Genetic Variation and Environmental Factors in Biological and Arterial Ageing

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Publisher : Leuven University Press
ISBN 13 : 9789058674609
Total Pages : 168 pages
Book Rating : 4.6/5 (746 download)

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Book Synopsis Genetic Variation and Environmental Factors in Biological and Arterial Ageing by : Tim Nawrot

Download or read book Genetic Variation and Environmental Factors in Biological and Arterial Ageing written by Tim Nawrot and published by Leuven University Press. This book was released on 2005 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ageing, the decline in survival and bodily functions, caused by damage to macromolecules and tissues is intrinsically linked to life. Although universal and unavoidable, ageing does not occur in a uniform way. In the general population, it is actually a continuously distributed phenotype, in which genetic as well as environmental factors play an interactive role and explain the large interindividual differences between biological and chronological age. Cardiovascular disorders, which find there origins in deterioration of the structure and function of the large arteries, explain a large part of morbidity and mortality in industrialized societies. In this doctoral dissertation, the focus was on telomere length and arterial stiffness as biomarkers of biological and arterial ageing, respectively. It was investigated to what extent genetic and environmental determinants of oxidative stress and inflammation impact on the ageing process. Contents include: Introduction, Arterial ageing in cardiovascular risk prediction, Genetic and environmental factors in biological and arterial ageing, Telomere length and possible link to X chromosome, Role of smoking, oxidative stress and the -174 G/C interleukin-6 polymorphism in biological and vascular ageing, Environmental factors in arterial ageing, Blood pressure and blood selenium: a cross-sectional and a longitudinal population study, Endothelial function and outdoor temperature, General Discussion, Summary, Short Curriculum Vitae.

Obesity and Cardiovascular Disease

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Publisher : CRC Press
ISBN 13 : 1420018906
Total Pages : 475 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Obesity and Cardiovascular Disease by : Malcolm K Robinson

Download or read book Obesity and Cardiovascular Disease written by Malcolm K Robinson and published by CRC Press. This book was released on 2006-03-07 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although cardiovascular disease remains the leading proximate cause of death in the United States, it is now estimated that obesity may be equivalent to smoking as the leading cause of preventable death in America. In light of these statistics, this reference presents our current understanding of the epidemiology, pathology, and genetics of the obe

Early Vascular Aging (EVA)

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Publisher : Elsevier
ISBN 13 : 0443155135
Total Pages : 772 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Early Vascular Aging (EVA) by : Pedro Guimarães Cunha

Download or read book Early Vascular Aging (EVA) written by Pedro Guimarães Cunha and published by Elsevier. This book was released on 2024-02-29 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early Vascular Aging (EVA): New Directions in Cardiovascular Protection, Second Edition continues to be the most comprehensive and authoritative resource on premature alterations in artery structure and function. The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. This second edition contains completely updated content with expanded coverage of basic and translational research, systematic reviews of the most prominent literature, discussion of applicability of new evidence and more. Written by an international team of clinicians and researchers, this is a valuable resource to basic and translational scientists, clinical researchers and clinicians in the cardiovascular field interested in prevention, diagnosis and treatment of EVA. - Contains all the relevant information available on the main paradigm shifts in vascular aging research, from different fields of knowledge (from basic biology to epidemiology) - Reviews the most prominent evidence produced on early vascular aging (EVA), highlighting recent research advances, clinical applications, and research opportunities - Formulates, in each chapter, a set of research questions that need to be addressed, challenging the vast research community to take on new directions and collaborations

Genetics of Hypertension

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Publisher : Elsevier Health Sciences
ISBN 13 : 0444514562
Total Pages : 284 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Genetics of Hypertension by : Anna F. Dominiczak

Download or read book Genetics of Hypertension written by Anna F. Dominiczak and published by Elsevier Health Sciences. This book was released on 2007-01-01 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Classic and modern tools of genetics have been applied to hypertension research for some 20 years. This volume in the Handbook of Hypertension series aims to go beyond a simple summary of discoveries and provides a critical commentary on many controversial issues. It will be particularly useful for clinician scientists at all stages of their careers, graduate students and post-doctoral scientists as well as all those interested in cardiovascular medicine and research throughout the entire spectrum from bench to bedside. As in every relatively young area of research, the initial excitement over the early positive observations has not always been confirmed by subsequent larger studies with greater statistical power. Issues related to current recommendations on design of studies and their analysis are therefore included. Pharmacogenetics and pharmacogenomics have been the subjects of many debates in recent years and are of particular importance in hypertension as life-long treatments, frequently with multiple drugs are given to millions of people world-wide. A critical appraisal of this controversial topic is provided. Several chapters on experimental genetics of hypertension with a special focus on physiological genomics are also included.

Cognitive Neuroscience of Aging

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Publisher : Oxford University Press
ISBN 13 : 0190660236
Total Pages : 633 pages
Book Rating : 4.1/5 (96 download)

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Book Synopsis Cognitive Neuroscience of Aging by : Roberto Cabeza

Download or read book Cognitive Neuroscience of Aging written by Roberto Cabeza and published by Oxford University Press. This book was released on 2016-10-31 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of the popular Cognitive Neuroscience of Aging provides up-to-date coverage of the most fundamental topics in this discipline. Like the first edition, this volume accessibly and comprehensively reviews the neural mechanisms of cognitive aging appropriate to both professionals and students in a variety of domains, including psychology, neuroscience, neuropsychology, neurology, and psychiatry. The chapters are organized into three sections. The first section focuses on major questions regarding methodological approaches and experimental design. It includes chapters on structural imaging (MRI, DTI), functional imaging (fMRI), and molecular imaging (dopamine PET, etc), and covers multimodal imaging, longitudinal studies, and the interpretation of imaging findings. The second section concentrates on specific cognitive abilities, including attention and inhibitory control, executive functions, memory, and emotion. The third section turns to domains with health and clinical implications, such as the emergence of cognitive deficits in middle age, the role of genetics, the effects of modulatory variables (hypertension, exercise, cognitive engagement), and the distinction between healthy aging and the effects of dementia and depression. Taken together, the chapters in this volume, written by many of the most eminent scientists as well as young stars in this discipline, provide a unified and comprehensive overview of cognitive neuroscience of aging.

Biosocial Surveys

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Publisher : National Academies Press
ISBN 13 : 0309108675
Total Pages : 429 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Biosocial Surveys by : National Research Council

Download or read book Biosocial Surveys written by National Research Council and published by National Academies Press. This book was released on 2008-01-06 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biosocial Surveys analyzes the latest research on the increasing number of multipurpose household surveys that collect biological data along with the more familiar interviewerâ€"respondent information. This book serves as a follow-up to the 2003 volume, Cells and Surveys: Should Biological Measures Be Included in Social Science Research? and asks these questions: What have the social sciences, especially demography, learned from those efforts and the greater interdisciplinary communication that has resulted from them? Which biological or genetic information has proven most useful to researchers? How can better models be developed to help integrate biological and social science information in ways that can broaden scientific understanding? This volume contains a collection of 17 papers by distinguished experts in demography, biology, economics, epidemiology, and survey methodology. It is an invaluable sourcebook for social and behavioral science researchers who are working with biosocial data.

Modulation of CFTR and ENaC Channel Function by Interacting Proteins and Trafficking

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Publisher : Leuven University Press
ISBN 13 : 9789058675101
Total Pages : 140 pages
Book Rating : 4.6/5 (751 download)

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Book Synopsis Modulation of CFTR and ENaC Channel Function by Interacting Proteins and Trafficking by : Lishuang Cao

Download or read book Modulation of CFTR and ENaC Channel Function by Interacting Proteins and Trafficking written by Lishuang Cao and published by Leuven University Press. This book was released on 2005 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Electrical Brain Stimulation in Psychiatric Disorders. Contributions from Research in Animal Models

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Publisher : Leuven University Press
ISBN 13 : 9789058675545
Total Pages : 182 pages
Book Rating : 4.6/5 (755 download)

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Book Synopsis Electrical Brain Stimulation in Psychiatric Disorders. Contributions from Research in Animal Models by : Kris Van Kuyck

Download or read book Electrical Brain Stimulation in Psychiatric Disorders. Contributions from Research in Animal Models written by Kris Van Kuyck and published by Leuven University Press. This book was released on 2006 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Expression and Function of a Serotoninergic System in the Rat Anterior Pituitary

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Publisher : Leuven University Press
ISBN 13 : 9789058675828
Total Pages : 166 pages
Book Rating : 4.6/5 (758 download)

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Book Synopsis Expression and Function of a Serotoninergic System in the Rat Anterior Pituitary by : Anna-Pia Papageorgiou

Download or read book Expression and Function of a Serotoninergic System in the Rat Anterior Pituitary written by Anna-Pia Papageorgiou and published by Leuven University Press. This book was released on 2006-12 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt:

12p Translocations in Acute Leukaemia

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Publisher : Leuven University Press
ISBN 13 : 9789058674654
Total Pages : 138 pages
Book Rating : 4.6/5 (746 download)

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Book Synopsis 12p Translocations in Acute Leukaemia by : Anniek Corveleyn

Download or read book 12p Translocations in Acute Leukaemia written by Anniek Corveleyn and published by Leuven University Press. This book was released on 2005 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Modes of Action of 1[alpha], 25-dihydroxyvitamin D3 and Analogs

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Publisher : Leuven University Press
ISBN 13 : 9789058674753
Total Pages : 206 pages
Book Rating : 4.6/5 (747 download)

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Book Synopsis Molecular Modes of Action of 1[alpha], 25-dihydroxyvitamin D3 and Analogs by : Guy Eelen

Download or read book Molecular Modes of Action of 1[alpha], 25-dihydroxyvitamin D3 and Analogs written by Guy Eelen and published by Leuven University Press. This book was released on 2005 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genes, Behavior, and the Social Environment

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Publisher : National Academies Press
ISBN 13 : 0309133815
Total Pages : 384 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Genes, Behavior, and the Social Environment by : Institute of Medicine

Download or read book Genes, Behavior, and the Social Environment written by Institute of Medicine and published by National Academies Press. This book was released on 2006-11-07 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical procedures; and, more recently, a growing understanding of the human genome have each played a role in extending the duration and raising the quality of human life. But research conducted over the past few decades shows us that this progress, much of which was based on investigating one causative factor at a time—often, through a single discipline or by a narrow range of practitioners—can only go so far. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but also for its workforce, resource, and infrastructural needs.

Concepts of Epidemiology

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Publisher : Oxford University Press
ISBN 13 : 0198739680
Total Pages : 481 pages
Book Rating : 4.1/5 (987 download)

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Book Synopsis Concepts of Epidemiology by : Raj S. Bhopal

Download or read book Concepts of Epidemiology written by Raj S. Bhopal and published by Oxford University Press. This book was released on 2016 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: First edition published in 2002. Second edition published in 2008.

Geriatric Gastroenterology

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Publisher : Springer Science & Business Media
ISBN 13 : 1441916237
Total Pages : 660 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Geriatric Gastroenterology by : C. S. Pitchumoni

Download or read book Geriatric Gastroenterology written by C. S. Pitchumoni and published by Springer Science & Business Media. This book was released on 2012-07-26 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: As aging trends in the United States and Europe in particular are strongly suggestive of increasingly older society, it would be prudent for health care providers to better prepare for such changes. By including physiology, disease, nutrition, pharmacology, pathology, radiology and other relevant associated topics, Geriatric Gastroenterology fills the void in the literature for a volume devoted specifically to gastrointestinal illness in the elderly. This unique volume includes provision of training for current and future generations of physicians to deal with the health problems of older adults. It will also serve as a comprehensive guide to practicing physicians for ease of reference. Relevant to the geriatric age group, the volume covers epidemiology, physiology of aging, gastrointestinal physiology, pharmacology, radiology, pathology, motility disorders, luminal disorders, hepato-biliary disease, systemic manifestations, neoplastic disorders, gastrointestinal bleeding, cancer and medication related interactions and adverse events, all extremely common in older adults; these are often hard to evaluate and judge, especially considering the complex aging physiology. All have become important components of modern medicine. Special emphasis is be given to nutrition and related disorders. Capsule endoscopy and its utility in the geriatric population is also covered. Presented in simple, easy to read style, the volume includes numerous tables, figures and key points enabling ease of understanding. Chapters on imaging and pathology are profusely illustrated. All chapters are written by specialists and include up to date scientific information. Geriatric Gastroenterology is of great utility to residents in internal medicine, fellows in gastroenterology and geriatric medicine as well as gastroenterologists, geriatricians and practicing physicians including primary care physicians caring for older adults.

Epigenetics of Aging

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Publisher : Springer Science & Business Media
ISBN 13 : 1441906398
Total Pages : 462 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Epigenetics of Aging by : Trygve O. Tollefsbol

Download or read book Epigenetics of Aging written by Trygve O. Tollefsbol and published by Springer Science & Business Media. This book was released on 2009-11-11 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Exploring the Biological Contributions to Human Health

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Publisher : National Academies Press
ISBN 13 : 0309132975
Total Pages : 287 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Exploring the Biological Contributions to Human Health by : Institute of Medicine

Download or read book Exploring the Biological Contributions to Human Health written by Institute of Medicine and published by National Academies Press. This book was released on 2001-07-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.

Metabolism and Biological Activities of C2-Ceramide

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Publisher : Leuven University Press
ISBN 13 : 9789058675804
Total Pages : 178 pages
Book Rating : 4.6/5 (758 download)

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Book Synopsis Metabolism and Biological Activities of C2-Ceramide by : Helena Van Overloop

Download or read book Metabolism and Biological Activities of C2-Ceramide written by Helena Van Overloop and published by Leuven University Press. This book was released on 2006-12 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: