Glutamate Receptors In Peripheral Tissue

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Glutamate Receptors in Peripheral Tissue

Author : Santokh Gill
Publisher : Springer Science & Business Media
ISBN 13 : 030648644X
Total Pages : 275 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Glutamate Receptors in Peripheral Tissue by : Santokh Gill

Download or read book Glutamate Receptors in Peripheral Tissue written by Santokh Gill and published by Springer Science & Business Media. This book was released on 2007-01-31 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutamate receptors (GluRs) in the central nervous system have been the subject of intense investigations for several decades, providing new avenues for the understanding of excitatory neurotransmission, excitotoxicity, mechanisms of injury, and therapeutics for several acute neurological conditions, such as brain trauma, and for neurodegenerative and neuropsychiatric disorders including addictions, Alzheimer disease, etc. Evidences of GluRs beyond the central nervous system were first reported in the early 1990s. When the idea of this book was conceived, the knowledge, specificity, and functional significance of GluRs in peripheral tissues was still in its embryonic stage. From our perspective, the idea of GluRs in peripheral tissues arose from our research on seafood toxins (see Chapter 1), and has now been reinforced by the results of other scientists working in similar areas. In this book, we have invited some of the leading authorities in the field to summarize their findings and to provide a framework for further investigations. The book is divided into three sections— Part I is on general concepts and concentrates on the distribution and cell-specific localiza tion of glutamate receptors, their transporters, and the pharmacology in peripheral tissues and organs. Part II emphasizes the presence and implications of these receptors in specific target tissues, organs, and systems, including liver, lungs, endocrine tissues, bone, immune system, etc. Part III focuses on glutamate receptors in plants to illustrate their presence beyond the animal kingdom.

Metabotropic Glutamate Receptors in Peripheral Tissues: Implications for Toxicology

Author : Daniela Durand
Publisher :
ISBN 13 : 9789533075921
Total Pages : pages
Book Rating : 4.0/5 (759 download)

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Book Synopsis Metabotropic Glutamate Receptors in Peripheral Tissues: Implications for Toxicology by : Daniela Durand

Download or read book Metabotropic Glutamate Receptors in Peripheral Tissues: Implications for Toxicology written by Daniela Durand and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Anxiety Disorders

Author : Vladimir Kalinin
Publisher : IntechOpen
ISBN 13 : 9789533075921
Total Pages : 338 pages
Book Rating : 4.0/5 (759 download)

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Book Synopsis Anxiety Disorders by : Vladimir Kalinin

Download or read book Anxiety Disorders written by Vladimir Kalinin and published by IntechOpen. This book was released on 2011-08-01 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last 2-3 decades drastic research progress in anxiety issues has been achieved. It concerns mostly the study of different subtypes of anxiety and their treatment. Nevertheless, the data on anxiety pathogenesis is less elaborated, although here a multidimensional approach exists. It includes neurochemistry, pathophysiology, endocrinology and psychopharmacology. Again, we are able to recognize the multifarious sense of anxiety, and the present collective monograph composed of 16 separate chapters depicting the different aspects of anxiety. Moreover, a great part of book includes chapters on neurochemistry, physiology and pharmacology of anxiety. The novel data on psychopathology and clinical signs of anxiety and its relationship with other psychopathological phenomena is also presented. The current monograph may represent an interest and be of practical use not only for clinicians but for a broad range of specialists, including biochemists, physiologists, pharmacologists and specialists in veterinary.

GLUTAMATE INDUCES IONOTROPIC AND METABOTROPIC GLUTAMATE RECEPTORS EXPRESSION IN PERIPHERAL MAST CELL POPULATIONS

Author : Magnus Peterson
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (116 download)

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Book Synopsis GLUTAMATE INDUCES IONOTROPIC AND METABOTROPIC GLUTAMATE RECEPTORS EXPRESSION IN PERIPHERAL MAST CELL POPULATIONS by : Magnus Peterson

Download or read book GLUTAMATE INDUCES IONOTROPIC AND METABOTROPIC GLUTAMATE RECEPTORS EXPRESSION IN PERIPHERAL MAST CELL POPULATIONS written by Magnus Peterson and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Background and aims: The peripheral nervous system exhibits a key role in regulating inflammation and pain signaling of the damaged tissue via afferent to efferent pathways. In a previous study, we used an Achilles tendon rupture rat model and showed that mast cells in the healing tendon were positive for the ionotropic glutamate receptor, NMDAR1. This raises the possibility that mast cells can be activated by glutamate release from peripheral nerve endings. Methods: We cultured mouse bone marrow derived mast cells (BMMC) and stimulated these cells with L-glutamate. Mast cell degranulation was quantified through u03b2-hexosaminidase release. We used immunofluorescence and Western blot techniques to quantify NMDARs and mgGluRs at the protein level, and RT-qPCR with microarray analysis to study the gene level expression. Results: We show that glutamate induces mast cell degranulation, and up-regulates the expression of glutamate receptors in mast cells. In agreement with this we found by qPCR and microarray analysis that mast cells upregulate the expression of a range of glutamate receptors in response to glutamate exposure, including ionotropic NMDAR1, NMDAR2A/2B, and metabotropic mGluR3, mGluR7. We also showed that the glutamate receptor, NMDAR1 co-localizes with glutamate in the cell membrane of mast cells exposed to glutamate, indicating the interaction between glutamate and its receptor(s) in the mast cell membrane.Conclusions: These findings introduce the possibility that glutamate signaling can have a functional impact on mast cells derived from peripheral tissue, suggesting a mechanism for neuro-immunological response.

mGLU Receptors

Author : Richard Teke Ngomba
Publisher : Springer
ISBN 13 : 3319561707
Total Pages : 283 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis mGLU Receptors by : Richard Teke Ngomba

Download or read book mGLU Receptors written by Richard Teke Ngomba and published by Springer. This book was released on 2017-08-22 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabotropic glutamate receptors (mGluRs) are members of the group C family of G-protein-coupled receptors. Eight different mGlu subtypes have been identified and classified into three groups based on amino acid sequence similarity, agonist pharmacology, and the signal transduction pathways to which they couple. They perform a variety of functions in the central and peripheral nervous systems, being involved in learning, memory, anxiety, and the perception of pain. They are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and cerebral cortex, as well as other parts of the bain and peripheral tissues. This volume will focus on the latest research in the role of Group I mGluRs in health and disease.

Biology of the NMDA Receptor

Author : Antonius M. VanDongen
Publisher : CRC Press
ISBN 13 : 142004415X
Total Pages : 368 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Biology of the NMDA Receptor by : Antonius M. VanDongen

Download or read book Biology of the NMDA Receptor written by Antonius M. VanDongen and published by CRC Press. This book was released on 2008-10-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written

The Metabotropic Glutamate Receptors

Author : P. Jeffrey Conn
Publisher : Humana Press
ISBN 13 : 9780896032910
Total Pages : 277 pages
Book Rating : 4.0/5 (329 download)

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Book Synopsis The Metabotropic Glutamate Receptors by : P. Jeffrey Conn

Download or read book The Metabotropic Glutamate Receptors written by P. Jeffrey Conn and published by Humana Press. This book was released on 1994-09-29 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is the goal of The Metabotropic Glutamate Receptors to provide acomprehensive and forward-thinking review ofthe tremen dous advances that have occurred in less than a decade of metabotropic glutamate receptors (mGluR) research. Virtually every areaof mGluR research is covered, including the molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles of mGluRs. It is our intention that this volume not only summarize what is now known about the mGluRs, but also illuminate the areas in which there is the greatest need for focused research. Glutamic acid is an amino acid that has long been known to play several important metabolic roles in central and peripheral tissues and to be a component of several naturally occurring molecules. The first evidence that glutamate mayaIso serve as a neurotransmitter in the central nervous system (CNS) came in the late 1950s and early 1960s when glutamate and other acidic amino acids were found to induce behavioral convulsions when topically applied to the cortex and to excite a wide variety of central neurons. These findings spurred a massive research effort that quickly established glutamate as the pri mary excitatory neurotransmitter in the vertebrate CNS. One of the most striking characteristics of glutamate that was quickly recognized was its ubiquitous role in serving as the neurotransmitter at the vast majority of excitatory synapses in the brain. It is now clear that most central neuronal circuits involve glutamatergic neurotransmission at some level.

Glutamate

Author : J. Storm-Mathisen
Publisher : Elsevier
ISBN 13 : 0080532578
Total Pages : 311 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Glutamate by : J. Storm-Mathisen

Download or read book Glutamate written by J. Storm-Mathisen and published by Elsevier. This book was released on 2000-11-03 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volume presents a comprehensive and up-to-date treatise of the glutamatergic synapse and its environment. Particular emphasis is on the localizations of the molecular constituents of the synaptic machinery. Immunogold and other high-resolution methods are used extensively. Each chapter presents new data that have not previously been reviewed. The material presented forms the basis for work directed to understanding the functional properties of excitatory synapses in greater depth, to discover mechanisms of neurological and psychiatric disorders and novel methods for treatment. Chapter 1 deals with the transmitter molecule itself, mechanisms of release and pathways for glutamate synthesis. The anatomy of glutamatergic nerve projection pathways in different brain regions is dealt with. In Chapter 2, focus is on aspartate, the enigmatic congener of glutamate, and its possible role in excitatory neurotransmission. Chapters 3 through 6 deal with glutamate receptors. Metabotropic glutamate receptors are presented in Chapter 3. Chapter 4 presents an in situ hybridization atlas of the different classes of ionotropic glutamate receptors. The localizations of these receptors at the regional and synaptic level are presented in Chapter 5. The ways in which the receptors are brought to the synapse and held in position are the subject of Chapter 6. Chapter 7 deals with the enzymes responsible for formation and catabolism of glutamate. In Chapter 8, the regulation of extracellular glutamate levels by glutamate transporters is discussed. The final two chapters of the volume focus on two "model synapses" that, due to special features, lend themselves particularly well to demonstrating properties of glutamatergic synapses. The hair cell-to-afferent nerve terminal synapses in the inner ear (Chapter 9), with their supporting cells, share essential properties with glutamatergic synapses in the central nervous system. The salient features of the latter are illustrated by the synapses of the giant reticulo-spinal axons of the lamprey, used to unravel molecular mechanisms of the cycling of synaptic vesicles (Chapter 10).

Rapid Acting Antidepressants

Author :
Publisher : Academic Press
ISBN 13 : 0128201908
Total Pages : 404 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Rapid Acting Antidepressants by :

Download or read book Rapid Acting Antidepressants written by and published by Academic Press. This book was released on 2020-06-29 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Advances in Pharmacology series presents a variety of chapters from the best authors in the field. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series

The Ionotropic Glutamate Receptors

Author : Daniel Monaghan
Publisher : Springer Science & Business Media
ISBN 13 : 1461239621
Total Pages : 381 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis The Ionotropic Glutamate Receptors by : Daniel Monaghan

Download or read book The Ionotropic Glutamate Receptors written by Daniel Monaghan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Ionotropic Glutamate Receptors provides the first detailed survey of the biochemical, physiological, and pharmacological properties of recombinant ionotropic glutamate receptors. The distinguished contributors show how the molecular characteristics of these receptors account for many of the properties of native ionotropic glutamate receptors. They also examine in detail the properties of glutamate receptor subunits, including receptor modulation by phosphorylation and the anatomical localization of specific glutamate receptor subunits as determined by in situ hybridization and immunochemistry. The Ionotropic Glutamate Receptors conveys the first clear insights into the molecular bases underlying the wealth of pharmacological and physiological data on these receptors.

Animal Models of Cognitive Impairment

Author : Edward D. Levin
Publisher : CRC Press
ISBN 13 : 1420004336
Total Pages : 395 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Animal Models of Cognitive Impairment by : Edward D. Levin

Download or read book Animal Models of Cognitive Impairment written by Edward D. Levin and published by CRC Press. This book was released on 2006-06-22 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen

Ionotropic Glutamate Receptors in the CNS

Author : Peter Jonas
Publisher : Springer Science & Business Media
ISBN 13 : 3662080222
Total Pages : 544 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Ionotropic Glutamate Receptors in the CNS by : Peter Jonas

Download or read book Ionotropic Glutamate Receptors in the CNS written by Peter Jonas and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts

Webvision

Author : Helga Kolb
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (53 download)

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Book Synopsis Webvision by : Helga Kolb

Download or read book Webvision written by Helga Kolb and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nerve-Driven Immunity

Author : Mia Levite
Publisher : Springer Science & Business Media
ISBN 13 : 3709108888
Total Pages : 374 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Nerve-Driven Immunity by : Mia Levite

Download or read book Nerve-Driven Immunity written by Mia Levite and published by Springer Science & Business Media. This book was released on 2012-02-14 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Nerve-Driven Immunity: Neurotransmitters and Neuropeptides in the Immune System” summarizes, analyzes and sheds new light on an unrecognized, yet very important role of key neurotransmitters and neuropeptides in the immune system. Each chapter of the book deals with a different neurotransmitter/neuropeptide from the following list: Dopamine, Adrenaline, Noradrenaline, Acetylcholine, Glutamate, GABA, Somatostatin, Neuropeptide Y (NPY), Vasoactive intestinal polypeptide (VIP), Calcitonin gene related peptide (CGRP), Opioids and Cannabinoids. For each of these neurotransmitters/neuropeptides, the following four topics are discussed: The specific receptors for the neurotransmitter/neuropeptide expressed in various types of immune cells The direct effects induced by the neurotransmitter/neuropeptide in various types of immune cells (either resting or activated), and the specific immune functions and features it activates/elevates or rather inhibits in specific concentrations The production of the neurotransmitter/neuropeptide in, and its release by, various types of immune cells The involvement of the neurotransmitter/neuropeptide in various diseases of the immune system (among them autoimmune diseases, immunodeficiency diseases and hematological cancers) The book includes many original figures, overview tables, and proposed models of events which are instrumental, enriching and stimulating for the reader. In light of the above-mentioned aspects, “Nerve-Driven Immunity: Neurotransmitters and Neuropeptides in the Immune System” is ideally suited as a textbook for new courses in Immunology, Neurology, Neuro-immunology or Pharmacology. The book chapters were written by highly skilled authors from 10 countries: the USA, the United Kingdom, Italy, Israel, Sweden, France, Germany, Spain, Serbia and Romania. “Nerve-Driven Immunity” is a term first coined by Dr. Mia Levite (the editor of the book).

The Glutamate Receptors

Author : Robert W. Gereau
Publisher : Springer Science & Business Media
ISBN 13 : 1597450553
Total Pages : 585 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis The Glutamate Receptors by : Robert W. Gereau

Download or read book The Glutamate Receptors written by Robert W. Gereau and published by Springer Science & Business Media. This book was released on 2008-02-23 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: This insightful and comprehensive book covers nearly every aspect of glutamate receptor structure and function for the working researcher and student. It condenses two previous landmark volumes into one easily accessible volume, and covers the extraordinary research and significant developments in the decade since the previous books were published. This includes the central role glutamate receptors play in neurotransmission.

GABA And Glutamate

Author : Janko Samardzic
Publisher : BoD – Books on Demand
ISBN 13 : 9535138219
Total Pages : 139 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis GABA And Glutamate by : Janko Samardzic

Download or read book GABA And Glutamate written by Janko Samardzic and published by BoD – Books on Demand. This book was released on 2018-03-21 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book collates the contributions of a selected number of neuroscientists that are interested in the molecular, preclinical, and clinical aspects of neurotransmission research. The seven chapters in this book address the latest research/review data related to GABA/glutamate system's organization and function, the structure of receptors, subtypes and their ligands, as well as the translational approach and clinical implications. The book offers readers a rich collection of data regarding current and future applications of GABA and glutamate neurotransmission, including promising research strategies and potential clinical benefits.

Acute Pain

Author : Lesley Bromley
Publisher : Oxford University Press
ISBN 13 : 0199234728
Total Pages : 205 pages
Book Rating : 4.1/5 (992 download)

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Book Synopsis Acute Pain by : Lesley Bromley

Download or read book Acute Pain written by Lesley Bromley and published by Oxford University Press. This book was released on 2010-06-03 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text covers the fundamentals of pain, the pharmacology of drugs used, and summarises the current evidence base for the management of acute pain. It provides practical direct clinical applications and strategies for the management of specific medical conditions in patient groups such as the elderly