Hematopoietic Stem Cell Transplantation And Cellular Therapies For Autoimmune Diseases

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Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

Author : Richard K. Burt
Publisher : CRC Press
ISBN 13 : 1351364766
Total Pages : 687 pages
Book Rating : 4.3/5 (513 download)

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Book Synopsis Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases by : Richard K. Burt

Download or read book Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases written by Richard K. Burt and published by CRC Press. This book was released on 2021-11-17 with total page 687 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications. Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight

Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

Author : Dominique Farge
Publisher :
ISBN 13 : 9781032827940
Total Pages : 0 pages
Book Rating : 4.8/5 (279 download)

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Book Synopsis Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases by : Dominique Farge

Download or read book Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases written by Dominique Farge and published by . This book was released on 2024-04-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the progress made across the international medical and scientific research communities towards the goal of converting a chronic autoimmune disease into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies to generate sustained immune tolerance.

EBMT HANDBOOK

Author :
Publisher :
ISBN 13 : 9783031440823
Total Pages : 0 pages
Book Rating : 4.4/5 (48 download)

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Book Synopsis EBMT HANDBOOK by :

Download or read book EBMT HANDBOOK written by and published by . This book was released on 2025 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Non-Myeloablative Allogeneic Transplantation

Author : Asad Bashey
Publisher : Springer Science & Business Media
ISBN 13 : 9780792376460
Total Pages : 240 pages
Book Rating : 4.3/5 (764 download)

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Book Synopsis Non-Myeloablative Allogeneic Transplantation by : Asad Bashey

Download or read book Non-Myeloablative Allogeneic Transplantation written by Asad Bashey and published by Springer Science & Business Media. This book was released on 2002-02-28 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.

The European Blood and Marrow Transplantation Textbook for Nurses

Author : Michelle Kenyon
Publisher : Springer
ISBN 13 : 3319500260
Total Pages : 318 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis The European Blood and Marrow Transplantation Textbook for Nurses by : Michelle Kenyon

Download or read book The European Blood and Marrow Transplantation Textbook for Nurses written by Michelle Kenyon and published by Springer. This book was released on 2018-03-14 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.

Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

Author : Richard K. Burt
Publisher : CRC Press
ISBN 13 : 1351364758
Total Pages : 1739 pages
Book Rating : 4.3/5 (513 download)

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Book Synopsis Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases by : Richard K. Burt

Thomas' Hematopoietic Cell Transplantation

Author : Stephen J. Forman
Publisher : John Wiley & Sons
ISBN 13 : 1118416120
Total Pages : 1416 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Thomas' Hematopoietic Cell Transplantation by : Stephen J. Forman

Download or read book Thomas' Hematopoietic Cell Transplantation written by Stephen J. Forman and published by John Wiley & Sons. This book was released on 2015-12-14 with total page 1416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research Combines the knowledge and expertise of over 170 international specialists across 106 chapters Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at www.wiley.com/go/forman/hematopoietic.

The Comprehensive Cancer Center

Author : Mahmoud Aljurf
Publisher : Springer Nature
ISBN 13 : 3030820521
Total Pages : 192 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis The Comprehensive Cancer Center by : Mahmoud Aljurf

Download or read book The Comprehensive Cancer Center written by Mahmoud Aljurf and published by Springer Nature. This book was released on 2021-10-28 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a valuable resource for hospitals, institutions, and health authorities worldwide in their plans to set up and develop comprehensive cancer care centers. The development and implementation of a comprehensive cancer program allows for a systematic approach to evidence-based strategies of prevention, early detection, diagnosis, treatment, and palliation. Comprehensive cancer programs also provide a nexus for the running of clinical trials and implementation of novel cancer therapies with the overall aim of optimizing comprehensive and holistic care of cancer patients and providing them with the best opportunity to improve quality of life and overall survival. This book's self-contained chapter format aims to reinforce the critical importance of comprehensive cancer care centers while providing a practical guide for the essential components needed to achieve them, such as operational considerations, guidelines for best clinical inpatient and outpatient care, and research and quality management structures. Intended to be wide-ranging and applicable at a global level for both high and low income countries, this book is also instructive for regions with limited resources. The Comprehensive Cancer Center: Development, Integration, and Implementation is an essential resource for oncology physicians including hematologists, medical oncologists, radiation oncologists, surgical oncologists, and oncology nurses as well as hospitals, health departments, university authorities, governments and legislators.

Mesenchymal Stem Cell Therapy

Author : Lucas G. Chase
Publisher : Springer Science & Business Media
ISBN 13 : 1627032002
Total Pages : 458 pages
Book Rating : 4.6/5 (27 download)

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Book Synopsis Mesenchymal Stem Cell Therapy by : Lucas G. Chase

Download or read book Mesenchymal Stem Cell Therapy written by Lucas G. Chase and published by Springer Science & Business Media. This book was released on 2012-12-12 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Stem Cell Therapy for Autoimmune Disease

Author : Richard K. Burt
Publisher : CRC Press
ISBN 13 : 1000716856
Total Pages : 512 pages
Book Rating : 4.0/5 (7 download)

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Book Synopsis Stem Cell Therapy for Autoimmune Disease by : Richard K. Burt

