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G Proteins Cytoskeleton And Cancer
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Book Synopsis G Proteins, Cytoskeleton, and Cancer by : Hiroshi Maruta
Download or read book G Proteins, Cytoskeleton, and Cancer written by Hiroshi Maruta and published by Landes Bioscience. This book was released on 1998 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building upon the pioneering work of Klaus Weber, who in the 1970s discovered a key to the malignant transformation of normal cells by tumor virus infection or mutations via the disruption of actin cables and subsequent induction of membrane ruffling occurring with oncogenes such as v-Ras and v-Src, the global contributors aim toward the quantum leap of creating an anticancer Holy Grail that would attenuate the malignant activity of oncogenic mutants. The two dozen papers are organized under the four major headings of: actin-cytoskeleton, Ras/Rho family GTPases, links between G proteins and actin, and new anticancer drugs (e.g. farnesyltransferase inhibitors, SCH51344, and azatyrosine). Annotation copyrighted by Book News, Inc., Portland, OR
Book Synopsis Cytoskeleton and G-proteins in the Regulation of Cancer by : Noboru Kuzumaki
Download or read book Cytoskeleton and G-proteins in the Regulation of Cancer written by Noboru Kuzumaki and published by . This book was released on 1998 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cytoskeleton and Small G Proteins by : Philippe Jeanteur
Download or read book Cytoskeleton and Small G Proteins written by Philippe Jeanteur and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: The internal structure of a cell can be affected by signals in the form of small molecules outside the cell. These changes can then alter the shape or adhesiveness of the cell. This volume centers particularly on one family of cellular proteins which transmit these signals, the Rho Ras-like GTPases, and examines their role in normal cellular processes and development. Also discussed are their roles in cancer formation and microbial pathogenesis.
Book Synopsis The Rho GTPases in Cancer by : Kenneth van Golen
Download or read book The Rho GTPases in Cancer written by Kenneth van Golen and published by Springer Science & Business Media. This book was released on 2009-12-04 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: Channing Der and colleagues provide an encyclopedic overview of the Rho GTPases, providing enough detail to make any reader well-versed in the Rho field. Finally, Sofia Merajver’s laboratory provides an overview, which details the roles of the Rho proteins in cancer progression. She provides us with the history of the study of the Rho GTPases, their regulatory and effector proteins in cancer and gives us a benchmark of where the field is today. The second section of the book details the current knowledge of the Rho regu- tory proteins in cancer progression: aberrant expression and activation of these proteins leads to dysfunctional Rho signaling and a cancer phenotype. Gary Bokoch’s laboratory has provided a detailed overview of the role of Rho guanine dissociation inhibitors (GDIs) in cancer. These molecules are involved in preventing the Rho protein from associating with the inner plasma membrane and exchanging GDP for GTP, and thus becoming active. Next, Tozu Kazasa’s labo- tory has worked on the link between heterotrimeric G proteins and Rho activation via the RGS–RhoGEFs. This aspect of Rho activation is particularly interesting in that heterotrimeric G proteins and their associated G-protein-coupled receptors are attractive and attainable therapeutic targets. Dan Billadeau’s laboratory has worked extensively on the Vav RhoGEFs, which are potent oncogenes in their own right.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Cytoskeleton in Health and Disease by : Heide Schatten
Download or read book The Cytoskeleton in Health and Disease written by Heide Schatten and published by Springer. This book was released on 2015-08-21 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses the structural and functional roles of the cytoskeleton and its dysfunctions which often lead to disease. It provides thorough discussion of microtubules, microfilaments, intermediate filaments, and cytoskeletal functions and dysfunctions in different organ systems. Comprehensive yet concise. The Cytoskeleton In Health And Disease presents cutting-edge discoveries balanced with background information and highlights the new aspects of the research and its impact on the design of new strategies or the identification of new targets for therapeutic intervention. There is a significant need for a book on this topic, as interest in the cytoskeleton continues to grow as causes and cures for cytoskeletal diseases are further explored in biomedical research. This book is essential reading for scientists, students, and teachers interested in expanding their knowledge related to the cytoskeleton. New researchers entering the field will find classic and well as contemporary information not easily found in the current literature or internet resources.
Book Synopsis Actin Cytoskeleton in Cancer Progression and Metastasis - Part B by :
Download or read book Actin Cytoskeleton in Cancer Progression and Metastasis - Part B written by and published by Academic Press. This book was released on 2020-10-14 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Actin Cytoskeleton in Cancer Progression and Metastasis (Part B), Volume 356 in the International Review of Cell and Molecular Biology series, provides an overview on the roles of the actin cytoskeleton and its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, and in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. Specific chapters in this release cover Actin dynamics during tumor cell dissemination, Actin cytoskeleton remodeling during cancer cell migration, Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer, and much more. - Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology - Offers a wide range of perspectives for basic and translational research - Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications
Book Synopsis Actin Cytoskeleton in Cancer Progression and Metastasis – Part C by :
Download or read book Actin Cytoskeleton in Cancer Progression and Metastasis – Part C written by and published by Academic Press. This book was released on 2021-05-04 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Actin Cytoskeleton in Cancer Progression and Metastasis - Part C, Volume 358 in the International Review of Cell and Molecular Biology series, provides an overview of the roles of the actin cytoskeleton and some of its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. New chapters cover Actin isoforms in cancer, Actin cytoskeleton regulators at invadopodia, Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer, and more. - Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology - Offers a wide range of perspectives for basic and translational research - Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications
Book Synopsis Actin Cytoskeleton in Cancer Progression and Metastasis - Part A by :
Download or read book Actin Cytoskeleton in Cancer Progression and Metastasis - Part A written by and published by Academic Press. This book was released on 2020-08-26 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Actin Cytoskeleton in Cancer Progression and Metastasis - Part A, Volume 355 in the International Review of Cell and Molecular Biology series, provides an overview of the roles of the actin cytoskeleton and some of its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. - Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology - Offers a wide range of perspectives for basic and translational research - Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications
Book Synopsis The Actin Cytoskeleton in Cell Motility, Cancer, and Infection by : Joel Pardee
Download or read book The Actin Cytoskeleton in Cell Motility, Cancer, and Infection written by Joel Pardee and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 57 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cell is no longer considered to be a bag full of enzymes dissolved in a liquid cytoplasm. It is now known that the cytoplasm is an exquisitely ordered structure of properly placed organelles and enzyme complexes that are suspended from an intricate network of structural protein polymers termed the cytoskeleton. All movement of organelles and vesicles within the cell is regulated by this cytoskeleton, and it is clear that the cytoskeleton is responsible for all of the cell's external movement as well. In this lecture, we will consider how the cytoskeleton elicits cell migration.The three main elements of the cytoskeleton are microtubules, intermediate filaments, and actin filaments. Microtubules are essential for (a) intracellular transport within the cytoplasm and transport between the nucleus and cytoplasm, (b) the structure and movement of all cilia and flagella, and (c) the structure of the mitotic spindle and movement of chromosomes on the spindle during cell division. Intermediate filaments give structural integrity to virtually all cells and tissues by providing an intracellular network of flexible cables that strengthen internal cell structure and stabilize cell-to-cell adhesion. It is this intercellular binding property that stably joins epithelial cells together to provide the protective functions of skin and the integrity of the intestinal mucosa.Actin is a highly conserved protein ubiquitous to all eukaryotic cells. Actin is absolutely required for (a) cell migration, (b) the contraction of muscle (both striated and smooth), (c) the structure and function of many cell protrusions (e.g., microvilli, filopodia, lamellopodia, blood platelet projections), (d) division of the cytoplasm (cytokinesis) during telophase of cell mitosis, and (e) movement and placement of organelles within the cell. Actin filaments are also called thin filaments because of their very slender (70 Ã…) diameter.
Book Synopsis Cytoskeleton by : Jose C. Jimenez-Lopez
Download or read book Cytoskeleton written by Jose C. Jimenez-Lopez and published by BoD – Books on Demand. This book was released on 2017-05-17 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.
Book Synopsis Cytoskeleton and Human Disease by : Maria Kavallaris
Download or read book Cytoskeleton and Human Disease written by Maria Kavallaris and published by Springer Science & Business Media. This book was released on 2012-04-23 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cytoskeleton is comprised of a variety of specialized proteins, and is a dynamic structure that is involved in the majority of key cellular events. There is increasing interest in the role of the cytoskeleton in human disease. This volume brings together human disease states where cytoskeletal disruptions are driving disease. Our emerging understanding of the molecular and cellular events that drive cytoskeletal mediated diseases including cancer, heart disease, myopathies and skin disorders, are also helping shape targeted therapeutic approaches to treating these diseases.
Book Synopsis Signal Transduction in Cancer by : David A. Frank
Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Book Synopsis Cytoskeletal Proteins in Tumor Diagnosis by : Mary Osborn
Download or read book Cytoskeletal Proteins in Tumor Diagnosis written by Mary Osborn and published by . This book was released on 1989 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprises presentations made at a meeting held at Cold Spring Harbor Lab., Oct. 1988. Emphasis was placed on how far antibodies could be used to distinguish different isoforms present in different cell types in normal and fetal tissues. No index. Annotation copyright Book News, Inc. Portland, Or.
Book Synopsis Ras Superfamily Small G Proteins: Biology and Mechanisms 1 by : Alfred Wittinghofer
Download or read book Ras Superfamily Small G Proteins: Biology and Mechanisms 1 written by Alfred Wittinghofer and published by Springer. This book was released on 2014-09-22 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Book Synopsis Cytoskeletal Proteins: Advances in Research and Application: 2011 Edition by :
Download or read book Cytoskeletal Proteins: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytoskeletal Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Cytoskeletal Proteins in a concise format. The editors have built Cytoskeletal Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cytoskeletal Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cytoskeletal Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
