Halcion

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Publisher : National Academies Press
ISBN 13 : 0309059763
Total Pages : 177 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Halcion by : Institute of Medicine

Download or read book Halcion written by Institute of Medicine and published by National Academies Press. This book was released on 1998-01-01 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory agencies within the United States and the United Kingdom, among several other countries, have reviewed extensively the safety and efficacy of Halcion (triazolam)â€"a once commonly used hypnotic drug. Concerns began to emerge about the safety of Halcion when a Dutch physician reported a possible link between it and a syndrome that included such effects as depression, amnesia, hallucinations, and increased anxiety. In addition, in 1991 its manufacturer, Upjohn, noted that "errors had been identified in a report of one of the clinical studies included in the original" application for approval. Since then, the drug has been removed from the market in several countries, whereas in the United States and Canada, the drug's labeling has been modified to reduce the recommended dose and duration of treatment and to heighten awareness of possible side effects. Yet different data and analyses have resulted in conflicting messages that are difficult to reconcile and interpret. In response to a request from the Food and Drug Administration to resolve these controversial issues related to the safety and efficacy of Halcion, this IOM book assesses the adequacy of the drug's clinical trials; the quality and quantity of data on adverse reactions; overall confidence in the data on effectiveness, adverse events, and side effects at different doses; and whether additional studies are needed.

Halcion

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Author :
Publisher : National Academies Press
ISBN 13 : 0309591457
Total Pages : 177 pages
Book Rating : 4.3/5 (95 download)

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Book Synopsis Halcion by : Committee on Halcion: An Assessment of Data Adequacy and Confidence

Download or read book Halcion written by Committee on Halcion: An Assessment of Data Adequacy and Confidence and published by National Academies Press. This book was released on 1997-12-15 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory agencies within the United States and the United Kingdom, among several other countries, have reviewed extensively the safety and efficacy of Halcion (triazolam)--a once commonly used hypnotic drug. Concerns began to emerge about the safety of Halcion when a Dutch physician reported a possible link between it and a syndrome that included such effects as depression, amnesia, hallucinations, and increased anxiety. In addition, in 1991 its manufacturer, Upjohn, noted that "errors had been identified in a report of one of the clinical studies included in the original" application for approval. Since then, the drug has been removed from the market in several countries, whereas in the United States and Canada, the drug's labeling has been modified to reduce the recommended dose and duration of treatment and to heighten awareness of possible side effects. Yet different data and analyses have resulted in conflicting messages that are difficult to reconcile and interpret. In response to a request from the Food and Drug Administration to resolve these controversial issues related to the safety and efficacy of Halcion, this IOM book assesses the adequacy of the drug's clinical trials; the quality and quantity of data on adverse reactions; overall confidence in the data on effectiveness, adverse events, and side effects at different doses; and whether additional studies are needed.

Guidelines for the Clinical Evaluation of Hypnotic Drugs

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Author :
Publisher :
ISBN 13 :
Total Pages : 24 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guidelines for the Clinical Evaluation of Hypnotic Drugs by : United States. Food and Drug Administration

Download or read book Guidelines for the Clinical Evaluation of Hypnotic Drugs written by United States. Food and Drug Administration and published by . This book was released on 1977 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Halcion

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (442 download)

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Book Synopsis Halcion by :

Download or read book Halcion written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Features information on Halcion, a treatment of insomnia, provided by New Media Systems, Inc. Discusses why the drug is prescribed, how to take the medication, side effects, possible food and drug interactions, and recommended dosages.

The Therapeutic Nightmare

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Author :
Publisher : Routledge
ISBN 13 : 1134195818
Total Pages : 231 pages
Book Rating : 4.1/5 (341 download)

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Book Synopsis The Therapeutic Nightmare by : John Abraham

Download or read book The Therapeutic Nightmare written by John Abraham and published by Routledge. This book was released on 2014-03-18 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: How do drugs get to the market? What controls are there and what procedures for monitoring their effects? And how adequate are the regulators in protecting public health when new drugs have serious side effects? The Therapeutic Nightmare tells the story of the sleeping pill Halcion - a story which is far from over. First marketed in the 1970s, Halcion has been taken by millions of patients around the world. For many years it has been associated with serious adverse effects such as amnesia, hallucinations, aggression and, in extreme cases, homicide. Thirteen years after its first release, it was banned by the British government. It remains on sale in the United States and many other countries. This book explains why patients have come to be exposed to Halcion's risks and examines the corporate interests of the manufacturers, the professional interests of the scientists and medical researchers and the interests of patients in safe and effective medication. It reveals how these contending forces shape the regulatory decision-making process about drug safety. As the number of new drugs and health products grows, a major challenge facing regulators and the medical profession is how to put the interests of public health decisively and consistently above the commercial interests of the drugs industry, while becoming more accountable to patient and consumer organizations.

Operation Shylock

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Publisher : Random House
ISBN 13 : 009930791X
Total Pages : 56 pages
Book Rating : 4.0/5 (993 download)

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Book Synopsis Operation Shylock by : Philip Roth

Download or read book Operation Shylock written by Philip Roth and published by Random House. This book was released on 1994 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phillip Roth confronts his double, an imposter whose self-appointed task is to lead the jews out of Israel and back to Europe, a moses in reverse and a monstrous nemesis to the 'real' Philip Roth. This work is at once a spy story, a political thriller, a meditation on identity, and a confession.

Toxic Psychiatry

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Author :
Publisher : Macmillan + ORM
ISBN 13 : 1250108721
Total Pages : 636 pages
Book Rating : 4.2/5 (51 download)

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Book Synopsis Toxic Psychiatry by : Peter R. Breggin

Download or read book Toxic Psychiatry written by Peter R. Breggin and published by Macmillan + ORM. This book was released on 2015-12-22 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prozac, Xanax, Halcion, Haldol, Lithium. These psychiatric drugs--and dozens of other short-term "solutions"--are being prescribed by doctors across the country as a quick antidote to depression, panic disorder, obsessive-compulsive disorder, and other psychiatric problems. But at what cost? In this searing, myth-shattering exposé, psychiatrist Peter R. Breggin, M.D., breaks through the hype and false promises surrounding the "New Psychiatry" and shows how dangerous, even potentially brain-damaging, many of its drugs and treatments are. He asserts that: psychiatric drugs are spreading an epidemic of long-term brain damage; mental "illnesses" like schizophrenia, depression, and anxiety disorder have never been proven to be genetic or even physical in origin, but are under the jurisdiction of medical doctors; millions of schoolchildren, housewives, elderly people, and others are labeled with medical diagnoses and treated with authoritarian interventions, rather than being patiently listened to, understood, and helped. Toxic Psychiatry sounds a passionate, much-needed wake-up call for everyone who plays a part, active or passive, in America's ever-increasing dependence on harmful psychiatric drugs.

European Drug Index

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Author :
Publisher : Elsevier Publishing Company
ISBN 13 :
Total Pages : 1388 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis European Drug Index by : Niels F. Muller

Download or read book European Drug Index written by Niels F. Muller and published by Elsevier Publishing Company. This book was released on 1992 with total page 1388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. Many health care providers are frequently dealing with problems related to the identification and interpretation of medicines and prescriptions of foreign origin. Health authorities, customs and travel agencies also encounter such problems, which are related to the increasing mobility of the European population. Thus the need for a European Drug Index is obvious. The EDI provides extended information for practitioners confronted with the enormous number of drug names available on the European pharmaceutical market. This market is increasing due to the rapidly changing palette of countries and economic restrictions in Europe. The listings have been derived from drug data sources from the increased number of participating countries in this second edition. Each item starts with a trade name, in alphabetical order, followed by (depending on the original source) dosage forms, strength, volume (if applicable), and generic name(s) of the active princi

The Organic Chemistry of Drug Design and Drug Action

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Publisher : Elsevier
ISBN 13 : 0080513379
Total Pages : 650 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Organic Chemistry of Drug Design and Drug Action by : Richard B. Silverman

Download or read book The Organic Chemistry of Drug Design and Drug Action written by Richard B. Silverman and published by Elsevier. This book was released on 2012-12-02 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization

Prescription for Disaster

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Publisher :
ISBN 13 :
Total Pages : 280 pages
Book Rating : 4.:/5 (321 download)

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Book Synopsis Prescription for Disaster by : Thomas J. Moore

Download or read book Prescription for Disaster written by Thomas J. Moore and published by . This book was released on 1998 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This hard-hitting expose does for prescription drugs what "Silent Spring" did for pesticides, revealing the hidden dangers of the most commonly prescribed medications--and what the consumer can do to minimize the risks of serious side effects.

The Benzo Book

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Publisher : Lulu.com
ISBN 13 : 1411692594
Total Pages : 262 pages
Book Rating : 4.4/5 (116 download)

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Book Synopsis The Benzo Book by : Jack Hobson-Dupont

Download or read book The Benzo Book written by Jack Hobson-Dupont and published by Lulu.com. This book was released on 2006-06-01 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: FROM THE BACK COVER: Are you--or is someone you care about--taking tranquilizers or sleeping pills? You could be at risk of addiction without even knowing it. Benzos are the most commonly prescribed tranquilizers and sleeping pills, in use by millions of people. Doctors prescribe these drugs routinely without ever warning patients that regular use may cause a dangerous dependency. For many people, Benzos are much harder to quit than heroin, cocaine, crack and other illegal substances, even when taken under a physician's supervision. Benzo Withdrawal may last for months, even years. Get the facts about the drugs in your medicine cabinet--facts the pharmaceutical companies, and even the FDA, don't want you to know. The Benzo Book recounts the author's experience as an unwitting addict, with full details about minimizing withdrawal symptoms, and exposes the sociological, medical and economic factors which cause this widespread--yet largely unknown--problem.

Health, Illness, and Medicine in Canada

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Author :
Publisher : Don Mills, Ont. : Oxford University Press
ISBN 13 :
Total Pages : 468 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Health, Illness, and Medicine in Canada by : Juanne Nancarrow Clarke

Download or read book Health, Illness, and Medicine in Canada written by Juanne Nancarrow Clarke and published by Don Mills, Ont. : Oxford University Press. This book was released on 2004 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using four different sociological perspectives--structural-funcational, conflict, symbolic interactionist, and feminist--Health, Illness, and Medicine in Canada 4e provides an essential study to the sociology of health. The text examines occupational diseases, environmental challenges, the inequalities of age, gender, class, race, and ethnicity, the experience of getting sick and going to the doctor, and the extensive and profit-motivated impact of the pharmaceutical and medical device industries.

A Universe from Nothing

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Publisher : Simon and Schuster
ISBN 13 : 1451624476
Total Pages : 240 pages
Book Rating : 4.4/5 (516 download)

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Book Synopsis A Universe from Nothing by : Lawrence M. Krauss

Download or read book A Universe from Nothing written by Lawrence M. Krauss and published by Simon and Schuster. This book was released on 2012-01-10 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bestselling author and acclaimed physicist Lawrence Krauss offers a paradigm-shifting view of how everything that exists came to be in the first place. “Where did the universe come from? What was there before it? What will the future bring? And finally, why is there something rather than nothing?” One of the few prominent scientists today to have crossed the chasm between science and popular culture, Krauss describes the staggeringly beautiful experimental observations and mind-bending new theories that demonstrate not only can something arise from nothing, something will always arise from nothing. With a new preface about the significance of the discovery of the Higgs particle, A Universe from Nothing uses Krauss’s characteristic wry humor and wonderfully clear explanations to take us back to the beginning of the beginning, presenting the most recent evidence for how our universe evolved—and the implications for how it’s going to end. Provocative, challenging, and delightfully readable, this is a game-changing look at the most basic underpinning of existence and a powerful antidote to outmoded philosophical, religious, and scientific thinking.

William Styron

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Publisher : Open Road Media
ISBN 13 : 1453202862
Total Pages : 476 pages
Book Rating : 4.4/5 (532 download)

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Book Synopsis William Styron by : James L. W. West

Download or read book William Styron written by James L. W. West and published by Open Road Media. This book was released on 2010-08-17 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: A “mesmerizing” biography of the #1 New York Times–bestselling author of Sophie’s Choice, The Confessions of Nat Turner, and Darkness Visible (Entertainment Weekly). William Styron was one of the most highly regarded and controversial authors of his generation. In this illuminating biography, James L. W. West III draws upon letters, papers, and manuscripts as well as interviews with Styron’s friends and family to recount in rich detail the experiences that shaped each of his groundbreaking books. From Styron’s Southern upbringing, which deeply influenced the Pulitzer Prize–winning The Confessions of Nat Turner and National Book Award–winning Sophie’s Choice, to his feud with Norman Mailer and the clinical depression that led to his acclaimed memoir Darkness Visible, West’s remarkable biography provides invaluable insight into the life and works of a giant of American literature.

Say Good Night to Insomnia

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Publisher : Henry Holt and Company
ISBN 13 : 1429932058
Total Pages : 257 pages
Book Rating : 4.4/5 (299 download)

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Book Synopsis Say Good Night to Insomnia by : Gregg D. Jacobs

Download or read book Say Good Night to Insomnia written by Gregg D. Jacobs and published by Henry Holt and Company. This book was released on 2009-09-15 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: The bestselling guide to curing insomnia without drugs by "a pioneer" of the field, now updated with the latest research (The Wall Street Journal) For the past 25 years, sleep-deprived Americans have found natural, drug-free relief from insomnia with the help of Dr. Gregg D. Jacobs's Say Good Night to Insomnia. Jacobs's program, developed and tested at Harvard Medical School and based on cognitive behavioral therapy, has been shown to improve sleep long-term in 80 percent of patients, making it the gold standard for treatment. He provides techniques for eliminating sleeping pills; establishing sleep-promoting behaviors and lifestyle practices; and improving relaxation, reducing stress, and changing negative thoughts about sleep. In this updated edition, Jacobs surveys the limitations and dangers of the new generation of sleeping pills, dispels misleading and confusing claims about sleep and health, and shares cutting-edge research on insomnia that proves his approach is more effective than sleeping pills. Say Good Night to Insomnia is the definitive guide to overcoming insomnia without drugs for the thousands of Americans who are looking for a healthy night's rest.

Forbes MediaCritic

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Author :
Publisher :
ISBN 13 :
Total Pages : 114 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Forbes MediaCritic by :

Download or read book Forbes MediaCritic written by and published by . This book was released on 1995 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mike Nichols

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Publisher : Penguin
ISBN 13 : 0399562249
Total Pages : 720 pages
Book Rating : 4.3/5 (995 download)

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Book Synopsis Mike Nichols by : Mark Harris

Download or read book Mike Nichols written by Mark Harris and published by Penguin. This book was released on 2021-02-02 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: A National Book Critics Circle finalist • One of People's top 10 books of 2021 • An instant New York Times bestseller • Named a best book of the year by NPR and Time A magnificent biography of one of the most protean creative forces in American entertainment history, a life of dazzling highs and vertiginous plunges—some of the worst largely unknown until now—by the acclaimed author of Pictures at a Revolution and Five Came Back Mike Nichols burst onto the scene as a wunderkind: while still in his twenties, he was half of a hit improv duo with Elaine May that was the talk of the country. Next he directed four consecutive hit plays, won back-to-back Tonys, ushered in a new era of Hollywood moviemaking with Who's Afraid of Virginia Woolf?, and followed it with The Graduate, which won him an Oscar and became the third-highest-grossing movie ever. At thirty-five, he lived in a three-story Central Park West penthouse, drove a Rolls-Royce, collected Arabian horses, and counted Jacqueline Kennedy, Elizabeth Taylor, Leonard Bernstein, and Richard Avedon as friends. Where he arrived is even more astonishing given where he had begun: born Igor Peschkowsky to a Jewish couple in Berlin in 1931, he was sent along with his younger brother to America on a ship in 1939. The young immigrant boy caught very few breaks. He was bullied and ostracized--an allergic reaction had rendered him permanently hairless--and his father died when he was just twelve, leaving his mother alone and overwhelmed. The gulf between these two sets of facts explains a great deal about Nichols's transformation from lonely outsider to the center of more than one cultural universe--the acute powers of observation that first made him famous; the nourishment he drew from his creative partnerships, most enduringly with May; his unquenchable drive; his hunger for security and status; and the depressions and self-medications that brought him to terrible lows. It would take decades for him to come to grips with his demons. In an incomparable portrait that follows Nichols from Berlin to New York to Chicago to Hollywood, Mark Harris explores, with brilliantly vivid detail and insight, the life, work, struggle, and passion of an artist and man in constant motion. Among the 250 people Harris interviewed: Elaine May, Meryl Streep, Stephen Sondheim, Robert Redford, Glenn Close, Tom Hanks, Candice Bergen, Emma Thompson, Annette Bening, Natalie Portman, Julia Roberts, Lorne Michaels, and Gloria Steinem. Mark Harris gives an intimate and evenhanded accounting of success and failure alike; the portrait is not always flattering, but its ultimate impact is to present the full story of one of the most richly interesting, complicated, and consequential figures the worlds of theater and motion pictures have ever seen. It is a triumph of the biographer's art.