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Functional Study Of The Coactivator Saga
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Book Synopsis Functional Study of the Coactivator SAGA by : Tiago Fidalgo Baptista
Download or read book Functional Study of the Coactivator SAGA written by Tiago Fidalgo Baptista and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prior studies suggested that SAGA and TFIID are alternative factors that promote RNA polymerase II (RNA Pol II) transcription with about 10% of genes in S. cerevisiae dependent on SAGA. The remainder 90% of the genome would be regulated by TFIID. We reassessed the role of SAGA by mapping its genome-wide location and role in global transcription in budding yeast. We observed that SAGA maps to regulatory elements of most genes, irrespective of previous designations of SAGA- or TFIID-dominated genes. Additionally, disruption of either SAGA or TFIID through mutation or rapid subunit depletion reduces transcription from nearly all genes, measured by newly-synthesized RNA or RNA Pol II chromatin immunoprecipitation. We also found that the acetyltransferase Gcn5 synergizes with Spt3 to promote global transcription and that Spt3 functions to stimulate TBP recruitment at all tested genes. Our data demonstrate that both SAGA and TFIID act as general cofactors required for essentially all RNA Pol II transcription and is not consistent with the previous classification of SAGA- and TFIID-dominated genes.
Book Synopsis Functional Study of the Coactivator Complexes SAGA and ATAC in Mouse Embryonic Stem Cells by : Véronique Fischer
Download or read book Functional Study of the Coactivator Complexes SAGA and ATAC in Mouse Embryonic Stem Cells written by Véronique Fischer and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies from my host laboratory indicate that the histone modifying complex SAGA acts as a general cofactor for RNA polymerase II transcription in budding yeast in contrast to its previously assumed specific functions. SAGA is evolutionarily well conserved, from yeast to mammals, and has a histone acetyltransferase (HAT) function. In metazoans, the HAT activity of SAGA is shared with another complex, the ATAC complex. New approaches have allowed me to demonstrate that SAGA and ATAC have crucial roles in maintaining stemness of mouse embryonic stem cells. Newly synthesized RNA analyses revealed that inactivation of the SAGA and ATAC complexes influences the expression of different groups of genes and results in relatively distinct phenotypes in these cells. Finally, I was able to show that the transcriptional anomalies and the observed phenotypes do not seem to be linked to the HAT activity shared by these two complexes. Therefore, our data indicate that SAGA and ATAC have important, HAT-independent roles in mammalian cells.
Book Synopsis Functional and Structural Analysis of the S. Cerevisiae SAGA Coactivator Complex by : Pei-Yun Jenny Wu
Download or read book Functional and Structural Analysis of the S. Cerevisiae SAGA Coactivator Complex written by Pei-Yun Jenny Wu and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Architecture of the Saccharomyces Cerevisiae SAGA Transcription Coactivator Complex by : Yan Han
Download or read book Architecture of the Saccharomyces Cerevisiae SAGA Transcription Coactivator Complex written by Yan Han and published by . This book was released on 2014 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evolutionarily conserved transcription coactivator SAGA (Spt-Ada-Gcn5 Acetyltransferase) is a multi-subunit complex with a modular structure, which has several distinct activities that are used to regulate activator-dependent transcription. SAGA covalently modifies histones using its histone acetyltransferase (HAT) and deubiquitination (DUB) modules. It also directly regulates the formation of the transcription preinitiation complex (PIC) through direct interactions with both transcriptional activators and the TATA-box Binding Protein (TBP). Despite SAGA's important roles in regulating transcription, its overall architecture and structural organization of its modules remain unclear. The large size and complex subunit composition of SAGA make it difficult to study its structure using high-resolution approaches such as X-ray crystallography. Using an alternative approach, I combined chemical crosslinking with mass spectrometry (CXMS) to investigate the architecture of SAGA. In Chapter 2, I describe the results of my efforts using this approach, finding that the SAGA Taf and Taf-like subunits form a TFIID-like core complex at the center of SAGA that makes extensive interactions with all other SAGA modules. In Chapter 3, I show that the HAT and DUB modules are in close proximity, and the DUB module modestly stimulates HAT function. In Chapter 4, I describe the finding that SAGA-TBP binding involves a network of interactions between subunits Spt3, Spt8, Spt20, and Spt7, and the attempts I have made toward solving the crystal structure of Spt8 in complex with TBP. Finally, in Chapter 5, I combine all of the data and derive a model for the molecular architecture of the SAGA complex. My results provide new insight into SAGA function in gene regulation, its structural similarity with TFIID, and functional interactions between the SAGA modules.
Book Synopsis Nucleoproteins: Advances in Research and Application: 2011 Edition by :
Download or read book Nucleoproteins: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nucleoproteins: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Nucleoproteins. The editors have built Nucleoproteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nucleoproteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nucleoproteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Nucleoproteins—Advances in Research and Application: 2012 Edition by :
Download or read book Nucleoproteins—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nucleoproteins—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Nucleoproteins. The editors have built Nucleoproteins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nucleoproteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nucleoproteins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Enzymes—Advances in Research and Application: 2012 Edition by :
Download or read book Enzymes—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 814 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymes—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Enzymes. The editors have built Enzymes—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Enzymes in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Enzymes—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Chromatin Signaling and Diseases by : Olivier Binda
Download or read book Chromatin Signaling and Diseases written by Olivier Binda and published by Academic Press. This book was released on 2016-08-06 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling. After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling. Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored. Explains molecular mechanisms that regulate gene expression, which governs everything from embryonic development, growth, and human pathologies associated with aging Educates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathology Explores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signaling Helps researchers learn about the quickly expanding field of chromatin signaling
Book Synopsis Cancer: New Insights for the Healthcare Professional: 2012 Edition by :
Download or read book Cancer: New Insights for the Healthcare Professional: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 3786 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer. The editors have built Cancer: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cancer: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Characterization and Functional Analysis of GCN5/PCAF-containing Complexes in Mammalian Cells by : Yuan-Liang Wang
Download or read book Characterization and Functional Analysis of GCN5/PCAF-containing Complexes in Mammalian Cells written by Yuan-Liang Wang and published by . This book was released on 2008 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Toxicoepigenetics by : Shaun D. McCullough
Download or read book Toxicoepigenetics written by Shaun D. McCullough and published by Academic Press. This book was released on 2018-11-02 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicoepigenetics: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Although its integration into the field of toxicology is in its infancy, epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. Increasing the presence of epigenetics in toxicological research allows for a more in-depth understanding of important aspects of toxicology such as the role of the environment and lifestyle influencing the individual susceptibility to these effects and the trans-generational transmission of these health effects and susceptibilities. Methods chapters are included to help improve efficacy and efficiency of protocols in both the laboratory and the classroom. Toxicoepigenetics: Core Principles and Applications is an essential book for researchers and academics using epigenetics in toxicology research and study. Introduces the fundamental principles and practices for understanding the role of the epigenome in toxicology Presents the foundation of epigenetics for toxicologists with a broad range of backgrounds Discusses the incorporation of epigenetics and epigenomics into current toxicological studies and interpretation of epigenetic data in toxicological applications
Book Synopsis Journal of the National Cancer Institute by :
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1999 with total page 934 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Issues in Biochemistry and Biophysics Research: 2011 Edition by :
Download or read book Issues in Biochemistry and Biophysics Research: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 1907 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Biochemistry and Biophysics Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biochemistry and Biophysics Research. The editors have built Issues in Biochemistry and Biophysics Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biochemistry and Biophysics Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biochemistry and Biophysics Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Handbook of Cell Signaling by : Ralph A. Bradshaw
Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field
Book Synopsis Regulation of Organelle and Cell Compartment Signaling by : Ralph A. Bradshaw
Download or read book Regulation of Organelle and Cell Compartment Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2011-04-12 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that they sense there. All cells have the capacity to achieve this to some degree, albeit with a wide variation in purpose, mechanism, and response. At the same time, there is a remarkable degree of similarity over quite a range of species, particularly in the eukaryotic kingdom, and comparative physiology has been a useful tool in the development of this field. The central importance of this general phenomenon (sensing of external stimuli by cells) has been appreciated for a long time, but it has truly become a dominant part of cell and molecular biology research in the past three decades, in part because a description of the dynamic responses of cells to external stimuli is, in essence, a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to human and animal health is already plainly evident"--Provided by publisher.
Book Synopsis Molecular Biology of B Cells by : Tasuku Honjo
Download or read book Molecular Biology of B Cells written by Tasuku Honjo and published by Elsevier. This book was released on 2014-10-09 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics. Covers signaling mechanisms regulating B cell differentiation Provides information on the development of therapeutics using monoclonal antibodies and clinical application of Ab Contains studies on B cell tumors from various stages of B lymphocytes Offers an integrated view of all aspects of B cells to produce a normal immune response
Book Synopsis DNA and Histone Methylation as Cancer Targets by : Atsushi Kaneda
Download or read book DNA and Histone Methylation as Cancer Targets written by Atsushi Kaneda and published by Springer. This book was released on 2017-09-04 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.
