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Author : Frederick Wright Hyde
Publisher :
ISBN 13 :
Total Pages : 246 pages
Book Rating : 4.:/5 (291 download)
Download or read book Genetic Studies on Relapsing Fever and Lyme Disease Borrelia written by Frederick Wright Hyde and published by . This book was released on 1985 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Justin D Radolf
Publisher :
ISBN 13 : 9781913652616
Total Pages : 770 pages
Book Rating : 4.6/5 (526 download)
Download or read book Lyme Disease and Relapsing Fever Spirochetes written by Justin D Radolf and published by . This book was released on 2021 with total page 770 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lyme disease (Lyme borreliosis) is the most prevalent vector-borne illness in the United States and Europe and a growing threat to global health. In addition Lyme disease is considered a model system of emerging infectious diseases. The book Borrelia: Molecular Biology, Host Interaction and Pathogenesis published in 2010 was the first state-of-the-art reference work covering the myriad, interlaced facets of the enzootic disorders caused by pathogenic Borrelia. This current volume, by the same editors, builds on the previous work and contains a vast amount of new information, a wider scope, and increased coverage of genomics, genetics, evolutionary biology, vector biology, physiology, pathogenicity, immune response, and immune evasion. Written by renowned scientists who have made seminal contributions to the field, this book contains an expansive treatment of the options to track live spirochetes and evaluate gene expression in ticks and mice, provides insights into the workings of the flagellar motor, presents up-to-date research on the modulation of gene expression, and reviews recent studies on the Lyme disease spirochete's networks of regulatory pathways. The volume highlights and describes in detail the tremendous advances in understanding of the Borrelia genus at the molecular and cellular levels as well as the pathogenesis of Lyme disease and relapsing fever. This comprehensive volume is indispensable for anyone involved in Borrelia and Lyme disease research and is highly recommended for microbiologists, immunologists, and physicians with an interest in spirochetes, vector-borne illness, or emerging infectious diseases. The book is a recommended reference volume for all microbiology libraries.
Author : Marcus Thein
Publisher : BoD – Books on Demand
ISBN 13 : 3844101950
Total Pages : 142 pages
Book Rating : 4.8/5 (441 download)
Download or read book Porins of Lyme Disease and Relapsing Fever Spirochetes written by Marcus Thein and published by BoD – Books on Demand. This book was released on 2012 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Justin D. Radolf
Publisher : Caister Academic Press Limited
ISBN 13 : 9781904455585
Total Pages : 0 pages
Book Rating : 4.4/5 (555 download)
Download or read book Borrelia written by Justin D. Radolf and published by Caister Academic Press Limited. This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genus Borrelia, in the spirochete phylum, is not closely related to any other bacteria and has a highly unusual genome composed of a linear chromosome and multiple circular and linear plasmids that appear to be in a constant state of rearrangement, recombination, and deletion. The determination of the genome sequence of Borrelia strains has facilitated tremendous advances in understanding this genus at the molecular and cellular level, as well as the pathogenesis of Lyme disease and relapsing fever. In recent years, there has been an explosion of new insights into the molecular biology, genetics, physiology, and ecology of Borrelia and its tick/vertebrate life cycle. This research is of particular importance as the incidence of Lyme borreliosis continues to increase. Written by renowned scientists who have made seminal contributions to the field, this book is a comprehensive guide to the pathogenic Borrelia, providing researchers, advanced students, clinicians, and other professionals with an encyclopedic overview of the molecular biology of this important genus and the pathogenesis of diseases. Leading authorities have made contributions on topics such as Borrelia genomics, DNA replication, gene regulation, transcriptomics, proteomics, metabolism and physiology, cellular structure, motility and chemotaxis, genetic manipulation, evolutionary genetics, ecology, tick interactions, Lyme disease and relapsing fever pathogenesis, animal models, host response, detection, and vaccines. The volume is essential for anyone involved in Borrelia research and is strongly recommended for microbiologists, immunologists, and physicians involved in spirochete research, Lyme borreliosis, or relapsing fever. The book is a recommended reference volume for all microbiology libraries.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464951799
Total Pages : 26 pages
Book Rating : 4.4/5 (649 download)
Download or read book Borrelia Infections: Advances in Research and Treatment: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: Borrelia Infections: Advances in Research and Treatment: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Borrelia Infections in a compact format. The editors have built Borrelia Infections: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Borrelia Infections in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Borrelia Infections: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Tanja Petnicki-Ocwieja
Publisher : Frontiers Media SA
ISBN 13 : 2889195570
Total Pages : 116 pages
Book Rating : 4.8/5 (891 download)
Download or read book Lyme Disease: Recent Advances and Perspectives written by Tanja Petnicki-Ocwieja and published by Frontiers Media SA. This book was released on 2015-08-08 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interplay between host and pathogen is a complex co-evolutionary battle of surveillance and evasion. The pathogen continuously develops mechanisms to subvert the immune response in order to establish infection while the immune system responds with novel mechanisms of detection. Because the majority of Lyme disease pathology is due to an over-exuberant immune response, much research in Borrelia burgdorferi pathogenesis has been devoted to understanding the mammalian host response to the bacterium. Immunological studies continue to be an active area of research employing emerging techniques, such as intra-vital imaging. These studies have furthered our understanding of inflammatory processes during long-term infection and provided some surprising insights, such as the continued presence of bacterial products after clearance. The field of Lyme disease has long debated the etiology of long-term inflammation and recent studies in the murine host have shed light on relevant cell types and inflammatory mediators that participate in the pathology of Lyme arthritis. Live imaging and bioluminescent studies have allowed for a novel view of the bacterial life cycle, including the tick mid-gut, tick-to-mammal transmission and dissemination throughout a mouse. A number of tick and bacterial proteins have been shown to participate in the completion of the enzootic cycle. Novel mechanisms of gene regulation are continuously being identified. However, B. burgdorferi lacks many traditional virulence factors, such as toxins or specialized secretion systems. Many genes in the B. burgdorferi genome have no known homolog in other bacteria. Therefore, studies focusing on host-pathogen interactions have therefore been limited by an incomplete understanding of the repertoire of bacterial virulence factors. Questions such as how the pathogen causes disease, colonizes the tick and evades host immune-surveillance have been difficult to address. Genetic studies involving single gene deletions have identified a number of important bacterial proteins, but a large-scale genomics approach to identify virulence factors has not been attempted until recently. The generation of a site-directed mutagenesis library is an important step towards a detailed analysis of the B. burgdorferi genome and pathogenome. Using this library, high-throughput genomic studies, utilizing techniques such as massively parallel sequencing have been promising and could be used to identify novel virulence determinants of disease in the mammalian host or persistence in the tick vector. Continued research on this unique pathogen and its specific interaction with host and vector may have far reaching consequences and provide insights for diverse disciplines including ecology, infectious disease, and immunology. Here, several reviews will discuss the most recent advances and future studies to be undertaken in the field of B. burgdorferi biology.
Author : Stanley Falkow
Publisher : Springer Science & Business Media
ISBN 13 : 0387254978
Total Pages : 1105 pages
Book Rating : 4.3/5 (872 download)
Download or read book The Prokaryotes written by Stanley Falkow and published by Springer Science & Business Media. This book was released on 2006-11-14 with total page 1105 pages. Available in PDF, EPUB and Kindle. Book excerpt: The revised Third Edition of The Prokaryotes, acclaimed as a classic reference in the field, offers new and updated articles by experts from around the world on taxa of relevance to medicine, ecology and industry. Entries combine phylogenetic and systematic data with insights into genetics, physiology and application. Existing entries have been revised to incorporate rapid progress and technological innovation. The new edition improves on the lucid presentation, logical layout and abundance of illustrations that readers rely on, adding color illustration throughout. Expanded to seven volumes in its print form, the new edition adds a new, searchable online version.
Author : Felipe C. Cabello
Publisher :
ISBN 13 :
Total Pages : 86 pages
Book Rating : 4.:/5 (5 download)
Download or read book Molecular Biology of Spirochetes written by Felipe C. Cabello and published by . This book was released on 1912 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diseases produced by spirochetes, including Lyme borreliosis, syphilis and leptospirosis, are on the rise worldwide. This volume focuses on a series of state-of-the-art presentations of the research taking place in the laboratories of the contributors, and serves as an introduction to those individuals entering in the field of spirochete research.
