Handbook of Animal Models and its Uses in Cancer Research

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Publisher : Springer Nature
ISBN 13 : 9811938245
Total Pages : 1158 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Handbook of Animal Models and its Uses in Cancer Research by : Surajit Pathak

Download or read book Handbook of Animal Models and its Uses in Cancer Research written by Surajit Pathak and published by Springer Nature. This book was released on 2023-01-31 with total page 1158 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book compiles together different animal models in cancer research. It provides knowledge and a better understanding of the advancement of the molecular and cellular mechanisms associated with the progression, formation, and clinical results of various types of cancer from the evidence collected from animal models utilized for cancer research. It discusses animal models for screening anti-cancer drugs and exploration of gene therapy. It presents different methods used to construct cancer animal models and the progress of each animal model in tumor research. The book also highlights the applications of genetic engineering, including CRISP/Cas9, in designing and developing animal models for cancer research. Further, it discusses strategies for modeling animals for investigating growth, metastasis, tumor-associated inflammation and microenvironment, cancer stem cells, tumor heterogeneity, and therapeutic resistance. This book is s a valuable resource for basic and translational cancer researchers, clinicians, and health care.

Animal Models in Cancer Drug Discovery

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Publisher : Academic Press
ISBN 13 : 9780128147047
Total Pages : 0 pages
Book Rating : 4.1/5 (47 download)

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Book Synopsis Animal Models in Cancer Drug Discovery by : Asfar Azmi

Download or read book Animal Models in Cancer Drug Discovery written by Asfar Azmi and published by Academic Press. This book was released on 2019-04-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field.

Animal Models in Cancer Research and Human Disease

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Publisher : Nova Biomedical Books
ISBN 13 : 9781624175886
Total Pages : 162 pages
Book Rating : 4.1/5 (758 download)

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Book Synopsis Animal Models in Cancer Research and Human Disease by : Sean A. Murray

Download or read book Animal Models in Cancer Research and Human Disease written by Sean A. Murray and published by Nova Biomedical Books. This book was released on 2014-05-14 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the applications, outcomes and controversies of using animal models in cancer research and human disease. Topics include murine models of sporadic and inflammation-related colon carcinogenesis with particular focus on the AOM/DSS chemically induced colorectal cancer model; large animal models of human cardiovascular disease; developments of cell therapeutic strategies for Alzheimer's disease using animal models; the techniques and limitations of murine models of human colorectal cancer; animal models for antineoplastic chemotherapy-induced alopecia; and development of columnar-lined esophagus with or without goblet cells in rate duodengastroesophageal reflux models through gut regenerative cell lineage (GRCL).

Animal Models for Human Cancer

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Publisher : John Wiley & Sons
ISBN 13 : 3527339973
Total Pages : 274 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Animal Models for Human Cancer by : Marianne I. Martic-Kehl

Download or read book Animal Models for Human Cancer written by Marianne I. Martic-Kehl and published by John Wiley & Sons. This book was released on 2016-08-15 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural cancer models in mice and dogs to humanized animals. An evaluation of previously unpublished long-term data from the Swiss canine and feline cancer registry is also included. The final part of the book reviews the lessons learned over the last decade on how to interpret data from animal studies for improving human therapy and gives recommendations for future drug development.

Animal Models in Cancer Research and Human Disease

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Publisher : Nova Science Publishers
ISBN 13 : 9781624175879
Total Pages : 0 pages
Book Rating : 4.1/5 (758 download)

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Book Synopsis Animal Models in Cancer Research and Human Disease by : Sean A. Murray

Download or read book Animal Models in Cancer Research and Human Disease written by Sean A. Murray and published by Nova Science Publishers. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the applications, outcomes and controversies of using animal models in cancer research and human disease. Topics include murine models of sporadic and inflammation-related colon carcinogenesis with particular focus on the AOM/DSS chemically induced colorectal cancer model; large animal models of human cardiovascular disease; developments of cell therapeutic strategies for Alzheimer's disease using animal models; the techniques and limitations of murine models of human colorectal cancer; animal models for antineoplastic chemotherapy-induced alopecia; and development of columnar-lined oesophagus with or without goblet cells in rate duodengastroesophageal reflux models through gut regenerative cell lineage (GRCL).

CRC Handbook of Animal Models of Pulmonary Disease

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Publisher : CRC Press
ISBN 13 : 1351079425
Total Pages : 266 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis CRC Handbook of Animal Models of Pulmonary Disease by : Jerome Owen Cantor

Download or read book CRC Handbook of Animal Models of Pulmonary Disease written by Jerome Owen Cantor and published by CRC Press. This book was released on 2018-01-18 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume handbook provides important information concerning the development, implementation, evaluation, uses, advantages, and limitations of a wide variety of animal model of pulmonary disease. While the work focuses on stepwise procedures for inducing and quantifying disease, additional emphasis is placed on each model's relationship to human counterparts and on comparisons with similar models of injury. Thus, even the novice researcher will be able to more sharply define a particular research question, find suitable animal models for study, gain access to specialized techniques, and evaluate results within the context of an up-to-date body of information about related forms of lung diseases.

Mouse Models of Human Cancer

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Publisher : John Wiley & Sons
ISBN 13 : 047144460X
Total Pages : 504 pages
Book Rating : 4.4/5 (714 download)

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Book Synopsis Mouse Models of Human Cancer by : Eric C. Holland

Download or read book Mouse Models of Human Cancer written by Eric C. Holland and published by John Wiley & Sons. This book was released on 2004-08-27 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments. Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text: Presents real experimental data Describes organ site-specific mouse models Clearly identifies suitable models for further drug testing Critically analyzes current methodologies and their limitations Features numerous recognizable expert contributors Lists key Web sites, reagents, and companies From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions. Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.

Connaissance univers. de Dieu, de l'homme et du monde

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (632 download)

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Book Synopsis Connaissance univers. de Dieu, de l'homme et du monde by :

Download or read book Connaissance univers. de Dieu, de l'homme et du monde written by and published by . This book was released on 1756 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Animal Modeling in Cancer

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Publisher : Mdpi AG
ISBN 13 : 9783036512761
Total Pages : 274 pages
Book Rating : 4.5/5 (127 download)

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Book Synopsis Animal Modeling in Cancer by : Vladimir Korinek

Download or read book Animal Modeling in Cancer written by Vladimir Korinek and published by Mdpi AG. This book was released on 2021-08-27 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dear Readers, Understanding the pathological mechanisms involved in human diseases and their possible treatment has been historically based on comparative analysis of diverse animal species that share a similar genetic, physiological and behavioural composition. The ancient Greeks were the first to use animals as models for anatomy and physiology, and this was consequently adopted by other cultures and led to important discoveries. In recent years, there have been many efforts to understand and fight cancer through new revolutionary personalized treatments and wider screenings that help diagnose and treat cancer. A fundamental part of this effort is to develop suitable cancer animal models that simulate the different disease variants and their progression. Ranging from tumor-derived xenografts to genetically engineered models, a wide variety of systems are applied for this purpose, and many technological breakthroughs are changing the way cancer is studied and analyzed. In this Special Issue, we collected a set of research articles and reviews that focus on the generation of cancer animal models that are used for understanding the disease and contribute to designing and testing new drugs for cancer prevention or treatment. Vladimir Korinek Collection Editor.

Mouse Models of Cancer

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Publisher :
ISBN 13 : 9781621820048
Total Pages : 0 pages
Book Rating : 4.8/5 (2 download)

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Book Synopsis Mouse Models of Cancer by : Cory Abate-Shen

Download or read book Mouse Models of Cancer written by Cory Abate-Shen and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The laboratory mouse is an important model for addressing questions in cancer biology. In recent years, the questions have become more refined, and mouse models are increasingly being used to develop and test cancer therapeutics. Thus, the need for more sophisticated and clinically relevant mouse models has grown, as has the need for innovative tools to analyze and validate them. This laboratory manual provides cutting-edge methods for generating and characterizing mouse models that accurately recapitulate many features of human cancer. The contributors describe strategies for producing genetic models, including transgenic germline models, gene knockouts and knock-ins, and conditional and inducible systems, as well as models derived using transposon-based insertional mutagenesis, RNA interference, viral-mediated gene delivery, and chemical carcinogens. Tissue recombination, organ reconstitution, and transplantation methods to develop chimeric, allograft, and xenograft models are covered. Approaches to characterize tumor development, progression, and metastasis in these models using state-of-the-art imaging and histopathological, surgical, and other techniques are also included. Other chapters cover the use of mouse models to test and optimize drugs in pre-, co-, and postclinical trials. An appendix specifically addresses the use of mouse cancer models in translational studies and the integration of mouse and human clinical investigations. This manual is therefore an indispensable laboratory resource for all researchers, from the graduate level upward, who study cancer and its treatment.

