Holland-Frei Cancer Medicine

Download Holland-Frei Cancer Medicine PDF Online Free

Author :
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)

DOWNLOAD NOW!


Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Glucocorticoid Action

Download Glucocorticoid Action PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 248 pages
Book Rating : 4.X/5 (4 download)

DOWNLOAD NOW!


Book Synopsis Glucocorticoid Action by : Tomoshige Kino

Download or read book Glucocorticoid Action written by Tomoshige Kino and published by . This book was released on 2004 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glucocorticoids regulate multiple metabolic and developmental processes and play a vital role in the maintenance of basal and stress-related homeostasis. For the last 50 years, pharmacologic doses of glucocorticoids have been used in the treatment of inflammatory, autoimmune, and lymphoproliferative diseases and in the prevention of allograft rejection, while substitution doses have been employed in the management of adrenocortical insufficiency. aspects of glucocorticoid action, in particular, (i) the impact of maternal and early life stress on stress-related gene regulation in the offspring; (ii) the importance of glucocorticoids and their receptors; (iii) further understanding of the mechanisms of GR action, including its effect on chromatin modulation, its interaction with coactivators and corepressors, and the genetic dissection of GR function in mice; (iv) The interaction of hGR with other transcription factors, such as NF-kappa-B, p53, transforming growth factor beta (TGF-beta) and the chicken ovalbumin upstream promoter transcription factor II (COUP-TFII); recycling, ubiquitination and degradation of the receptor, actions of the GR-beta isoform, a novel synthetic nonsteroidal target gene-specific agonist, the importance of target tissue activity of 11-beta-hydroxysteroid dehydrogenase type 1 in glucocorticoid action in health and disease, the interaction of the receptor with the nutrient carnitine, the anthrax products protective antigen (PA) and lethal factor (LF), and the human immunodeficiency virus type-1 (HIV-1)-encoded molecules Vpr and Tat; (vi) an update on the effects of glucocorticoids on the immune system; and (vii) the clinical implications of glucocorticoid action, including glucocorticoid resistance/hypersensitivity, familial and sporadic glucocorticoid resistance, and the effects of stress and depression.

Glucocorticoid Signaling

Download Glucocorticoid Signaling PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 1493928953
Total Pages : 387 pages
Book Rating : 4.4/5 (939 download)

DOWNLOAD NOW!


Book Synopsis Glucocorticoid Signaling by : Jen-Chywan Wang

Download or read book Glucocorticoid Signaling written by Jen-Chywan Wang and published by Springer. This book was released on 2015-07-27 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.

Glucocorticoid-induced Osteoporosis

Download Glucocorticoid-induced Osteoporosis PDF Online Free

Author :
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805572964
Total Pages : 213 pages
Book Rating : 4.8/5 (55 download)

DOWNLOAD NOW!


Book Synopsis Glucocorticoid-induced Osteoporosis by : Andrea Giustina

Download or read book Glucocorticoid-induced Osteoporosis written by Andrea Giustina and published by Karger Medical and Scientific Publishers. This book was released on 2002 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteoporosis is one of the most clinically relevant disabling chronic disease encountered in clinical practice. A common cause of osteoporosis is glucocorticoid excess, as glucocorticoids may increase bone resorption, inhibit bone formation, have indirect actions on bone by decreasing intestinal calcium absorption and induce hypercalciuria. This book presents a comprehensive overview of the effects of glucocorticoids on bone metabolism and structure and on the diagnosis and treatment of glucocorticoid-induced osteoporosis. It aims at providing updated information on the pathogenesis, diagnosis and treatment of this often dramatic complication of glucocorticoid excess. Being one of the few publications completely devoted to glucocorticoid-induced osteoporosis it will heighten the awareness of specialists who prescribe glucocorticoids of the clinical relevance of this treatment complication. 'Glucocorticoid-Induced Osteoporosis' is addressed to clinical experts as well as to general practitioners who will both benefit from the comprehensive and integrative view of the management of patients exposed to glucocorticoids.

The Hypothalamus-Pituitary-Adrenal Axis

Download The Hypothalamus-Pituitary-Adrenal Axis PDF Online Free

Author :
Publisher : Elsevier
ISBN 13 : 0080559360
Total Pages : 413 pages
Book Rating : 4.0/5 (85 download)

DOWNLOAD NOW!


Book Synopsis The Hypothalamus-Pituitary-Adrenal Axis by :

Download or read book The Hypothalamus-Pituitary-Adrenal Axis written by and published by Elsevier. This book was released on 2008-09-12 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hypothalamic-pituitary-adrenal axis controls reactions to stress and regulates various body processes such as digestion, the immune system, mood and sexuality, and energy usage. This volume focuses on the role it plays in the immune system and provides substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. - Evidence presented in this book suggests that the nervous, endocrine, and immune systems form the Neuroendoimmune Supersystem, which integrates all the biological functions of higher organisms both in health and disease for their entire life cycle - Contributors include both the scientists who initiated the work on the HPA axis and on the autonomic nervous system, and those who joined the field later

The Placenta and Human Developmental Programming

Download The Placenta and Human Developmental Programming PDF Online Free

Author :
Publisher : Cambridge University Press
ISBN 13 : 1139494228
Total Pages : 267 pages
Book Rating : 4.1/5 (394 download)

DOWNLOAD NOW!


Book Synopsis The Placenta and Human Developmental Programming by : Graham J. Burton

Download or read book The Placenta and Human Developmental Programming written by Graham J. Burton and published by Cambridge University Press. This book was released on 2010-12-16 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental programming is a rapidly advancing discipline of great importance to basic scientists and health professionals alike. This text integrates, for the first time, contributions from world experts to explore the role of the placenta in developmental programming. The book considers the materno-fetal supply line, and how perturbations of placental development impact on its functional capacity. Chapters examine ways in which environmental, immunological and vascular insults regulate expression of conventional and imprinted genes, along with their impact on placental shape and size, transport, metabolism and endocrine function. Research in animal models is integrated with human clinical and epidemiological data, and questions for future research are identified. Transcripts of discussions between the authors allow readers to engage with controversial issues. Essential reading for researchers in placental biology and developmental programming, as well as specialists and trainees in the wider field of reproductive medicine.

Clinical Applications of Mifepristone (RU486) and Other Antiprogestins

Download Clinical Applications of Mifepristone (RU486) and Other Antiprogestins PDF Online Free

Author :
Publisher : National Academies Press
ISBN 13 : 0309049490
Total Pages : 303 pages
Book Rating : 4.3/5 (9 download)

DOWNLOAD NOW!


Book Synopsis Clinical Applications of Mifepristone (RU486) and Other Antiprogestins by : Institute of Medicine

Download or read book Clinical Applications of Mifepristone (RU486) and Other Antiprogestins written by Institute of Medicine and published by National Academies Press. This book was released on 1993-02-01 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mifepristone (RU486), the first clinically available antiprogestin, has generated great interest since its discovery in the early 1980s. Today, it is recognized that mifepristone, along with other antiprogestins, has a potentially significant therapeutic role in human health and disease, with likely applicability to a variety of pregnancy-related conditions (e.g., management of labor) and to contraception, endometriosis, and cancer, among others. But because mifepristone has been studied and used most widely as a means of nonsurgical abortion, political issues have thus far limited research on the drug and prevented its introduction into the U.S. market. This book provides an unbiased evaluation of current knowledge about both the fundamental nature of antiprogestins as well as their possible use in treating numerous diseases and conditions, and it contains recommendations for future research.

Nuclear Receptors in Development and Disease

Download Nuclear Receptors in Development and Disease PDF Online Free

Author :
Publisher : Academic Press
ISBN 13 : 0128021969
Total Pages : 422 pages
Book Rating : 4.1/5 (28 download)

DOWNLOAD NOW!