Author : S. H. Gillespie
Publisher : Cambridge University Press
ISBN 13 : 9780521843126
Total Pages : 396 pages
Book Rating : 4.8/5 (431 download)
Download or read book Microbe-vector Interactions in Vector-borne Diseases written by S. H. Gillespie and published by Cambridge University Press. This book was released on 2004-05-06 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several billion people are at daily risk of life-threatening vector-borne diseases such as malaria, trypanosomiasis and dengue. This volume describes the way in which the causal pathogens of such diseases interact with the vectors that transmit them, detailing the biological adaptations that enable pathogens to live with their vectors and, in some circumstances, to control them. This knowledge has led to novel preventative strategies in the form of antibiotics and new vaccines which are targeted not at the pathogen itself but at its specific vector.
Author : Elitza S. Theel
Publisher : Elsevier Health Sciences
ISBN 13 : 0323402542
Total Pages : 193 pages
Book Rating : 4.3/5 (234 download)
Download or read book Tickborne Borrelia Infections, An Issue of Clinics in Laboratory Medicine written by Elitza S. Theel and published by Elsevier Health Sciences. This book was released on 2016-03-09 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topics in this publication on tickborne borrelia infections include: Lyme disease epidemiology and transmission; Clinical manifestation and treatment of Lyme disease; Neuroborreliosis; Prevention of Lyme disease; Lyme disease diagnosis - serology; Lyme disease diagnosis - alternatives to serology; Lyme disease co-infections; Relapsing fever borrelia (global review); Emerging tickborne borrelia - B. miyamotoi; Lyme Disease and the immune response. Led by Elli Theel Director of the Infectious Diseases Serology Laboratory of Mayo Clinic, this issue includes authors from the United States, United Kingdom, and Canada to present their expertise on tickborne disease for the clinical pathologist, the infectious disease specialist, and other clinicians who work with patients with these diseases.
Author : Felipe C. Cabello
Publisher : IOS Press
ISBN 13 : 1586036653
Total Pages : 426 pages
Book Rating : 4.5/5 (86 download)
Download or read book Molecular Biology of Spirochetes written by Felipe C. Cabello and published by IOS Press. This book was released on 2006 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diseases produced by spirochetes, including Lyme borreliosis, syphilis and leptospirosis, are on the rise worldwide. This volume focuses on a series of state-of-the-art presentations of the research taking place in the laboratories of the contributors, and serves as an introduction to those individuals entering in the field of spirochete research.
Author : Douglas I. Johnson
Publisher : Springer
ISBN 13 : 3319676512
Total Pages : 451 pages
Book Rating : 4.3/5 (196 download)
Download or read book Bacterial Pathogens and Their Virulence Factors written by Douglas I. Johnson and published by Springer. This book was released on 2017-11-23 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacterial Pathogens and their Virulence Factors contains a detailed description of 32 major bacterial pathogens that affect human health and their associated virulence determinants. Chapter 1 gives an overview of the different types and classes of general virulence factors involved in host cell adherence and invasion, dissemination within the host, host cell damage, and evasion of host defense systems, as well as mechanisms by which these virulence factors are regulated. Chapters 2 through 33 give concise descriptions of the disease states associated with the 32 bacterial genera and their major pathogenic species, along with an in-depth description of the individual virulence factors that have been found to be functionally involved in pathogenicity. A detailed bibliography derived from primary literature and review articles accompanies each of these chapters, allowing the reader to delve more deeply into individual pathogens and their virulence determinants. Chapter 34 discusses the exciting possibilities and initial successes of using detailed information on a pathogen’s virulence toolkit to design new therapeutics aimed at specific virulence traits.
Author : Jesse L. Goodman
Publisher :
ISBN 13 :
Total Pages : 442 pages
Book Rating : 4.3/5 (91 download)
Download or read book Tick-borne Diseases of Humans written by Jesse L. Goodman and published by . This book was released on 2005 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive information on the biology, ecology, and clinical aspects of these diseases. Features in-depth profiles of specific diseases, including information on disease history, biology, epidemiology, ecology, transmission, clinical manifestations, diagnosis, treatment and prevention.
Author : David S. Younger
Publisher : Rowman & Littlefield
ISBN 13 : 1538117711
Total Pages : 289 pages
Book Rating : 4.5/5 (381 download)
Download or read book The Autoimmune Brain written by David S. Younger and published by Rowman & Littlefield. This book was released on 2019-11-10 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are millions of people who experience issues related to brain health—depression, attention issues, anxiety, forgetfulness, fatigue, and even chronic pain—yet can’t figure out what’s causing their problems and can’t find any relief. They may have seen a myriad of doctors, many of whom do not take their complaints seriously, or worse, turn to the easy, often inappropriate fix of antidepressants or anti-anxiety medications. Traditional medications, supplements, or other therapies haven’t worked. No matter what their age—from children to teens or seniors—people and their loved ones are frustrated, scared, and confused by their continued poor health. Countless others display severe psychiatric symptoms that seem to come out of nowhere, ranging from tics, obsessive-compulsive behaviors and anxiety, to depression, bipolar-like mood swings, and even borderline personality disorder and suicidal ideas. Sometimes, the people affected are the only ones that notices a change to the way they think or feel, and they suffer in silence. Or, they reach out to try to get help, and are all too frequently misdiagnosed. David Younger, a world-renowned physician, provides relief to these patients and their families. His diagnostic techniques and treatment protocols will help readers identify the true cause of their symptoms and put them on a clear path to healing so they no longer feel unbalanced, out of control, forgetful, and exhausted. The Autoimmune Brain connects common brain health symptoms to the changes in the immune system, and particularly bacterial, viral, and parasitic infections. Younger explains his groundbreaking research and adds a new component: how traumatic stress (whether physical or emotional) and genetics affects this same triad as inextricable factors in initiating disease and brain health symptoms. In fact, a change in personality, behavior, coping style, and one’s emotional state may be the first clue that there is a health problem brewing somewhere else in the body. Readers will find new answers to troubling conditions, including: Alzheimer’s disease; Anxiety; Arthritis; Autism; Autonomic disturbances; Bacterial and viral infections; Bipolar Disorder; Cancer; Celiac disease and gluten intolerances; Chronic Fatigue Syndrome (now referred to as Systemic Exertion Intolerance Disease); Chronic Pain; Dementia; Depression; Endocrine Disorders; Immune modulatory therapy using IVIg; Lyme disease and co-infections; Mast cell activation syndrome; Medical cannabis; Obsessive Compulsive Disorder; Orthostatic hypotension; Peripheral Neuropathy; Porphyria; Post-Traumatic Stress Disorder; and Postural orthostatic tachycardia.
Author : John Freedman
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (78 download)
Download or read book Cyclic-di-GMP Signaling in the Borrelia Spirochetes written by John Freedman and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Lyme disease is the most common tick-borne disease in North America, with approximately 35,000 cases reported to the Centers for Disease Control in 2008. The genome of its causative agent, Borrelia burgdorferi, encodes for a set of genes involved in the metabolism and regulatory activities of the second messenger nucleotide, cyclic-di-GMP (c-di-GMP). Rrp1 is a response regulatory-diguanylate cyclase, and its regulatory capability is likely mediated via production of c-di-GMP, as it lacks a DNA-binding domain. One known class of c-di-GMP effector/binding proteins are those that harbor a PIlZ domain. The genome of B. burgdorferi strain 5A4 encodes for one chromosomally-carried PilZ domain, which we have designated PlzA. Additionally, certain B. burgdorferi strains encode for a second PilZ domain-containing protein (PlzB) which is plasmid-carried. Both PlzA and PlzB were found to bind specifically to c-di-GMP, and c-di-GMP binding by PlzA was found to be dependant upon arginine residues in the c-di-GMP binding region. Additionally, expression of PlzA was found to be upregulated by tick feeding and was constitutive in the mammalian host. We next constructed two deletion/allelic exchange mutants - one with the targeted deletion of PlzA, and on ethat replaced PlzA with PlzB in a strain lacking the plzB gene. Our studies demonstrated that [Delta]plzA was deficient in motility and was also non-infectious in the mouse model of B. burgdorferi infection. Additionally, this strain remained viable in larval Ixodes ticks. Also, B31-plzB KI was deficient in motility, as well as infectivity, demonstrating that PlzB is unable to complement for functions fo PlzA in vitro and in vivo and that it may play other roles in the biology of B. burgdorferi strains carrying the plzB gene. These studies represent the first identification of a c-di-GMP binding protein in any spirochete, but also represent the first demonstration of the importance of PilZ domain proteins in a spirochetal system. We additionally examined the effects of c-di-GMP synthesis and breakdown in the related bacterium, B. hermsii, a causative agent of tick-borne relapsing fever (TBRF). Deletion mutants in Rrp1 (B. hermsii's sole diguanylate cyclase) and PdeA (B. hermsii's only EAL domain-containing phosphodiesterase) were created. These strains were analyzed in order to determine: 1) the effect(s) of the losse of Rrp1/PdeA on intracellular spirochete c-di-GMP levels, and 2) the effects of Rrp1/PdeA on the establishment of murine infection and on gross motility/chemotaxis. It was demonstrated that c-di-GMP accumulates intracellularly in the cells lacking PdeA. Additionally, spirochetes were shown to chemotax towards N-acetyl-glucosamine (NAG) and they did not form soft agar swarms. In contrast, cells lacking Rrp1 did not accumulate detectable levels of c-di-GMP, demonstrated a reduced ability to chemotax towards NAG, and swarmed on soft agar in a fashion indistinguishable from wild type. Despite these differences in phenotype, both mutant strains display an attenuated murine infectivity. These results indicate that c-di-GMP is indeed important in the TBRF spirochete, B. hermsii and this vital second messenger plays key roles in virulence, motility, and chemotaxis. These studies also pave the way for future investigation of B. hermsii through use of targeted genetic manipulation.
Author : Fabrice Chretien
Publisher : John Wiley & Sons
ISBN 13 : 1119467799
Total Pages : 850 pages
Book Rating : 4.1/5 (194 download)
Download or read book Infections of the Central Nervous System written by Fabrice Chretien and published by John Wiley & Sons. This book was released on 2020-01-08 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Der neue Band aus der Reihe International Society of Neuropathology wurde anlässlich der British Medical Association (BMA) Awards 2019 wärmstens empfohlen. Die Herausgeber sind Experten des Fachgebiets und beschreiben Infektionen des Nervensystems mit ihren klinischen, pathologischen und genetischen Eigenheiten. Auch seltene Erkrankungen werden in übersichtlichen Kapiteln erläutert, zusammen mit Definitionen, mikrobiologischen Eigenschaften, Epidemiologie, klinischen Ausprägungen, Labortests, Pathologie, Genetik und Behandlungsoptionen.
Author : Qiyuan Dai
Publisher :
ISBN 13 : 9781109910070
Total Pages : 318 pages
Book Rating : 4.9/5 (1 download)
Download or read book Genetic Mechanisms for Antigenic Variation in a Relapsing Fever Borrelia Species written by Qiyuan Dai and published by . This book was released on 2007 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major findings of these studies have revealed that antigenic variation by B. hermsii occurs through recombination between repetitive elements flanking the vsp or vlp genes. By analyzing and annotating large fragments of plasmids of strain HS1, I identified fifty-nine unique vsp and vlp genes, which represents ∼85% of the linear plasmids bearing archival vsp and vlp genes. In addition, the UHS and DHS elements, which overlap 5' ends of vsp and vlp genes and locate downstream from vsp and vlp genes at variable distance respectively, were fully characterized. An experimental relapsing fever study was performed in 60 mice and the crossover points for vsp or vlp recombination during antigenic variation were mapped (chapter 2). For most recombinations, the upstream crossover occurred in the UHS's second half, and the downstream crossover was in the DHS's second half. Next, I investigated how strain HS1 of B. hermsii determines switch rates in two experimental infections: one where serotypes were identified by specific antisera and one based on identification by DNA sequence. Statistical analyses indicated that archival vsp or vlp genes copy into a single expression site at rates determined by extragenic features of archival loci rather than similarity between coding sequences of vsp or vlp genes at archival sites and single expression site (Chapter 3). Greater sequence identity between the UHS of the expressed gene and the archival locus is associated with a higher switch rate. The nearer a DHS to an archival locus, the greater the switch rate of that locus into the expression site is. Finally, genetic components and organization of another strain (CC1) of B. hermsii, were examined by DNA sequencing, restriction enzyme digestion, and Southern blot analyses (chapter 4). The similarity and diversity of vlp and vsp genes, DHS elements, and genetic organizations between strain HS1 and CC1 indicated similar mechanisms for antigenic variation in both strains and recombination events during strain divergence.