The "Companion Animal Model"

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (921 download)

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Book Synopsis The "Companion Animal Model" by : Sarah Touyz

Download or read book The "Companion Animal Model" written by Sarah Touyz and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Animal experimentation is a fundamental part of pre-clinical research. Among primary goals of animal research is to benefit the health and wellbeing of humankind. Animal experimentation in biomedical scientific research is a contentious topic in research ethics. On one side, animal experimentation is considered to be ethically acceptable because it benefits human interests. Alternatively, many consider reifying and inflicting pain on animals for humanity's gain as violating animal moral rights, and thus it is deemed unethical. There remains no clear-cut universal consensus regarding the ethical legitimacy of animal use in laboratories, and the number of animals used in pre-clinical research has grown in the last two decades. This has resulted in a strong movement urging for reforms to current animal models in biomedical research. However, some types of pre-clinical research cannot replace animal models, and continue to need them for proper scientific results, such as cancer research. Cancer research is extremely strenuous and demanding on animal subjects. Consequently, numerous researchers and animal activists have developed moral malaise regarding experimental animal use in pre-clinical cancer research. Further concerns have emerged regarding transferability and relevancy of data gathered from experimental animal subjects to human clinical trials. Accordingly, a novel in-vivo reform to address these concerns is the Companion Animal Model (CAM), where pets who spontaneously develop cancer are used as pre-clinical cancer research subjects. While the use of pets as subjects is starting to be recognized in the pre-clinical research field, the ethical considerations and complications associated with the CAM have not been explored in depth. This thesis discusses the pragmatic benefits and limitations of the CAM, as well as suggests additional ethical responsibilities that researchers should uphold to respect the owner-companion animal relationship. Further, certain potential ethical complications that may emerge when using the CAM are introduced. The ethical discussion is based on owner-companion animal and researcher-animal relationships, as well as the moral rights, interests, obligations, and responsibilities of the owner, companion animal, and researchers. Finally, this thesis encourages further ethical discussion regarding the CAM prior to any policy or guideline formalization." --

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

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Publisher : National Academies Press
ISBN 13 : 030916785X
Total Pages : 223 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research by : National Research Council

Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

The Biomedical Investigator's Handbook

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Publisher :
ISBN 13 :
Total Pages : 102 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis The Biomedical Investigator's Handbook by : Foundation for Biomedical Research (Washington, D.C.)

Download or read book The Biomedical Investigator's Handbook written by Foundation for Biomedical Research (Washington, D.C.) and published by . This book was released on 1987 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Animal Models in the Study of Cancer

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Publisher :
ISBN 13 :
Total Pages : 98 pages
Book Rating : 4.:/5 (254 download)

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Book Synopsis Animal Models in the Study of Cancer by :

Download or read book Animal Models in the Study of Cancer written by and published by . This book was released on 2008 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Guide for the Care and Use of Laboratory Animals

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Publisher : National Academies Press
ISBN 13 : 0309154006
Total Pages : 246 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guide for the Care and Use of Laboratory Animals by : National Research Council

Download or read book Guide for the Care and Use of Laboratory Animals written by National Research Council and published by National Academies Press. This book was released on 2011-01-27 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

Cancer Stem Cells and Signaling Pathways

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Publisher : Elsevier
ISBN 13 : 0443132119
Total Pages : 703 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Cancer Stem Cells and Signaling Pathways by : Surajit Pathak

Download or read book Cancer Stem Cells and Signaling Pathways written by Surajit Pathak and published by Elsevier. This book was released on 2023-11-01 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Stem Cells and Signaling Pathways explores the mechanism of cancer stem cell signaling pathways in cancer advancement, serving as an ideal reference guide for investigators with valuable answers to problems associated with anti-cancer treatments and an understanding of the crosstalk among the signaling pathways in CSC regulation. Despite recent advances in tumor therapy and a greater understanding of their biology, tumors continue to be a prevalent and fatal worldwide. According to a novel paradigm in tumor biology, a small percentage of the cells within a tumor known as cancer stem cells (CSCs) are predicted as a crucial population for tumor progression. - Presents cancer stem characteristics and their signaling pathways - Highlights the use of animal models for cancer research, the use of genetically modified stem cells to deliver antitumor agents, and the significance of stem cell signaling in drug discovery - Covers basic and translational research appropriate for scientists and clinicians exploring alternative treatments for various cancers

Microbial Omics in Environment and Health

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Publisher : Springer Nature
ISBN 13 : 9819717698
Total Pages : 427 pages
Book Rating : 4.8/5 (197 download)

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Book Synopsis Microbial Omics in Environment and Health by : Minu Kesheri

Download or read book Microbial Omics in Environment and Health written by Minu Kesheri and published by Springer Nature. This book was released on with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: