Innovations for Next-Generation Antibody-Drug Conjugates

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Publisher : Springer
ISBN 13 : 3319781545
Total Pages : 358 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Innovations for Next-Generation Antibody-Drug Conjugates by : Marc Damelin

Download or read book Innovations for Next-Generation Antibody-Drug Conjugates written by Marc Damelin and published by Springer. This book was released on 2018-05-29 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.

Latin Literatures of Medieval and Early Modern Times in Europe and Beyond

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Publisher : John Benjamins Publishing Company
ISBN 13 : 9027247293
Total Pages : 726 pages
Book Rating : 4.0/5 (272 download)

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Book Synopsis Latin Literatures of Medieval and Early Modern Times in Europe and Beyond by : Francesco Stella

Download or read book Latin Literatures of Medieval and Early Modern Times in Europe and Beyond written by Francesco Stella and published by John Benjamins Publishing Company. This book was released on 2024-07-15 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: The textual heritage of Medieval Latin is one of the greatest reservoirs of human culture. Repertories list more than 16,000 authors from about 20 modern countries. Until now, there has been no introduction to this world in its full geographical extension. Forty contributors fill this gap by adopting a new perspective, making available to specialists (but also to the interested public) new materials and insights. The project presents an overview of Medieval (and post-medieval) Latin Literatures as a global phenomenon including both Europe and extra-European regions. It serves as an introduction to medieval Latin's complex and multi-layered culture, whose attraction has been underestimated until now. Traditional overviews mostly flatten specificities, yet in many countries medieval Latin literature is still studied with reference to the local history. Thus the first section presents 20 regional surveys, including chapters on authors and works of Latin Literature in Eastern, Central and Northern Europe, Africa, the Middle East, Asia, and the Americas. Subsequent chapters highlight shared patterns of circulation, adaptation, and exchange, and underline the appeal of medieval intermediality, as evidenced in manuscripts, maps, scientific treatises and iconotexts, and its performativity in narrations, theatre, sermons and music. The last section deals with literary “interfaces,” that is motifs or characters that exemplify the double-sided or the long-term transformations of medieval Latin mythologemes in vernacular culture, both early modern and modern, such as the legends about King Arthur, Faust, and Hamlet.

The Next Generation Companion

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Publisher : Simon and Schuster
ISBN 13 : 1471106799
Total Pages : 582 pages
Book Rating : 4.4/5 (711 download)

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Book Synopsis The Next Generation Companion by : Larry Nemecek

Download or read book The Next Generation Companion written by Larry Nemecek and published by Simon and Schuster. This book was released on 2012-09-25 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1992 and last revised in 1995, this is a fitting record of a show that changed the rules by which television was made. The first adventure drama series ever to run to seven seasons and more than 170 episodes, Star Trek: The Next Generation broke audience records wherever it was shown and remains the most widely viewed and consistently popular of all the Star Trek series. This new edition of the series companion has been brought bang up to date to include not only all seven years of the TV series but also all four films which have featured the Next Generation crew. In addition to Generations (1994), we now have full details of First Contact (1997), Insurrection (1998) and the very latest incarnation, Nemesis (2002). A positive feast of information, the Companion includes complete plot summaries and credits for each invidiual episode and film. There are fascinating behind-the-scenes glimpses into how each one was made, and in-depth analysis really brings The Next Generation universe to life. Illustrated throughout with more than 150 black and white photographs, this is a truly invaluable reference guide.

The Other Renaissance

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Publisher : University of Chicago Press
ISBN 13 : 022618613X
Total Pages : 407 pages
Book Rating : 4.2/5 (261 download)

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Book Synopsis The Other Renaissance by : Rocco Rubini

Download or read book The Other Renaissance written by Rocco Rubini and published by University of Chicago Press. This book was released on 2014-12-22 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title offers a cultural translation of modern Italian intellectual and philosophical history, a development book-ended by Giambattista Vico and Antonio Gramsci. It shows Italian philosophy to have emerged during the age of the Risorgimento in reaction to 18th century French revolutionary and rationalist standards in politics and philosophy and in critical assimilation of the German reaction to the same, mainly Hegelian idealism and, eventually, Heideggerian existentialism. This is the story of modern Italian philosophy told through the lens of Renaissance scholarship.

Rebel Barons

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Publisher : Oxford University Press
ISBN 13 : 019109272X
Total Pages : 319 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Rebel Barons by : Luke Sunderland

