Hedgehog Signaling

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Hedgehog Signaling

Author : Xiaochun Li
Publisher : Humana
ISBN 13 : 9781071617038
Total Pages : 0 pages
Book Rating : 4.6/5 (17 download)

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Book Synopsis Hedgehog Signaling by : Xiaochun Li

Download or read book Hedgehog Signaling written by Xiaochun Li and published by Humana. This book was released on 2022-10-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book explores the technical breakthroughs with biophysical and cell biological approaches that have advanced the study of molecular mechanisms underlying the generation and transduction of the hedgehog (HH) signal, indicating the important role of sterols in this pathway. Within its pages, the volume examines techniques involving several key protein components in this pathway, including HH, the signaling ligand; Dispatched, a HH secretion regulator; Patched, the receptor of HH; Smoothened, the signal transducer used to transduce the HH signal across the plasma membrane; and GLI, the transcription factor to turn on HH target genes. Written in the highly successful Methods in Molecular Biology series format, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Hedgehog Signaling: Methods and Protocols provides researchers in clinical and basic science with a fresh and reliable reference for analyzing HH signal transduction through cell biological, biochemical, and biophysical approaches.

Endless Forms Most Beautiful

Author : Sean B. Carroll
Publisher : W. W. Norton & Company
ISBN 13 : 9780393060164
Total Pages : 388 pages
Book Rating : 4.0/5 (61 download)

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Book Synopsis Endless Forms Most Beautiful by : Sean B. Carroll

Download or read book Endless Forms Most Beautiful written by Sean B. Carroll and published by W. W. Norton & Company. This book was released on 2005 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: As described in this fascinating book, Evo Devo is evolutionary development biology, the third revolution in the science, which shows how the endless forms of animals--butterflies and zebras, trilobites and dinosaurs, apes and humans--were made and evolved.

Primary Cilia

Author :
Publisher : Academic Press
ISBN 13 : 0080962823
Total Pages : 423 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Primary Cilia by :

Download or read book Primary Cilia written by and published by Academic Press. This book was released on 2009-11-30 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the role of cilia in the study of health, development and disease has been increasingly clear, and new discoveries have made this an exciting and important field of research. This comprehensive volume, a complement to the new three-volume treatment of cilia and flagella by King and Pazour, presents easy-to-follow protocols and detailed background information for researchers working with cilia and flagella. - Covers protocols for primary cilia across several systems and species - Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time - Relevant to clinicians and scientists working in a wide range of fields

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Liver Growth and Repair

Author : A. Strain
Publisher : Springer Science & Business Media
ISBN 13 : 9780412712609
Total Pages : 1320 pages
Book Rating : 4.7/5 (126 download)

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Book Synopsis Liver Growth and Repair by : A. Strain

Download or read book Liver Growth and Repair written by A. Strain and published by Springer Science & Business Media. This book was released on 1997-12-31 with total page 1320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nelson Fausto The Greek myth of Prometheus with its picture of a vulture feasting on its chained victimhas traditionallyprovided a visualimageofliverregeneration. Itis apowerful and frightening representationbut ifone were to substitute the vulture by a surgeon and Prometheus by a patient laying on a properly prepared operating table, the outcomeoftheprocedurewould not differ significantlyfrom that describedbyGreek poets. Yet few of us who work in the field have stopped long enough to ask where this myth originated. Did the poet observe a case of liver regeneration in a human being? Was it brilliant intuition or perhaps, literally, just a 'gut feeling' of a poet looking for good rhymes that led to the prediction that livers grow when part of the tissueisremoved? Thisbookdoesnotattemptto solve these historical issues. Itdoes, instead, cover in detail some of the major modem themes of research on liver regen eration, injury and repair. As indicated in Dr. N. Bucher's chapter, the modem phase ofexperimental studies on liver regeneration started in 1931 with the publication by Higgins and Anderson of a method to perform a two-thirds resection of the liver of a rat. The technique described has 3 remarkable features: 1) it is highly reproducible, resulting in the removal of 68% of the liver, 2) it has minimal if any mortality, and 3) it consists only of blood vessel ligation and does not involve cutting through or wounding hepatic tissue.

Hedgehog Signaling

Author : Gerald Litwack
Publisher : Academic Press
ISBN 13 : 0123946220
Total Pages : 571 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Hedgehog Signaling by : Gerald Litwack

Download or read book Hedgehog Signaling written by Gerald Litwack and published by Academic Press. This book was released on 2012-03-12 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on hedgehog signaling. Contributions from leading authorities Informs and updates on all the latest developments in the field

Innovative Medicine

Author : Kazuwa Nakao
Publisher : Springer
ISBN 13 : 4431556516
Total Pages : 330 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Innovative Medicine by : Kazuwa Nakao

Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

The Hedgehog and the Fox

Author : Isaiah Berlin
Publisher : Princeton University Press
ISBN 13 : 1400846633
Total Pages : 143 pages
Book Rating : 4.4/5 (8 download)

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Book Synopsis The Hedgehog and the Fox by : Isaiah Berlin

Download or read book The Hedgehog and the Fox written by Isaiah Berlin and published by Princeton University Press. This book was released on 2013-06-02 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The fox knows many things, but the hedgehog knows one big thing." This ancient Greek aphorism, preserved in a fragment from the poet Archilochus, describes the central thesis of Isaiah Berlin's masterly essay on Leo Tolstoy and the philosophy of history, the subject of the epilogue to War and Peace. Although there have been many interpretations of the adage, Berlin uses it to mark a fundamental distinction between human beings who are fascinated by the infinite variety of things and those who relate everything to a central, all-embracing system. Applied to Tolstoy, the saying illuminates a paradox that helps explain his philosophy of history: Tolstoy was a fox, but believed in being a hedgehog. One of Berlin's most celebrated works, this extraordinary essay offers profound insights about Tolstoy, historical understanding, and human psychology. This new edition features a revised text that supplants all previous versions, English translations of the many passages in foreign languages, a new foreword in which Berlin biographer Michael Ignatieff explains the enduring appeal of Berlin's essay, and a new appendix that provides rich context, including excerpts from reviews and Berlin's letters, as well as a startling new interpretation of Archilochus's epigram.

Hedgehog Signaling Protocols

Author : Jamila I. Horabin
Publisher : Springer Science & Business Media
ISBN 13 : 158829692X
Total Pages : 267 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Hedgehog Signaling Protocols by : Jamila I. Horabin

Download or read book Hedgehog Signaling Protocols written by Jamila I. Horabin and published by Springer Science & Business Media. This book was released on 2007-09-13 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: In both vertebrates and invertebrates, Hedgehog signaling regulates the development of the tissues and structures of the body. In addition, many cancers and diseases arise as a result of misregulation of the pathway, which makes it an incredibly important system to understand. This volume examines various methods used in the analysis of the Hedgehog signaling pathway, bringing together different lines of analyses into one accessible and comprehensive text. This volume provides a single source for investigators, presenting several different experimental approaches, which are all varied and broad in nature, as well as procedures for a variety of different model systems. Researchers will find this volume to be an invaluble tool as they work towards deeper understanding of the underlying molecular events that the Hedgehog signaling pathway regulates.

Cancer Signaling

Author : Christoph Wagener
Publisher : John Wiley & Sons
ISBN 13 : 352780045X
Total Pages : 357 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Cancer Signaling by : Christoph Wagener

Download or read book Cancer Signaling written by Christoph Wagener and published by John Wiley & Sons. This book was released on 2016-08-12 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells. In contrast to the complexity of its topic, the text is easy to read. 32 specially prepared teaching videos on key concepts and pathways in cancer signaling are available online for users of the print edition and have been integrated into the text in the enhanced e-book edition.

Branching Morphogenesis

Author : Jamie Davies
Publisher : Springer Science & Business Media
ISBN 13 : 0387308733
Total Pages : 255 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Branching Morphogenesis by : Jamie Davies

Download or read book Branching Morphogenesis written by Jamie Davies and published by Springer Science & Business Media. This book was released on 2007-03-20 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.

Textbook of Cell Signalling in Cancer

Author : Jacques Robert
Publisher : Springer
ISBN 13 : 3319143409
Total Pages : 341 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Textbook of Cell Signalling in Cancer by : Jacques Robert

Download or read book Textbook of Cell Signalling in Cancer written by Jacques Robert and published by Springer. This book was released on 2015-02-17 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a simplified, yet comprehensive, overview of the signalling pathways operating between and inside cells, which will help younger oncologists find their way in the labyrinth of signalling pathways and in the multitude of signals and signal receptors, transducers and effectors that contribute to oncogenesis. This comprehensive reference text is based on the master’s courses delivered by Prof. Jacques Robert to graduate students at the University of Bordeaux, France. It includes a large number of colour schemas and figures that have been improved year after year for educational purposes. Signalling pathways are described individually and in depth, but without ignoring the multiplicity of interconnections and crosstalk. The presentation of each pathway is followed by a brief description of the alterations found in cancers as well as of the targeted pharmacological approaches that can be used to prevent or overcome the consequences of these oncogenic alterations. The basic mechanisms of molecular biology at the DNA replication, RNA transcription and protein activity levels are presented in a series of didactic annexes, enabling readers to better understand the alterations in signalling pathways.

Hedgehog-Gli Signaling in Human Disease

Author : Ariel Ruiz i Altaba
Publisher : Springer Science & Business Media
ISBN 13 : 0387337776
Total Pages : 240 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Hedgehog-Gli Signaling in Human Disease by : Ariel Ruiz i Altaba

Download or read book Hedgehog-Gli Signaling in Human Disease written by Ariel Ruiz i Altaba and published by Springer Science & Business Media. This book was released on 2007-06-24 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.

Human Reproductive and Prenatal Genetics

Author : Peter C.K. Leung
Publisher : Elsevier
ISBN 13 : 0323913814
Total Pages : 930 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Human Reproductive and Prenatal Genetics by : Peter C.K. Leung

Download or read book Human Reproductive and Prenatal Genetics written by Peter C.K. Leung and published by Elsevier. This book was released on 2023-03-22 with total page 930 pages. Available in PDF, EPUB and Kindle. Book excerpt: **Selected for Doody's Core Titles® 2024 in Clinical Genetics** Human Reproductive and Prenatal Genetics, Second Edition provides application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined are the genetics and epigenetics of the placenta in normal and abnormal pregnancy, preimplantation genetic diagnosis and screening, and cutting-edge advances in noninvasive prenatal screening, prenatal genetic counseling, and bioethical and medicolegal aspects of relevance in the lab and clinic. This new edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications. - Features chapter contributions from leading international scientists and clinicians - Provides in-depth coverage of key topics in human reproductive and prenatal genetics, including genetic controls, fertilization, placental development, embryo implantation, in vitro culture of the human embryo for the study of post-implantation development, and more - Identifies how researchers and clinicians can implement the latest genetic, epigenetic, and –omics-based approaches - Includes all new chapters on evolving technologies and recent genetic discoveries of relevance to reproductive medicine

Signal Transduction in Cancer

Author : David A. Frank
Publisher : Springer Science & Business Media
ISBN 13 : 1402073402
Total Pages : 358 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Signal Transduction in Cancer by : David A. Frank

Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

Cell Biology of the Ovary

Author : Hidetaka Katabuchi
Publisher : Springer
ISBN 13 : 9811079412
Total Pages : 165 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Cell Biology of the Ovary by : Hidetaka Katabuchi

Download or read book Cell Biology of the Ovary written by Hidetaka Katabuchi and published by Springer. This book was released on 2018-05-11 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique compilation focuses on a very curious organ, the ovary. There are still many unknown facts about the origins of ovarian tissue and ovarian cancer, and each chapter describes in detail the latest insights into the ovary from basic to clinical aspects. Expert authors reveal the most recent findings on ovariogenesis and ovarian carcinogenesis by shedding light on stem cell biology for the ovarian surface epithelial cells or primordial germ cells. Readers will greatly increase their understanding of the relevance of the cells that constitute the ovary, which is of vast significance in comprehending the occurrence mechanism of ovarian tissue and ovarian cancer. In this way the book covers a wide range of fields concerned with the ovary. This work benefits not only gynecologists and obstetricians, but also basic researchers in the field of stem cell biology and all clinicians who are involved in the management of fertility preservation or ovarian cancer.

Basal Cell Carcinoma

Author : Michael R. Migden
Publisher : Springer Nature
ISBN 13 : 303026887X
Total Pages : 297 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Basal Cell Carcinoma by : Michael R. Migden

Download or read book Basal Cell Carcinoma written by Michael R. Migden and published by Springer Nature. This book was released on 2019-12-17 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basal Cell Carcinoma: Advances in Treatment and Research provides a comprehensive overview of evidence-based treatment approaches for the most common cancer worldwide - basal cell carcinoma. The first part of this book details the epidemiology, risk factors, pathophysiology, and different histologic subtypes of basal cell carcinoma highlighted with high-resolution histopathology images. The second part of the book provides an in-depth review of different treatment modalities including topical therapy, local immunotherapy with interferon, cryotherapy, electrodesiccation and curettage, radiotherapy, and surgical approaches with Mohs micrographic surgery, head and neck surgery, and oculoplastic surgery. The final part of book highlights the utilization of innovative technology such as photodynamic therapy and laser for the treatment of basal cell carcinoma while providing excellent cosmetic outcome as well as emerging systemic therapeutic options utilizing hedgehog pathway inhibitors and immunotherapy for the difficult-to-treat disease state, advanced basal cell carcinoma. Meant for a multi-disciplinary audience of dermatologists, Mohs Surgeons, oncologists, head and neck surgeons, oculoplastic surgeons, radiation oncologists, this book serves as an informative practical guide for physicians, mid-level providers and trainees. Basal Cell Carcinoma, is edited and written by leaders with expertise in cutaneous oncology, pathology, dermatology, Mohs micrographic surgery, plastic surgery, and many more specialties.