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Genetically Modified Model Report On Toxicology And Carcinogeneticity Studies Of Dichloroacetic Acid Cas No 79 43 6 In Genetically Modified Fvb Tb Acv Hemizygous Mice Dermal And Drinking Water Studies And Carcinogenecity Studies Of Dichloroacetic Acid In Genetically Modified B6 129 Trp53tm1brd N5 Haploinsufficient Mice Drinking Water Studies
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Book Synopsis Genetically Modified Model Report on Toxicology and Carcinogeneticity Studies of Dichloroacetic Acid (CAS No. 79-43-6) in Genetically Modified (FVB Tb. ACV Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenecity Studies of Dichloroacetic Acid in Genetically Modified [B6. 129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water Studies) by : G. A. Boorman
Download or read book Genetically Modified Model Report on Toxicology and Carcinogeneticity Studies of Dichloroacetic Acid (CAS No. 79-43-6) in Genetically Modified (FVB Tb. ACV Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenecity Studies of Dichloroacetic Acid in Genetically Modified [B6. 129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water Studies) written by G. A. Boorman and published by . This book was released on 2007-08-01 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dichloroacetic acid was nominated for study by the EPA because of its widespread occurrence in drinking water as a byproduct of water disinfection using chlorination. It was also nominated because dicholoroacetic acid is the most studied representative of the class of haloacetic acids & has been shown to cause liver tumors in both rats & mice. Haloacetic acids are second only to trihalomethanes as a family of disinfection byproducts found in many drinking water supplies. Dichloroacetic acid is one of several disinfection byproducts being evaluated to determine whether genetically modified mouse models can serve as a more rapid & cost-effective means of evaluating & ranking potential hazards of disinfection byproducts. Illustrations.
Book Synopsis Genetically Modified Model Report on Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in Genetically Modified (FVB Tb. AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6. 129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies) by : G. A. Boorman
Download or read book Genetically Modified Model Report on Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in Genetically Modified (FVB Tb. AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6. 129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies) written by G. A. Boorman and published by . This book was released on 2007-08-01 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bromodichloromethane (BD) is a by-product of the chlorination of drinking water. It is formed by the halogen substitution & oxidation reactions of chlorine & naturally occurring organic matter (e.g., humic or fluvic acids) in water containing bromide. BD was nominated to the Nat. Toxicology Program for toxicology & carcinogenecity studies. Male & female Tb.AC hemizygous mice received bromodichloromethane (at least 99% pure) by dermal application for 26 or 39 weeks, in drinking water for 26 or 42 weeks, or by gavage for 26 or 41 weeks. p53 Haploinsufficient mice received BD in drinking water for 26 or 42 weeks or by gavage for 26 or 42 weeks. Genetic toxicology studies were conducted in mouse peripheral blood erythrocytes. Illustrations.
Book Synopsis Genetically Modified Model Report on Toxicology Studies of Dicyclohexylcarbodiimide and Carcinogenicity Study of Dicyclohexylcarbodiimide by : R. S. Chabra
Download or read book Genetically Modified Model Report on Toxicology Studies of Dicyclohexylcarbodiimide and Carcinogenicity Study of Dicyclohexylcarbodiimide written by R. S. Chabra and published by . This book was released on 2008-01 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dicyclohexylcarbodiimide is used in industry as a stabilizing agent, coupling agent, & condensing agent. Its widespread use during protein synthesis in the recombinant DNA industry & in the synthesis of polypeptides in the chemical & pharmaceutical industries provides an increasing potential for low-level human exposure. Dicyclohexylcarbodiimide was nominated for study as a key representative of the carbodiimide chemical class because of its acute toxicity & the absence of data on potential health effects. Under the conditions of this 27-week dermal study, there was no evidence of carcinogenic activity of dicyclohexylcarbodiimide in female p53 haplo-insufficient mice administered 0.75, 3, 6, or 12 mg/kg in ethanol. Female Tg.AC hemizygous mice dermally dosed with dicyclohexylcarbodiimide for 20 weeks had significantly increased incidences of squamous cell papilloma of the skin at the site of application. Non-neoplastic lesions noted at the site of application included chronic active inflammation & epidermal hyperplasia in female p53 haplo-insufficient mice & female Tg.AC hemizygous mice. Illus.
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