Download or read book Rebel Barons written by Luke Sunderland and published by Oxford University Press. This book was released on 2017-08-15 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ambivalence towards kings, and other sovereign powers, is deep-seated in medieval culture: sovereigns might provide justice, but were always potential tyrants, who usurped power and 'stole' through taxation. Rebel Barons writes the history of this ambivalence, which was especially acute in England, France, and Italy in the twelfth to fifteenth centuries, when the modern ideology of sovereignty, arguing for monopolies on justice and the legitimate use of violence, was developed. Sovereign powers asserted themselves militarily and economically provoking complex phenomena of resistance by aristocrats. This volume argues that the chansons de geste, the key genre for disseminating models of violent noble opposition to sovereigns, offer a powerful way of understanding acts of resistance. Traditionally seen as France's epic literary monuments - the Chanson de Roland is often presented as foundational of French literature - chansons de geste in fact come from areas antagonistic to France, such as Burgundy, England, Flanders, Occitania, and Italy, where they were reworked repeatedly from the twelfth century to the fifteenth and recast into prose and chronicle forms. Rebel baron narratives were the principal vehicle for aristocratic concerns about tyranny, for models of violent opposition to sovereigns and for fantasies of escape from the Carolingian world via crusade and Oriental adventures. Rebel Barons reads this corpus across its full range of historical and geographical relevance, and through changes in form, as well as placing it in dialogue with medieval political theory, to bring out the contributions of literary texts to political debates. Revealing the widespread and long-lived importance of these anti-royalist works supporting regional aristocratic rights to feud and revolt, Rebel Barons reshapes our knowledge of reactions to changing political realities at a crux period in European history.

A Renaissance Education

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Publisher : University of Toronto Press
ISBN 13 : 0802092543
Total Pages : 457 pages
Book Rating : 4.8/5 (2 download)

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Book Synopsis A Renaissance Education by : Christopher Carlsmith

Download or read book A Renaissance Education written by Christopher Carlsmith and published by University of Toronto Press. This book was released on 2010-01-01 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carlsmith's A Renaissance Education uses a case study approach to examine educational practices in the north-eastern Italian city of Bergamo from 1500 to 1650.

Humanism and Education in Medieval and Renaissance Italy

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Publisher : Cambridge University Press
ISBN 13 : 1139429019
Total Pages : 507 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Humanism and Education in Medieval and Renaissance Italy by : Robert Black

Download or read book Humanism and Education in Medieval and Renaissance Italy written by Robert Black and published by Cambridge University Press. This book was released on 2001-09-20 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the study of over 500 surviving manuscript school books, this comprehensive 2001 study of the curriculum of school education in medieval and Renaissance Italy contains some surprising conclusions. Robert Black's analysis finds that continuity and conservatism, not innovation, characterize medieval and Renaissance teaching. The study of classical texts in medieval Italian schools reached its height in the twelfth century; this was followed by a collapse in the thirteenth century, an effect on school teaching of the growth of university education. This collapse was only gradually reversed in the two centuries that followed: it was not until the later 1400s that humanists began to have a significant impact on education. Scholars of European history, of Renaissance studies, and of the history of education will find that this deeply researched and broad-ranging book challenges much inherited wisdom about education, humanism and the history of ideas.

The Homes of Other Days

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Publisher :
ISBN 13 :
Total Pages : 542 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Homes of Other Days by : Thomas Wright

Download or read book The Homes of Other Days written by Thomas Wright and published by . This book was released on 1871 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Roots of Rabbinic Judaism

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Publisher : Wm. B. Eerdmans Publishing
ISBN 13 : 9780802843616
Total Pages : 252 pages
Book Rating : 4.8/5 (436 download)

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Book Synopsis Roots of Rabbinic Judaism by : Boccaccini

Download or read book Roots of Rabbinic Judaism written by Boccaccini and published by Wm. B. Eerdmans Publishing. This book was released on 2002 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a bold challenge to the long-held scholarly notion that Rabbinic Judaism already was an established presence during the Second Temple period, Boccaccini argues that Rabbinic Judaism was a daring reform movement that developed following the destruction of the Jerusalem temple and took shape in the first centuries of the common era.

mRNA 3' End Processing and Metabolism

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Publisher : Academic Press
ISBN 13 : 0128235748
Total Pages : 504 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis mRNA 3' End Processing and Metabolism by :

Download or read book mRNA 3' End Processing and Metabolism written by and published by Academic Press. This book was released on 2021-06-26 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: mRNA 3' End Processing and Stability, Volume 655 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Enzymology series - Updated release includes the latest information on mRNA 3' End Processing and Stability

Contesting the Renaissance

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Publisher : John Wiley & Sons
ISBN 13 : 1444391321
Total Pages : 329 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis Contesting the Renaissance by : William Caferro

Download or read book Contesting the Renaissance written by William Caferro and published by John Wiley & Sons. This book was released on 2010-08-24 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, William Caferro asks if the Renaissance was really a period of progress, reason, the emergence of the individual, and the beginning of modernity. An influential investigation into the nature of the European Renaissance Summarizes scholarly debates about the nature of the Renaissance Engages with specific controversies concerning gender identity, economics, the emergence of the modern state, and reason and faith Takes a balanced approach to the many different problems and perspectives that characterize Renaissance studies

Routledge Revivals: Medieval France (1995)

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Author :
Publisher : Taylor & Francis
ISBN 13 : 1351665669
Total Pages : 1078 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Routledge Revivals: Medieval France (1995) by : William W. Kibler

Download or read book Routledge Revivals: Medieval France (1995) written by William W. Kibler and published by Taylor & Francis. This book was released on 2017-07-05 with total page 1078 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1995, Medieval France: An Encyclopedia is the first single-volume reference work on the history and culture of medieval France. It covers the political, intellectual, literary, and musical history of the country from the early fifth to the late fifteenth century. The shorter entries offer succinct summaries of the lives of individuals, events, works, cities, monuments, and other important subjects, followed by essential bibliographies. Longer essay-length articles provide interpretive comments about significant institutions and important periods or events. The Encyclopedia is thoroughly cross-referenced and includes a generous selection of illustrations, maps, charts, and genealogies. It is especially strong in its coverage of economic issues, women, music, religion and literature. This comprehensive work of over 2,400 entries will be of key interest to students and scholars, as well as general readers.

Scientific and Technical Revolution: Yesterday, Today and Tomorrow

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Author :
Publisher : Springer Nature
ISBN 13 : 3030479455
Total Pages : 1763 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Scientific and Technical Revolution: Yesterday, Today and Tomorrow by : Elena G. Popkova

Download or read book Scientific and Technical Revolution: Yesterday, Today and Tomorrow written by Elena G. Popkova and published by Springer Nature. This book was released on 2020-06-05 with total page 1763 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a system view of the digital scientific and technological revolution, including its genesis and prerequisites, current trends, as well as current and potential issues and future prospects. It gathers selected research papers presented at the 12th International Scientific and Practical Conference, organized by the Institute of Scientific Communications. The conference “Artificial Intelligence: Anthropogenic Nature vs. Social Origin” took place on December 5–7, 2019 in Krasnoyarsk, Russia. The book is intended for academic researchers and independent experts studying the social and human aspects of the Fourth Industrial Revolution and the associated transition to the digital economy and Industry 4.0, as well as the creators of the legal framework for this process and its participants – entrepreneurs, managers, employees and consumers. It covers a variety of topics, including “intelligent” technologies and artificial intelligence, the digital economy, the social environment of the Fourth Industrial Revolution and its consequences for humans, the regulatory framework of the Fourth Industrial Revolution, and the “green” consequences, prospects and financing of the Fourth Industrial Revolution.

Medieval France

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Publisher : Psychology Press
ISBN 13 : 0824044444
Total Pages : 2071 pages
Book Rating : 4.8/5 (24 download)

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Book Synopsis Medieval France by : William W. Kibler

Download or read book Medieval France written by William W. Kibler and published by Psychology Press. This book was released on 1995 with total page 2071 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arranged alphabetically, with a brief introduction that clearly defines the scope and purpose of the book. Illustrations include maps, B/W photographs, genealogical tables, and lists of architectural terms.

Next Generation Sequencing Based Clinical Molecular Diagnosis of Human Genetic Disorders

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Author :
Publisher : Springer
ISBN 13 : 3319564188
Total Pages : 366 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Next Generation Sequencing Based Clinical Molecular Diagnosis of Human Genetic Disorders by : Lee-Jun C. Wong

Download or read book Next Generation Sequencing Based Clinical Molecular Diagnosis of Human Genetic Disorders written by Lee-Jun C. Wong and published by Springer. This book was released on 2017-05-15 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Next Generation Sequencing technology has been applied to clinical diagnoses in the past three to five years using various approaches, including target gene panels and whole exomes. The purpose of this book is to summarize the experiences, the results, advantages and disadvantages, along with future development in the area of NGS-based molecular diagnosis. This up-to-date volume will not only provide the readers working with Next Generation Sequencing the basics on how to apply the technology to molecular diagnosis, but will present the results and experience of practical application.

Circulating Molecular Biomarkers: Next-Generation Tools for Monitoring Minimal Residual Disease in Cancer Patients

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 283253192X
Total Pages : 137 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Circulating Molecular Biomarkers: Next-Generation Tools for Monitoring Minimal Residual Disease in Cancer Patients by : Zohreh Amoozgar

Download or read book Circulating Molecular Biomarkers: Next-Generation Tools for Monitoring Minimal Residual Disease in Cancer Patients written by Zohreh Amoozgar and published by Frontiers Media SA. This book was released on 2023-08-16 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditional cancer diagnosis relies on tissue biopsy, blood testing as well as medical imaging. By the detection moment, in most cases the tumor size may reach several millimeters and the risk of distant metastasis is unavoidable. Even, following drug treatment, there is no accurate and timely way to follow up the success of treatment. New reliable tumor-specific biomarkers/tools that allow non-invasive early cancer detection as well as monitoring of anti-cancer therapeutic regime is highly demanded. To tackle limitations of traditional cancer management, liquid biopsy has emerged which screen bodily fluids using ultrasensitive biosensing systems capable of simultaneous capturing and studying horizontal gene transfer (HGT) materials including circulating tumor cells (CTCs), exosomes, cell-free DNA, and apoptotic bodies. These are messengers and/or delivery systems by which tumor cells are communicating as well as transforming/sharing new phenotypes with each other resulting in drug resistance, distant metastatic outbreaks, and cancer recurrence. Acting as next-generation prognostic and therapeutic tools call for understanding the molecular mechanisms by which HGT works to tran

Pictorial Korea

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Author :
Publisher :
ISBN 13 :
Total Pages : 582 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Pictorial Korea by :

Download or read book Pictorial Korea written by and published by . This book was released on 2004 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: