Glutathione Conjugation

Download Glutathione Conjugation full books in PDF, epub, and Kindle. Read online Glutathione Conjugation ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Biological Reactive Intermediates III

Author : James J. Kocsis
Publisher : Springer Science & Business Media
ISBN 13 : 1468451340
Total Pages : 1028 pages
Book Rating : 4.4/5 (684 download)

DOWNLOAD NOW!

Book Synopsis Biological Reactive Intermediates III by : James J. Kocsis

Download or read book Biological Reactive Intermediates III written by James J. Kocsis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1028 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.

Glutathione Conjugation

Author : Helmut Sies
Publisher :
ISBN 13 :
Total Pages : 506 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Glutathione Conjugation by : Helmut Sies

Download or read book Glutathione Conjugation written by Helmut Sies and published by . This book was released on 1988 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Conjugation Reactions In Drug Metabolism

Author : Gerard J. Mulder
Publisher : CRC Press
ISBN 13 : 0203489993
Total Pages : 423 pages
Book Rating : 4.2/5 (34 download)

DOWNLOAD NOW!

Book Synopsis Conjugation Reactions In Drug Metabolism by : Gerard J. Mulder

Download or read book Conjugation Reactions In Drug Metabolism written by Gerard J. Mulder and published by CRC Press. This book was released on 1990-02-21 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text investigates the molecular biology of conjugation, and the subsequent activity of the transfered genes "in vivo". Conjugation may be very important when considering biotransformations, as expression of transfered genes may allow organisms to metabolize certain substrates.

Aflatoxins

Author : Mehdi Razzaghi-Abyaneh
Publisher : BoD – Books on Demand
ISBN 13 : 9535109049
Total Pages : 410 pages
Book Rating : 4.5/5 (351 download)

DOWNLOAD NOW!

Book Synopsis Aflatoxins by : Mehdi Razzaghi-Abyaneh

Download or read book Aflatoxins written by Mehdi Razzaghi-Abyaneh and published by BoD – Books on Demand. This book was released on 2013-01-23 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is broadly divided into five sections and 17 chapters, highlighting recent advances in aflatoxin research from epidemiology to molecular genomics and control measures, biocontrol approaches, modern analytical techniques, economic concerns and underlying mechanisms of contamination processes. This book will update readers on several cutting-edge aspects of aflatoxins research with useful up-to-date information for mycologists, toxicologists, microbiologists, agriculture scientists, plant pathologists and pharmacologists, who may be interest to understanding of the impact, significance and recent advances within the field of of aflatoxins with a focus on control strategy.

Hydrolysis in Drug and Prodrug Metabolism

Author : Bernard Testa
Publisher : John Wiley & Sons
ISBN 13 : 9783906390253
Total Pages : 808 pages
Book Rating : 4.3/5 (92 download)

DOWNLOAD NOW!

Book Synopsis Hydrolysis in Drug and Prodrug Metabolism by : Bernard Testa

Download or read book Hydrolysis in Drug and Prodrug Metabolism written by Bernard Testa and published by John Wiley & Sons. This book was released on 2003-08 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.

Introduction to Drug Metabolism

Author : G. Gordon Gibson
Publisher : Nelson Thornes
ISBN 13 : 9780748760114
Total Pages : 274 pages
Book Rating : 4.7/5 (61 download)

DOWNLOAD NOW!

Book Synopsis Introduction to Drug Metabolism by : G. Gordon Gibson

Download or read book Introduction to Drug Metabolism written by G. Gordon Gibson and published by Nelson Thornes. This book was released on 2001 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of drug-metabolising reactions. p. 25.

Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity

Author : Frederick C. Kauffman
Publisher : Springer Science & Business Media
ISBN 13 : 3642784291
Total Pages : 544 pages
Book Rating : 4.6/5 (427 download)

DOWNLOAD NOW!

Book Synopsis Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity by : Frederick C. Kauffman

Download or read book Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity written by Frederick C. Kauffman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: In-depth coverage of advances in molecular biology, indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds. Part One describes molecular events associated with the expression and regulation of transferases and hydrolases involved in Phase II drug conjugation and deconjugation. Part Two deals with the regulation of Phase II conjugation, while Part Three critically reviews the importance of drug conjugates in pharmacology and toxicology. An up-to-date source of information of broad interest to pharmacologists and toxicologists.

Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds

Author :
Publisher : Academic Press
ISBN 13 : 0080581188
Total Pages : 538 pages
Book Rating : 4.0/5 (85 download)

DOWNLOAD NOW!

Book Synopsis Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds by :

Download or read book Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds written by and published by Academic Press. This book was released on 1994-07-06 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.Conjugation reactions have long been associated with the detoxification of xenobiotics. Recent studies suggest that Phase II reactions are an important mechanism for the bioactivation of xenobiotics.This special volume of Advances in Pharmacology features a two-color dust jacket.Summarizes the most recent information on: - Xenobiotic conjugation - Drug toxicity, hypersensitivity, and targeting - Chemical carcinogenesis - Glutathione-, sulfate conjugate-, and glucuranide conjugate-dependent toxicity - Bioactivation and bioconversion

Nutrition and Skeletal Muscle

Author : Stéphane Walrand
Publisher : Academic Press
ISBN 13 : 0128104104
Total Pages : 590 pages
Book Rating : 4.1/5 (281 download)

DOWNLOAD NOW!

Book Synopsis Nutrition and Skeletal Muscle by : Stéphane Walrand

Download or read book Nutrition and Skeletal Muscle written by Stéphane Walrand and published by Academic Press. This book was released on 2018-10-24 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrition and Skeletal Muscle provides coverage of the evidence of dietary components that have proven beneficial for bettering adverse changes in skeletal muscle from disuse and aging. Skeletal muscle is the largest tissue in the body, providing elements of contraction and locomotion and acting as an important contributor to whole body protein and amino metabolism, glucose disposal and lipid metabolism. However, muscle loss, atrophy or weakness can occur when there are metabolic imbalances, disuse or aging. This book addresses the topic by providing insight and research from international leaders, making it the go-to reference for those in skeletal muscle physiology. - Provides an understanding of the crucial role of skeletal muscle in global metabolic homeostasis regulation - Delivers the information needed to understand the utilization of crucial supplements for the preservation of skeletal muscle - Presents insights on research from international leaders in the field

Measuring Oxidants and Oxidative Stress in Biological Systems

Author : Lawrence J. Berliner
Publisher : Springer Nature
ISBN 13 : 303047318X
Total Pages : 237 pages
Book Rating : 4.0/5 (34 download)

DOWNLOAD NOW!

Book Synopsis Measuring Oxidants and Oxidative Stress in Biological Systems by : Lawrence J. Berliner

Download or read book Measuring Oxidants and Oxidative Stress in Biological Systems written by Lawrence J. Berliner and published by Springer Nature. This book was released on 2020-08-08 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.

Thiol Redox Transitions in Cell Signaling, Part B

Author :
Publisher : Academic Press
ISBN 13 : 0123810043
Total Pages : 389 pages
Book Rating : 4.1/5 (238 download)

DOWNLOAD NOW!

Book Synopsis Thiol Redox Transitions in Cell Signaling, Part B by :

Download or read book Thiol Redox Transitions in Cell Signaling, Part B written by and published by Academic Press. This book was released on 2010-08-19 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, along with its companion (volume 474), presents methods and protocols dealing with thiol oxidation-reduction reactions and their implications as they relate to cell signaling. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Over 450 volumes have been published to date, and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. - Along with companion volume, provides a full overview of techniques necessary to the study of thiol redox in relation to cell signaling - Gathers tried and tested techniques from global labs, offering both new and tried-and-true methods - Relevant background and reference information given for procedures can be used as a guide to developing protocols in a number of disciplines

Integrative Medicine

Author : David Rakel
Publisher : Elsevier Health Sciences
ISBN 13 : 1416029540
Total Pages : 1262 pages
Book Rating : 4.4/5 (16 download)

DOWNLOAD NOW!

Book Synopsis Integrative Medicine by : David Rakel

Download or read book Integrative Medicine written by David Rakel and published by Elsevier Health Sciences. This book was released on 2007-01-01 with total page 1262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawing on solid scientific evidence as well as extensive first-hand experience, this manual provides the practical information you need to safely and effectively integrate complementary and alternative treatment modalities into your practice. It explains how alternative therapies can help you fight diseases that do not respond readily to traditional treatments... presents integrative treatments for a full range of diseases and conditions, including autism, stroke, chronic fatigue syndrome, and various forms of cancer...explores how to advise patients on health maintenance and wellness...and offers advice on topics such as meditation, diet, and exercises for back pain. 24 new chapters, a new organization, make this landmark reference more useful than ever. Provides dosages and precautions to help you avoid potential complications.Delivers therapy-based pearls to enhance your patient care.Facilitates patient education with helpful handouts. Offers helpful icons that highlight the level and quality of evidence for each specific modality.Includes bonus PDA software that lets you load all of the therapeutic review sections onto your handheld device.Presents a new organization, with numerous section headings and subheadings, for greater ease of reference.Provides additional clinical practice and business considerations for incorporating integrative medicine into clinical practice.

Fundamentals of Toxicology

Author : PK Gupta
Publisher : Academic Press
ISBN 13 : 0128054034
Total Pages : 424 pages
Book Rating : 4.1/5 (28 download)

DOWNLOAD NOW!

Book Synopsis Fundamentals of Toxicology by : PK Gupta

Download or read book Fundamentals of Toxicology written by PK Gupta and published by Academic Press. This book was released on 2016-08-26 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Toxicology: Essential Concepts and Applications provides a crisp, easy-to-understand overview of the most important concepts, applications, and ideas needed to learn the basics of toxicology. Written by a pre-eminent toxicologist with over five decades of teaching experience, this comprehensive resource offers the hands-on knowledge needed for a strong foundation in the wide field of toxicology. Fundamentals of Toxicology includes a clear structure divided into five units to assist learning and understanding. The first unit provides extensive coverage on the background of toxicology including commonly used definitions and historical perspective, while following units cover: basic concepts; regulatory requirements and good laboratory practices, including types of toxicology testing and evaluation; toxic agents and adverse effects on health; and analytical, forensic, and diagnostic toxicology. This is an essential book for advanced students in toxicology and across the biomedical sciences, life sciences, and environmental sciences who want to learn the concepts of toxicology, as well as early researchers needing to refresh outside of their specialty. - Explains the essential concepts of toxicology in a clear fashion - Provides in-depth coverage of testing protocols, common drugs, chemicals, and laboratory-based diagnostic and analytical toxicology - Explores the history, foundations, and most recent concepts of toxicology - Serves as an essential reference for advanced students in toxicology and across the biomedical, life, and environmental sciences who want to learn the concepts of toxicology

Essentials of Organic Chemistry

Author : Paul M. Dewick
Publisher : John Wiley & Sons
ISBN 13 : 0470016655
Total Pages : 711 pages
Book Rating : 4.4/5 (7 download)

DOWNLOAD NOW!

Book Synopsis Essentials of Organic Chemistry by : Paul M. Dewick

Download or read book Essentials of Organic Chemistry written by Paul M. Dewick and published by John Wiley & Sons. This book was released on 2006-05-26 with total page 711 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essentials of Organic Chemistry is an accessible introduction to the subject for students of Pharmacy, Medicinal Chemistry and Biological Chemistry. Designed to provide a thorough grounding in fundamental chemical principles, the book focuses on key elements of organic chemistry and carefully chosen material is illustrated with the extensive use of pharmaceutical and biochemical examples. In order to establish links and similarities the book places prominence on principles and deductive reasoning with cross-referencing. This informal text also places the main emphasis on understanding and predicting reactivity rather than synthetic methodology as well as utilising a mechanism based layout and featuring annotated schemes to reduce the need for textual explanations. * tailored specifically to the needs of students of Pharmacy Medical Chemistry and Biological Chemistry * numerous pharmaceutical and biochemical examples * mechanism based layout * focus on principles and deductive reasoning This will be an invaluable reference for students of Pharmacy Medicinal and Biological Chemistry.

Xenobiotics and Cancer

Author : Takamatsu no Miya Hi Gan Kenkyū Kikin. International Symposium
Publisher : Taylor & Francis
ISBN 13 : 9780748400379
Total Pages : 394 pages
Book Rating : 4.4/5 (3 download)

DOWNLOAD NOW!

Book Synopsis Xenobiotics and Cancer by : Takamatsu no Miya Hi Gan Kenkyū Kikin. International Symposium

Download or read book Xenobiotics and Cancer written by Takamatsu no Miya Hi Gan Kenkyū Kikin. International Symposium and published by Taylor & Francis. This book was released on 1991 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 21st International Symposium of the Princess Takamatsu Cancer Resarch Fund covered advances in chemical carcinogenesis and cancer chemotherapy. It notes that humans are continuously exposed to carcinogens, so the amount of carcinogenic xenobiotics and the human response to them is important.

Principles and Methods of Toxicology, Fifth Edition

Author : A. Wallace Hayes
Publisher : CRC Press
ISBN 13 : 9780849337789
Total Pages : 2304 pages
Book Rating : 4.3/5 (377 download)

DOWNLOAD NOW!

Book Synopsis Principles and Methods of Toxicology, Fifth Edition by : A. Wallace Hayes

Download or read book Principles and Methods of Toxicology, Fifth Edition written by A. Wallace Hayes and published by CRC Press. This book was released on 2007-09-25 with total page 2304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology. Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.

Drug Metabolism and Pharmacokinetics

Author :
Publisher : BoD – Books on Demand
ISBN 13 : 0850141478
Total Pages : 136 pages
Book Rating : 4.8/5 (51 download)

DOWNLOAD NOW!

Book Synopsis Drug Metabolism and Pharmacokinetics by :

Download or read book Drug Metabolism and Pharmacokinetics written by and published by BoD – Books on Demand. This book was released on 2024-02-14 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, Drug Metabolism and Pharmacokinetics, delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug discovery. The evaluation of various pharmacokinetic parameters such as aqueous solubility, lipophilicity, cell permeability, bioavailability, protein binding, and metabolism and elimination half-life, drug–drug interactions (DDIs), and toxicokinetics is essential for a candidate drug to become a successful therapeutic agent. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied in pharmacokinetic, metabolomic, and bioanalytical studies. Key Features: • Presents pharmacokinetic and biotransformation parameters used for pre-clinical safety evaluations • Depicts experimental and biophysical techniques used in bioanalytical and metabolomic studies • Summarizes in silico, in vitro, and in vivo methods used in drug–enzyme interactions, drug– drug interactions, and toxicokinetics Written by a global team of experts, this book is a valuable resource for drug discovery scientists, drug developers, medicinal chemists, pharmacologists, biochemists, clinicians, biomedical scientists, healthcare professionals, researchers, teaching faculty, and students.