Book Synopsis Nuclear Receptors in Development and Disease by :

Download or read book Nuclear Receptors in Development and Disease written by and published by Academic Press. This book was released on 2017-05-17 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Receptors in Development and Disease, Volume 125, the latest volume in the Current Topics in Developmental Biology series, covers nuclear receptors in development and disease, and includes contributions from an international board of authors. New chapters in this release cover the Evolution of Nuclear Receptors and Ligand Signaling: Towards a Soft Key–Lock Model?, The Function and Evolution of Nuclear Receptors in Insect Embryonic Development, Nuclear Receptors in Skeletal Homeostasis, Estrogen Hormone Biology, and the Mechanisms of Glucocorticoid Action During Development. The book's chapters provide a comprehensive set of reviews that cover such topics as nuclear differentiation and remodeling, evolution of receptors, ligand signaling and neural development. - Covers the area of nuclear receptors in development and disease - Includes contributions from an International board of authors - Provides a comprehensive set of reviews on topics as nuclear differentiation and remodeling, evolution of receptors, ligand signaling and neural developments

Immunopharmacology and Inflammation

Download Immunopharmacology and Inflammation PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 3319776584
Total Pages : 330 pages
Book Rating : 4.3/5 (197 download)

DOWNLOAD NOW!


Book Synopsis Immunopharmacology and Inflammation by : Carlo Riccardi

Download or read book Immunopharmacology and Inflammation written by Carlo Riccardi and published by Springer. This book was released on 2018-06-09 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of the current research on inflammation and immunopharmacology, with particular attention to the use of anti-inflammatory drugs, this book discusses future trends in this area of pharmacological research. It addresses an audience with basic knowledge in the inflammatory process, immune system and pharmacology. The book meets the needs of graduate students, junior and senior researchers and is useful as a source of the most current information for those already working in these fields.

Core Topics in Endocrinology in Anaesthesia and Critical Care

Download Core Topics in Endocrinology in Anaesthesia and Critical Care PDF Online Free

Author :
Publisher : Cambridge University Press
ISBN 13 : 1139486128
Total Pages : 203 pages
Book Rating : 4.1/5 (394 download)

DOWNLOAD NOW!


Book Synopsis Core Topics in Endocrinology in Anaesthesia and Critical Care by : George M. Hall

Download or read book Core Topics in Endocrinology in Anaesthesia and Critical Care written by George M. Hall and published by Cambridge University Press. This book was released on 2010-04-01 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Core Topics in Endocrinology in Anesthesia and Critical Care provides a comprehensive, practical overview of the perioperative management of patients with endocrine disorders, giving clear diagnostic advice and management guidelines. This book considers the management of patients with endocrine disorders of the pituitary, thyroid, parathyroid and adrenal glands, including rarer disorders such as MEN syndrome. It then considers all aspects of the perioperative management of diabetic patients, including paediatric, obstetric and ambulatory patients. Finally it discusses endocrine disorders in the critically ill patient, covering such issues as the topical conundrum of glucose control and the management of diabetic metabolic acidosis, thyroid storm and myxoedema coma. Every chapter reviews the relevant anatomy and pathophysiology and the latest developments in defining the genetic causes are also considered where appropriate. Core Topics in Endocrinology in Anesthesia and Critical Care is an invaluable tool for all anaesthetists and intensivists in their daily clinical practice.

Lahita's Systemic Lupus Erythematosus

Download Lahita's Systemic Lupus Erythematosus PDF Online Free

Author :
Publisher : Elsevier
ISBN 13 : 0128205830
Total Pages : 730 pages
Book Rating : 4.1/5 (282 download)

DOWNLOAD NOW!


Book Synopsis Lahita's Systemic Lupus Erythematosus by : Robert G. Lahita

Download or read book Lahita's Systemic Lupus Erythematosus written by Robert G. Lahita and published by Elsevier. This book was released on 2021-07-27 with total page 730 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries. Completely updated, revised, and expanded with the most comprehensive and accessible reference on SLE for clinicians and scientists Full-color presentation throughout the book Provides the latest information available on diagnosis and treatment Incorporates an international panel of authors who are experts in their fields, with an emphasis on young, cutting-edge scientists and physicians

Principles of Endocrine Pharmacology

Download Principles of Endocrine Pharmacology PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1468450360
Total Pages : 303 pages
Book Rating : 4.4/5 (684 download)

DOWNLOAD NOW!


Book Synopsis Principles of Endocrine Pharmacology by : John A. Thomas

Download or read book Principles of Endocrine Pharmacology written by John A. Thomas and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authors have provided an overview of the relationships between hormones that are physiologic constituents of the body as well as their pharmacologic use in replacement therapies and related endocrine dys function. Principles of Endocrine Pharmacology concerns itself with the ther apeutic use of hormones, and hormone like substances, or drugs that can act either by suppressing or enhancing the metabolism of certain glands of internal secretion. Other drugs used for nonendocrine ther apies can likewise affect the endocrine system. Endocrine pharmacology emerged in the early 1900s with the use of crude pituitary extracts. By the mid-1900s several investigators had isolated and begun to synthesize hormones or hormonelike substances. Recognizing the limited supply of hormones that could be obtained both from animal sources and human autopsy material, the search for so called hormone substitutes also began early in the 1900s. Recently, re combinant DNA technologies have been used to provide alternative therapeutic sources of human insulin and human growth hormone. Aside from insulin, perhaps no other use of hormonally-active sub stance is better exemplified by those drugs which affect fertility. The synthesis of an orally-effective steroid represented one of the first major breakthroughs in the chemical suppression of ovulation. Since the orally active 19-norsteroids were introduced in the 1950s, several oral contra ceptive steroid preparations have been marketed. Indeed, the advent of oral contraceptives for birth control has led to a renewed interest in endocrine pharmacology.

Anesthetic Pharmacology

Download Anesthetic Pharmacology PDF Online Free

Author :
Publisher : Cambridge University Press
ISBN 13 : 1139497022
Total Pages : 2902 pages
Book Rating : 4.1/5 (394 download)

DOWNLOAD NOW!


Book Synopsis Anesthetic Pharmacology by : Alex S. Evers

Download or read book Anesthetic Pharmacology written by Alex S. Evers and published by Cambridge University Press. This book was released on 2011-03-10 with total page 2902 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.

Steroid Hormone Resistance

Download Steroid Hormone Resistance PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1468451014
Total Pages : 436 pages
Book Rating : 4.4/5 (684 download)

DOWNLOAD NOW!


Book Synopsis Steroid Hormone Resistance by : George P. Chrousos

Download or read book Steroid Hormone Resistance written by George P. Chrousos and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents the first attempt to present in one place the clinical syndromes and the pathophysiologic basis for the "resistance states" to each of the classes of steroid hormones. Glucocorticoids, mineralocorticoids, androgens, estrogens, progesterone and vitamin D have widely diverse roles ranging from the control of homeostasis to reproduction and bone formation. They are similar in that they share a chemical structure and that their action is in the cell nucleus where they induce transcription of specific genes leading to synthesis of function-specific proteins. Clinical syndromes of steroid hormone resistance to androgens (complete and partial testicular feminization), aldosterone (pseudo hypoaldosteronism) and vitamin D (vitamin D-dependent rickets type II) have been known for many years. Progesterone and glucocorticoid resistance syndromes have been described only recently. Resistance to estrogens has not been reported in man or in animals. It is hoped that a detailed reexamination of what is known about each of these conditions at the clinical and molecular levels will enhance our understanding of the function of these hormones and their mechanisms of action. New insight and research initiatives should result. G.P. Chrousos D.L. Loriaus M.B. Lipsett vii ACKNOWLEDGMENTS The contents of this volume are based in part on the proceedings of an International Conference held in Bethesda in the summer of 1984. This conference was sponsored by the National Institute of Child Health and Human Development, Bethesda, Maryland.

Handbook of Veterinary Pain Management - E-Book

Download Handbook of Veterinary Pain Management - E-Book PDF Online Free

Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323062903
Total Pages : 661 pages
Book Rating : 4.3/5 (23 download)

DOWNLOAD NOW!


Book Synopsis Handbook of Veterinary Pain Management - E-Book by : James S. Gaynor

Download or read book Handbook of Veterinary Pain Management - E-Book written by James S. Gaynor and published by Elsevier Health Sciences. This book was released on 2008-01-29 with total page 661 pages. Available in PDF, EPUB and Kindle. Book excerpt: You can trust this user-friendly guide to help you meet the increasing need for effective pain management in the animals you treat. It provides instant access to clinically relevant information on pain assessment, pharmaceutical and non-pharmaceutical treatment options, guidelines for managing acute and chronic pain, and unique aspects of pain management in dogs, cats, horses, cattle, birds, reptiles, ferrets, and rabbits. User-friendly format helps you quickly and easily find essential pain management information. Helpful boxes and tables provide at-a-glance access to pharmacologic protocols and clinical applications, including dosages, indications, contraindications, and side effects. Complementary and alternative treatment strategies are included throughout to assist you in using the latest non-pharmacological pain interventions. Case studies clearly illustrate the practical applications of key concepts in the clinical setting and help you sharpen your pain assessment and management skills. New contributors — many of the most respected experts in the field — share their insights and experiences to bring you the most current thinking in this ever-changing discipline. Completely revised and updated content throughout ensures you are using the best and most current information available on analgesic drugs and pain management techniques. An expanded chapter on Pain Management in Horses and Cattle explores the latest advances in treating this group of animals. Eight new chapters offer cutting-edge coverage of hot topics in the field, including: Pain Management in the Cat Pain Management for the Pet Bird Clinical Approaches to Analgesia in Reptiles Clinical Approaches to Analgesia in Ferrets and Rabbits Physical Therapy and Rehabilitation in Dogs Rehabilitation Methods and Modalities for the Cat Quality of Life Issues Hospice and Palliative Care

Cytokines, Stress, and Depression

Download Cytokines, Stress, and Depression PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 058537970X
Total Pages : 335 pages
Book Rating : 4.5/5 (853 download)

DOWNLOAD NOW!


Book Synopsis Cytokines, Stress, and Depression by : Robert Dantzer

Download or read book Cytokines, Stress, and Depression written by Robert Dantzer and published by Springer Science & Business Media. This book was released on 2007-11-23 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokines had been characterized in the early eighties as communication mole cules between immune cells, and between immunocytes and other peripheral cells, such as fibroblasts and endothelial cells. They play a key role in the regulation of the immune response and the coordination of the host response to infection. Based on these biological properties, nobody would have predicted that one decade later cytokines would burst upon neurosciences and permeate into several avenues of current research. In neurology, the connection between cytokines and inflammation, and the demonstration of a pivotal role of some of these molecules in cell death by apoptosis, prompted the investigation of their involvement in several neurological diseases involving an inflammatory component, including multiple sclerosis, brain trauma, stroke, and Alzheimer's disease. This movement started in the late eighties, and the corresponding field of research, known as neuroimmunology, is presently booming. In psychiatry, however, the relationship between cytokines and mental disorders was much less evident and took longer to materialize. The first indication that cytokines might be involved in psychopathology came from cancerology and internal medicine.

Encyclopedia of Endocrine Diseases: E-Im

Download Encyclopedia of Endocrine Diseases: E-Im PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 816 pages
Book Rating : 4.:/5 ( download)

DOWNLOAD NOW!


Book Synopsis Encyclopedia of Endocrine Diseases: E-Im by : Luciano Martini

Download or read book Encyclopedia of Endocrine Diseases: E-Im written by Luciano Martini and published by . This book was released on 2004 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: