G Protein Signaling Pathways In Health And Disease

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G Protein Signaling Pathways in Health and Disease

Author :
Publisher : Academic Press
ISBN 13 : 0128167254
Total Pages : 229 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis G Protein Signaling Pathways in Health and Disease by :

Download or read book G Protein Signaling Pathways in Health and Disease written by and published by Academic Press. This book was released on 2019-01-30 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: G Protein Signaling Pathways in Health and Disease, Volume 161 in the Progress in Molecular Biology and Translational Science series, provides informative and exciting monographs on a wide variety of research topics related to G Protein Signaling Pathways in Health and Disease. The series gives in-depth knowledge on the important molecular biological aspects of organismal physiology and function, along with insights on how this knowledge can be applied to understand and ameliorate human disease. This updated release covers Diseases associated with mutations in CNGA3, Mutations in arrestins, Diseases caused by mutations in GPR101, Diseases caused by mutations in lutropin receptor, and much more. Comprises 15-20 chapters, providing substantial coverage on a given topic Contains ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided in each chapter Provides a comprehensive guide to the latest information available on prions, viruses, bacteria, and eukaryotes

Signal Transduction: Pathways, Mechanisms and Diseases

Author : Ari Sitaramayya
Publisher : Springer Science & Business Media
ISBN 13 : 3642021123
Total Pages : 429 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Signal Transduction: Pathways, Mechanisms and Diseases by : Ari Sitaramayya

Download or read book Signal Transduction: Pathways, Mechanisms and Diseases written by Ari Sitaramayya and published by Springer Science & Business Media. This book was released on 2009-12-02 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.

Cellular Signaling in Health and Disease

Author : Martin Beckerman
Publisher : Springer Science & Business Media
ISBN 13 : 038798173X
Total Pages : 477 pages
Book Rating : 4.3/5 (879 download)

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Book Synopsis Cellular Signaling in Health and Disease by : Martin Beckerman

Download or read book Cellular Signaling in Health and Disease written by Martin Beckerman and published by Springer Science & Business Media. This book was released on 2009-05-28 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: In today’s world, three great classes of non-infectious diseases – the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders – have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling web operates properly in health and improperly in disease. The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional details integrated into the chapters dealing directly with the diseases. The connections responsible for maintaining stability are explored in depth.

Signal Transduction in Health and Disease

Author : Paul Greengard
Publisher : Academic Press
ISBN 13 : 9780120361311
Total Pages : 336 pages
Book Rating : 4.3/5 (613 download)

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Book Synopsis Signal Transduction in Health and Disease by : Paul Greengard

Download or read book Signal Transduction in Health and Disease written by Paul Greengard and published by Academic Press. This book was released on 1998-07 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains papers presented at the Ninth International Conference on Second Messengers and Phosphoproteins. Written by leading scientists - including two Nobel Laureates - the papers highlight contemporary advances in the rapidly evolving field of signal transduction. The findings presented are of vital significance to researchers in virtually all biomedical fields, including pharmacology, molecular biology, cell biology, biochemistry, the neurosciences, and physiology. The contributors offer new insights into fundamental cell signalling mechanisms and explore the role of these mechanisms in physiological and pathophysiological responses in a variety of systems. Coverage includes many topics that are currently under intensive study, such as growth factors and special signalling systems; protein phosphatases and metabolic pathways; calcium and ion channels; cyclic GMP and cyclic AMP; and receptors and G proteins.

Glucocorticoid Signaling

Author : Jen-Chywan Wang
Publisher : Springer
ISBN 13 : 1493928953
Total Pages : 387 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Glucocorticoid Signaling by : Jen-Chywan Wang

Download or read book Glucocorticoid Signaling written by Jen-Chywan Wang and published by Springer. This book was released on 2015-07-27 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.

Metabotropic GPCRs: TGR5 and P2Y Receptors in Health and Diseases

Author : Senthilkumar Rajagopal
Publisher : Springer
ISBN 13 : 981131571X
Total Pages : 85 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Metabotropic GPCRs: TGR5 and P2Y Receptors in Health and Diseases by : Senthilkumar Rajagopal

Download or read book Metabotropic GPCRs: TGR5 and P2Y Receptors in Health and Diseases written by Senthilkumar Rajagopal and published by Springer. This book was released on 2018-11-19 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will provide current understandings about two ubiquitously expressed metabotropic GPCRs, G-coupled purinoreceptor type 2 (P2Y) and Takeda G-protein-coupled bile acid receptor 5 (TGR5). G protein coupled receptors (GPCRs) are the largest family of proteins implicated in majority of cellular responses. The two receptor sub-families play a central role in many physiological functions as well as in many pathological conditions. This book offers up-to-date information on the physiological functions, signaling pathways and regulatory mechanisms of P2Y and TGR5 receptors. In addition, this book provides a comprehensive overview about the abnormalities of P2Y/TGR5 receptors and their contribution in the development and progression of pathological conditions. It also covers the currently available natural, chemical and pharmacological agents targeting these two receptor families and their therapeutic implications in P2Y and TGR5 associated disorders. This book is a valuable source for beginners and researchers to follow the rapidly progressing field of these two GPCR subfamily members.

Principles of Endocrinology and Hormone Action

Author : Antonino Belfiore
Publisher : Springer
ISBN 13 : 9783319446745
Total Pages : 0 pages
Book Rating : 4.4/5 (467 download)

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Book Synopsis Principles of Endocrinology and Hormone Action by : Antonino Belfiore

Download or read book Principles of Endocrinology and Hormone Action written by Antonino Belfiore and published by Springer. This book was released on 2018-02-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.

Neuromorphic Olfaction

Author : Krishna C. Persaud
Publisher : CRC Press
ISBN 13 : 1439871728
Total Pages : 237 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Neuromorphic Olfaction by : Krishna C. Persaud

Download or read book Neuromorphic Olfaction written by Krishna C. Persaud and published by CRC Press. This book was released on 2016-04-19 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)-a challenging and innovative European-funded project-introduce novel computing p

G Proteins, Receptors, and Disease

Author : Allen M. Spiegel
Publisher : Springer Science & Business Media
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis G Proteins, Receptors, and Disease by : Allen M. Spiegel

Download or read book G Proteins, Receptors, and Disease written by Allen M. Spiegel and published by Springer Science & Business Media. This book was released on 1998-01-23 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of cutting-edge chapters summarizes in depth the state of our knowledge today concerning how cells communicate via G protein-coupled signal transduction and how defects in these proteins and their receptors can cause serious human disease involving many different organ systems. Written by leading investigators, each chapter describes in detail the structure and function of a particular G protein or receptor, lists possible mutations, and discusses fully the molecular pathogenesis of associated diseases. Full advantage is taken of insights from artificially created disorders using transgenic and gene knockout approaches. Diagnostic and therapeutic implications are also discussed where relevant. In its unique blend of basic science and clinical medicine, G Proteins, Receptors, and Disease offers deep insights into the physiological significance of this key signal transduction pathway and into the molecular basis of diseases ranging from obesity to malignancy.

G Protein-Coupled Receptors in Health and Disease, Part B

Author :
Publisher : Academic Press
ISBN 13 : 0080911943
Total Pages : 192 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis G Protein-Coupled Receptors in Health and Disease, Part B by :

Download or read book G Protein-Coupled Receptors in Health and Disease, Part B written by and published by Academic Press. This book was released on 2009-09-19 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field. This series provides a forum for discussion of new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields

Signal Transduction and Human Disease

Author : Toren Finkel
Publisher : John Wiley & Sons
ISBN 13 : 0471448370
Total Pages : 490 pages
Book Rating : 4.4/5 (714 download)

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Book Synopsis Signal Transduction and Human Disease by : Toren Finkel

Download or read book Signal Transduction and Human Disease written by Toren Finkel and published by John Wiley & Sons. This book was released on 2003-07-18 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.

Structural Insights Into G Protein-coupled Receptor Activation and Signaling

Author : Antoine Koehl
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Structural Insights Into G Protein-coupled Receptor Activation and Signaling by : Antoine Koehl

Download or read book Structural Insights Into G Protein-coupled Receptor Activation and Signaling written by Antoine Koehl and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: G protein coupled receptors (GPCRs) are a class of cell-surface receptors that mediate complex cellular responses to a myriad of physiological stimuli, from photons and neurotransmitters, to hormones, peptides, and even full proteins. GPCR signaling underlies almost all of physiology; this central importance to human health and disease is reflected in the fact that approximately 30% of all FDA approved drugs target GPCRs. Ligand action at GPCRs mediates intracellular signaling through heterotrimeric G proteins, as well as G protein-independent pathways. Over the past decade, a structural framework has allowed for a more precise understanding of ligand-mediated activation in rhodopsin-like GPCRs, as well as the molecular mechanism for GPCR signaling through the stimulatory G protein, Gs. My work expands this structural understanding of GPCR activation and signaling by exploring two novel signaling systems in the GPCR family for which structural information is lacking. First, I describe work on the structure of a peptide-activated mu-opioid receptor (muOR) in complex with the inhibitory G protein, Gi. As signaling through Gi is responsible for the beneficial aspects of opioids, the structure of this complex can help guide the design and discovery of novel therapeutics with reduced liabilities. I then show the structural mechanism of activation in a family C GPCR, the metabotropic glutamate receptor 5 (mGlu5). Family C receptors are unusual in that, as well as the GPCR-defining 7-transmembrane (7TM) domain, they possess relatively large amino-terminal extracellular domains (ECDs) that form obligate dimers and contain the orthosteric ligand-binding sites. Taken together, this work presents novel insights into GPCR activation and signaling.

Signal Transduction in the Cardiovascular System in Health and Disease

Author : Ashok K. Srivastava
Publisher : Springer Science & Business Media
ISBN 13 : 0387095519
Total Pages : 426 pages
Book Rating : 4.3/5 (87 download)

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Book Synopsis Signal Transduction in the Cardiovascular System in Health and Disease by : Ashok K. Srivastava

Download or read book Signal Transduction in the Cardiovascular System in Health and Disease written by Ashok K. Srivastava and published by Springer Science & Business Media. This book was released on 2008-10-17 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signal Transduction in Cardiovascular System Health and Disease highlights the major contributions of different signaling systems in modulating normal cardiovascular functions and how a perturbation in these signaling events leads to abnormal cell functions and cardiovascular disorders. This title is volume 3 in the new Springer series, Advances in Biochemistry in Health and Disease.

Cellular Endocrinology in Health and Disease

Author : Alfredo Ulloa-Aguirre
Publisher : Academic Press
ISBN 13 : 012819801X
Total Pages : 486 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Cellular Endocrinology in Health and Disease by : Alfredo Ulloa-Aguirre

Download or read book Cellular Endocrinology in Health and Disease written by Alfredo Ulloa-Aguirre and published by Academic Press. This book was released on 2021-02-19 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts Explores endocrine cells biology in normal and pathologic conditions Covers new aspects of endocrine cell function in distinct tissues Provides a view into the biological effect in local and systemic levels 15 new chapters covering the recent developments in the field

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cellular Signal Processing

Author : Friedrich Marks
Publisher : Garland Science
ISBN 13 : 1351677225
Total Pages : 640 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Cellular Signal Processing by : Friedrich Marks

Download or read book Cellular Signal Processing written by Friedrich Marks and published by Garland Science. This book was released on 2017-05-17 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular Signal Processing offers a unifying view of cell signaling based on the concept that protein interactions act as sophisticated data processing networks that govern intracellular and extracellular communication. It is intended for use in signal transduction courses for undergraduate and graduate students working in biology, biochemistry, bioinformatics, and pharmacology, as well as medical students. The text is organized by three key topics central to signal transduction: the protein network, its energy supply, and its evolution. It covers all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling, and also highlights the clinical aspects of cell signaling in health and disease. This new edition includes expanded coverage of prokaryotes, as well as content on new developments in systems biology, epigenetics, redox signaling, and small, non-coding RNA signaling.

The Language of Life

Author : Debra Niehoff
Publisher : National Academies Press
ISBN 13 : 0309167787
Total Pages : 336 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Language of Life by : Debra Niehoff

Download or read book The Language of Life written by Debra Niehoff and published by National Academies Press. This book was released on 2005-04-15 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cooperation requires conversation. Human beings speak to one another. Sounds, scents, and postures allow animals to make their point. While individual cells can't talk, hiss, growl, or bare their teeth, they nevertheless communicate regularly. Their language is based not on words or gestures, but on chemistry â€"using molecules where we would use words, constructing sentences from chains of proteins. The cells that make up the bodies of muticellular organisms inform, wheedle, command, exhort, reassure, nurture, criticize, and instruct each other to direct every physiological function, report every newsworthy event, record every memory, heal every wound. And each of those chemical conversations represents an opportunity for scientists and physicians. The molecular biologists who worked for over a decade to sequence the human genome have sometimes referred to that sequence as the "book of life." To our cells, that "book" is no more than a dictionaryâ€"only living cells can converse, forming the network that allows our 60 trillion cells to function as a single organism. For nearly a century, researchers have been straining to hear the whispered conversations among cells, hoping to master the basics of their language. They know that if we can decipher and translate this cellular chatter, we have the potential for sending signals of our own that could repair wounds, reduce cholesterol, control insulin levels, or even block the reproduction of cancer cells. The possibilities are as endless as they are intriguing. The Language of Life is a fantastic story of discovery, blending the vision of science with the poetry of life itself.