Download or read book Stem Cell Therapy for Autoimmune Disease written by Richard K. Burt and published by CRC Press. This book was released on 2019-11-11 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell transplantation may be complicated by treatment-related mortality and like the immune system that it regenerates has equal potential to either create and preserve or destroy. The dual nature that defines stem cells is differentiation that ultimately leads to death and self-renewal, which leads to immortality. What types of stem cells are there? How are they collected? What are their attributes and characteristics? This textbook devotes many chapters to familiarize the reader with the basic science, clinical aspects, and new questions being raised in the field of stem cell biology. Blood stem cells for tolerance and tissue regeneration are a rapidly developing research and clinical field that is being applied to autoimmune diseases. In clinical trials, autologous hematopoietic (blood) stem cells are being used to reduce the cytopenic interval following intense immune suppressive transplant regimens. While as yet not delineated, some possible mechanisms and pathways leading to tolerance after hematopoietic stem cell transplantation are suggested in these chapters. Tissue regeneration from blood stem cells is also suggested by animal experiments on stem cell plasticity or metamoirosis (i.e., change in fate) as described within this textbook. Ongoing early clinical trials on tissue regeneration from blood stem cells are described in the chapter on stem cell therapy for cardiac and peripheral vascular disease. Whether autologous hematopoietic stem cells, through the process of mobilization and reinfusion, may be manipulated to contribute to tissue repair in autoimmune diseases is a future area for translational research.

Chronic Graft Versus Host Disease

Author : Georgia B. Vogelsang
Publisher : Cambridge University Press
ISBN 13 : 1139478893
Total Pages : 427 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Chronic Graft Versus Host Disease by : Georgia B. Vogelsang

Download or read book Chronic Graft Versus Host Disease written by Georgia B. Vogelsang and published by Cambridge University Press. This book was released on 2009-04-20 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant.

Manual of Stem Cell and Bone Marrow Transplantation

Author : Joseph H. Antin
Publisher : Cambridge University Press
ISBN 13 : 1107661544
Total Pages : 204 pages
Book Rating : 4.1/5 (76 download)

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Book Synopsis Manual of Stem Cell and Bone Marrow Transplantation by : Joseph H. Antin

Download or read book Manual of Stem Cell and Bone Marrow Transplantation written by Joseph H. Antin and published by Cambridge University Press. This book was released on 2013-10-17 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fully revised second edition is a practical manual for all members of the stem cell and bone marrow transplant team.

Cellular Transplantation

Author : Craig Halberstadt
Publisher : Elsevier
ISBN 13 : 0080469043
Total Pages : 699 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Cellular Transplantation by : Craig Halberstadt

Download or read book Cellular Transplantation written by Craig Halberstadt and published by Elsevier. This book was released on 2011-10-10 with total page 699 pages. Available in PDF, EPUB and Kindle. Book excerpt: There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy. Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier. The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices. - Provides detailed description of clinical trials in cell transplantation - Review of current therapeutic approaches - Coverage of the broad range of diseases addressed by cell therapeutics - Discussion of stem cell biology and its role in transplantation

Stem Cells – From Hype to Real Hope

Author : Khawaja Husnain Haider
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110587041
Total Pages : 220 pages
Book Rating : 4.1/5 (15 download)

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Book Synopsis Stem Cells – From Hype to Real Hope by : Khawaja Husnain Haider

Download or read book Stem Cells – From Hype to Real Hope written by Khawaja Husnain Haider and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-12-17 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.

The BMT Data Book

Author : Reinhold Munker
Publisher : Cambridge University Press
ISBN 13 : 0521711002
Total Pages : 545 pages
Book Rating : 4.5/5 (217 download)

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Book Synopsis The BMT Data Book by : Reinhold Munker

Download or read book The BMT Data Book written by Reinhold Munker and published by Cambridge University Press. This book was released on 2009-02-26 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential guide to the data, outcome studies and complex decision-making processes involved in blood and marrow stem cell transplantation.

Hematopoietic Stem Cell Therapy

Author : Edward David Ball
Publisher :
ISBN 13 :
Total Pages : 794 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Hematopoietic Stem Cell Therapy by : Edward David Ball

Download or read book Hematopoietic Stem Cell Therapy written by Edward David Ball and published by . This book was released on 2000 with total page 794 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will be the only current practical guide to a widely used procedure for treating leukemias and disseminated cancers. The contents are organized chronologically, to serve as a step-by-step guide throughout the transplant process. Comprehensive yet concise, it emphasizes the latest techniques, such as peripheral blood stem cell grafts.

The EBMT/EHA CAR-T Cell Handbook

Author : Nicolaus Kröger
Publisher : Springer Nature
ISBN 13 : 3030943534
Total Pages : 221 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis The EBMT/EHA CAR-T Cell Handbook by : Nicolaus Kröger

Download or read book The EBMT/EHA CAR-T Cell Handbook written by Nicolaus Kröger and published by Springer Nature. This book was released on 2022-02-07 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first open access European CAR-T Handbook, co-promoted by the European Society for Blood and Marrow Transplantation (EBMT) and the European Hematology Association (EHA), covers several aspects of CAR-T cell treatments, including the underlying biology, indications, management of side-effects, access and manufacturing issues. This book, written by leading experts in the field to enhance readers’ knowledge and practice skills, provides an unparalleled overview of the CAR-T cell technology and its application in clinical care, to enhance readers’ knowledge and practice skills.