Guanine Nucleotides In The Regulation Of Synthesis And Function Of Cyclic Gmp In The Cardiovascular System And Blood Cells

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The Endothelium

Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041230
Total Pages : 309 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis The Endothelium by : Michel Félétou

Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Research Awards Index

Author :
Publisher :
ISBN 13 :
Total Pages : 742 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Research Awards Index by :

Download or read book Research Awards Index written by and published by . This book was released on 1989 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Research Grants Index

Author : National Institutes of Health (U.S.). Division of Research Grants
Publisher :
ISBN 13 :
Total Pages : 1074 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Research Grants Index by : National Institutes of Health (U.S.). Division of Research Grants

Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1969 with total page 1074 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Subject Index of Current Research Grants and Contracts Administered by the National Heart, Lung and Blood Institute

Author : National Heart, Lung, and Blood Institute
Publisher :
ISBN 13 :
Total Pages : 652 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Subject Index of Current Research Grants and Contracts Administered by the National Heart, Lung and Blood Institute by : National Heart, Lung, and Blood Institute

Download or read book Subject Index of Current Research Grants and Contracts Administered by the National Heart, Lung and Blood Institute written by National Heart, Lung, and Blood Institute and published by . This book was released on 1979 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mechanisms of Neuroinflammation

Author : Gonzalo Emiliano Aranda Abreu
Publisher : BoD – Books on Demand
ISBN 13 : 9535134515
Total Pages : 320 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Mechanisms of Neuroinflammation by : Gonzalo Emiliano Aranda Abreu

Download or read book Mechanisms of Neuroinflammation written by Gonzalo Emiliano Aranda Abreu and published by BoD – Books on Demand. This book was released on 2017-08-23 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.

Subject Index of Current Research Grants and Contracts Administered by the National Heart and Lung Institute

Author : National Heart and Lung Institute
Publisher :
ISBN 13 :
Total Pages : 482 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Subject Index of Current Research Grants and Contracts Administered by the National Heart and Lung Institute by : National Heart and Lung Institute

Download or read book Subject Index of Current Research Grants and Contracts Administered by the National Heart and Lung Institute written by National Heart and Lung Institute and published by . This book was released on 1975 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Echinoderms Part B

Author :
Publisher : Academic Press
ISBN 13 : 0128170735
Total Pages : 552 pages
Book Rating : 4.1/5 (281 download)

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Download or read book Echinoderms Part B written by and published by Academic Press. This book was released on 2019-04-02 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Echinoderms, Volume 151, the latest release in the Methods in Cell Biology series, highlights advances in the field, with this update presenting chapters on Echinoderm Genome Databases, analysis of gene regulatory networks, using ATAC-seq and RNA-seq to increase resolution in GRN connectivity, multiplex cis-regulatory analysis, experimental approaches GRN/signal pathways, BACs, analysis of chromatin accessibility using ATAC-seq, analysis of sea urchin proteins /Click IT, CRISPR/Cas9-mediated genome editing in sea urchins, super-resolution and in toto imaging of echinoderm embryos, and methods for analysis of intracellular ion signals in sperm, eggs and embryos. - Presents clear, concise protocols provided by experts who have established the echinoderms as a model systems - Highlights new advances in the field, with this update presenting interesting chapters on echinoderms

Bibliography of Medical Reviews

Author :
Publisher :
ISBN 13 :
Total Pages : 1818 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Bibliography of Medical Reviews by :

Download or read book Bibliography of Medical Reviews written by and published by . This book was released on 1976 with total page 1818 pages. Available in PDF, EPUB and Kindle. Book excerpt:

From Neuroscience to Neurology

Author : Stephen Waxman
Publisher : Elsevier
ISBN 13 : 0080506984
Total Pages : 549 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis From Neuroscience to Neurology by : Stephen Waxman

Download or read book From Neuroscience to Neurology written by Stephen Waxman and published by Elsevier. This book was released on 2004-11-05 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson's disease, and migraine, were developed, and explores evolving themes and technologies that offer hope for even more effective treatments and ultimately cures for currently untreatable disorders of the brain and spinal cord. The first part of this book reviews the development of new therapies in neurology, from their inception in terms of basic science to their introduction into the clinical world. It also explores evolving themes and new technologies. This book will be of interest to everyone – clinicians and basic scientists alike – interested in diseases of the brain and spinal cord, and in the quest for new treatments for these disorders.* Presents the evolution of the field of neurology into a therapeutic discipline * Discusses lessons learned from past successes and applications to ongoing work* Explores the future of this field

DNA Sensors and Inflammasomes

Author :
Publisher : Academic Press
ISBN 13 : 9780128183595
Total Pages : 0 pages
Book Rating : 4.1/5 (835 download)

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Download or read book DNA Sensors and Inflammasomes written by and published by Academic Press. This book was released on 2019-08-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Sensors and Inflammasomes, Volume 625, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New sections in this release include Phosphorylation and dimerization of STING and IRF3, cGAS enzymology, Synthesis and identification of immuno-stimulatory CDNs, Tracking cGAS activity/ cGAMP formation using SPR/NMR, Using an enzyme coupled assay to track cGAS activity under steady states, Tracking the polymerization of DNA sensors, inflammasome receptors, and downstream signaling partners using FRET, NLRC4 structure, Tracking TREX1 activity, DNA association and dissociation kinetics of PARP1, and more.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1586 pages
Book Rating : 4.3/5 (243 download)

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Download or read book Cumulated Index Medicus written by and published by . This book was released on 1976 with total page 1586 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Chemistry and Biology of Nitroxyl (HNO)

Author : Fabio Doctorovich
Publisher : Elsevier
ISBN 13 : 0128011645
Total Pages : 425 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Chemistry and Biology of Nitroxyl (HNO) by : Fabio Doctorovich

Download or read book The Chemistry and Biology of Nitroxyl (HNO) written by Fabio Doctorovich and published by Elsevier. This book was released on 2016-09-01 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Chemistry and Biology of Nitroxyl (HNO) provides first-of-its-kind coverage of the intriguing biologically active molecule called nitroxyl, or azanone per IUPAC nomenclature, which has been traditionally elusive due to its intrinsically high reactivity. This useful resource provides the scientific basis to understand the chemistry, biology, and technical aspects needed to deal with HNO. Building on two decades of nitric oxide and nitroxyl research, the editors and authors have created an indispensable guide for investigators across a wide variety of areas of chemistry (inorganic, organic, organometallic, biochemistry, physical, and analytical); biology (molecular, cellular, physiological, and enzymology); pharmacy; and medicine. This book begins by exploring the unique molecule's structure and reactivity, including important reactions with small molecules, thiols, porphyrins, and key proteins, before discussing chemical and biological sources of nitroxyl. Advanced chapters discuss methods for both trapping and detecting nitroxyl by spectroscopy, electrochemistry, and fluorescent inorganic cellular probing. Expanding on the compound's foundational chemistry, this book then explores its molecular physiology to offer insight into its biological implications, pharmacological effects, and practical issues. - Presents the first book on HNO (nitroxyl or azanone), an increasingly important molecule in biochemistry and pharmaceutical research - Provides a valuable coverage of HNO's chemical structure and significant reactions, including practical guidance on working with this highly reactive molecule - Contains high quality content from recognized experts in both industry and academia

Biology of Vascular Smooth Muscle: Vasoconstriction and Dilatation

Author : Yuansheng Gao
Publisher : Springer
ISBN 13 : 981104810X
Total Pages : 287 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Biology of Vascular Smooth Muscle: Vasoconstriction and Dilatation by : Yuansheng Gao

Download or read book Biology of Vascular Smooth Muscle: Vasoconstriction and Dilatation written by Yuansheng Gao and published by Springer. This book was released on 2017-06-14 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a concise yet comprehensive review of the morphological, biochemical, electrical, mechanical, and metabolic properties of vascular smooth muscle, the regulation of vascular activities and the intracellular signaling involved. It particularly focuses on recently identified vasoactive agents, enzymes and transduction mechanisms. It also discusses the latest findings in the regulation of cerebral, coronary and pulmonary circulation as well as vascular activity under hypoxia and ageing. The contraction and dilatation activities of vasculature are of fundamental importance for maintaining circulation homeostasis and adapting physiological changes. Over the last four decades, there have been significant advances in our understanding of the biochemical, structural, genetic, physiological, and pharmacological aspects of vascular activity regulation, and these insights into the responsiveness of blood vessels under normal and pathophysiological conditions help to provide valuable weapons in the fight vascular diseases. The book is of interest to researchers and graduate students, both in basic research and in clinic settings, in the field of vascular biology.

International Books in Print

Author :
Publisher :
ISBN 13 :
Total Pages : 1140 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis International Books in Print by :

Download or read book International Books in Print written by and published by . This book was released on 1998 with total page 1140 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cyclic Nucleotide Phosphodiesterases in Health and Disease

Author : Joseph A. Beavo
Publisher : CRC Press
ISBN 13 : 1420020846
Total Pages : 766 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Cyclic Nucleotide Phosphodiesterases in Health and Disease by : Joseph A. Beavo

Download or read book Cyclic Nucleotide Phosphodiesterases in Health and Disease written by Joseph A. Beavo and published by CRC Press. This book was released on 2006-12-05 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph

Drug Discovery and Evaluation

Author : Hans G. Vogel
Publisher : Springer Science & Business Media
ISBN 13 : 366203333X
Total Pages : 790 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Drug Discovery and Evaluation by : Hans G. Vogel

Download or read book Drug Discovery and Evaluation written by Hans G. Vogel and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.