Zsuzsa Bagoly
Publisher : Frontiers Media SA
ISBN 13 : 2889714292
Total Pages : 171 pages
Book Rating : 4.8/5 (897 download)
Download or read book Hemostasis and Stroke written by Zsuzsa Bagoly and published by Frontiers Media SA. This book was released on 2021-09-30 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Christof M. Kessler
Publisher : CRC Press
ISBN 13 : 9780849376504
Total Pages : 182 pages
Book Rating : 4.3/5 (765 download)
Download or read book Hemostasis and Stroke written by Christof M. Kessler and published by CRC Press. This book was released on 1994-03-24 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hemostasis and Stroke presents an exciting and new understanding of current investigations and applications in stroke therapy. Although research in stroke, hematology, and related fields has made enormous progress in the last decade, stroke still remains one of the leading causes of death today. To achieve an interdisciplinary approach to current research and practice in the management of thrombosis of cerebrovascular disorders, scientists and clinicans worldwide met in Lübeck, Germany, in May 1993 for an International Symposium on Hemostasis and Stroke. This book represents the proceedings of the symposium. It also summarizes the results of recent stroke prevention trials, including critical reviews on current recommendations of acetylsalicyclic acid and the usefulness of ticlopidine. In addition, animal models of experimental cerebral ischemia are viewed under their possible application for research in embolic stroke.
Author : Judit Tu00f3th
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (116 download)
Download or read book HEMOSTASIS BIOMARKERS IN THE PROGNOSIS OF NON-TRAUMATIC INTRACEREBRAL HEMORRHAGE written by Judit Tu00f3th and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction and Objectives. Non-traumatic intracerebral hemorrhage (ICH) accounts for 10-15% of all strokes and results in higher rate of mortality as compared to ischemic strokes. In the IRONHEART study we aimed to find potential hemostasis biomarkers with prognostic value in patients with ICH.Patients and methods. In this prospective, observational study, 183 acute stroke patients and 140 healthy controls were included. Patients were grouped: 51 primary ICH patients (PICH), 118 acute ischemic stroke patients who underwent thrombolysis without hemorrhagic events (AIS), 13 patients with AIS who suffered hemorrhagic complications after intravenous thrombolysis (AIS-ICH). On admission, CT angiography, detailed clinical and laboratory investigations were performed. The following hemostasis measurements were carried out from blood samples: hemostasis screening tests, von Willebrand factor (VWF) antigen, factor XIII (FXIII), plasminogen and uf0612 antiplasmin activity, D-dimer. Patients were followed for 90 days, long term outcomes were defined using the modified Rankin Scale. Results. VWF level was significantly higher in all patient groups as compared to controls. VWF levels were significantly higher in patients with worse long-term outcomes (mRS>3) in all patient cohorts. FXIII activity was significantly elevated in the PICH group as compared to controls and to both AIS groups. FXIII activity in the lowest quartile was associated with a significant risk of mortality in the PICH group (OR: 9.9; 95%CI:1.6-61.6, p=0.015). Among fibrinolytic markers, only D-dimer showed association with worse long-term outcomes (mRS>3).Conclusion.VWF antigen, FXIII activity and D-dimer could serve as biomarkers of long-term outcomes in PICH patients. Funding: GINOP-2.3.2-15-2016-00043, NKFI-K120042.
Author : Michel T. Torbey
Publisher : Cambridge University Press
ISBN 13 : 1107634725
Total Pages : 395 pages
Book Rating : 4.1/5 (76 download)
Download or read book The Stroke Book written by Michel T. Torbey and published by Cambridge University Press. This book was released on 2013-07-18 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential companion for busy professionals seeking to navigate stroke-related clinical situations successfully and make quick informed treatment decisions.
Author : Ekaterina Kimelfeld
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (116 download)
Download or read book THE ASSOCIATION OF HEMOSTASIS SYSTEM GENES WITH THE DEVELOPMENT OF ISCHEMIC STROKE IN MEN WITH EARLY ONSET OF THE DISEASE written by Ekaterina Kimelfeld and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Background and AimsThe etiology and pathogenesis of the ischemic stroke (IS) in young people is differ from those in older age group. The results of research devoted to the effect of the polymorphisms of hemostasis system genes on the risk of development an IS are ambiguous. The aim of our research is to study an influence of polymorphisms hemostasis system genes on the risk of ischemic stroke (IS) in patients of the Slavic population under the age of 50 years.MethodSeventy three males (aged 23-49 years) with IS and 186 healthy males (aged 19-49 years) were examined. The diagnosis of stroke was confirmed by neuroimaging (CT or MRI) in all patients. Polymorphic alleles of GP1BA, F2, F5 were studied by a real time polymerase chain reaction using the TaqMan technology. ResultsAn analysis of the GP1BA -5T/C polymorphism showed that it was associated with the risk of IS in young men. The -5C allele and the genotypes -5T/C and -5C/C (p = 0,02; OR=1,84; CI [1,13; 2,99]) indicated an elevated the risk of IS. However, no significant association between the F5 G1691A polymorphism and the F2 G20210A polymorphism and the risk of IS was observed (p u02c3 0.05).ConclusionOur findings suggest that the GP1BA -5T/C polymorphism is associated with the risk of IS in u201cyoungu201d men, whereas the F5 G1691A and the F2 G20210A polymorphisms are not associated with the risk of IS in this group .
Author : Judit Tóth
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (134 download)
Download or read book HEMOSTASIS BIOMARKERS IN THE PROGNOSIS OF NON-TRAUMATIC INTRACEREBRAL HEMORRHAGE written by Judit Tóth and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction and Objectives. Non-traumatic intracerebral hemorrhage (ICH) accounts for 10-15% of all strokes and results in higher rate of mortality as compared to ischemic strokes. In the IRONHEART study we aimed to find potential hemostasis biomarkers with prognostic value in patients with ICH.Patients and methods. In this prospective, observational study, 183 acute stroke patients and 140 healthy controls were included. Patients were grouped: 51 primary ICH patients (PICH), 118 acute ischemic stroke patients who underwent thrombolysis without hemorrhagic events (AIS), 13 patients with AIS who suffered hemorrhagic complications after intravenous thrombolysis (AIS-ICH). On admission, CT angiography, detailed clinical and laboratory investigations were performed. The following hemostasis measurements were carried out from blood samples: hemostasis screening tests, von Willebrand factor (VWF) antigen, factor XIII (FXIII), plasminogen and uf0612 antiplasmin activity, D-dimer. Patients were followed for 90 days, long term outcomes were defined using the modified Rankin Scale. Results. VWF level was significantly higher in all patient groups as compared to controls. VWF levels were significantly higher in patients with worse long-term outcomes (mRS>3) in all patient cohorts. FXIII activity was significantly elevated in the PICH group as compared to controls and to both AIS groups. FXIII activity in the lowest quartile was associated with a significant risk of mortality in the PICH group (OR: 9.9; 95%CI:1.6-61.6, p=0.015). Among fibrinolytic markers, only D-dimer showed association with worse long-term outcomes (mRS>3).Conclusion.VWF antigen, FXIII activity and D-dimer could serve as biomarkers of long-term outcomes in PICH patients. Funding: GINOP-2.3.2-15-2016-00043, NKFI-K120042.
Author : Carsten Deppermann
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (11 download)
Download or read book The Role of Platelet Granules in Thrombosis, Hemostasis, Stroke and Inflammation written by Carsten Deppermann and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jong S. Kim
Publisher : John Wiley & Sons
ISBN 13 : 1444300687
Total Pages : 272 pages
Book Rating : 4.4/5 (443 download)
Download or read book Intracranial Atherosclerosis written by Jong S. Kim and published by John Wiley & Sons. This book was released on 2009-01-26 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intracranial atherosclerosis is the dominant cause of stroke inover 70% of the world’s population. Globalization is leadingto an increasingly heterogeneous society everywhere. Advances inimaging techinology allow this previously inaccessible pathology tobe clinically studied. Edited by internationally renowned clinicians, IntracranialAtherosclerosis is the first book to examine intracranialcauses of stroke. Clinical practice is allied with basic science toguide all those with an interest in stroke on the diagnosis andmanagement of intracranial atherosclerosis.
Author : S andrine Delbosc
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (116 download)
Download or read book INFLAMMATORY AND HEMOSTASIS BLOOD BIOMARKERS PREDICT THE CLINICAL OUTCOME OF STROKE PATIENTS TREATED BY THROMBOLYSIS/THROMBECTOMY. written by S andrine Delbosc and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction In ischemic stroke, the lack of blood flow triggers local inflammation and vascular injury, which further promotes tissue remodeling and angiogenesis. The aim of the present study was to investigate whether biomarkers of inflammation, hemostasis, vascular injury, and tissue remodeling measured in the plasma of stroke patients could stratify stroke patients concerning their clinical outcome. MethodsWe included 153 patients consecutively admitted for ischemic stroke treated by thrombolysis with or without thrombectomy. Blood was sampled at admission and 21 biomarkers related to inflammation (MPO, Osteopontin, CCL2/MCP-1, Adiponectin, Resistin, CD40L), hemostasis (uPA/Urokinase, alpha 2-macroglobulin, Serpin C1/Antithrombin-III, Serpin E1/PAI-1, Kallikrein 6/Neurosin, CD40L), endothelium activation (VCAM-1, ICAM-1 , CD31/PECAM-1, CD40L, Neuropilin-1), and tissue remodeling (Osteopontin, MMP-2, MMP-3, MMP-9, MMP-13, Cathepsin S, Cystatin C, Neuropilin-1) were assayed by a quantitative Luminex multiplex technic. ResultsPatients with higher NIHSS at admission presented higher levels of the inflammatory biomarker MPO, the hemostasis biomarker uPA/Urokinase and the endothelial activation biomarker VCAM. Logistic regression analyses correlated levels of uPA/Urokinase to NIHSS at arrival (p=0.0037), suggesting the major role of hemostasis in initial stroke gravitymRS>1 at 3 months was correlated to higher levels of MPO, the endothelial activation biomarkers ICAM-1, VCAM-1 and the tissue remodeling biomarkers Osteopontin, Cathepsine S, and lower levels of MMP-13. Logistic regression analyses correlated mRS 0-1 at three months to levels of Cathepsine S (p=0.0201) and VCAM-1 (p=0.0048). The area under ROC curve of both biomarkers was 0.75. Symptomatic hemorrhagic transformation, defined according to ECASS-3 criteria, was correlated to MMP-9 (p=0.0382)ConclusionsAs expected, initial NIHSS was related to early hemostasis response. Importantly, initial inflammatory response, endothelial activation and tissue remodeling biomarkers significantly impact the three-month outcome and the hemorrhagic transformation.
Author : Michael Brainin
Publisher : Cambridge University Press
ISBN 13 : 1107047498
Total Pages : 425 pages
Book Rating : 4.1/5 (7 download)
Download or read book Textbook of Stroke Medicine written by Michael Brainin and published by Cambridge University Press. This book was released on 2014-09-11 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully revised throughout, the new edition of this concise textbook is aimed at doctors preparing to specialize in stroke care.
Author : Paul A. Lapchak
Publisher : Springer Science & Business Media
ISBN 13 : 1441995293
Total Pages : 926 pages
Book Rating : 4.4/5 (419 download)
Download or read book Translational Stroke Research written by Paul A. Lapchak and published by Springer Science & Business Media. This book was released on 2012-03-23 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume sets a basis for effective translational research. Authored by experts in the field of translational stroke research, each chapter specifically addresses one or more components of preclinical stroke research. The emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design.
Author : Juerg Hodler
Publisher : Springer Nature
ISBN 13 : 303038490X
Total Pages : 252 pages
Book Rating : 4.0/5 (33 download)
Download or read book Diseases of the Brain, Head and Neck, Spine 2020–2023 written by Juerg Hodler and published by Springer Nature. This book was released on 2020-02-14 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.
Author : Louis Caplan
Publisher : Elsevier Health Sciences
ISBN 13 : 1437711162
Total Pages : 667 pages
Book Rating : 4.4/5 (377 download)
Download or read book Caplan's Stroke E-Book written by Louis Caplan and published by Elsevier Health Sciences. This book was released on 2009-06-24 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated and revised, this new edition of Caplan’s Stroke continues to provide a concise and pragmatic approach to the evaluation, diagnosis, and management of adult and pediatric stroke patients. Dr. Caplan—a highly esteemed stroke authority— shares with you his vast experience and wisdom as a stroke clinician, including his time-tested strategies and unique clinical pearls that you can implement into your own practice. Expanded coverage of imaging and laboratory diagnosis and treatment as well as extensive revisions throughout, brings you the latest advances on prevention, complications, and rehabilitation. The use of case studies illustrates the types of clinical scenarios you may experience in practice. And, its conversational, easy-to-read format make Caplan’s Stroke an ideal resource for general neurologists, non-neurologists, and stroke specialists alike. Discusses all cerebrovascular diseases to help you differentiate among all types of stroke so you can treat each patient appropriately. Takes a distinctly personal and individual approach to general principles, pathophysiology, diagnosis, treatment, and rehabilitation, offering practical, clinical guidance on stroke and stroke related issues. Provides detailed discussions on stroke syndromes in children and adults, including large artery occlusive disease of the anterior circulation, brain embolism, spinal cord stroke, and many, many more, to help you better manage every condition you see. Uses case studies to highlight and emphasize clinical points. Includes expanded coverage of imaging and laboratory diagnosis and treatment to help you make better informed evaluation and management decisions. Presents meticulous revisions and updates throughout, particularly to the chapters on stroke prevention and rehabilitation to keep you current on today’s best practices. Features a new two-color design with updated artwork and more images that elucidates key points and enhances visual guidance.
Author : José Biller
Publisher : Cambridge University Press
ISBN 13 : 1316351726
Total Pages : 281 pages
Book Rating : 4.3/5 (163 download)
Download or read book Common Pitfalls in Cerebrovascular Disease written by José Biller and published by Cambridge University Press. This book was released on 2015-07-09 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical case studies have long been recognized as a useful adjunct to problem-based learning and continuing professional development. They emphasize the need for clinical reasoning, integrative thinking, problem-solving, communication, teamwork and self-directed learning – all desirable generic skills for health care professionals. This book is a teaching tool that bridges the gap between textbook information and everyday experience of clinicians 'in the trenches'. Leading practitioners bring a practical approach to these complex conditions, highlighting specific areas of diagnostic uncertainty in evaluation and treatment. Each case is taken from real-world clinical practice and reviews the diagnostic and treatment process in a systematic manner, identifying common challenges and potential pitfalls. This concise and useful guide in the Common Pitfalls series provides a step-by-step guide for everyday clinical practice, invaluable to anyone dealing with cerebrovascular disease on a front-line basis. The intended readership is trainees and non-specialist practitioners in neurology, stroke medicine, and neurosurgery.
Author : Victor S. Blanchette
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318021970
Total Pages : 274 pages
Book Rating : 4.3/5 (18 download)
Download or read book SickKids Handbook of Pediatric Thrombosis and Hemostasis written by Victor S. Blanchette and published by Karger Medical and Scientific Publishers. This book was released on 2013 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: SickKids Handbook of Pediatric Thrombosis and Hemostasis takes the reader through the entire field of paediatric thrombosis and hemostasis. This practical reference book will be a convenient, comprehensive, source of information and provides up-to-date, evidence-based guidance in the diagnosis and management of inherited and acquired bleeding disorders and thrombotic events of the venous, arterial, cardiac and central nervous systems that affect children, including the neonate. Written and reviewed by international experts in the field, SickKids Handbook of Pediatric Thrombosis and Hemostasis will guide health care professionals involved in the assessment and care of children with all types of bleeding and clotting disorders, including general and specialist pediatricians, in particular intensivists, neonatologists, cardiologists/cardiac surgeons, rheumatologists and nephrologists; hematologists/oncologists as well as nurses, nurse practitioners and pharmacists. Written in a user-friendly, algorithmic approach, the resource will serve students and trainees and assist teachers in developing practical lessons.
Author : Patrick D. Lyden
Publisher : Springer Science & Business Media
ISBN 13 : 1592591310
Total Pages : 398 pages
Book Rating : 4.5/5 (925 download)
Download or read book Thrombolytic Therapy for Stroke written by Patrick D. Lyden and published by Springer Science & Business Media. This book was released on 2001-02-23 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thrombolytic Therapy for Stroke is intended for physicians who will be treating patients in the first few hours after stroke: neurologists, neurosurgeons, emergency medicine physicians, internists, and radiologists. In some areas, fam ily medicine general practice physicians may provide the majority of acute stroke care. We will provide the reader with all the data necessary to understand the utility and limitations of thrombolytic therapy. By reading the protocols, and working through the case tutorials, the reader will become sufficiently familiar with the indications and contraindications of thrombolytic therapy to begin evalu ating potential patients. Although nothing can replace direct instruction by more experienced physicians, we hope that by imparting our accumulated knowledge we may guide those physicians who cannot attend a "hands-on" workshop, or who, having heard the appropriate lectures, feel the need for further guidance. We will review the scientific rationale for thrombolysis: first, most ischemic stroke is caused by thrombo-emboli; second, a portion of brain, the penumbra, remains salvageable for a few hours after vascular occlusion; and third, promptly delivered thrombolysis can remove the offending occlusion and restore cerebral blood flow to the penumbra in time to salvage brain and neurologic function. Then we will review the preclinical development of thrombolytics for stroke pa tients and the early pilot trials. Next, we will present the pivotal clinical trials that demonstrated the efficacy and safety of thrombolysis.
Author : Hunter B. Moore
Publisher : Springer Nature
ISBN 13 : 3030536068
Total Pages : 802 pages
Book Rating : 4.0/5 (35 download)
Download or read book Trauma Induced Coagulopathy written by Hunter B. Moore and published by Springer Nature. This book was released on 2020-10-12 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities. Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.
