Glutamine And Glucose Metabolism In The Rat Small Intestin

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Regulation of Gastrointestinal Mucosal Growth

Author : Rao N. Jaladanki
Publisher : Biota Publishing
ISBN 13 : 1615047352
Total Pages : 150 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Regulation of Gastrointestinal Mucosal Growth by : Rao N. Jaladanki

Download or read book Regulation of Gastrointestinal Mucosal Growth written by Rao N. Jaladanki and published by Biota Publishing. This book was released on 2016-11-30 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mammalian gastrointestinal mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. The control of the growth of gastrointestinal mucosa is unique and, compared with most other tissue in the body, complex. Mucosal growth is regulated by the same hormones that alter metabolism in other tissues, but the gastrointestinal mucosa also responds to host events triggered by the ingestion and presence of food within the digestive tract. These gut hormones and peptides regulate the growth of the exocrine pancreas, gallbladder epithelium, and the mucosa of the oxyntic gland region of the stomach and the small and large intestines. Luminal factors, including nutrients or other dietary factors, secretions, and microbes that occur within the lumen and distribute over a proximal-to-distal gradient, are also crucial for maintenance of normal gut mucosal regeneration and could explain the villous-height-crypt-depth gradient and variety of adaptation, since these factors are diluted, absorbed, and destroyed as they pass down the digestive tract. Recently, intestinal stem cells, cellular polyamines, and noncoding RNAs are shown to play an important role in the regulation of gastrointestinal mucosal growth under physiological and various pathological conditions. In this book, we highlight key issues and factors that control gastrointestinal mucosal growth and homeostasis, with special emphasis on the mechanisms through which epithelial renewal and apoptosis are regulated at the cellular and molecular levels.

Glutamine Metabolism in Mammalian Tissues

Author : D. Häussinger
Publisher : Springer
ISBN 13 : 9783642697562
Total Pages : 0 pages
Book Rating : 4.6/5 (975 download)

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Book Synopsis Glutamine Metabolism in Mammalian Tissues by : D. Häussinger

Download or read book Glutamine Metabolism in Mammalian Tissues written by D. Häussinger and published by Springer. This book was released on 2011-11-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutamine is a key aminoacid for the synthesis of numerous biologic ally important compounds in mammalian cells and is a carrier form of ammonia. The advance in knowledge on the metabolic significance of this amino acid is presented in in-depth treatments by experts in this active research field. This includes the enzymology of glutamine synthe tase and glutaminase activities in different mammalian organs, notably liver, kidney and brain; properties of glutamine transport across bio logical membranes; role of glutamine metabolism in the liver, with emphasis on the recent discovery of intercellular heterogeneity with respect to enzyme distribution and its functional consequences for ammonia/urea metabolism and pH regulation; renal and intestinal glutamine metabolism; cerebral glutamine/ glutamate interrelationships; skeletal muscle; role of glutamine in cell culture; and finally the clinical aspects, including the new outlook of glutamine antagonists in cancer therapy as well as the role of glutamine in hepatic coma and encephalo pathy. Some, but not all, of the contributors to this work attended the 48th Conference of the Gesellschaft fur Biologische Chemie on glutamine metabolism held in Gottingen, W. Germany, in September 1983. This conference was supported by the Stiftung Volkswagenwerk, Dr. H. Falk Foundation, Freiburg, and the J. Pfrimmer Co. , Erlangen. The abstracts of the contributions to the conference were published in Hoppe-Seyler's Z. Physiol. Chem. 364,1237-125,6,1983, and this book is not intended as the proceedings of that meeting.

Military Strategies for Sustainment of Nutrition and Immune Function in the Field

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309173183
Total Pages : 722 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Military Strategies for Sustainment of Nutrition and Immune Function in the Field by : Institute of Medicine

Download or read book Military Strategies for Sustainment of Nutrition and Immune Function in the Field written by Institute of Medicine and published by National Academies Press. This book was released on 1999-05-13 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.

Glutamine in Clinical Nutrition

Author : Rajkumar Rajendram
Publisher : Springer
ISBN 13 : 1493919326
Total Pages : 562 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Glutamine in Clinical Nutrition by : Rajkumar Rajendram

Download or read book Glutamine in Clinical Nutrition written by Rajkumar Rajendram and published by Springer. This book was released on 2014-12-16 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutamine is the most abundant amino acid and is a major contributor to whole body nitrogen metabolism and is considered to be “conditionally essential.” Glutamine in Health and Disease presents the application of current nutritional knowledge by physicians and dietitians and incorporates emerging fields of science and important discoveries. Section 1 covers glutamine structure and function, glutamine synthetase, glutamine binding protein, glutamine transport, glutamine-rich activation domains and transcription, glutamine transaminase and cell biochemistry. Section 2 covers glucose-independent glutamine metabolism, intestinal barrier function, thyroid-stimulating hormone, glutamine resonances, focal ischemia, plasma glutamine, metabolic stress, cancer and absorption. Section 3 covers dipeptide-bound glutamine, DNA protection, oxidative stress, NF-KB, the inflammatory response, the lung, kidney, GI tract and liver, autophagy, ethanol and diabetes. Finally, Section 4 covers the use of glutamine in preoperative states, enteral and parenteral nutrition, pulmonary infections, cancer, hypoxic injury, arginyl-glutamine, paediatrics, pancreatic surgery, the elderly, gastric emptying gastric bypass and use glutamine cocktails. Written by authors of international and national standing, leaders in the field and trendsetters, Glutamine in Health and Disease is essential reading for nutritionists and dietitians, public health scientists, physicians, epidemiologists, policy makers, and health care professionals of various disciplines.

Amino Acids in Nutrition and Health

Author : Guoyao Wu
Publisher : Springer Nature
ISBN 13 : 3030544621
Total Pages : 256 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Amino Acids in Nutrition and Health by : Guoyao Wu

Download or read book Amino Acids in Nutrition and Health written by Guoyao Wu and published by Springer Nature. This book was released on 2021-03-26 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amino acids (AAs) are not only building blocks of protein, but are also signalling molecules as well as regulators of gene expression and the protein phosphorylation cascade. Additionally, AAs are key precursors for syntheses of hormones and low-molecular weight nitrogenous substances with each having enormous biological importance. For example, physiological concentrations of AA metabolites (e.g., nitric oxide, polyamines, glutathione, taurine, thyroid hormones, and serotonin) are required for cell functions. Growing evidence shows that humans and animals have dietary requirements for all proteinogenic AAs. Mammals, birds and fish also have species- and age-dependent needs for some AA-related substances. However, elevated levels of other products (e.g., ammonia, homocysteine, H2S, and asymmetric dimethylarginine) are pathogenic factors for neurological disorders, oxidative stress, and cardiovascular disease. Thus, optimal amounts of AAs and their ratios in diets and circulation are crucial for whole body homeostasis and health. Adequate provision of one or a mixture of functional AAs or metabolites may be beneficial for ameliorating health problems at various stages of the life cycle (e.g., fetal growth restriction, neonatal morbidity and mortality, weaning-associated intestinal dysfunction and wasting syndrome, obesity, diabetes, cardiovascular disease, the metabolic syndrome, and infertility). Dietary supplementation of these nutrients can also optimize the efficiency of metabolic transformations to enhance muscle growth, milk production, and athletic performance, while preventing excess fat deposition and reducing adiposity. Therefore, functional AAs hold great promise in improving the growth, health and well-being of individuals. Chapter 7 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Metabolic & Therapeutic Aspects of Amino Acids in Clinical Nutrition

Author : Luc A. Cynober
Publisher : CRC Press
ISBN 13 : 0203010264
Total Pages : 778 pages
Book Rating : 4.2/5 (3 download)

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Book Synopsis Metabolic & Therapeutic Aspects of Amino Acids in Clinical Nutrition by : Luc A. Cynober

Download or read book Metabolic & Therapeutic Aspects of Amino Acids in Clinical Nutrition written by Luc A. Cynober and published by CRC Press. This book was released on 2003-11-13 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of this innovative book brought a new perspective to the metabolic and therapeutic aspects of amino acids in clinical nutrition. Since its publication, a number of very important advances have been made in the field and interesting new findings have emerged. Until now, no reference has fully explored the promising new developments

Glutamine Metabolism in Mammalian Tissues

Author : D. Häussinger
Publisher : Springer Science & Business Media
ISBN 13 : 3642697542
Total Pages : 301 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Glutamine Metabolism in Mammalian Tissues by : D. Häussinger

Download or read book Glutamine Metabolism in Mammalian Tissues written by D. Häussinger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Glutamine and Glutamate Mammals

Author : Elling Kvamme
Publisher : CRC Press
ISBN 13 : 1351080741
Total Pages : 280 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Glutamine and Glutamate Mammals by : Elling Kvamme

Download or read book Glutamine and Glutamate Mammals written by Elling Kvamme and published by CRC Press. This book was released on 2018-01-18 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the joint effort of a great many top scientists, this book covers most aspects of the metabolism and function of glutamine and glutamate in mammals.

Intestinal Absorption and Malabsorption

Author : T. Z. Csáky
Publisher :
ISBN 13 : 9780720475388
Total Pages : 308 pages
Book Rating : 4.4/5 (753 download)

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Book Synopsis Intestinal Absorption and Malabsorption by : T. Z. Csáky

Download or read book Intestinal Absorption and Malabsorption written by T. Z. Csáky and published by . This book was released on 1975 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Heterogeneity of Cancer Metabolism

Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

The Pancreatic Beta Cell

Author :
Publisher : Academic Press
ISBN 13 : 0128004401
Total Pages : 517 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Pancreatic Beta Cell by :

Download or read book The Pancreatic Beta Cell written by and published by Academic Press. This book was released on 2014-02-20 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on the pancreatic beta cell. - Expertise of the contributors - Coverage of a vast array of subjects - In depth current information at the molecular to the clinical levels - Three-dimensional structures in color - Elaborate signaling pathways

The Role of Protein and Amino Acids in Sustaining and Enhancing Performance

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309172810
Total Pages : 448 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Role of Protein and Amino Acids in Sustaining and Enhancing Performance by : Institute of Medicine

Download or read book The Role of Protein and Amino Acids in Sustaining and Enhancing Performance written by Institute of Medicine and published by National Academies Press. This book was released on 1999-09-15 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is a commonly held belief that athletes, particularly body builders, have greater requirements for dietary protein than sedentary individuals. However, the evidence in support of this contention is controversial. This book is the latest in a series of publications designed to inform both civilian and military scientists and personnel about issues related to nutrition and military service. Among the many other stressors they experience, soldiers face unique nutritional demands during combat. Of particular concern is the role that dietary protein might play in controlling muscle mass and strength, response to injury and infection, and cognitive performance. The first part of the book contains the committee's summary of the workshop, responses to the Army's questions, conclusions, and recommendations. The remainder of the book contains papers contributed by speakers at the workshop on such topics as, the effects of aging and hormones on regulation of muscle mass and function, alterations in protein metabolism due to the stress of injury or infection, the role of individual amino acids, the components of proteins, as neurotransmitters, hormones, and modulators of various physiological processes, and the efficacy and safety considerations associated with dietary supplements aimed at enhancing performance.

Carbohydrate Metabolism in Cultured Cells

Author : M.J. Morgan
Publisher : Springer Science & Business Media
ISBN 13 : 1468476793
Total Pages : 529 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Carbohydrate Metabolism in Cultured Cells by : M.J. Morgan

Download or read book Carbohydrate Metabolism in Cultured Cells written by M.J. Morgan and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is perhaps obvious to any student of Biology that the discovery of chemical processes in whole organisms has usually preceded the elucidation of the compo nent steps. However, it is perhaps less obvious that the unravelling of the se quences in which those chemical steps occur in living matter, of the precise mechanisms involved, and of the manner in which they are regulated, would have been achieved neither by the study of intact plants and animals nor even of extracts derived from them. Our ability to understand the nature and regulation of metabolism rests on two main premises: the postulate that life processes can indeed be validly investigated with individual cells and cell-free extracts, and the thesis that there is an essential "unity in biochemistry" (as Kluyver put it, 60 years ago) that enables events in one organism to be legitimately studied in another. Of particular utility in this latter respect has been the use of cultures of single-celled organisms, growing in defined media-especially prokaryotes, such as Escherichia coli, and eukaryotes, such as Neurospora and Sac charomyces sp. , to which both biochemical and genetical techniques could be applied. It was, of course, Pasteur's observations of bacterial fermentations that first overthrew the belief that oxygen was essential for all energy-yielding pro cesses: his recognition that "La fermentation . . . . . c' est La vie sans air" laid the foundations of our knowledge of glycolysis.

Biology of Metabolism in Growing Animals

Author : Douglas Burrin, PhD
Publisher : Elsevier Health Sciences
ISBN 13 : 0444510133
Total Pages : 498 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Biology of Metabolism in Growing Animals by : Douglas Burrin, PhD

Download or read book Biology of Metabolism in Growing Animals written by Douglas Burrin, PhD and published by Elsevier Health Sciences. This book was released on 2005-04-19 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is intended to provide in-depth reviews of the recent advances in major areas of metabolism in growing domestic animals. The study of metabolism represents a nexus of biological phenomenon that integrates the impact of nutrition, physiology, endocrinology, immunology, biochemistry, and cell biology in an organism. The development of new methodological techniques and experimental approaches have provide scientists with a greater understanding of how key nutrients or substrates are metabolized at the cellular, organ, and whole animal level. This book presents contributions from leading scientists in nutrition and physiology that highlight important new developments in interorgan and tissue-specific metabolism of protein and amino acids, lipids and fatty acids, and carbohydrates in monogastric and runinant species. Authors will describe the impact of specific biochemical pathways and expression of critical enzymes, routes of nutrient or substrate input, and anatomical or structural influences on the rates of metabolism in a given tissue or cell type. Major substrates/ fuels for oxidative metabolism, key signaling pathways, and intracellular molecules that regulate the major metabolic processes will be described. Also included is how the metabolism of growing animals is influenced by ontogeny, stage of differentiation, and major changes in diet, or the environment. The concepts and specific findings in each area are discussed in the context of their impact on the nutrient requirements, growth, environmental impact, healt and well-being of animals. The book will be a useful reference for research scientists, teachers and students interested in and advanced understanding of metabolism in growing animals. The book is written by leading experts and highlights some of the most recent advances in the field of metabolism. It is a useful reference for researchers and advanced level graduate students in nutrition, physiology and animal science. Presents recent advances in the field of metabolism.

Amino Acids in Nutrition and Health

Author : Guoyao Wu
Publisher : Springer Nature
ISBN 13 : 3030453286
Total Pages : 218 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Amino Acids in Nutrition and Health by : Guoyao Wu

Download or read book Amino Acids in Nutrition and Health written by Guoyao Wu and published by Springer Nature. This book was released on 2020-08-06 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume comprehensively highlights recent advances in the metabolism, nutrition, physiology, and pathobiology of amino acids in all the systems of humans and other animals (including livestock, poultry, companion animals, and fish). It enables readers to understand the crucial roles of amino acids and their metabolites in the health and diseases of the circulatory, digestive, endocrine, immune, muscular, nervous, reproductive, respiratory, skeletal, and urinary systems, as well as the sense organs (eyes, ears, nose, skin, and tongue). Readers will learn that amino acids are not only the building blocks of protein, but are also signalling molecules, as well as regulators of gene expression, metabolic processes and developmental changes in the body. This knowledge will guide nutritional practices to improve the growth, development and health of humans and other animals, as well as prevent and treat chronic (e.g., obesity, diabetes, and cardiovascular disorders) and infectious (e.g., bacterial, fungal, parasite, and viral) diseases. Editor of this volume is an internationally recognized expert in nutritional biochemistry. He has over 38 years of experience with research and teaching at world-class universities in the area of amino acid biochemistry, nutrition, and physiology. He has published more than 625 papers in peer-reviewed journals, 62 chapters in books, and authored two text/reference books, with an H-index of 117 and more than 55,000 citations in Google Scholar. This publication is a useful reference for professionals as well as undergraduate and graduate students in animal science, biochemistry, biomedical engineering, biology, human medicine, food science, kinesiology, nursing, nutrition, pharmacology, physiology, toxicology, veterinary medicine, and other related disciplines. In addition, all chapters provide general and specific references to amino acids in systems health for researchers and practitioners in biomedicine, animal and plant agriculture, and aquaculture, and for government policy makers.

Environmental Health Perspectives

Author :
Publisher :
ISBN 13 :
Total Pages : 368 pages
Book Rating : 4.:/5 (3 download)

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Book Synopsis Environmental Health Perspectives by :

Download or read book Environmental Health Perspectives written by and published by . This book was released on 1993 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nutrient Requirements of Laboratory Animals,

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309051266
Total Pages : 188 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Nutrient Requirements of Laboratory Animals, by : National Research Council

Download or read book Nutrient Requirements of Laboratory Animals, written by National Research Council and published by National Academies Press. This book was released on 1995-02-01 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparationâ€"including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.